*  Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide...
... processing of native antigens to produce immunogenic peptides that bind to major histocompatibility complex class II (MHC-II) ... In functional studies of antigen processing by elicited peritoneal macrophages, MHC-II-peptide complexes were formed ... The intracellular pool of MHC-II molecules was only slightly decreased by treatment with cycloheximide for 3 hr, indicating ... These ultrastructural studies support the notion that there is endocytosis of MHC-II molecules into endocytic compartments, ...
  https://www.semanticscholar.org/paper/Functional-and-ultrastructural-evidence-for-intrac-Harding-Unanue/7463c22d9cb71ee412f3484ad6c32c00394a5ff6
*  The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species...
Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type ... encoded nonclassical class II molecule called DM. To further examine the role of DM in class II-restricted antigen presentation ... linked protein that lead to defects in class II-restricted antigen presentation and a defect in the formation of class II SDS- ... Characterization of naturally processed antigen bound to major histocompatibility complex class II molecules. Proc Natl Acad ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2191808/?lang=en-ca
*  T Helper Subset Differentiation in the Absence of Invariant Chain | JEM
... mice have impaired ability to present major histocompatibility complex class II-restricted antigens, and reduced numbers of CD4 ... as described for some endogenous class II-dependent antigen presentation pathways ((45)), or could load class II via a ... Ii is required for stable expression of surface class II molecules and, as predicted, cells from Ii −/− mice have substantially ... Cohorts of C57BL/6 Ii −/− or Ii +/− mice, together with class II −/− and susceptible BALB/c mice, were infected with L. major ...
  http://jem.rupress.org/content/185/1/31
*  Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. - Nuffield...
... requires the interaction between antigen-presenting cells and T lymphocytes restricted at the major histocompatibility complex ... A critical test of this hypothesis would be to determine whether epithelial cells bearing MHC class II molecules (class II+ ... We report here that class II+ thyroid follicular epithelial cells (thyrocytes) can indeed present viral peptide antigens to ... class II molecules may be expressed on epithelial cells that normally do not express them. We speculated that these cells may ...
  https://www.ndorms.ox.ac.uk/publications/481830
*  Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain | Science
This may serve to differentiate the MHC class I and II antigen presentation pathways and enable class II molecules to ... The invariant chain (Ii) binds nascent major histocompatibility complex (MHC) class II molecules, blocking peptide binding ... Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain ... Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain ...
  http://science.sciencemag.org/content/263/5151/1284
*  Gentaur Molecular :Ray Biotech \ Mouse Anti-Mouse Major Histocompatability Complex Class I H-2Kb \ 129-10448
Mouse Anti-Mouse Major Histocompatability Complex Class I H-2Kb \ 129-10448 for more molecular products just contact us ... Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2). [Tp53 P53 Trp53] Cellular tumor antigen p53 ( ... WP1005: GPCRs, Class B Secretin-like. WP1051: GPCRs, Class C Metabotropic glutamate, pheromone. WP1072: GPCRs, Class A ... WP1123: GPCRs, Class B Secretin-like. WP1167: GPCRs, Class C Metabotropic glutamate, pheromone. WP1188: GPCRs, Class A ...
  http://www.antibody-antibodies.com/product_det.php?id=1782577&supplier=search&name=Mouse%20Anti_Mouse%20Major%20Histocompatability%20Complex%20Class%20I%20H_2Kb
*  HLA class II histocompatibility antigen, DRB1-8 beta chain
To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta ... GO Component for HLA class II histocompatibility antigen, DRB1-8 beta chain. ... UniProt Keyword for HLA class II histocompatibility antigen, DRB1-8 beta chain. ... HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) ...
  https://pharos.nih.gov/idg/targets/Q30134
*  Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41...
Ii) chain associated with major histocompatibility complex (MHC) class II molecules. Spleen cells from these mice appear ... and intact CD4+ T-dependent proliferative responses towards a soluble antigen. In short, MHC class II expression and function ... indistinguishable from wild type with respect to class II subunit assembly, transport, peptide acquisition, surface expression ... and the ability to present intact protein antigens. Moreover, these mutant mice have normal numbers of thymic and peripheral ...
  https://www.neuroscience.ox.ac.uk/publications/22827
*  Inducibility of Class II Major Histocompatibility Complex Antigens by Interferon y Is Associated with Reduced Tumorigenicity in...
IFN-y induction of class II antigens on the tumor cell surface operates to limit tumor growth ; ras expression, which inhibits ... were prepared that express high or low levels ofclass II major histocompatibility complex antigen after treatment with ... induction of class II antigens, prevents this and so allows tumor growth . ... The class II-inducible cells are clearly less tumorigenic than the noninducible cells in syngeneic mice, but of similar ...
  https://www.semanticscholar.org/paper/Inducibility-of-Class-II-Major-Histocompatibility-Morris/0fc63c9a983a78e04f453013d3e63540820f4ae2
*  Frontiers | HLA-DO and Its Role in MHC Class II Antigen Presentation | Immunology
Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Class II molecules. Degradation of a full protein into small peptide fragments is a lengthy process consisting of many steps ... Class II molecules. Degradation of a full protein into small peptide fragments is a lengthy process consisting of many steps ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00260/full
*  HLA class II histocompatibility antigen, DRB1-4 beta chain
To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta ... antigen processing and presentation of exogenous peptide antigen via MHC class II 104 ... GO Component for HLA class II histocompatibility antigen, DRB1-4 beta chain. ... GO Process for HLA class II histocompatibility antigen, DRB1-4 beta chain. ...
  https://pharos.nih.gov/idg/targets/P13760
*  Reactome | HLA class II histocompatibility antigen, DP [plasma membrane]
HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] HLA class II histocompatibility antigen, DR beta 5 ... Homologues of HLA class II histocompatibility antigen, DP [plasma membrane] (Danio rerio) * HLA class II histocompatibility ... HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] HLA class II histocompatibility ... Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Danio rerio) * MHC class II alpha/beta/Ii nonamer [plasma ...
  https://reactome.org/content/detail/R-DRE-197648-4
*  Reactome | HLA class II histocompatibility antigen, DQ [plasma membrane]
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQ [trans-Golgi network ... HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] HLA class II histocompatibility antigen, DQ [ ... HLA class II histocompatibility antigen, DQ [transport vesicle membrane] HLA class II histocompatibility antigen, DQ [clathrin- ... HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] HLA class II histocompatibility antigen, DQ [endocytic ...
  https://reactome.org/content/detail/R-RNO-197585
*  RCSB PDB - Protein Feature View - HLA class II histocompatibility antigen, DR alpha chain - P01903 (DRA HUMAN)
3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen ... To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in ... HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to ...
  http://www.rcsb.org/pdb/protein/Q9TP70
*  RCSB PDB - Protein Feature View - HLA class II histocompatibility antigen, DQ beta 1 chain - P01920 (DQB1 HUMAN)
3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen ... To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... HLA class II histocompatibility antigen, DQ beta 1 chain - P01920 (DQB1_HUMAN) ... leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in ...
  http://www.rcsb.org/pdb/protein/P01920
*  Reactome | HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] HLA class II histocompatibility antigen, DR ... Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen ... Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen ... Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen peptide ...
  https://reactome.org/content/detail/R-RNO-197588
*  HLA-DRB1 - HLA class II histocompatibility antigen, DRB1-13 beta chain precursor - Homo sapiens (Human) - HLA-DRB1 gene &...
To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to ... Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ...
  http://www.uniprot.org/uniprot/Q5Y7A7
*  Mamu class II histocompatibility antigen elisa and antibody
Recombinant Protein and Mamu class II histocompatibility antigen Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein ... Shop Mamu class II histocompatibility antigen ELISA Kit, ... Mamu class II histocompatibility antigen. LOG IN MY ACCOUNT ... Mamu class II histocompatibility antigen, DR alpha chain. Mamu class II histocompatibility antigen, DR alpha chain ELISA Kit. ... Mamu class II histocompatibility antigen, DR alpha chain Antibody. Also known as Mamu class II histocompatibility antigen, DR ...
  https://www.mybiosource.com/protein_family.php?root=mamu-class-ii-histocompatibility-antigen
*  Reactome | HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal membrane]
HLA class II histocompatibility antigen, DRB1-14 beta chain [Golgi membrane] HLA class II histocompatibility antigen, DRB1-14 ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ...
  http://www.reactome.org/content/detail/2130616
*  Reactome | HLA class II histocompatibility antigen, DRB1-11 beta chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [Golgi membrane] HLA class II histocompatibility antigen, DRB1-11 ... HLA class II histocompatibility antigen, DRB1-11 beta chain [lysosomal membrane] HLA class II histocompatibility antigen, DRB1- ... HLA II beta chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1- ... HLA II beta chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1- ...
  http://www.reactome.org/content/detail/2130346
*  Reactome | HLA class II histocompatibility antigen, DQ [integral component of lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] HLA class II histocompatibility antigen, DQB1*0602 ... HLA class II histocompatibility antigen, DQ [plasma membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [lysosomal membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ...
  http://www.reactome.org/content/detail/2130611
*  Reactome | HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [plasma membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [lysosomal membrane] HLA class II histocompatibility antigen, DQB1*0602 beta chain ... HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] HLA class II histocompatibility antigen, DQB1*0602 ...
  http://www.reactome.org/content/detail/2130334
*  H2-K1 recombinant protein | H-2 class I histocompatibility antigen, K-D alpha chain Recombinant Protein-XP 011241831.1
H-2 class I histocompatibility antigen, K-D alpha chain Recombinant Protein-XP_011241831.1 (MBS1158913) product datasheet at ... antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen ... Antigen Processing And Presentation Pathway Diagram. Antigen Processing And Presentation Pathway antibodies. Antigen Processing ... antigen processing and presentation of peptide antigen via MHC class I; defense response to bacterium; immune response; immune ...
  https://www.mybiosource.com/prods/Recombinant-Protein/H-2-class-I-histocompatibility-antigen-K-D-alpha-chain/H2-K1/datasheet.php?products_id=1158913
*  ASMscience | Lyme Borreliosis
Early infection consists of stage 1 (localized skin infection), followed within days to weeks by stage 2 (disseminated ... these two species also seem to be responsible for the illness in Asia. This chapter presents biology and enzootic cycles of B. ... Major histocompatibility complex class II-independent generation of neutralizing antibodies against T-cell-dependent Borrelia ... Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. J. Infect. Dis. 165:471-478.. ...
  http://www.asmscience.org/content/book/10.1128/9781555816490.chap11
*  HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B...
Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific ... The three classical human leukocyte antigen (HLA) class I genes, HLA-A, HLA-B, and HLA-C, are extremely polymorphic and exhibit ... Saper MA, Bjorkman PJ, Wiley DC (1991) Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J ... 1a). More than 75 % of populations present at least two different NCBs (Fig. 1b), and only two populations lack one of these ...
  https://link.springer.com/article/10.1007/s00251-015-0875-9