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*  MHC class I - Wikipedia
HLA-E, -F, and -G) as well as MHC class I pseudogenes arose from MHC class Ia loci (HLA-A, -B, and -C) in this birth-and-death ... Only the α chain is polymorphic and encoded by a HLA gene, while the b2m subunit is not polymorphic and encoded by the Beta-2 ... MHC class I molecules are one of two primary classes of major histocompatibility complex (MHC) molecules (the other being MHC ... There are, however, documented cases of trans-species polymorphisms in MHC class I genes, where a particular allele in an ...
  https://en.wikipedia.org/wiki/MHC_class_I
*  Major histocompatibility complex, class II, DQ alpha 1 - Wikipedia
... in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products. The other DQA1 alleles have ... Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates". Proc. Natl. Acad. Sci ... HLA-DQA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha ( ... Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of ...
  https://en.wikipedia.org/wiki/Major_histocompatibility_complex,_class_II,_DQ_alpha_1
*  HLA-DQB1 - Wikipedia
Within the DQ molecule, both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding ... Several alleles of HLA-DQB1 are associated with an increased risk of developing type 1 diabetes. The locus also has the genetic ... Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic ... HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA ...
  https://en.wikipedia.org/wiki/HLA-DQB1
*  Patent WO1989004875A2 - Characterization and detection of sequences associated with autoimmune diseases - Google Patents
... which detect either directly or indirectly the identity of the codon encoding for the amino acid at position 57 of the DQ-beta ... DNA sequences and corresponding amino acid sequences from the HLA class II beta region of the human genome that are associated ... DQ and DP, each with its distinct alpha and beta chains. The class II loci of the human major histocompatibility complex (MHC) ... Figure 4 illustrates the alignment of HLA-DQ-beta protein sequences. DNA sequences of DQ-beta alleles were translated to the ...
  http://www.google.com.au/patents/WO1989004875A2?cl=en
*  HLA-DQ - Wikipedia
The first identified DQ were DQw1 to DQw3. DQw1 (DQ1) recognized the alpha chain of DQA1*01 alleles. This group was later split ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. ... DQ Function in AutoimmunityEdit. HLA D (-P,-Q,-R) genes are members of the Major histocompatibility complex (MHC) gene family ... HLA DQ- subunit alleles, mature chains, contact variants Known. HLA-DQ. Potential ...
  https://en.m.wikipedia.org/wiki/HLA-DQ
*  C H O R I
The human major histocompatibility complex (MHC), or human leukocyte antigen (HLA) complex, consists of many genetic loci, ... The class I cell surface heterodimer has one highly polymorphic alpha chain, with variable residues clustering within the ... The class I molecules, HLA-A, HLA-B and HLA-C, and the class II molecules, DR, DQ and DP, are encoded in a ~3500 kbp segment of ... The allelic diversity of the HLA class I and class II loci is extensive, with ,13,000 alleles described (Figure 1) (http://hla. ...
  http://www.chori.org/Principal_Investigators/Trachtenberg_Elizabeth_A/tracht_research.html
*  History and naming of human leukocyte antigens - Wikipedia
... but complicated by 4 beta chain loci (DRB1, DRB3, DRB4, and DRB5). Serotypes to DQ reacted with alpha and beta chains, or both ... "HLA Nomenclature @ Hla.alleles.org." HLA Nomenclature @ Hla.alleles.org. Anthony Nolan Research Institute, 10 Nov. 2013. Web. ... Bach FH, Amos DB (1967). "Hu-1: Major histocompatibility locus in man". Science. 156 (3781): 1506-8. doi:10.1126/science. ... The next portion (HLA-A or HLA-B) identifies which gene the allele is a modification of. The first two numbers (HLA-A*02) ...
  https://en.wikipedia.org/wiki/History_and_naming_of_human_leukocyte_antigens
*  HLA-DQA2 - Wikipedia
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the HLA-DQA2 gene. Also ... Gyllensten UB, Erlich HA (1990). "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates". Proc. Natl. Acad. Sci ... 1992). "Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles". Immunogenetics. 36 (2): 71-8. doi:10.1007/ ... 1987). "Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene ...
  https://en.wikipedia.org/wiki/HLA-DQA2
*  MHC Evolution [M.Tevfik Dorak]
Moriuchi J, Moriuchi T, Silver J: Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and ... The origin of diversity of MHC alleles. The major histocompatibility complex (MHC) loci are known to be highly polymorphic in ... Gyllensten UB, Erlich HA: Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. Proceedings of the National ... the class II MHC alpha chain and beta 2-microglobulin and between the class II MHC beta-chain and the class I alpha chain 1. ...
  http://dorakmt.tripod.com/mhc/mhcevol.html
*  Association of Neovascular Age-Related Macular Degeneration with Specific Gene Expression Patterns in Peripheral White Blood...
HLA-DQA2 HLA class II histocompatibility antigen, DQ(6) alpha chain precursor. NM_020056.2 Hs.591798. 1.6. ... Specific alleles of such HLA genes have been associated with the risk for AMD. 44 Abnormal antigen presentation of retinal or ... alpha chain precursor. NM_020056.2 Hs.591798. 1.6. IGHG1 * IgG heavy chain locus. AF013620.1. Hs.510635. 2. ... HLA-DQA2 HLA class II histocompatibility antigen, DQ(6) ... IgG heavy chain locus. AF013620.1. Hs.510635. 2. ISOC1 CGI-111 ...
  https://iovs.arvojournals.org/article.aspx?articleid=2186361
*  HLA-DQ - Wikipedia
The first identified DQ were DQw1 to DQw3. DQw1 (DQ1) recognized the alpha chain of DQA1*01 alleles. This group was later split ... The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different ... HLA-DQ#Effects of heterogeneity of isoform pairing-Expanded HLA D (-P,-Q,-R) genes are members of the Major histocompatibility ... Both α-chain and β-chain vary greatly. A person often produces two α-chain and two β-chain variants and thus 4 isoforms of DQ. ...
  https://en.wikipedia.org/wiki/HLA-DQ
*  HLA-DQ7 - Wikipedia
DQ alpha chain) genes, producing in cis-haplotype form, a large number of DQ αβ isoforms. These DQ alpha chains are also known ... DQB1*0304 is the minor DQ7 allele DQ haplotypes of this serotype are formed between the cis-chromosomal genes of the DQA1 locus ... derived from IMGT/HLA Arnett FC, Olsen ML, Anderson KL, Reveille JD (1991). "Molecular analysis of major histocompatibility ... HLA-DQ7 (DQ7) is an HLA-DQ serotype that recognizes the common HLA DQB1*0301 and the less common HLA DQB1*0304 gene products. ...
  https://en.wikipedia.org/wiki/HLA-DQ7
*  HLA-DP - Wikipedia
It is distal from HLA-DR and HLA-DQ encoding loci and therefore is much more equilibrated with respect to other HLA loci. In ... HLA-DPA1 Alleles HLA-DPB1 Alleles Before the April 2010 HLA nomenclature update, new HLA-DPB1 allele names were assigned within ... The α-chain and β- of DP is encoded by the HLA-DPA1 locus and HLA-DPB1 loci, respectively. This cluster is located at the ... The name 'HLA-DP' originally describes a transplantation antigen of MHC class II category of the major histocompatibility ...
  https://en.wikipedia.org/wiki/HLA-DP
*  HLA-DPB1 - Wikipedia
HLA class II histocompatibility antigen, DP(W2) beta chain is a protein that in humans is encoded by the HLA-DPB1 gene. HLA-DPB ... 1992). "Family study on HLA-DPB1 polymorphism: linkage analysis with HLA-DR/DQ and two "new" alleles". Hum. Immunol. 34 (3): ... "Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci". ... 1988). "A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity". J. ...
  https://en.wikipedia.org/wiki/HLA-DPB1
*  HLA-DQ5 - Wikipedia
The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently ... Since DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning that DQ1 is corecognized with DQ5 and DQ6. ... 1996). "Investigation of the association of major histocompatibility complex genes, including HLA class I, class II and TAP ... HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA ...
  https://en.wikipedia.org/wiki/HLA-DQ5
*  Risk factors for celiac disease | Italian Journal of Pediatrics | Full Text
... nevertheless at least 39 non-HLA loci are associated with CD. Gluten is the main environmental trigger of the disease. In ... Among genetic risk factors, the strongest association is with the HLA class II DQ region; ... alpha chain) and the DQB1∗02 (beta chain) genes. HLA-DQ2.2 is highly homologous to DQ2.5, but is associated with a lower risk ... Among genetic risk factors, the strongest association is with the HLA class II DQ region; nevertheless at least 39 non-HLA loci ...
  https://ijponline.biomedcentral.com/articles/10.1186/s13052-015-0166-y
*  HLA-DR - Wikipedia
... not all new alleles are functional variants of the mature subunits]). The DR β-chain is encoded by 4 loci, however no more than ... "Organization of the transcriptional unit of a human class II histocompatibility antigen: HLA-DR heavy chain". Nucleic Acids Res ... "Rapid nonlysosomal degradation of assembled HLA class II glycoproteins incorporating a mutant DR alpha-chain". J. Immunol. 145 ... It is also closely linked to HLA-DQ and this linkage often makes it difficult to resolve the more causative factor in disease. ...
  https://en.wikipedia.org/wiki/HLA-DR
*  HLA-DRB4 - Wikipedia
The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It ... HLA-DR "Human PubMed Reference:". "Entrez Gene: HLA-DRB4 major histocompatibility complex, class II, DR beta 4". Germain RN ( ... 1986). "Analysis of DR beta and DQ beta chain cDNA clones from a DR7 haplotype". J. Immunol. 137 (9): 2886-90. PMID 3020127. ... Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney ...
  https://en.wikipedia.org/wiki/HLA-DRB4
*  CSA El Bagre EPF
... in that the antibodies to DQ1 react to the alpha chain of HLA DQ, these DQA1 allele gene products [7]. The other DQA1 alleles ... We specifically study the microsatellite loci neighboring the major histocompatibility complex region on the 6p chromosome, ... HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA ... DQ alpha 1 (HLA-II), also known as HLA-DQA1, is a human gene 169 www.najms.org North American Journal of Medical Sciences 2009 ...
  https://studylib.net/doc/25161912/csa-el-bagre-epf
*  Autoimmune Disorders | SpringerLink
Structural analysis of the HLA-DR,-DQ and-DP alleles on the celiac disease-associated HLA-DR3 (DRw 17) haplotype. Proc. Natl. ... Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci. J ... Three-dimensional structure of the human class II histocompatibility antigen HLA-DRL Nature 364:33-39.PubMedCrossRefGoogle ... Importance of HLA-DRB1 and DQA1 genes and of the amino-acid polymorphisms in the functional domain of DR-beta-1 chain in ...
  https://link.springer.com/chapter/10.1007%2F978-0-585-31180-7_5
*  HLA-DP Antigens - HLA-DP Summary Report | CureHunter
These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often ... A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. ... HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1). ". 03/01/1999 - "HLA-DR-DQ alleles and HLA-DP alleles are independently ... Histocompatibility Antigens: 1123*HLA Antigens: 2336*HLA-D Antigens: 214*HLA-DP Antigens: 231*HLA-DPB1: 174 ...
  http://www.curehunter.com/public/keywordSummaryD006682-HLA-DP-Antigens-HLA-DP.do
*  HLA-01:03 Allele in Lung Transplant Recipients Correlates with Higher Chronic Lung Allograft Dysfunction Occurrence
Although the two alleles only differ by a single amino acid in alpha 2 domain of the HLA-E heavy chain, HLA-. 01:03 is ... The major risks for CLAD were HLA class I DSA detected at M3 and/or M12, recipient/donor mismatches at HLA-DR and HLA-DQ loci, ... L. C. Sullivan, C. S. Clements, J. Rossjohn, and A. G. Brooks, "The major histocompatibility complex class Ib molecule HLA-E at ... 01:04~UTR3 on CLAD occurrence seems to be independent of the HLA-. 01:03 allele; finally, contrary to HLA-G alleles, HLA-. 01: ...
  https://www.hindawi.com/journals/jir/2016/1910852/
*  Gary Peltz | Stanford Medicine Profiles
All of the T cell clones which proliferated in response to Borrelia proteins were CD3 + CD4 + CD8 - TCR alpha beta + and HLA-DR ... Tests of the individual loci show that resistance to this disease is most strongly associated with the DQA1*0102 allele shared ... One T cell clone promiscuously recognized an epitope in the context of different HLA-DQ molecules. In addition, the binding of ... Nine bound to the 210-kD heavy chain and one (My8) bound to the 18-kD light chain. They defined six topographically distinct ...
  https://med.stanford.edu/profiles/gary-peltz
*  HLA-DQB1 | Cancer Genetics Web
Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding ... The genotype of HLA-A, HLA-B, HLA-DR, and HLA-DQ alleles was typed by means of PCR sequence-specific priming.. RESULTS: HLA-B* ... HLA-DQA1, and HLA-DQB1. Although the genetic effects of two HCC susceptibility loci were not replicated, the two loci were ... The DEGs, including major histocompatibility complex (MHC) class II, DQβ1, MHC class II, DRβ1, MHC class IB, MHC class II, DMα ...
  http://www.cancerindex.org/geneweb/HLA-DQB1.htm
*  The Past, Present and Future of HLA Typing ( The Human Leukocyte Antigen (HLA) regi...)
For many years HLA polymorphisms were typed by serological respons...,The,Past,,Present,and,Future,of,HLA,Typing,medicine, ... DQ and DP loci. Each locus is highly polymorphic; for example, there appear to be 300+ alleles in the HLA-B or DRB1 loci. A ... AmpliType HLA-DQ-alpha Forensic assay system). Of course, each HLA DNA typing technique has its advantages and disadvantages, ... sequence specific oligonucleotide probes to HLA loci amplified by the polymerase chain reaction (PCR), or by using PCR to ...
  http://www.bio-medicine.org/medicine-technology/The-Past--Present-and-Future-of-HLA-Typing-22-1/