DSpace at EWHA: Repertoires of T cell receptors specific for a single minor histocompatibility antigen during primary and...
Repertoires of T cell receptors specific for a single minor histocompatibility antigen during primary and recall CD8 T cell responses ...http://dspace.ewha.ac.kr/handle/2015.oak/215708
Epitopes described in Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1...
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.http://www.iedb.org/pmId/12218130
"Recognition of gix-linked minor histocompatibility antigens by h-2-res" by W R. Green
Green, W R., "Recognition of gix-linked minor histocompatibility antigens by h-2-restricted cytotoxic t lymphocytes from c57bl/6-gix+ mice: an approach to mapping the genes controlling gix." (1982). Subject Strain Bibliography 1982. 22 ...http://mouseion.jax.org/ssbb1982/22/
The immunogenomics of minor histocompatibility antigens.
Abstract Minor histocompatibility (H) antigens are a diverse assemblage of major histocompatibility complex (MHC)-bound peptides with the unifying property of acting as alloantigen..https://www.omicsonline.org/references/the-immunogenomics-of-minor-histocompatibility-antigens-479419.html
"Priming for a cytotoxic response to minor histocompatibility antigens." by M J. Bevan
Organs:, Serology: Antigen,, Transplantation:, Congenic Resistant Lines: B10.LP, B10.C (47N), B6.C, BALB.B, Genes: H-2 - Histocompatibility-2, H-7 - Histocompatibility-7, Strains: BALB/C, C57BL/6, C57BL/10, L (P), LP. ...http://mouseion.jax.org/ssbb1977/2988/
H-2 antigens of the thymus determinelymphocyte specificity | JEM
After immunization, normal H-2 heterozygous mice (for example H-2(b) × H-2(d)) generate two populations of cytotoxic effector T cells, one specific for target cells expressing H-2(b)-plus-antigen and the other specific for H- 2(d)-plus-antigen. With a multideterminant antigen, these two populations have about the same activity. We show here that the H-2 type of resident cells in the thymus determines the H-2 preference of cytotoxic T lymphocytes. F(1)(B 10 × B 10.D2) (H-2(b) × H-2 (d)) mice were thymectomized, lethally irradiated, and reconstituted with T-cell-depleted syngeneic hematopoietic cells. Groups of such ATXBM mice were grafted subcutaneously with neonatal thymus lobes from parental mice, either B10 (H-2 (b)) or ...http://jem.rupress.org/content/148/3/766
"Failure of neuraminidase to unmask histocompatibility antigens on trop" by R L. Simmons, M L. Lipschultz et al.
Simmons, R L.; Lipschultz, M L.; Rios, A; and Ray, P K., "Failure of neuraminidase to unmask histocompatibility antigens on trophoblast." (1971). Subject Strain Bibliography 1971. 542 ...https://mouseion.jax.org/ssbb1971/542/
"Histocompatibility antigens on mouse blastocysts and ectoplacental con" by M Vandeputte and H Sobis
Vandeputte, M and Sobis, H, "Histocompatibility antigens on mouse blastocysts and ectoplacental cones." (1972). Subject Strain Bibliography 1972. 2276 ...http://mouseion.jax.org/ssbb1972/2276/
Inter-strain graft-vs.-host disease T-cell responses to immunodominan" by R Korngold, C Leighton et al.
Immunodominance affects the in vitro generation of cytotoxic T lymphocytes (CTL) specific for minor histocompatibility antigens (miHA), as exemplified in the C57BL/6By (B6) anti-BALB.B H2b-matched strain combination. Despite the potential of responding to numerous individual miHA on BALB.B antigen presenting cells, the focus of the CTL response is largely directed to only a limited number of target antigens. These miHA are differentially expressed by the CXBE, CXBG, CXBI, CXBJ, and CXBK recombinant inbred (RI) strains, all of which ...https://mouseion.jax.org/stfb1990_1999/996/
Because native gp96 molecules are recognized by the immobilized scFv Abs, we tested whether they are still associated with antigenic peptides and able to induce specific immune responses. The recombinant scFv column was loaded with hypotonic lysates of IGELa2 cells (of BALB/c origin; expressing H2d), and the gp96/scFv-Sepharose beads were injected into C57BL/6 mice. BSA-Sepharose beads incubated with the cell lysate were used as a negative control. Ten days after immunization, recipient splenocytes were stimulated with irradiated BALB.B spleen cells (of the H2b haplotype). Because mice of BALB origin differ from C57BL/6 mice ...http://cancerres.aacrjournals.org/content/60/15/4175
Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and...
Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gene polymorphisms, such as minor histocompatibility antigens (mHas) and genes coding for cytokines. However, a detailed genetic background for aGVHD has not yet been established. To find novel susceptibility and/or protective loci for aGVHD, a whole genome-wide association study of donors and recipients needs to be performed. As the first step to such a study, we retrospectively ...http://researchrepository.murdoch.edu.au/id/eprint/10318/
"Major histocompatibility complex products restrict the adher- ence of " by M A. Vadas, A E. Butterworth et al.
Vadas, M A.; Butterworth, A E.; Burakoff, S; and Sher, A, "Major histocompatibility complex products restrict the adher- ence of cytolytic t lymphocytes to minor histocompatibility antigens or to trinitrophenyl determinants on schistosomula of schistosoma mansoni." (1979). Subject Strain Bibliography 1979. 511 ...http://mouseion.jax.org/ssbb1979/511/
Clinical Trial Roy - BioCanRx
About the project. Hematologic cancers (HCs), i.e. cancers that effect the blood and lymph system, represent about 10% of all cancers. The number of new cases of HCs in Canada is 16,000 per year. HC affects both adults and children, and while around 50% of patients with HC can be cured by chemotherapy, the other 50% develop resistance to chemotherapy and die. This project's objective is to provide safer and more effective treatments for patients with resistant HCs. For most of these patients, allogeneic hematopoietic cell transplantation (AHCT) is the only curative treatment. It is now known that the curative effects of AHCT results from immune system cells that recognize or target tumor Minor Histocompatibility Antigens (MiHAs), small cell-surface proteins that function as 'signals' for immune system cells. ...https://biocanrx.com/clinical-trial-roy
Re: MHC reponses to erythrocyte antigens vs protein antigens
http://www.biolegend.com/media_assets/support_resource/BioLegend_Mouse_Alloantigens.pdf Both sheep erythrocytes and hen egg lysozyme (HEL) are protein antigens. They are both presented by MHC II if they are encountered by an antigen presenting cell such as a dendritic cell or a B cell. HEL will be endocytosed, cleaved and presented directly by the MHC II while sheep erythrocytes will have to be phagocytosed, destroyed in the lysosome and their protein antigens will then be cleaved and presented by the MHC II. MHC I presents antigens that are synthesized by the cell itself, and is mostly important to identify cells that are ...http://www.madsci.org/posts/archives/2010-08/1283206018.Im.r.html
Armistead receives Mentored Clinical Scientist Development Award - UNC Lineberger Comprehensive Cancer Center
Paul Armistead, MD, PhD, has received a grant of more than $396,000 from the National Heart, Lung and Blood Institute (part of the National Institutes of Health) to study leukemia stem cell-associated minor histocompatibility antigens.http://unclineberger.org/news/2012-news/armistead-receives-mentored-clinical-scientist-development-award
Histological changes of the liver in experimental graft-versus-host disease across minor histocompatibility barriers. VIII....
Wiley Online Library will be unavailable on Saturday 7th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 08.00 EDT / 13.00 BST / 17:30 IST / 20.00 SGT and Sunday 8th Oct from 03.00 EDT / 08:00 BST / 12:30 IST / 15.00 SGT to 06.00 EDT / 11.00 BST / 15:30 IST / 18.00 SGT for essential maintenance. Apologies for the inconvenience caused ...http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0676.1996.tb00702.x/references
Miha Lavric | BMS - IEBIS
Miha is a Tech4People funded postdoctoral researcher working primarily on the Tech4People project entitled "Use of predictive modeling tools to aid in the identification of child abuse and neglect, as well as other risks to child health and well-being". For his research, Miha is analyzing structured and unstructured (e.g. doctors' and nurses' free text notes) data that has been collected during regular consultation visits of children between the ages zero and four at regional preventive child health care organizations. The data is provided by the regional public health organization GGD Twente, Enschede.. Miha is also co-supervising BIT students during their bachelor research assignments that involve analysis of healthcare-related structured and unstructured data using prediction modeling and machine learning approaches.. As a part-time ETL Data Researcher at the company ...https://www.utwente.nl/en/bms/iebis/staff/lavric/
Cutting Edge: Roles for Batf3-Dependent APCs in the Rejection of Minor Histocompatibility Antigen-Mismatched Grafts | The...
Next, to confirm that the absence of male cells in female mice after the recall response was due to the induction of endogenous male Ag-specific CTLs, we employed an in vivo CTL killing assay (17, 19). Ten days after the AT of male OT-I T cells and administration of the OVA Ag, CFSE-labeled target cells, WT CD45.2 male and CD45.1 female splenocytes, were i.v. delivered at a 1:1 ratio for the measurement of male Ag-specific killing. Three days later, in vivo CTL responses were assessed by measuring the killing of male target cells compared with female target cells (Fig. 1B). As expected, WT female mice that received male OT-I T cells displayed almost complete killing of male target cells compared with WT male mice, where no killing was observed (Fig. 1B). This experiment concurs with the well-established finding that cells expressing male Ag are rejected in female mice via the induction of ...http://www.jimmunol.org/content/195/1/46
"Antibodies to t cell receptors and to histocompatibility antigens." by H Ramseier
Ramseier, H, "Antibodies to t cell receptors and to histocompatibility antigens." (1974). Subject Strain Bibliography 1974. 1138 ...https://mouseion.jax.org/ssbb1974/1138/
"Variation in histocompatibility antigen expression on murine tumors: d" by M Imamura and W J. Martin
Imamura, M and Martin, W J., "Variation in histocompatibility antigen expression on murine tumors: differences in expression and immunogenicity of h-2k region-coded unique antigens." (1982). Subject Strain Bibliography 1982. 411 ...https://mouseion.jax.org/ssbb1982/411/
Most recent papers with the keyword Minor antigen | Read by QxMD
Autoimmune hepatitis is an uncommon idiopathic syndrome of immunemediated destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is incompletely understood but includes a clear association with human leukocyte antigen (HLA) variants and other non- HLA gene variants, female sex, and the environment. Pathologically, there is a CD4+ T cell-rich lymphocytic inflammatory infiltrate with variable hepatocyte necrosis and subsequent hepatic fibrosis. Attempts to understand pathogenesis are informed by several monogenetic syndromes that may include autoimmune liver injury, by several drug and environmental agents that have been identified as triggers in a minority of cases, by human studies that point toward a central role for CD4+ effector and regulatory T cells, ...https://www.readbyqxmd.com/keyword/49407
Identification of histocompatibility antigens and mechanism of action | ari.info
George Snell, Jean Dausset and Baruj Benacerraf were awarded the Nobel Prize in Physiology or Medicine in 1980 for their discovery of how the immune system differentiates between 'self' and 'other'.http://www.animalresearch.info/es/avances-medicos/premios-nobel/identification-of-histocompatibility-antigens-and-mechanism/
A change in the expression of histocompatibility antigens could lead to autoimmunity]. - The Kennedy Institute of Rheumatology
Head To Head | Matej Svjetlicic vs Miha Mlakar H2H
Head To Head. Matej Svjetlicic vs Miha Mlakar all matches, with stats on their H2H rivalry. ATP & WTA Matej Svjetlicic head to head tennis search.http://www.stevegtennis.com/head-to-head/men/Matej_Svjetlicic/Miha_Mlakar/
PILIPOS 2 | Bible.is
PILIPOS 2. 1Ampakapakhaw nayi̇̀ nin nakem moyo ya pamakilamo moyo koni Pangino--on Hisokristo? Ampakahahaliwa nayi̇̀ komoyo ya panlalabi na? Ma--in kawo nayi̇̀ nin pamakilamo ha Ispirito nin Diyos? Mahampat nayi̇̀ ya nakem moyo nin mangingangalo ha miha ta miha? 2No ombayro, pimimihawen moyoy ihip, panlalabi, boy nakem moyo emen moyo malobos ya kaligawan ko. 3Anyaman ya bagay ya gaw--en moyo ay agmoyo gaw--en nin banà ha kalabayan moyo nin maka-igit ha kanayon, o banà et ha kahambogan moyo, no alwan magmaka-aypà kawo nin nakem ha miha ta miha. Agmoyo ihipen nin hikawo ay mas mahampat kisa ha kanayon. 4Alwan bongat sarili moyon ikahampat ya ihipen moyo, no alwan ihipen moyo et ya ikahampat nin kanayon. 5Magkama--in kawo nin ka-ihipan ya bilang ha ka-ihipan ni Pangino--on Hisokristo. 6Hiya, maski Diyos ya ...http://www.bible.is/SBLTBL/Phil/2