*  A Candidate Hypertension Gene | Circulation Research
The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several ... Bornstein P. Thrombospondins: structure and regulation of expression. Faseb J. 1992; 6: 3290-3299. ... Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses. Cardiovasc Res. 2006; 71: 785-793. ... CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol. 1997; 138: 707-717. ...
  http://circres.ahajournals.org/content/100/7/940
*  PROSITE
Vertebrate thrombospondin 1 and 2. Thrombospondins are a class of extracellular adhesive proteins that mediate cell-to-cell and ... The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several ... The thrombospondin type-1 repeat (TSP1) was first identified as an about 55 amino acids long module present in thrombospondin 1 ... TSP1, PS50092; Thrombospondin type-1 (TSP1) repeat profile (MATRIX). * Sequences in UniProtKB/Swiss-Prot known to belong to ...
  https://prosite.expasy.org/PDOC50092
*  Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization | BMC Evolutionary Biology |...
... that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins ... A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence ... ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins have homology with the metalloprotease ... de Fraipont F, Nicholson AC, Feige JJ, Van Meir EG: Thrombospondins and tumor angiogenesis. Trends Mol Med. 2001, 9 (7): 401- ...
  https://0-bmcevolbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2148-5-11
*  Biomolecules | Free Full-Text | Comparative Studies of Vertebrate Platelet Glycoprotein 4 (CD36) | HTML
... and may contribute to fatty acid and thrombospondin binding. Vertebrate CD36 genes usually contained 12 coding exons. The human ... CD36 serves as a ligand receptor of thrombospondin, long chain fatty acids, oxidized low density lipoproteins (LDLs) and ... Bentley, A.A.; Adams, J.C. The evolution of thrombospondins and their ligand-binding activities. Mol. Biol. Evol. 2010, 27, ... sequence homology) which is predominantly conserved, particularly near Thr92, which is phosphorylated by protein kinase C alpha ...
  http://mdpi.com/2218-273X/2/3/389/htm
*  SMART: VWD domain annotation
Furthermore, we describe homology with antistasin, an anticoagulant peptide from a leech. We also discuss some implications ... Each module has homologues in other extracellular mosaic proteins such as Von Willebrand factor, slit, thrombospondins, ... and XII collagens was found to be homologous to the heparin binding domain of thrombospondin; (ii) the modular architecture of ... Here, we have employed full length vWF cDNA to construct a series of deletion mutants, based on the homology between the ...
  http://smart.embl-heidelberg.de/smart/do_annotation.pl?DOMAIN=VWD&BLAST=DUMMY
*  Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down...
Thrombospondin-2 (TSP-2) is a secreted matricellular glycoprotein that is found to mediate cell-to-extracellular matrix ... Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Sci. 2008;65:700-12.View ArticlePubMedPubMed Central ... Since, TSP-2 is the homology to TSP-1, we considered that TSP-2 may share the similar mechanism to TSP-1, showing the promotion ... Mechanisms of thrombospondin-1-mediated metastasis and angiogenesis. Semin Thromb Hemost. 2004;30:127-36.View ArticlePubMed ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0390-6
*  MODULATION OF SYNAPTOGENESIS - Patent application
The thrombospondin gene family is divided into two subgroups. Subgroup A thrombospondins includes TSP1 and 2, which are ... One domain identified by sequence homology in the extracellular sequence of all α2δ subunits is the von Willebrand factor type ... a thrombospondin. [0013] In some embodiments, the thrombospondin antagonist agent binds to a thrombospondin and blocks the ... thrombospondin type I domain, thrombospondin type 3 repeat, and/or thrombospondin C-terminal region. In some embodiments, the ...
  http://www.patentsencyclopedia.com/app/20110104181
*  VLDL receptor - Wikipedia
This level of homology between species is much higher than that found for LDLR. Hence, these gene comparisons suggest that ... Receptor-associated protein (RAP) and thrombospondin-1 (THBS1) have been identified as compounds that bind VLDLR. In many cases ... Oganesian A, Armstrong LC, Migliorini MM, Strickland DK, Bornstein P (February 2008). "Thrombospondins use the VLDL receptor ... VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely ...
  https://en.wikipedia.org/wiki/VLDL_receptor
*  Subcommissural organ - Wikipedia
Meiniel A, Meiniel R, Gonçalves-Mendes N, Creveaux I, Didier R, Dastugue B (2003). "The thrombospondin type 1 repeat (TSR) and ... Nevertheless, SCO-spondin is also present during the adult life, and similarly to thrombospondins, which act on various ... The putative function of SCO-spondin in neuronal differentiation is discussed regarding these features and homologies with ... The motifs coagulation factor 5/8 type C or discoidin and thrombospondin type 1 repeat (TSR) present in SCO-spondin consensus ...
  https://en.wikipedia.org/wiki/Subcommissural_organ