*  Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability | Journal of Cell Science
2004). Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J. Cell Sci. 117, 2491-2501. ... 2004). A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 18, 1251-1262 ... 2001). Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110-113. ... The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. ...
  http://jcs.biologists.org/content/123/16/2853
*  Hypoxia suffocates histone demethylases to change gene expression: a metabolic control of histone methylation
The trimethylation of the 4th lysine residue of histone 3 (H3K4me3) are found at TSS in active genes. H3K9me3 and H3K27me3 are ... often found in repressed genes within a heterochromatin region. The histones are ornamented with diverse modifications by ... H3K4me3: tri-methylation of 4th lysine residue of histone 3. JMJD: Jumonji C domain-containing histone demethylase. TF: ... Therefore, the TFs assign specifically localized histones to the histone modifiers.. Most of the histone demethylases contain ...
  http://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2017.50.11.200
*  Polycomb Group Proteins and Cancer - Wikipedia
EZH2, a histone-lysine N-methyltransferase and the functional enzymatic component of PRC2, encoded by the EZH2 gene, is a ... MACROH2A is a replacement for histone H2A that also supports heterochromatin formation. In particular, one subtype of MACROH2A ... One study is investigating the safety and clinical activity of GSK2816126, a histone-lysine N-methyltransferase EZH2 inhibitor ... Proteins then bind the Xist RNA, modifying the histones. PRC2 inserts a histone 3 lysine 27 trimethylation mark, indicative of ...
  https://en.wikipedia.org/wiki/Polycomb_Group_Proteins_and_Cancer
*  Conservation and divergence of the histone code in nucleomorphs | Biology Direct | Full Text
Cryptophyte nucleomorph histones are generally more similar to the conventional eukaryotic state; however, they also display ... This study examines the sequences of nucleomorph histone proteins in order to address these issues. Remarkably, all classical ... in particular in terms of the functioning of the histone code, which is common to almost all eukaryotes and plays a central ... significant deviations from the typical histone code. Based on the analysis of specific components of the code, we discuss the ...
  https://0-biologydirect-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s13062-016-0119-4
*  Transcriptional correlations (ρpg:g) between pseudogen | Open-i
Further integrated analysis of transcriptomics and epigenomics data, however, demonstrated that trimethylation of histone 3 at ... lysine 9 (H3K9me3), a posttranslational modification typically associated with gene repression and heterochromatin, was ... Further integrated analysis of transcriptomics and epigenomics data, however, demonstrated that trimethylation of histone 3 at ... demonstrated that trimethylation of histone 3 at lysine 9 (H3K9me3), a posttranslational modification typically associated with ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3974860_pone.0093972.g003&req=4
*  Frontiers | Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones | Plant...
OTLD1 was found to be interacting with the histone lysine demethylase KDM1C in planta. Indeed, OTLD1 has H2B deubiquitination ... PRC2 mediates the deposition of trimethylation of histone 3 on lysine 27 (H3K27me3), a repressive epigenetic mark (Schatlowski ... Recent published data show the in vivo interaction between UBP12 and 13 with LIKE HETEROCHROMATIN PROTEIN 1 (LHP1), a PcG ... Jamieson, K., Rountree, M. R., Lewis, Z. A., Stajich, J. E., and Selker, E. U. (2013). Regional control of histone H3 lysine 27 ...
  https://www.frontiersin.org/articles/10.3389/fpls.2017.02274/full
*  Histone - Wikipedia
Trimethylation of H4 lysine 20 (H4K20me3) This modification is tightly associated with heterochromatin, although its functional ... Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1/H5 are known as the linker histones. The core ... Histone variants Chromatin Gene silencing Genetics Histone acetyltransferase Histone deacetylases Histone methyltransferase ... Two histone modifications are particularly associated with active transcription: Trimethylation of H3 lysine 4 (H3K4me3) This ...
  https://en.wikipedia.org/wiki/Histone
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... marked by the presence of tri-methylation of lysine 9 on histone H3. The results achieved demonstrate the potential of ChroP in ... methylated histone H3 at lysine 9 (H3K9me1, H3K9me2, H3K9me3) which are epigenetic imprints of constitutive heterochromatin and ... Lysine methylation is an emerging post-translation modification and it has been identified on several histone and non-histone ... H3 and H4 histone modifications include methylation of lysine and arginine, acetylation of lysine, and phosphorylation of ...
  https://www.jove.com/visualize/abstract/23844048/posttranslational-modifications-histone-3-tail-their-impact-on
*  Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin | JCB
Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J. Cell Sci. 117:2491-2501. ... Surprisingly, trimethylation of K9H3 and the high affinity binding of HP1 to pericentric heterochromatin were neither necessary ... Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals. Chromosoma. 111:22-36. ... Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol ...
  http://jcb.rupress.org/content/174/2/185
*  Tri-Methyl Histone H3-K9 Quantification Kit (Fluorometric) Kit-0827 - Creative BioMart
Tri-Methyl Histone H3-K9 Quantification Kit (Fluorometric) can be used for research. ... Purified Tri-Methyl Histone H3-K9 Quantification Kit (Fluorometric) from Creative Biomart. ... H3-K9 trimethylation mediates heterochromatin formation by forming a binding site for HP and is a stable heterochromatin mark ... Dim-5 and Eu-HMTase are histone methyltransferases that catalyze methylation of histone H3 at lysine 9 (H3-K9) in mammalian ...
  https://www.creativebiomart.net/tri-methyl-histone-h3-k9-quantification-kit-fluorometric-463826.htm
*  Di-Methyl Histone H3-K27 Quantification Kit (Colorimetric) Kit-0279 - Creative BioMart
Di-Methyl Histone H3-K27 Quantification Kit (Colorimetric) can be used for research. ... Purified Di-Methyl Histone H3-K27 Quantification Kit (Colorimetric) from Creative Biomart. ... G9a and polycomb group enzymes such as EZH2 are histone methyltransferases that catalyze methylation of histone H3 at lysine 27 ... Histone H3-K27 dimethylation, a modification enriched at pericentromeric heterochromatin, is observed to be broadly distributed ...
  https://www.creativebiomart.net/di-methyl-histone-h3-k27-quantification-kit-colorimetric-462712.htm
*  Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9a | Genome...
Here we have investigated the 'histone code' associated with the histone methyltransferases Suv39h1 and G9a by combining double ... Moreover, this method allowed us to demonstrate for the first time an association of acetylated histones with the repressor ... Our results confirm the previously reported histone modifications associated with Suv39h1 and G9a. ... Specific combinations of post-translational modifications of histones alter chromatin structure, facilitating gene ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-12-r270
*  Long non-coding RNA - Wikipedia
It appears that Kcnqot1 is able to direct the trimethylation of lysine 9 (H3K9me3) and 27 of histone 3 (H3K27me3) to an ... A detailed analysis showed the p15 antisense ncRNA (CDKN2BAS) was able to induce changes to heterochromatin and DNA methylation ... December 2002). "Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes". The EMBO ... including histone and DNA methylation, histone acetylation and sumoylation, affect many aspects of chromosomal biology, ...
  https://en.wikipedia.org/wiki/Long_non-coding_RNA
*  A 'selfish' B chromosome induces genome elimination by disrupting the histone code in the jewel wasp Nasonia vitripennis
In contrast, di- and tri-methylation of histone H3 at Lysine residue 9 (H3K9me2 and H3K9me3) appear at later mitotic cleavage ... Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. ... Lachner M., O′Carroll N., Rea S., Mechtler K. & Jenuwein T. Methylation of histone H3 lysine 9 creates a binding site for HP1 ... Monomethylation of Histone H4-Lysine 20 Is Involved in Chromosome Structure and Stability and Is Essential for Mouse ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5304203/
*  Joshua Mylne A-5581-2009 - ResearcherID.com
Title: Vernalization requires epigenetic silencing of FLC by histone methylation. Author(s): BASTOW, R; MYLNE, JS; LISTER, C; ... Title: LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC. Author(s): ... Title: ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation. Author( ... Issue: 3. Pages: 179-194. Published: MAR 2012. Times Cited: 66. DOI: 10.1517/17460441.2012.661554. added. 24-Jun-12 ...
  http://www.researcherid.com/ProfileView.action?returnCode=ROUTER.Unauthorized&Init=Yes&SrcApp=CR&queryString=KG0UuZjN5WldB4oT1Y6gbExiqxRNrIu9eFOvUFg%252Brp8%253D
*  Histone methylation - Wikipedia
For example, trimethylation of histone H3 at lysine 4 (H3K4me3) is an active mark for transcription and is upregulated in ... Histone methylation plays an important role on the assembly of the heterochromatin mechanism and the maintenance of gene ... Histones can be methylated on lysine (K) and arginine (R) residues only, but methylation is most commonly observed on lysine ... The histone methyltransferases are specific to either lysine or arginine. The lysine-specific transferases are further broken ...
  https://en.wikipedia.org/wiki/Histone_methylation
*  Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing | The EMBO Journal
... and tri‐methylation states of histone H3 lysine 9 or of H4 lysine 20, and ubiquitination of histone H2A lysine 119 were not ... The H3K27me1 mark on pericentric heterochromatin was unaffected in Eed deficient ES cells (Figure 3A). ... wide tri‐methylation of histone H3 on lysine 27 (H3K27me3), mono‐methylation of histone H4 on lysine 20 (H4K20m1) and ... Cao R, Wang L, Wang H, Xia L, Erdjument‐Bromage H, Tempst P, Jones RS, Zhang Y (2002) Role of histone H3 lysine 27 methylation ...
  http://emboj.embopress.org/content/25/13/3110
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... we also observed the accumulation of histone H3 lysine 9 trimethylation (H3K9me3) and heterochromatin protein 1 gamma (HP1?), ... The formation of this epigenetic modifying complex requires interaction of DNMT3L with DNMT3A as well as with histone H3. In ... Here, we demonstrate that DNMT3L enhances the interaction of repressive epigenetic modifiers, including histone deacetylase 1 ( ... Monometallic (UO2)(X)2(L)3 (L?=?pyridine (py), X?=?F (1), Cl (2), Br (3) and I (4); L?=?tetrahydrofuran (thf), X?=?Cl (5); L?=? ...
  https://www.jove.com/visualize?author=Xing+Zhang
*  Anti-Histone H3 (mono methyl K79) antibody - ChIP Grade (ab2886) References
Anti-Histone H3 (mono methyl K79) antibody - ChIP Grade (ab2886) has been cited in 35 publications. References for Human, Mouse ... Chang MJ et al. Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes. Cancer Res 70: ... Jones B et al. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. ... Singh P et al. Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions. ...
  http://www.abcam.com/histone-h3-mono-methyl-k79-antibody-chip-grade-ab2886-references.html
*  Cancers | Free Full-Text | Epigenetics, Nervous System Tumors, and Cancer Stem Cells | HTML
In this review, we describe the major epigenetic mechanisms (i.e., DNA methylation, histone and chromatin modification, non- ... Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat. Genet. 2008, 40, ... Papait, R.; Magrassi, L.; Rigamonti, D.; Cattaneo, E. Temozolomide and carmustine cause large-scale heterochromatin ... These include the histone lysine methyltransferases, EHMT1 and SMYD4; histone lysine demethylases, JMJD2C and JMJD2B; histone ...
  http://www.mdpi.com/2072-6694/3/3/3525/htm
*  The Histone Acetylase Activator Pentadecylidenemalonate 1b Rescues Proliferation and Differentiation in the Human Cardiac...
The results indicate a consistent reduction of lysine 9 acetylation paralleled by the elevation of lysine 27 trimethylation ... Histone H4K20me3 and HP1α are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells ... A global histone code profiling of D-CMSC revealed that acetylation on histone H3 lysine 9 (H3K9Ac) and lysine 14 (H3K14Ac) was ... Further histone code analyses showed a decrease in histone H4 lysine 16 acetylation (H4K16Ac) in D-CMSC, suggesting a ...
  http://diabetes.diabetesjournals.org/content/63/6/2132.full
*  Anti-Histone H3 (mono methyl K9) antibody - ChIP Grade (ab9045) References
Anti-Histone H3 (mono methyl K9) antibody - ChIP Grade (ab9045) has been cited in 59 publications. References for Human, Mouse ... Udugama M et al. Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres. Nucleic Acids ... Garrigues JM et al. Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 ... Wen H et al. Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation. J ...
  http://www.abcam.com/histone-h3-mono-methyl-k9-antibody-chip-grade-ab9045-references.html
*  Anti-Histone H3 (di methyl K79) antibody - ChIP Grade (ab3594) References
Anti-Histone H3 (di methyl K79) antibody - ChIP Grade (ab3594) has been cited in 128 publications. References for Human, Mouse ... Huyen Y et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432:406-11 (2004). PubMed: ... Jones B et al. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. ... Luense S et al. Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular ...
  http://www.abcam.com/histone-h3-di-methyl-k79-antibody-chip-grade-ab3594-references.html
*  The Requirements for COMPASS and Paf1 in Transcriptional Silencing and Methylation of Histone H3 in Saccharomyces cerevisiae |...
Set1 is a histone methyltransferase that is required for the mono-, di-, and trimethylation of lysine 4 (K4) of histone H3 in S ... 2004 Methylation of H3 lysine 4 at euchromatin promotes Sir3p association with heterochromatin. J. Biol. Chem. 279: 47506-47512 ... and trimethylation of histone H3 on K4 and that Bre2 and Sdc1 are required for trimethylation of histone H3 on K4. While the ... Total histone H3 was measured using antisera that recognizes the C terminus of histone H3, and K4-monomethylated histone H3, K4 ...
  http://www.genetics.org/content/173/2/557
*  Cancers | Free Full-Text | Induction of Chromosomal Instability via Telomere Dysfunction and Epigenetic Alterations in Myeloid...
Several studies link chromosome rearrangements and aberrant DNA and histone methylation. Genes implicated in epigenetic control ... Suv39h1 mediates the trimethylation of lysine 9 of histone 3 (H3K9me3) leading to condensed chromatin. ... 90], heterochromatin can be a barrier for physiological DSB repair and Suv39h1 and Suv39h2 double knock-out diminish DSB repair ... is a histone methyltransferase that catalyzes trimethylation of H3K27 and is a subunit of the polycomb repressive complex 2 ( ...
  http://mdpi.com/2072-6694/5/3/857/htm