Predator-induced stress and the ecology of fear - Clinchy - 2012 - Functional Ecology - Wiley Online Library
Allostasis, Homeostasis and the Costs of Physiological Adaptation (ed. J. Schulkin), pp. 164-227. Cambridge University Press, ... Rosen, J.B. & Schulkin, J. (2004) Adaptive fear, allostasis, and the pathology of anxiety and depression. ... of the stress axis is to maintain homeostasis, chronic stress must be maladaptive and pathological, and hence cannot exist in ... sustained psychological stress', the physiological stress effects reported could also result from 'chronic physical challenges ...http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.12007/full?globalMessage=0
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy
The UPR is tailored essentially to reestablish ER homeostasis also through adaptive mechanisms involving the stimulation of ... Various physiological and pathological conditions, including hypoxia, ER-. depletion, oxidative injury, high-fat diet, ... From ER Stress to Cell Death. When the initial cellular responses fail to restore ER homeostasis, sustained ER stress causes ... dependent and independent stress signals. Another -activated kinase that regulates autophagy in response to ER stress is the ...https://www.hindawi.com/journals/ijcb/2010/930509/
Rumination as a Mediator of Chronic Stress Effects on Hypertension: A Causal Model
... which can be described as a resetting of the physiological set points in an attempt to maintain homeostasis and thus function, ... but at a new set point (e.g., higher blood pressure). In the short-run, achieving allostasis is adaptive (e.g., the higher ... Thus, rumination helps explain how chronic stress causes repeated (acute) activation of one's stress-mediating physiological ... often stemming from the chronic stress context) that cause activation of stress-mediating physiological systems. Previous ...https://www.hindawi.com/journals/ijhy/2012/453465/
Mechanism of Inflammation in Age-Related Macular Degeneration
Although the physiological purposes of normal parainflammation are to preserve tissues homeostasis and to restore their ... Parainflammation is defined as a condition of tissue adaptive response to noxious stress or malfunction, and it has features ... and consequently can also promote adaptive immunity in either direct or indirect manner . To restore tissue homeostasis, by ... Light-related stress and other oxidative damages increase in retinal tissue with the aging, as does the para-inflammatory ...https://www.hindawi.com/journals/mi/2012/546786/
In Vivo Effect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive...
Mammalian cells cope with xenobiotics by adaptive defense mechanisms to maintain cellular homeostasis and physiological ... Trace elements play an important role in maintaining normal homeostasis of the body. Oxidative stress results from changes in ... Oxidative stress is a relatively new theory in assessment of arsenic toxicity [51, 52]. Arsenic causes oxidative stress by ... involvement of cellular adaptive response to oxidative stress," Environmental Health Perspectives, vol. 118, no. 6, pp. 864-870 ...https://www.hindawi.com/journals/isrn/2013/817693/
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
... and oxidative stress. Distress differs from stress, which is a physiological reaction that can lead to an adaptive response [22 ... Today, stress can be defined as a process of altered biochemical homeostasis produced by psychological, physiological, or ... Stress is a commonly used term for oxidative stress. Any alteration in homeostasis leads to an increased production of these ... 5. Physiological Role of Stress. Stress has a significant ecological and evolutionary role and may help in understanding the ...https://www.hindawi.com/journals/bmri/2014/761264/
Reality as the leading cause of stress: rethinking the impact of chronic stress in nature - Boonstra - 2012 - Functional...
First, homeostasis was used for the coordinated physiological processes to maintain a steady state in an animal. This was ... If it is adaptive to be chronically stressed, they will evolve in that direction; if not, they will only respond acutely. If ... The Ecology Of Stress. Reality as the leading cause of stress: rethinking the impact of chronic stress in nature. Authors. *. ... A brief history of stress physiology and chronic stress. The history of how we have come to think of the role of stress in ...http://onlinelibrary.wiley.com/doi/10.1111/1365-2435.12008/full
Frontiers | Neural control of chronic stress adaptation | Frontiers in Behavioral Neuroscience
... likely due to altered limbic control of stress effector pathways. Stress-related disorders, such as depression and PTSD, are ... likely due to altered limbic control of stress effector pathways. Stress-related disorders, such as depression and PTSD, are ... The long-term impact of stress is kept in check by the process of habituation, which reduces HPA axis responses upon repeated ... The long-term impact of stress is kept in check by the process of habituation, which reduces HPA axis responses upon repeated ...https://www.frontiersin.org/articles/10.3389/fnbeh.2013.00061/full
All Hardgainers are Not Created Equal | T Nation
Skinny-fat hardgainers suffer from an overactive sympathetic nervous system, and an extreme hypersensitivity to stress of any ... This is the physiological system that kicked in when we had to escape predators back in the Paleolithic Age, and now takes over ... This intricate and highly adaptive response is known as the "fight or flight" response, and is mediated by one branch of your ... This is referred to as homeostasis, the body's ability to maintain a relatively constant internal environment. Anything from ...https://www.t-nation.com/training/all-hardgainers-are-not-created-equal
Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic...
Therefore, the ER stress-autophagy pathway presents a potential molecular target for therapeutic intervention. The objective of ... Co-administration of modulators of ER stress-mediated autophagy with chemotherapy presents a novel therapeutic approach in PDAC ... this study was to evaluate the therapeutic efficacy of ER stress and autophagy modulators in the context of pancreatic ductal ... stress and its consequent unfolded protein response (UPR) are believed to be associated with progression, survival and ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1562-z
Fibromyalgia: When Distress Becomes (Un)sympathetic Pain
An acceptable physiological definition of stress could be "any stimuli, physical or emotional, that threatens homeostasis" [7 ... FM can be viewed as a failed attempt of our main complex adaptive system to accommodate to a hostile environment. A disease in ... 2. Stress, Distress, and Allostasis. The term stress is used in various ways and has different interpretations. Stress has been ... "The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis," Journal of the American ...https://www.hindawi.com/journals/prt/2012/981565/
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Arguments are presented here that bleaching provides the final control to minimize physiological damage from stress as an ... As such, bleaching meets the requirements of a stress response syndrome/general adaptive mechanism that is sensitive to ... The control processes for homeostasis are compromised by environmental stress, resulting in metabolic imbalance between the ... Operationalizing resilience for adaptive coral reef management under global environmental change.. Kenneth R N Anthony, Paul A ...https://www.jove.com/visualize?author=David+Obura
Amino acids regulate salinity-induced potassium efflux in barley root epidermis - Open Access Repository
in salt-stressed plants. The physiological relevance. of this phenomenon remains largely unknown.. Using the MIFE ion Xux ... on K+ homeostasis. Our results suggest that physiologically. relevant concentrations of free amino acids. might contribute to ... plant adaptive responses to salinity. by regulating K+ transport across the plasma membrane,. thus enabling maintenance of an ... plant damage by stress. Investigating the speciWc mechanisms. of such amelioration remains a key issue for. future studies. ...https://eprints.utas.edu.au/3857/
Developmental origins of non-communicable disease: Implications for research and public health | Environmental Health | Full...
... cellular plasticity and a variety of stress signals such oxidative and endoplasmic reticulum stress. These influence epigenetic ... If there is a mismatch between the adaptive change and the subsequent lifetime environment then the response will likely be in ... In both cases, alterations in physiological functions can be induced and may lead to the development of non-communicable ... In contrast, the human body has evolved mechanisms of developmental plasticity and homeostasis to cope with changes in ...https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-11-42
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Medicine, Issue 56, Stress, anxiety, laboratory stressor, cortisol, physiological response, psychological stressor ... Macrophages are critical components of the innate and adaptive immune responses, and they are the first line of defense against ... is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via ... Of psychological stress protocols, meta-analysis suggests that the Trier Social Stress Test (TSST) is the most useful and ...https://www.jove.com/visualize/abstract/23431364/acute-stress-reduces-wound-induced-activation-microbicidal-potential
Transcriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin...
... energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate ... J. J. Wu, C. Quijano, E. Chen et al., "Mitochondrial dysfunction and oxidative stress mediate the physiological impairment ... N. Wu, L. Yin, E. A. Hanniman, S. Joshi, and M. A. Lazar, "Negative feedback maintenance of heme homeostasis by its receptor, ... indicating that this adaptive response requires ROS signal . Together, autophagy-dependent mitochondrial turnover in ...https://www.hindawi.com/journals/ppar/2012/348245/
Frontiers | Dissecting the Biochemical and Transcriptomic Effects of a Locally Applied Heat Treatment on Developing Cabernet...
These physiological alterations could be partly explained by the deep remodelling of transcriptome in heated berries. More than ... These physiological alterations could be partly explained by the deep remod... ... depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of ... depending on the developmental stage and the stress duration. When applied at the herbaceous stage, HT delayed the onset of ...https://www.frontiersin.org/articles/10.3389/fpls.2017.00053/full
Antioxidants | Free Full-Text | 4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa: Implications for the Stomach...
... are important mediators in physiological adaptive reactions and signaling, but they are also thought to be implicated in the ... The health of the gastric epithelium highly depends on redox homeostasis, antioxidant defense, and activity of detoxifying ... or the relevance of antioxidants for HNE-related redox homeostasis in GM, still need more studies and new comprehensive ... Exercise-Induced Oxidative Stress and the Effects of Antioxidant Intake from a Physiological Viewpoint ...https://www.mdpi.com/2076-3921/7/9/118
Heinz Baumann, PhD | Roswell Park Comprehensive Cancer Center
Regulation of Gene Expression and Cell Proliferation by Hormones and Cytokines as Part of Homeostasis, Stress Response, ... The second program focuses on the genetics and biology of the hepatic acute phase response and the physiological role of the ... and direct the innate and adaptive immune responses. This laboratory pursues two long-term research programs. The first program ... Regulation of Gene Expression and Cell Proliferation by Hormones and Cytokines as Part of Homeostasis, Stress Response, ...https://www.roswellpark.org/heinz-baumann
alpha 1b Adrenergic Receptor Proteins
... for the physiological hypertrophy of normal postnatal cardiac development and for an adaptive response to cardiac stress ... provide new evidence for the physiological importance of alpha1B-adrenoceptor signalling in bone homeostasis ... alpha 1b Adrenergic Receptor in Carbohydrate Homeostasis * alpha 1b Adrenergic Receptor in Regulation of Carbohydrate Metabolic ...https://www.antikoerper-online.de/ampk-signaling-pathway-15/alpha-1b-adrenergic-receptor-protein-43992/
IJMS | Free Full-Text | Oxidative Stress and Neurodegenerative Disorders | HTML
ROS at low or moderate concentration can play important physiological roles. However, an excessive amount of ROS under ... Thus, oxidative stress elicits various neurodegenerative diseases. In addition, chemotherapy could result in severe side ... In this review, we summarize the source, balance maintenance and physiologic functions of ROS, oxidative stress and its toxic ... The central nervous system (CNS) is particularly vulnerable to oxidative stress due to its high oxygen consumption, weakly ...http://www.mdpi.com/1422-0067/14/12/24438/htm
Tissue stress - Wikipedia
This universal physiological reaction plays a role of TAS executive mechanism. Thus, the adaptive function of tissue stress is ... These effectors cause tissuespecific self-damage of homologous cells via disturbance of their ion homeostasis and energy- ... Tissue stress (tissue adaptive syndrome) is an unspecific adaptive reaction universal for all tissues of adult organism which ... two physiological functions of tissue stress, which are realized in the process of participation of its adaptive mechanism, can ...https://en.wikipedia.org/wiki/Tissue_stress
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
... and whether the physiological consequences of mRNA decay are adaptive or destructive. IRE1α was also linked to pro-apoptotic c- ... If ER stress is successfully reduced, negative feedback causes UPR signaling to wane as homeostasis becomes restored (Merksamer ... Moreover, all these compounds allow XBP1 mRNA splicing to proceed fully under ER stress. Under Tg-induced ER stress, APY29 ... These results argue that under low ER stress conditions, IRE1α preferentially splices XPB1, while at higher stress it also ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2762408/?lang=en-ca
Relationship between Glycemic Levels and Treatment Outcome among Critically Ill Children admitted into Emergency Room in Enugu ...
Initially, stress induced hyperglycemia during critical illness was thought to be an adaptive response that was either ... However, any form of stress that follows critical states may lead to profound impairments in this homeostasis . ... unimportant or improved survival . However, it is no longer considered a physiological or benign condition as it results ... Srinivasan V. Stress Hyperglycemia in Pediatric Critical Illness: The Intensive Care Unit adds to the stress! J Diabetes Sci ...https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-017-0879-8
Rab7b modulates autophagic flux by interacting with Atg4B | EMBO Reports
... is a catabolic cellular process essential in several physiological processes such as maintenance of basal homeostasis, stress ... and innate and adaptive immunity , , , . During autophagy, cytosolic components are sequestered by unique double‐ ... The autophagic pathway maintains basal cellular homeostasis and helps cells adapt during stress; thus, defects in autophagy can ... Mizushima N (2009) Physiological functions of autophagy. Curr Top Microbiol Immunol 335: 71-84. ...http://embor.embopress.org/content/18/10/1727