Loading...


*  Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta...
... are expressed in pancreatic islets as well as glucagon-secreting and insulin-secreting cell lines. Culture of pancreatic islets ... Liver X receptors (LXRs), members of a nuclear hormone receptor family of transcription factors, control cholesterol ... An increase in insulin secretion with T0901317 was also observed in insulin-secreting MIN6 cells. Incubation of MIN6 cells with ... Activation of LXRs modulates insulin secretion in pancreatic β-cells. A: Effects of T0901317 and 9cRA on insulin secretion in ...
  http://diabetes.diabetesjournals.org/content/53/suppl_3/S75
*  Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas | Diabetes
Effect of OXA on glucagon and insulin secretion from isolated pancreatic islets. A: OXA (80 and 100 nmol/l) potentiates the ... cells that becomes activated when blood glucose levels fall. OXA may modulate islet hormone secretion to maintain blood glucose ... We have previously shown that OXA and orexin receptor immunoreactivity is displayed by the insulin-secreting β-cells in the rat ... OXA modulates glucagon and insulin secretion from isolated islets.. We examined the effects of OXA on hormone release from ...
  http://diabetes.diabetesjournals.org/content/52/1/111.full
*  Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in...
... of various signaling proteins in a variety of cellular functions including hormone secretion, survival and apoptosis. In the ... We report herein that exposure of insulin-secreting INS 832/13 cells or normal rat islets to etoposide leads to significant ... of various signaling proteins in a variety of cellular functions including hormone secretion, survival and apoptosis. In the ... prenyl transferase degradation and loss in cell viability in pancreatic β-cells. ...
  http://www.biomedsearch.com/nih/Nifedipine-prevents-etoposide-induced-caspase/23054080.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The β-cells of the pancreatic islets of Langerhans are responsible for appropriately secreting insulin in response to elevated ... Physiology, Issue 88, islet, isolation, insulin secretion, β-cell, diabetes, cAMP production, mouse ... grow the cells as a monolayer or in suspension, and image for cell proliferation, pancreatic markers and human hormones ... Pancreatic beta cells are clustered together within pancreatic islets and act in a coordinated fashion to maintain glucose ...
  https://www.jove.com/visualize/abstract/19956728/perk-regulates-proliferation-development-insulin-secreting-beta-cell
*  Interaction of the Antidiabetic Vanadium Compounds with Hemoglobin and Red Blood Cells | HubPages
... mellitus habitually referred to as diabetes is caused by a decline in insulin secretion by the cells of the pancreatic islet ... The Type 1 diabetes mellitus is portrayed by a deficiency of the insulin-secreting beta cells of the islets of Langerhans found ... but it is assumed that the hormones secreted during gestation decrease a woman's receptivity to insulin, thus, elevated blood ... Two randomized studies comparing NPH insulin to the insulin equivalents; insulin glargine and insulin detemir, correspondingly ...
  https://hubpages.com/health/Interaction-of-the-Antidiabetic-Vanadium-Compounds-with-Hemoglobin-and-Red-Blood-Cells-and-their-distribution
*  Q-RNA, Inc. Company Profile
Lysosomes in nutrient signalling: A focus on pancreatic β-cells.. Regulated insulin secretion from pancreatic β-cells is a ... The islet of Langerhans plays a key role in glucose homeostasis through regulated secretion of the hormones insulin and ... Islet research has focused on the insulin-secreting β-cells, even tho... ... Biosynthesis, structure, and folding of the insulin precursor protein.. Insulin synthesis in pancreatic β-cells is initiated as ...
  https://www.bioportfolio.com/corporate/company/30108/Q-RNA-Inc.html
*  Assays for the Expression and Release of Insulin and Glucose-Regulating Peptide Hormones from Pancreatic β-Cell | SpringerLink
Zhou YP, Grill VE (1994) Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion ... Patch-clamp characterization of somatostatin-secreting 5-cells in intact mouse pancreatic islets. J Physiol 528:497-507 ... Insulin Secretion KATP Channel INS1 Cell RINm5F Cell Photoaffinity Label These keywords were added by machine and not by the ... Assays for the Expression and Release of Insulin and Glucose-Regulating Peptide Hormones from Pancreatic β-Cell. ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-642-27728-3_158-1
*  Diabetes, Diet and Biochemistry | ari.info | ari.info
Insulin appears to be formed from proinsulin before the hormone is liberated from the fi cells of the pancreatic islet. The ... In time perhaps hypertrophy of and then damage to the insulin secreting cells of the pancreatic islets might occur, and ... But this hormone plays a much wider part in metabolic control in general, and the secretion of growth hormone is of ... In the islets of Langerhans-the insulin secreting cell of the pancreas-were revealed. A persist-ing diabetic condition had thus ...
  http://www.animalresearch.info/it/progressi-medicina/articoli-e-conferenze/diabetes-diet-and-biochemistry/
*  FGF21-KO mice display islet hyperplasia and increased b | Open-i
a) Representative photomicrographs of islets stained with hematoxylin and eosin, ... FGF21-KO mice display islet hyperplasia and increased beta-cell proliferation. ( ... beta-cell proliferation and GH-impaired glucose-stimulated insulin secretion (GSIS) in islets. Furthermore, distorted islet ... Islet morphology and insulin-secreting capacity were further evaluated. FGF21-KO mice exhibited insulin resistance while being ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4385948_cddis201580f2&req=4
*  Pancreatic Cancer-Associated Diabetes Is an "Exosomopathy" | Clinical Cancer Research
PCC-derived exosomes were then shown to inhibit insulin secretion in human islets and in INS-1 rat insulinoma cells. ... T3cDM observed in chronic pancreatitis is associated with decreased insulin levels due to the loss of insulin-secreting β cells ... Adrenomedullin was originally identified as a hypotensive hormone isolated from pheochromocytoma and subsequently shown to ... Having previously shown that PCC-derived adrenomedullin inhibits insulin secretion by the β cell, they now focused on how ...
  http://clincancerres.aacrjournals.org/content/21/7/1508
*  endocrine system | anatomy | Britannica.com
Any of the systems found in animals for the production of hormones, substances that regulate the functioning of the organism. ... In primitive fishes the cells responsible for secreting the pancreatic hormones are scattered within the wall of the intestine ... in reptiles and birds there is a predominance of glucagon-secreting cells and relatively few insulin-secreting cells. ... The endocrine cells of all tetrapods are organized into distinct islets as described for humans, although the abundance of the ...
  https://www.britannica.com/science/endocrine-system
*  Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of...
... and peripherally modulates insulin secretion in the pancreatic islets [19]. Nafadotride, a preferential antagonist of dopamine ... are similar with previous reports as a result of the marked destruction of insulin secreting pancreatic β-cells by STZ [25]. ... hormone secretion, vascular tone, renal function, and gastrointestinal motility [38]. Dopamine receptors are reported to be ... Modulation of insulin secretion and 45Ca2+ efflux by dopamine in glucose-stimulated pancreatic islets. Gen Pharmacol. 1994, 25 ...
  https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-43
*  pancreas | Taber's Medical Dictionary
... delta cells secrete somatostatin, which inhibits the secretion of insulin, glucagon, growth hormone from the anterior pituitary ... SEE: pancreatic juice. The islets of Langerhans contain alpha, beta, and delta cells. Alpha cells secrete glucagon, which ... a disease in which insulin secretion is insufficient or completely absent. Insulin-secreting tumors of the pancreas, called ... SEE: diabetes mellitus; SEE: insulin; SEE: pancreatic function tests. -- To view the remaining sections of this topic, please ...
  https://www.tabers.com/tabersonline/view/Tabers-Dictionary/736805/all/pancreas
*  Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet | Diabetes
... receptors in β-cells and M1 muscarinic receptors in δ-cells to modulate hormone secretion from the human pancreatic islet (Fig ... 4A). These cells were somatostatin-secreting δ-cells, and no other cell type within the human islet expressed M1 receptors (Fig ... Pancreatic Islets. We obtained human pancreatic islets from deceased donors from the Human Islet Cell Processing Facility at ... Acetylcholine Elicits Diverse Responses in Endocrine Cells of the Human Islet. We examined hormone secretion from human islets ...
  http://diabetes.diabetesjournals.org/content/63/8/2714?rss=1
*  You Must Know: Toxic Study List
... genistein increases rapid glucose-stimulated insulin secretion in both insulin-secreting cell lines and mouse pancreatic islets ... Low levels of insulin may cause of diabetes type 1. Leptin is a hormone involved in regulating appetite, body weight, fat and ... 2006 Soy Genistein acutely stimulates insulin secretion in pancreatic beta-cells through cAMP-dependent protein kinase pathway ... Soy IS A Dangerous HORMONE DISRUPTOR:. Soy causes agonistic and antagonistic properties on ER alpha and ER Beta in human cells ...
  http://toxicstudylist.blogspot.com
*  Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and...
... this methodology to answer questions not resolved by patch-clamp experiments on isolated single insulin-secreting beta-cells. ... Using this approach, the integrity of the islet is preserved and intercellular communication via gap junctions and paracrine ... and somatostatin-secreting delta-cells and the different mechanisms for glucose-sensing in these cells could be explored. The ... First, the role of a K(+)-current dependent on Ca(2+)-influx for the termination of burst of action potentials in beta-cells ...
  https://www.rdm.ox.ac.uk/publications/15706
*  List of distinct cell types in the adult human body - Wikipedia
Beta cells (secreting insulin and amylin) Delta cells (secreting somatostatin) PP cells (gamma cells) (secreting pancreatic ... renin secretion) Macula densa cell of kidney Peripolar cell of kidney Mesangial cell of kidney Pancreatic islets (islets of ... Parathyroid gland cells Parathyroid chief cell Oxyphil cell Adrenal gland cells Chromaffin cells secreting steroid hormones ( ... Hybridoma cell Mast cell Helper T cell Suppressor T cell Cytotoxic T cell Natural killer T cell B cell Natural killer cell ...
  https://en.wikipedia.org/wiki/List_of_distinct_cell_types_in_the_adult_human_body
*  Streptozotocin - Wikipedia
In the mid-1960s, streptozotocin was found to be selectively toxic to the beta cells of the pancreatic islets, the cells that ... Rerup CC (1970). "Drugs producing diabetes through damage of the insulin secreting cells". Pharmacol Rev. 22 (4): 485-518. PMID ... "Treatment of multiple-hormone-producing malignant islet-cell tumour with streptozotocin". Lancet. 2 (7574): 895-8. doi:10.1016/ ... especially hypoglycemia due to excessive insulin secretion by insulinomas). A typical dose is 500 mg/m2/day by intravenous ...
  https://en.wikipedia.org/wiki/Streptozotocin
*  Mir-375 - Wikipedia
"Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid ... "miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein ... It is expressed in the pancreas and pituitary gland, organs linked by their role in hormone secretion, and expression levels ... This shows the importance of miR-375 in the establishment of normal pancreatic cell mass through the targeting of a group of ...
  https://en.wikipedia.org/wiki/Mir-375
*  Lateral hypothalamus - Wikipedia
... autoimmune mediated destruction of these neurons in analogy with the autoimmune destruction of insulin-secreting β-islet cells ... stimulating pancreatic exocrine secretion (Miyasaka et al., 2002). Administration of orexin-A, i.a., increases duodenal ... melanin-concentrating hormone, nociceptin, glucose, the dynorphin peptides, and the appetite-regulating peptide hormones leptin ... Activity of PT cholinergic neurons (REM-on cells) promotes REM sleep. During waking, REM-on cells are inhibited by a subset of ...
  https://en.wikipedia.org/wiki/Lateral_hypothalamus
*  Pancreas - Wikipedia
... in the various cells of the endocrine pancreatic islets and have functions related to secreted hormones such as insulin, ... decreases secretion from beta cells, increases secretion from alpha cells, β2: increases secretion from beta cells ... and PP cells, or γ (gamma) cells, secrete pancreatic polypeptide. These act to control blood glucose through secreting glucagon ... The multi-potent pancreatic progenitor cells have the capacity to differentiate into any of the pancreatic cells: acinar cells ...
  https://en.wikipedia.org/wiki/Pancreas
*  12-Hydroxyeicosatetraenoic acid - Wikipedia
... secretion and caused apoptosis in cultured human pancreatic insulin-secreting Beta cell lines and prepared Pancreatic islets. ... Unlike hormones which are secreted by cells, travel in the circulation to alter the behavior of distant cells, and thereby act ... T lymphocye cell line), Hut78 cells (T cell lymphoma cell line), HEK 293 cells (primary embryonic kidney cell line), MCF7 cells ... TNFα, IL-1β, and IFNγ also reduced insulin secretion in cultured human pancreatic INS-1 beta cells, apparently by inducing the ...
  https://en.wikipedia.org/wiki/12-Hydroxyeicosatetraenoic_acid