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*  Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway
... as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. ... studies tried to better assess the cellular localization and molecular mechanisms underlying ANGPTL4 role in lipid metabolism, ... glucose homoeostasis, lipid metabolism, energy homeostasis, wound healing, inflammation, and redox regulation [80]. ... glucose homoeostasis, lipid metabolism, energy homeostasis, wound healing, inflammation, and redox regulation. The ...
  https://www.hindawi.com/journals/ppar/2017/8187235/
*  Negative Iron Balance Predicts Acute Heart Failure Survival | Science 2.0
Iron is needed for cellular metabolism and deficiency leads to severely impaired energy metabolism and mitochondrial ... She continued: "Previous studies have shown that patients at high cardiovascular risk - for example diabetics with coronary ... Iron is a key micronutrient that is required for the maintenance of homeostasis. ... to assess iron utilisation in the cell. These measures cannot be reliably interpreted in acute clinical settings because they ...
  http://www.science20.com/news_articles/negative_iron_balance_predicts_acute_heart_failure_survival-136544
*  Changes in Bone Biomarkers, BMC, and Insulin Resistance Following a 10-Week Whole Body Vibration Exercise Program in Overweight...
2, 28] established the novel link between bone metabolism and glucose homeostasis, insulin sensitivity, and fat metabolism ... Lee NK, Karsenty G. Reciprocal regulation of bone and energy metabolism. Trends Endocrinol Metab. 2008;19:161-166 ... With studies suggesting that bone metabolism may be closely linked to metabolic disorders, the present study was designed to: 1 ... Within group changes were determined using a paired samples t-test, while independent t-tests were used to assess between group ...
  http://www.medsci.org/v12p0494.htm
*  Physiology of ageing | Interface Focus
The same is true for processes related to metabolism which lead to cellular damage. An attempt was made to model energy ... These studies of human metabolism can be used to determine shifts in metabolism during ageing. The shifts in metabolic fluxes ... Metabolism and homeostasis. Nutrients, absorbed in the gut and delivered to the cells via the blood, are extensively processed ... HRV analysis has also been applied to assess athletic training [54]. Decline of HRV during ageing may therefore be considered ...
  http://rsfs.royalsocietypublishing.org/content/6/2/20150079
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Mitochondria from rat heart is one of the most common preparations for past and current studies of cellular metabolism ... These methods allow for a selective activation/inhibition of individual PKC isozymes to assess their role in cellular functions ... Mitochondria are cytoplasmic organelles that have a primary role in cellular metabolism and homeostasis, regulation of the cell ...
  https://www.jove.com/visualize/abstract/22194845/galactose-enhances-oxidative-metabolism-reveals-mitochondrial
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Methods to Assess Subcellular Compartments of Muscle in C. elegans. Authors: Christopher J. Gaffney, Joseph J. Bass, Thomas F. ... A high rate of new mutations may in part explain why genetic studies have so far failed to identify many genes predisposing to ... 1), not disposed of by autophagy, can represent a threat to cellular homeostasis and cell survival. In the yeast, Saccharomyces ...
  https://www.jove.com/visualize/abstract/21359198/distinct-early-molecular-responses-to-mutations-causing-vlincl-jncl
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Real time metabolic studies in this crypt organoid culture system are a powerful tool to study crypt organoid energy metabolism ... Methods to Assess Subcellular Compartments of Muscle in C. elegans. Authors: Christopher J. Gaffney, Joseph J. Bass, Thomas F. ... Cellular Biology, Issue 46, Mitochondrial dysfunction, cellular, bioenergetics, metabolism, cancer, obesity, diabetes, aging, ...
  https://www.jove.com/visualize/abstract/23520503/metabolic-adaptation-to-chronic-inhibition-mitochondrial-protein
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Recent studies have uncovered links between protein homeostasis (proteostasis), metabolism, development, aging, and temperature ... These methods allow for a selective activation/inhibition of individual PKC isozymes to assess their role in cellular functions ... Cellular Biology, Issue 46, Mitochondrial dysfunction, cellular, bioenergetics, metabolism, cancer, obesity, diabetes, aging, ...
  https://www.jove.com/visualize/abstract/23285122/inactivation-march5-prevents-mitochondrial-fragmentation-interferes
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Mitochondria from rat heart is one of the most common preparations for past and current studies of cellular metabolism ... To assess how central myelinated axons of the spinal cord respond to injury, we developed an ex vivo living spinal cord model ... Mitochondria are cytoplasmic organelles that have a primary role in cellular metabolism and homeostasis, regulation of the cell ...
  https://www.jove.com/visualize/abstract/22563492/alternative-splicing-spg7-gene-involved-hereditary-spastic-paraplegia
*  The Use of Anti-Diabetic Drugs in Alzheimer's Disease, New Therapeutic Options and Future Perspective
Clinical studies and preclinical data in the last decade proved that AD and Diabetes mellitus share a pathophysiological ... Since there's a connection between AD pathogenesis and cellular mechanisms of energy homeostasis, targeting AMPK pathway in ... Based on the shared pathophysiology between diabetes and AD, several studies have been conducted to assess the neuroprotective ... Studies show that impaired glucose metabolism in the brain can increase the risk of dementia [15] . Hypertension and high blood ...
  http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85437
*  Our Funded Projects - 2011 - Rettsyndrome.org
... mitochondria are the most important supplier of cellular energy, contribute to cellular Ca2+ regulation, constitute a major ... These studies will be complemented by biochemical assays rating the efficiency of mitochondrial metabolism under normal and ... Attempts to assess cognitive functioning in patients with Rett Syndrome (RTT) have been extremely difficult. At the Rett Center ... Following this concept we will clarify whether modulating Ca2+ homeostasis and redox balance is capable of restoring neuronal ...
  https://www.rettsyndrome.org/research/our-funded-programs/research-awardees/2011
*  Frontiers | Rodent Models for the Analysis of Tissue Clock Function in Metabolic Rhythms Research | Endocrinology
Clock function and metabolism are tightly coupled, from the cellular to the organismal level. Genetic and non-genetic ... to the ubiquitous expression of clock genes and the intricate interaction between the circadian system and energy metabolism, ... special requirements regarding specificity and efficiency have to be met to allow for valid conclusions from such studies. In ... genetic approaches targeting specific tissue clocks has been used to assess their contribution in systemic metabolic processes ...
  https://www.frontiersin.org/articles/10.3389/fendo.2017.00027/full
*  Deletion of the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Results in Impaired Insulin Secretion
Future studies will be designed to examine whether the absence of ZnT-8 affects glucose metabolism under conditions more ... mice carrying a Slc30a8 exon 3 deletion were analyzed histologically and phenotyped for energy metabolism and pancreatic ... To directly assess the impact of ZnT-8 on islet function, GSIS was compared in islets isolated from male wild type and ZnT-8 ... Zinc homeostasis is maintained by two types of proteins, namely metallothioneins and zinc transporters [1], the former being ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2929527/
*  PubMed Journals Articles About 'A Study To Assess The Effect Of Ketoconazole On The Metabolism Of ABT-263 (Navitoclax).'
A Study To Assess The Effect Of Ketoconazole On The Metabolism Of ABT-263 (Navitoclax). PubMed Journal Articles published on ... This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 ... Earlier studies on glucose metabolism in B-cells suggested an active TCA cycle in both naïve B cells and differentiated IgA ... ACSL5 Genotype Influence On Fatty Acid Metabolism: A Cellular, Tissue, And Whole-Body Study. ...
  https://www.bioportfolio.com/resources/pubmed/?keyword=A+Study+to+Assess+the+Effect+of+Ketoconazole+on+the+Metabolism+of+ABT-263+%28Navitoclax%29.&orderfield=score&orderval=desc
*  Protocols and Video Articles Authored by Werner J. H. Koopman
To gain cell-biochemical knowledge about the operation and regulation of the cellular energy metabolism in the healthy and ... Our findings demonstrate a key role for PINK1 in the regulation of mitochondrial homeostasis and energy metabolism under ... In these studies chemical compounds were used that target cellular aberrations induced by complex I dysfunction. Before the ... cellular ROS levels is a challenging task. In this chapter we describe two strategies to measure ROS: one approach to assess ...
  https://www.jove.com/author/Werner++J.+H._Koopman
*  Cardiomyocyte ATP Production, Metabolic Flexibility, and Survival Require Calcium Flux through Cardiac Ryanodine Receptors in...
... is required to maintain cellular energy homeostasis and survival in vivo. We used tissue-specific inducible gene ablation to ... In vitro studies have shown that Ca2+ flux from ER/SR stimulates metabolism in adjacent mitochondria (2, 3, 12). We used cRyr2 ... Future studies will be required to assess Ca2+ in these compartments in beating cardiomyocytes, ideally within the intact heart ... In our previous studies of other cell types, loss of metabolism-pacing Ca2+ communication between RyR channels and mitochondria ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3696672/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Methods to Assess Subcellular Compartments of Muscle in C. elegans. Authors: Christopher J. Gaffney, Joseph J. Bass, Thomas F. ... During our studies of death-initiation in Streptococcus pneumoniae (pneumococcus), we wanted to elucidate the role of membrane ... Cellular Biology, Issue 46, Mitochondrial dysfunction, cellular, bioenergetics, metabolism, cancer, obesity, diabetes, aging, ...
  https://www.jove.com/visualize/abstract/23626747/penetrating-cations-enhance-uncoupling-activity-anionic-protonophores
*  Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells...
... immune-related biomarkers for future studies. Although the different levels of dietary fish and vegetable oils involved in this ... Further studies are required to characterise fabp4 in Atlantic salmon and to determine the fatty acid metabolism- and immune- ... and to assess the antiviral response and cellular function of each individual fish fed a given experimental diet. However, it ... was suggested to be a modulator of energy homeostasis [65]. Further, fabp4-deficient macrophages of mice developed impaired ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4099-2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... Mitochondria from rat heart is one of the most common preparations for past and current studies of cellular metabolism ... These methods allow for a selective activation/inhibition of individual PKC isozymes to assess their role in cellular functions ... A? oligomers further impair energy metabolism by decreasing neuronal ATP levels. A?-induced HKI cellular redistribution was ...
  https://www.jove.com/visualize/abstract/21179577/amyloid-triggers-release-neuronal-hexokinase-1-from
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... These methods allow for a selective activation/inhibition of individual PKC isozymes to assess their role in cellular functions ... During our studies of death-initiation in Streptococcus pneumoniae (pneumococcus), we wanted to elucidate the role of membrane ... Vitamin C (ascorbate) plays numerous important roles in cellular metabolism, many of which have only come to light in recent ...
  https://www.jove.com/visualize/abstract/22870326/the-effect-gonadotropin-on-glucose-transport-apoptosis-rat
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Mitochondria have roles in many cellular processes, from energy metabolism and calcium homeostasis to control of cellular ... These methods allow for a selective activation/inhibition of individual PKC isozymes to assess their role in cellular functions ... Here, we consider the zebrafish embryo as a useful in vivo system to perform such studies and present a protocol to measure in ... situations such as cellular metabolism 3, 4. Indeed, ROS play important roles in many cellular signaling pathways ( ...
  https://www.jove.com/visualize/abstract/19956735/multiple-functions-of-nm23-h1-are-regulated-by-oxido-reduction-system
*  Insulin Deprivation Decreases Caspase-Dependent Apoptotic Signaling in Cultured Rat Sertoli Cells
... that key proteins involved in apoptotic signaling interact with and have effects on cellular energy metabolism and homeostasis ... Several studies using animal models strongly suggest that T1DM impairs male fertility [29, 30]; however, the involved ... Specific protein markers, anti-mullerian hormone (AMH) and vimentin, were used to assess the purity of rat SCs cultures as ... F. Boussouar and M. Benahmed, "Lactate and energy metabolism in male germ cells," Trends in Endocrinology and Metabolism, vol. ...
  https://www.hindawi.com/journals/isrn/2013/970370/
*  Neuroprotection: A New Therapeutic Approach of Relapsing Remitting Multiple Sclerosis | IntechOpen
... which couple the electrical activity of the cell to energy metabolism [61, 62]. An increase in the cellular ATP concentration ... to analyse the metabolic effects of EGCG and to assess the importance of lipid oxidation in fuel muscle's energy metabolism and ... On the other hand, considering the unique role that KATP channels play in the maintenance of cellular homeostasis, KCOs add ... Efficacy studies in the EAE models for MS have shown that, alone or in combination with approved treatments for MS, oral EGCG ...
  https://www.intechopen.com/books/trending-topics-in-multiple-sclerosis/neuroprotection-a-new-therapeutic-approach-of-relapsing-remitting-multiple-sclerosis/
*  Repositorio da Producao Cientifica e Intelectual da Unicamp: Estudo da expressão genica global na fase tardia da proteção...
Our results indicate that various cellular responses, including the energetic metabolism, ion homeostasis and changes in cell ... Studies focusing the mechanistic modifications of these groups of genes will contribute to elucidate their involvement in the ... effect of DMA and also the expression of genes and proteins associated with modifications in cardiac energy metabolism. ... of differentially expressed genes in terms of metabolic and signaling pathways in which they are inserted allowed us to assess ...
  http://repositorio.unicamp.br/jspui/handle/REPOSIP/310219
*  31P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism | Diabetes
Under basal conditions, protein synthesis and the maintenance of ion homeostasis are likely to be the major cellular processes ... Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 2000;275:16258-16266pmid:10748196. ... Different experimental techniques to assess muscle metabolism in vivo (e.g. Pi → ATP flux by 31P-ST, oxidative capacity by PCr ... As such, these studies can be accomplished under conditions that minimize the perturbation of resting muscle metabolism, are ...
  http://diabetes.diabetesjournals.org/content/61/11/2669