*  Frontiers | HLA-DO and Its Role in MHC Class II Antigen Presentation | Immunology
Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Malfunctions during any step of antigen processing could lead to the development of self-reactive T cells or defective immune ... DO was discovered in association with another chaperone HLA-DM (DM) but unlike DM, its distribution is more tissue specific, ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00260/full
*  Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity...
Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ... Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity ...
  http://www.pnas.org/content/80/22/6962
*  HLA-DR4 - Wikipedia
"Strong association between IgA nephropathy and HLA-DR4 antigen". Kidney Int. 22 (4): 377-82. doi:10.1038/ki.1982.185. PMID ... HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of ... "HLA-DR antigens in pemphigus among Japanese". Tissue Antigens. 17 (2): 238-9. doi:10.1111/j.1399-0039.1981.tb00689.x. PMID ... derived from IMGT/HLA Roudier J (2006). "HLA-DRB1 genes and extraarticular rheumatoid arthritis". Arthritis Research & Therapy ...
  https://en.wikipedia.org/wiki/HLA-DR4
*  Juvenile chronic arthritis | definition of juvenile chronic arthritis by Medical dictionary
Patients with juvenile chronic arthritis with the HLA-DR4 antigen have a 57.. Slipped capital femoral epiphysis in identical ... twins: is there an HLA predisposition? Report of a case and review of the literature ...
  https://medical-dictionary.thefreedictionary.com/juvenile+chronic+arthritis
*  Structure Cluster - 1J8H: Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen...
HLA-DR4 (DRA*0101 and DRB1*0401): insight into TCR cross-restriction and alloreactivity. ... Description: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR-4 BETA CHAIN protein , Length: 192 ... Description: HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN protein , Length: 181 ... Crystal Structure of a Complex of a Human alpha/beta-T cell Receptor, Influenza HA Antigen Peptide, and MHC Class II Molecule, ...
  http://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1J8H
*  Felty's syndrome - Wikipedia
Some patients have Human Leukocytic Antigen (HLA-DR4) in their serum. This syndrome is mostly present in people having extra ...
  https://en.wikipedia.org/wiki/Felty's_syndrome
*  Antiperinuclear factors are present in polyarthritis before ACR criteria for rheumatoid arthritis are fulfilled | Annals of the...
1995) How useful are tests for rheumatoid factors, antiperinuclear factors, antikeratin antibody and the HLA DR4 antigen for ... 1994) The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis. J Rheumatol 21:1027-1033, . ... An enzyme linked immunosorbent assay for these antibodies is unlikely to be available in the near future as the antigen is ... 1990) Histologic and electronic microscopic characterization of the antiperinuclear factor antigen. Arthritis Rheum 33:960-969 ...
  http://ard.bmj.com/content/56/2/123
*  Rheumatoid arthritis
... is a common sequence of amino acids on the HLA-DR4 antigen seen in the vast majority of patients with RA.4 Certain antigen ... Smoking in patients with the HLA-DR4 antigen seems to act as an important risk factor for citrullination of synovial protein, ... but probably resemble or mimic synovial tissue antigens. Antigen stimulation leads to a cascade of events in a genetically ... The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin N Am 2004 ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2010000100003&lng=es&nrm=iso&tlng=es
*  Dermatologic Manifestations of Mixed Connective Tissue Disease: Background, Pathophysiology, Etiology
MCTD is considered an autoimmune disease to which individuals who express specific HLA antigens such as HLA-DR4 or HLA-DQB1 are ... The frequency of HLA-DR4 in patients with MCTD is estimated to be 52%. Its strong HLA association with MCTD was further shown ... HLA-DR4 is more common in patients with MCTD than in patients with other connective-tissue diseases (see Pathophysiology). A ... Association of HLA-DRB1 alleles with susceptibility to mixed connective tissue disease in Polish patients. HLA. 2016 Jan. 87 (1 ...
  https://emedicine.medscape.com/article/1066445-overview
*  Mark Genovese, MD | Stanford Medicine Profiles
AG4263 is a soluble complex of native HLA-DR4 (beta*0401) complexed to Org 36601, a 13-mer peptide derived from HC gp-39 (also ... There was no loss of reactivity to recall antigens, change in cell counts, or antibodies to HLA-DR. The mean half-life of ... were assessed for HLA-DRB1*04 (primary end point), HLA-DRB1*SE and HLA-DRB1 position 11 V/L (HLA-DRB1*pos11 V/L) allelic groups ... As the HLA-DRB1*SE and HLA-DRB1*pos11 V/L results were driven by lack of placebo response in carriers, the hypothesis of ...
  https://med.stanford.edu/profiles/mark-genovese
*  Polymyalgia rheumatica - Wikipedia
Persons having the HLA-DR4 type of human leucocyte antigen appear to have a higher risk of PMR. No specific test exists to ...
  https://en.wikipedia.org/wiki/Polymyalgia_rheumatica
*  Buy Prednisone Online
There is a significant association of RP with the antigen HLA-DR4. RP includes loss of basophilic staining of cartilage matrix ... Analyses showed that >16 HLA-DQ epitope mismatches and pretransplant, buy prednisone online peripheral blood, donor-reactive ... surface antigen (HBsAg) are at risk for reactivation of HBV. ...
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*  HLA-DR4-associated T and B cell responses to specific determinants on the IA-2 autoantigen in type 1 diabetes. - Radcliffe...
This study identifies a region of focus for B and T cell responses to IA-2 in HLA-DR4 diabetic patients that may explain HLA ... suggesting influences of HLA-DR4-restricted T cells on IA-2-specific B cell responses. The aim of this study was to investigate ... Abs to juxtamembrane and central region constructs were both DR4 associated. ... 10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA ...
  https://www.rdm.ox.ac.uk/publications/634135
*  Frontiers | Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection | Immunology
... provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens ... provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens ... HLA-DR antigen frequencies in Mexican patients with dengue virus infection: HLA-DR4 as a possible genetic resistance factor for ... IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells. ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00531/full
*  NewYork-Presbyterian Queens - Juvenile Rheumatoid Arthritis
The HLA antigen associated with JRA is called DR4. Children with the DR4 HLA antigen are thought to have an increased chance ( ... This means HLA antigen testing is not diagnostic or accurate for prediction of the condition. Females are affected with JRA ... When a child has the specific HLA antigen type associated with the disease, he or she is thought to have an increased chance to ... Specific HLA antigens influence the development of many common disorders. Some of these disorders, like JRA, are autoimmune ...
  http://www.nyhq.org/diw/Content.asp?PageID=DIW002766&More=DIW
*  A Rare Case of Unilateral Progressive Vision Loss and Pachymeningitis
We know from previous studies that HLA-DR4 (human leukocyte antigen) is strongly associated with VKH disease, but most recently ... 5] Davis JL, Mittal KK, Freidlin V, et al HLA associations and ancestry in Vogt-Koyanagi-Harada's disease and sympathetic ... and HLA-DRB1/DQA1, rs3021304.20-22 Despite advances in research, we have yet to come up with a specific serologic testing to ... Yamamoto JH T-cell recognition and cytokine profile induced by melanocyte epitopes in patients with HLA-DRB1*0405-positive and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5123095/
*  Early Onset of Diabetes in the Proband Is the Major Determinant of Risk in HLA DR3-DQ2/DR4-DQ8 Siblings | Diabetes
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study ... HLA Class I and II Genotyping. HLA class II DRB1 and DQB1 and HLA class I A and B genotyping was carried out by PCR using a ... HLA genotype data were available for 1,440 siblings (67%). Of these, 191 had the high-risk HLA DR3/DR4 genotype. Haplotype ... HLA class II determined risk can also be modulated by other factors close to or within the HLA region as well as by non-HLA ...
  http://diabetes.diabetesjournals.org/content/63/3/1041.full?cited-by=yes&legid=diabetes
*  Sequence Similarity - 1D5Z: X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB Sequence...
Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity ... PROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN) protein, length: 181 (BLAST) Sequence Similarity Cutoff. Rank. Chains in ... PROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN) protein, length: 192 (BLAST) Sequence Similarity Cutoff. Rank. Chains in ... X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB. ...
  http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1D5Z
*  Ocular Cicatricial Pemphigoid (OCP): Background, Pathophysiology, Epidemiology
Human leukocyte antigen DR2 (HLA-DR2), human leukocyte antigen DR4 (HLA-DR4 [HLA-DR*0401]), and human leukocyte antigen DQw7 ( ... Multiple antigens in the BMZ of squamous epithelia may serve as targets for a spectrum of autoantibodies observed in OCP. ... On the molecular level, the initial trigger may be a process by which the OCP antigen undergoes a conformational change that ... This signal results in the generation of B-cell clones that produce antibodies against antigens located at the basement ...
  https://emedicine.medscape.com/article/1191261-overview
*  Arthritis - What Causes the Pain? | Catalyst Pain Solutions
It is also linked to the inherited tissue type major histocompatibility complex (MHC) antigen HLA-DR4. ...
  http://www.catalystpainsolutions.com/2011/02/08/arthritis-what-causes-the-pain-2/
*  GIANT CELL AND TAKAYASU ARTERITIS | Color Atlas and Synopsis of Vascular Diseases | AccessCardiology | McGraw-Hill Medical
Human leukocyte antigen (HLA)-DR4 positivity.4. ++. Takayasu Arteritis. ++. *. 80% to 90% of cases are in women between the ... However, current understanding implicates a foreign antigen in a cascade of events that under-standing results in arterial ...
  http://accesscardiology.mhmedical.com/content.aspx?bookid=1201§ionid=71015746
*  SMART: IG domain annotation
Crystal Structure of the DM1 TCR in complex with HLA-B*4405 and decamer EBV antigen. ... HLA-DR4. 1jew. CRYO-EM STRUCTURE OF COXSACKIEVIRUS B3(M STRAIN) WITH ITS CELLULAR RECEPTOR, COXSACKIEVIRUS AND ADENOVIRUS ... Structure of New Antigen Receptor variable domain from sharks. 1ves. Structure of New Antigen Receptor variable domain from ... Structure of new antigen receptor variable domain from sharks. 2ywz. Structure of new antigen receptor variable domain from ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=IG&START=94&END=176&E_VALUE=5.75e-4&TYPE=SMART&BLAST=GPATLIFEGDTLVLHCRAWQDWPLTQVIFYREGSALGPPGPKSEFSITMVQKSDGGHYHCSGIFRSPGPGSREAASPVAITVQ
*  JCI - Volume 120, Issue 12
... cloned a previously identified tumor-reactive HLA-DR4-restricted CD4+ TCR specific for the melanocyte differentiation antigen ... Most importantly, large numbers of CD4+ T cells expressing the Tyrp1-specific TCR were detected in secondary HLA-DR4-transgenic ... high-efficiency TCR gene transfer following long-term transplantation into lethally irradiated mice transgenic for HLA-DR4. ... Illustration of a dendritic cell, the main antigen-presenting cell of the immune system. In the current issue, two studies show ...
  https://www.jci.org/120/12
*  Epidemiology of laboratory animal allergy | Springer for Research & Development
Laboratory animal allergy - Possible association with HLA B15 and DR4. Tissue Antigens 31: 224-226CrossRefPubMedGoogle Scholar ... HLA DR4,DRw11(5), and DR17(3) function as restriction elements for Mus m1 allergic human t cells. J Allergy Clin Immunol 91: ... Allergy to murine antigens in a biological research institute. J Allergy Clin Immunol 68: 310-318CrossRefPubMedGoogle Scholar ... HLA associations with occupational sensitization to rat lipocalin allergens: A model for other animal allergies? J Allergy Clin ...
  https://rd.springer.com/chapter/10.1007/978-3-7643-8556-9_3