*  Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide...
... processing of native antigens to produce immunogenic peptides that bind to major histocompatibility complex class II (MHC-II) ... In functional studies of antigen processing by elicited peritoneal macrophages, MHC-II-peptide complexes were formed ... The intracellular pool of MHC-II molecules was only slightly decreased by treatment with cycloheximide for 3 hr, indicating ... These ultrastructural studies support the notion that there is endocytosis of MHC-II molecules into endocytic compartments, ...
  https://www.semanticscholar.org/paper/Functional-and-ultrastructural-evidence-for-intrac-Harding-Unanue/7463c22d9cb71ee412f3484ad6c32c00394a5ff6
*  The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species...
Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type ... encoded nonclassical class II molecule called DM. To further examine the role of DM in class II-restricted antigen presentation ... linked protein that lead to defects in class II-restricted antigen presentation and a defect in the formation of class II SDS- ... Characterization of naturally processed antigen bound to major histocompatibility complex class II molecules. Proc Natl Acad ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2191808/?lang=en-ca
*  Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. - Nuffield...
... requires the interaction between antigen-presenting cells and T lymphocytes restricted at the major histocompatibility complex ... A critical test of this hypothesis would be to determine whether epithelial cells bearing MHC class II molecules (class II+ ... We report here that class II+ thyroid follicular epithelial cells (thyrocytes) can indeed present viral peptide antigens to ... class II molecules may be expressed on epithelial cells that normally do not express them. We speculated that these cells may ...
  https://www.ndorms.ox.ac.uk/publications/481830
*  ASMscience | Antigen Processing and Presentation Mechanisms in Myeloid Cells
These antigenic peptides are expressed on the surface of antigen presenting cells bound to MHC class I and MHC class II ... Here, we review the basics of antigen acquisition by antigen presenting cells, antigen proteolysis into polypeptide fragments, ... antigenic peptide binding to MHC proteins, and surface display of both MHC class I-peptide and MHC class II-peptide complexes. ... immune system do not recognize intact foreign proteins but instead recognize polypeptide fragments of potential antigens. ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.MCHD-0008-2015
*  Gentaur Molecular :Ray Biotech \ Mouse Anti-Mouse Major Histocompatability Complex Class I H-2Kb \ 129-10448
Mouse Anti-Mouse Major Histocompatability Complex Class I H-2Kb \ 129-10448 for more molecular products just contact us ... Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2). [Tp53 P53 Trp53] Cellular tumor antigen p53 ( ... WP1005: GPCRs, Class B Secretin-like. WP1051: GPCRs, Class C Metabotropic glutamate, pheromone. WP1072: GPCRs, Class A ... WP1123: GPCRs, Class B Secretin-like. WP1167: GPCRs, Class C Metabotropic glutamate, pheromone. WP1188: GPCRs, Class A ...
  http://www.antibody-antibodies.com/product_det.php?id=1782577&supplier=search&name=Mouse%20Anti_Mouse%20Major%20Histocompatability%20Complex%20Class%20I%20H_2Kb
*  HLA-DOB - Wikipedia
HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene. HLA-DOB ... DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen ... "Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene ... class II, DO beta". Beck S, Kelly A, Radley E, et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region ...
  https://en.wikipedia.org/wiki/HLA-DOB
*  HLA class II histocompatibility antigen, DRB1-8 beta chain
To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta ... GO Component for HLA class II histocompatibility antigen, DRB1-8 beta chain. ... UniProt Keyword for HLA class II histocompatibility antigen, DRB1-8 beta chain. ... HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) ...
  https://pharos.nih.gov/idg/targets/Q30134
*  Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41...
Ii) chain associated with major histocompatibility complex (MHC) class II molecules. Spleen cells from these mice appear ... and intact CD4+ T-dependent proliferative responses towards a soluble antigen. In short, MHC class II expression and function ... indistinguishable from wild type with respect to class II subunit assembly, transport, peptide acquisition, surface expression ... and the ability to present intact protein antigens. Moreover, these mutant mice have normal numbers of thymic and peripheral ...
  https://www.neuroscience.ox.ac.uk/publications/22827
*  Inducibility of Class II Major Histocompatibility Complex Antigens by Interferon y Is Associated with Reduced Tumorigenicity in...
IFN-y induction of class II antigens on the tumor cell surface operates to limit tumor growth ; ras expression, which inhibits ... were prepared that express high or low levels ofclass II major histocompatibility complex antigen after treatment with ... induction of class II antigens, prevents this and so allows tumor growth . ... The class II-inducible cells are clearly less tumorigenic than the noninducible cells in syngeneic mice, but of similar ...
  https://www.semanticscholar.org/paper/Inducibility-of-Class-II-Major-Histocompatibility-Morris/0fc63c9a983a78e04f453013d3e63540820f4ae2
*  Frontiers | HLA-DO and Its Role in MHC Class II Antigen Presentation | Immunology
Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its ... Class II molecules. Degradation of a full protein into small peptide fragments is a lengthy process consisting of many steps ... Class II molecules. Degradation of a full protein into small peptide fragments is a lengthy process consisting of many steps ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00260/full
*  "Accurate prediction of major histocompatibility complex class II epito" by Clemente Aguilar-Bonavides, Reinaldo Sanchez-Arias...
... on the surface of antigen-presenting cells (APCs). When pathogen-derived epitopes are presented by MHC class II on an APC ... Prediction of MHC-II epitopes is particularly challenging because the open binding cleft of the MHC-II molecule allows epitopes ... Among the methods proposed to predict MHC-II epitopes, artificial neural networks (ANNs) and support vector machines (SVMs) are ... The prediction performance of MHC-II epitopes of the 1-minimization algorithm was generally comparable and, in some cases, ...
  http://trace.tennessee.edu/utk_biolpubs/34/
*  Anti-MHC Class II antibody (Biotin) [ER-TR3] | Abcam
Anti-MHC Class II antibody conjugated to Biotin [ER-TR3] validated for IHC, Flow Cyt, ICC/IF and tested in Mouse. Referenced in ... HLA class II histocompatibility antigen, DP beta 1 chain antibody. *HLA class II histocompatibility antigen, DP(W4) beta chain ... To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... HLA class II histocompatibility antigen DM beta chain antibody. * ... MHC class II antigen DMB antibody. *MHC class II antigen DPB1 ...
  http://www.abcam.com/mhc-class-ii-antibody-er-tr3-biotin-ab15631.html
*  HLA class II histocompatibility antigen, DRB1-4 beta chain
To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta ... antigen processing and presentation of exogenous peptide antigen via MHC class II 104 ... GO Component for HLA class II histocompatibility antigen, DRB1-4 beta chain. ... GO Process for HLA class II histocompatibility antigen, DRB1-4 beta chain. ...
  https://pharos.nih.gov/idg/targets/P13760
*  HLA-DPB1 - Wikipedia
HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain ... 1991). "Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated ... 1989). "Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules". Proc. Natl. Acad. Sci. U.S. ...
  https://en.wikipedia.org/wiki/HLA-DPB1
*  CD74 - Wikipedia
HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster ... 1993). "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1". Nature. 364 (6432): 33-9. doi: ... "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein ... "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens". Nucleic Acids Res. 13 ...
  https://en.wikipedia.org/wiki/CD74
*  Reactome | HLA class II histocompatibility antigen, DP [plasma membrane]
HLA class II histocompatibility antigen, DP [trans-Golgi network membrane] HLA class II histocompatibility antigen, DR beta 5 ... Homologues of HLA class II histocompatibility antigen, DP [plasma membrane] (Danio rerio) * HLA class II histocompatibility ... HLA class II histocompatibility antigen, DP [clathrin-coated endocytic vesicle membrane] HLA class II histocompatibility ... Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Danio rerio) * MHC class II alpha/beta/Ii nonamer [plasma ...
  https://reactome.org/content/detail/R-DRE-197648-4
*  Reactome | HLA class II histocompatibility antigen, DQ [plasma membrane]
HLA class II histocompatibility antigen, DQ [Golgi membrane] HLA class II histocompatibility antigen, DQ [trans-Golgi network ... HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane] HLA class II histocompatibility antigen, DQ [ ... HLA class II histocompatibility antigen, DQ [transport vesicle membrane] HLA class II histocompatibility antigen, DQ [clathrin- ... HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane] HLA class II histocompatibility antigen, DQ [endocytic ...
  https://reactome.org/content/detail/R-RNO-197585
*  RCSB PDB - Protein Feature View - HLA class II histocompatibility antigen, DR alpha chain - P01903 (DRA HUMAN)
3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen ... To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in ... HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to ...
  http://www.rcsb.org/pdb/protein/Q9TP70
*  Reactome | HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane]
HLA class II histocompatibility antigen, DR beta 5 chain [Golgi membrane] HLA class II histocompatibility antigen, DR beta 5 ... Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane] (Sus scrofa) * HLA class II ... Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane] (Sus scrofa) * HLA class II ... Homologues of HLA class II histocompatibility antigen, DR beta 5 chain [plasma membrane] (Sus scrofa) * HLA class II ...
  https://reactome.org/content/detail/R-SSC-1235083-3
*  RCSB PDB - Protein Feature View - HLA class II histocompatibility antigen, DQ beta 1 chain - P01920 (DQB1 HUMAN)
3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen ... To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... HLA class II histocompatibility antigen, DQ beta 1 chain - P01920 (DQB1_HUMAN) ... leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in ...
  http://www.rcsb.org/pdb/protein/P01920
*  Reactome | HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane]
HLA class II histocompatibility antigen, DR alpha chain precursor [Golgi membrane] HLA class II histocompatibility antigen, DR ... Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen ... Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen ... Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus) * MHC Class II bearing antigen peptide ...
  https://reactome.org/content/detail/R-RNO-197588
*  HLA-DRB1 - HLA class II histocompatibility antigen, DRB1-13 beta chain precursor - Homo sapiens (Human) - HLA-DRB1 gene &...
To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta ... HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to ... Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and ... In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) ...
  http://www.uniprot.org/uniprot/Q5Y7A7
*  Mamu class II histocompatibility antigen elisa and antibody
Recombinant Protein and Mamu class II histocompatibility antigen Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein ... Shop Mamu class II histocompatibility antigen ELISA Kit, ... Mamu class II histocompatibility antigen. LOG IN MY ACCOUNT ... Mamu class II histocompatibility antigen, DR alpha chain. Mamu class II histocompatibility antigen, DR alpha chain ELISA Kit. ... Mamu class II histocompatibility antigen, DR alpha chain Antibody. Also known as Mamu class II histocompatibility antigen, DR ...
  https://www.mybiosource.com/protein_family.php?root=mamu-class-ii-histocompatibility-antigen
*  Reactome | HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal membrane]
HLA class II histocompatibility antigen, DRB1-14 beta chain [Golgi membrane] HLA class II histocompatibility antigen, DRB1-14 ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ... HLA II beta chain [lysosomal membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1-14 beta chain [lysosomal ...
  http://www.reactome.org/content/detail/2130616
*  Reactome | HLA class II histocompatibility antigen, DRB1-11 beta chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [Golgi membrane] HLA class II histocompatibility antigen, DRB1-11 ... HLA class II histocompatibility antigen, DRB1-11 beta chain [lysosomal membrane] HLA class II histocompatibility antigen, DRB1- ... HLA II beta chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1- ... HLA II beta chain [clathrin-coated endocytic vesicle membrane] (Homo sapiens) * HLA class II histocompatibility antigen, DRB1- ...
  http://www.reactome.org/content/detail/2130346