The fate of Nissl-stained dark neurons following traumatic brain injury in rats: difference between neocortex and hippocampus...
We studied the fate of Nissl-stained dark neurons (N-DNs) following traumatic brain injury (TBI). N-DNs were investigated in ... Calpain inhibitors protect against depolarization-induced neurofilament protein loss of septo-hippocampal neurons in culture. ... Dash PK, Mach SA, Moore AN (2002) The role of extracellular signal-regulated kinase in cognitive and motor deficits following ... difference between neocortex and hippocampus regarding survival rate. ...https://link.springer.com/article/10.1007%2Fs00401-006-0108-2
Activity-mediated secretion of progranulin-containing granules - UBC Library Open Collections
2009). Progranulin is expressed within motor neurons and promotes neuronal cell survival. BMC Neurosci 10, 130. ... we treated hippocampal neurons with different concentrations of recombinant PGRN protein (R&D Systems). The cells were ... can act as a survival factor for cultured cortical and motor neurons (Ryan et al., 2009; Van Damme et al., 2008). Conversely, ... these motor proteins require an adaptor/scaffolding proteins associated with them in order to recognize, bind and transport the ...https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0073145
IJMS | Free Full-Text | Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic...
In EAE, DMF ameliorates the disease course and improves preservation of myelin, axons and neurons. Finally, Nrf2 is also up- ... Furthermore, application of FAE involves direct modification of the inhibitor of Nrf2, Kelch-like ECH-associated protein 1. On ... cellular levels, the application of FAE enhances neuronal survival and protects astrocytes against oxidative stress. Increased ... activation of Nrf2-dependent transcriptional activity and abundant synthesis of detoxifying proteins. ...http://www.mdpi.com/1422-0067/13/9/11783/htm
Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease | PNAS
It is possible that Miro1 is required for the survival of motor neurons that form the NA. Preliminary studies of E15.5 Miro1 KO ... 2013) TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 77(3):485-502. ... In hippocampal neurons, the Trak1 and Trak2 adaptors differentially control mitochondrial movement in axons and dendrites, and ... There are both inherited and sporadic forms of MNDs, which can affect upper motor neurons, lower motor neurons, or both. ...https://www.pnas.org/content/111/35/E3631?ijkey=7fbc3617ffc5feefa00580427d9d8a6bd6d3ec57&keytype2=tf_ipsecsha
Hgs HGF-regulated tyrosine kinase substrate [Mus musculus (house mouse)] - Gene - NCBI
... is indispensable for the autophagic clearance of neurodegeneration-related proteins and for the survival of hippocampal neurons ... HGS expression in the nervous system is developmentally regulated.HGS is required for motor neuron function. Title: Motor and ... BASP1; Brain acid soluble protein 1 (BASP1 protein). pfam07223. Location:525 → 769. DUF1421; Protein of unknown function ( ... BASP1; Brain acid soluble protein 1 (BASP1 protein). pfam07223. Location:525 → 743. DUF1421; Protein of unknown function ( ...https://www.ncbi.nlm.nih.gov/gene/?term=15239
Protocols and Video Articles Authored by Patrick Doherty (Translated to Arabic)
... motor function, muscle contractile characteristics, motor unit and motor neuron survival. These results therefore strongly ... enhances laminin-dependent extension of axonal processes in hippocampal neurons, whereas knockdown of PITPalpha protein by ... retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (cerebellar granule cells). The neurite ... SW4 supported the survival of rat postnatal cerebellar granule neurons plated in serum-free medium and limited the death of ...https://www.jove.com/author/Patrick_Doherty?language=Arabic
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies |...
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis 8: 479 ... Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell ... Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a ... Decreased hippocampal cell proliferation in R6/1 Huntington's mice. Neuroreport 15: 811-813, 2004.PubMedGoogle Scholar ...https://link.springer.com/article/10.1602%2Fneurorx.2.3.447
PI3K/AKT/mTOR pathway - Wikipedia
This is better for survival of the neurons as a whole but is at the expense of generating motor neurons. Therefore, it can be ... "Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons". Neuron ... Additionally, AKT localizes PtdIns-3Ps in the post synapse, which recruits docking proteins such as tSNARE and Vam7. This ... "Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons". Neuron ...https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway
Journal Artikel - Zentrum für Neuropathologie und Prionforschung - LMU München
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in ... Loss of the cellular prion protein affects the Ca(2+) homeostasis in hippocampal CA1 neurons. J Neurochem 98 (6), 1876-85. ... Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J. Neurochem. 98:1876-85. ... Effects of copper on survival of prion protein knockout neurons and glia. J. Neurochem. 70, 1686-1693 ...http://www.neuropathologie.med.uni-muenchen.de/publikationen/publikationen/index.html
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult...
... survival, or BrdU labeling of new hippocampal neurons. None of the latter effects have been described, but in principle they ... 1994) Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell ... Cell-specific markers used were: β-tubulin-III for neurons (Easter, et al., 1993), glial fibrillary acidic-protein (GFAP) ( ... Thus, external stimulators of the number of new neurons in the hippocampal formation, such as exercise may modulate hippocampal ...http://www.jneurosci.org/content/21/5/1628.long
Neurotrophic factors - Wikipedia
CNTF prevents degeneration of motor neurons in rats and mice which increases survival time and motor function of the mice. ... dorsal root ganglion sensory neurons, and ciliary neuron hippocampal neurons. It is structurally related to leukemia inhibitory ... Neurotrophic factors are polypeptides or small proteins that support the growth, differentiation, and survival of neurons. They ... survival, and differentiation of both developing and mature neurons. Most NTFs exert their trophic effects on neurons by ...https://en.wikipedia.org/wiki/Neurotrophic_factors
Protocols and Video Articles Authored by Grady E. Carlson (Translated to Chinese)
... culminating in greater neuron survival at 10d after CCI injury. Hippocampal neuroprotection achieved by IGF-1 overexpression ... Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined ... as well as the influence of sensory and motor systems on behavioral diversification and speciation. Here, we review the ... Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits ...https://www.jove.com/author/Grady+E._Carlson?language=Chinese
Protocols and Video Articles Authored by Grady E. Carlson (Translated to Russian)
... culminating in greater neuron survival at 10d after CCI injury. Hippocampal neuroprotection achieved by IGF-1 overexpression ... The protein encoded by one of these genes, YP_003504839, clustered with respiratory arsenate reductases on a phylogenetic tree ... as well as the influence of sensory and motor systems on behavioral diversification and speciation. Here, we review the ... Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits ...https://www.jove.com/author/Grady+E._Carlson?language=Russian
Protocols and Video Articles Authored by Baljit S. Khakh
Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels', 'Imaging Intracellular Ca2+ Signals in ... Using Lck-GCaMP2 in rat hippocampal astrocyte-neuron cocultures, we measured near-membrane calcium signals that were evoked ... some aspects of motor dysfunction and increased survival time in a HD mouse model. Overall, the data show that aspects of ... Here, we report that neuronal depolarization in hippocampal slices induces a calcium and protein phosphatase 1/2A-dependent ...https://www.jove.com/author/Baljit+S._Khakh
Neurotrophic Factors and Neurodegeneration | Springer for Research & Development
... are molecules which act to promote the differentiation of neurons and to maintain their phenotype. The discovery by Hamburger ... Eagleson KL, Bennett MR (1983) Survival of purified motor neurons in vitro: effects of skeletal muscle conditioned medium. ... Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite-extension. Proc Natl Acad ... Halegoua S, Patrick J (1980) Nerve growth factor mediates phosphorylation of specific proteins. Cell 22: 571-581PubMedGoogle ...https://rd.springer.com/chapter/10.1007/978-1-4471-1871-8_12
Expression and Neuroprotective Effect of Hepatocyte Growth Factor in Retinal Ischemia-Reperfusion Injury | IOVS | ARVO Journals
13 14 15 16 HGF is as potent a survival factor for motor neurons as other survival factors described to date, 17 such as brain- ... and functional coupling between HGF and the c-Met-HGF receptor is known to enhance the survival of hippocampal neurons in ... rhHGF was prepared as described previously. 3 14 The purity of rhHGF exceeds 98%, as determined by SDS-PAGE and after protein ... Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron ...https://iovs.arvojournals.org/article.aspx?articleid=2162305
Most recent papers with the keyword Christopher C Thompson | Read by QxMD
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor neuron disease with a variable ... Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake ... The Adverse Survival Implications of Bland Thrombus in Renal Cell Carcinoma with Venous Tumor Thrombus. ... with hippocampal abnormalities from an exome sequencing study of 10 cases of SIDS but no history of seizures. One harbored ...https://www.readbyqxmd.com/keyword/79154
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC...
doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't ... Immunoblot demonstrating the levels of the 54 kD mouse C9ORF72 protein. GAPDH was used as a loading control. (D) Survival curve ... No motor neuron loss and motor deficits in C9ORF72 transgenic mice with 450 repeats ... accompanied by loss of hippocampal neurons, increased anxiety, and impaired cognitive function. Single-dose injection of ...https://www.ncbi.nlm.nih.gov/pubmed/27112497?access_num=27112497&link_type=MED&dopt=Abstract
Neurotrophins in the Regulation of Cellular Survival and Death | SpringerLink
The four neurotrophins exert profound and crucial survival effects on developing... ... The neurotrophins play crucial roles regulating survival and apoptosis in the developing and injured nervous system. ... TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy- ... Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA (2000) NRAGE, a novel MAGE protein, interacts ...https://link.springer.com/chapter/10.1007%2F978-3-642-45106-5_8
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation |...
1997) under the prion protein promoter. The phenotype of this line is represented by the onset of motor symptoms (also ... In previous studies, DFP treatment increased the survival of dopaminergic neurons in the SNpc in toxin-induced animal models of ... From each brain region, namely cortex (CX), hippocampal CA3 region (CA3), hippocampal dentate gyrus (DG), deep mesencephalic ... 2012). Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of ...https://link.springer.com/article/10.1007/s12017-017-8447-9
Association of the Kinesin Superfamily Motor Protein KIF1Bα with Postsynaptic Density-95 (PSD-95), Synapse-Associated Protein...
C-F, Overlapping subcellular distribution of KIF1Bα with PSD-95, SAP97, and S-SCAM in cultured hippocampal neurons (at 6 d in ... In a previous study, culturedkif1B−/− neurons exhibiting reduced survival and differentiation were rescued only by KIF1Bβ, but ... enabling motors to interact with a large number of proteins. Second, PDZ proteins may help the cargo-PDZ protein-motor complex ... Association of the Kinesin Superfamily Motor Protein KIF1Bα with Postsynaptic Density-95 (PSD-95), Synapse-Associated Protein- ...http://www.jneurosci.org/content/22/13/5253
Succinic semialdehyde dehydrogenase deficiency - Wikipedia
... simultaneously releasing excitatory neurotransmitters onto motor neurons. Because the number and function of GABAB receptors ... Taurine is a non-protein sulfur amino acid that is found in high concentrations in human milk. It has been shown to have ... Although vigabatrin has not been consistently successful in patients with SSADH deficiency, it has shown enhanced survival of ... "Gamma-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices". European Journal of Pharmacology ...https://en.wikipedia.org/wiki/Succinic_semialdehyde_dehydrogenase_deficiency
Protocols and Video Articles Authored by Junling Gao (Translated to Japanese)
The increased motor neuron differentiation was accompanied by a decrease in the number of glial fibrillary acidic protein (GFAP ... The therapeutic efficacy of stem cell therapy depends greatly on the survival of grafted stem cell-derived motor neurons in the ... To explore the correlation between cognition disorder and morphologic change of hippocampal neurons after traumatic brain ... motor neurons in vitro. More importantly, blocking PI3K not only enhances motor neuron differentiation from hNSCs grafted into ...https://www.jove.com/author/Junling_Gao?language=Japanese
Cytoplasmic polyadenylation element binding protein regulates neurotrophin 3-dependent β-catenin mRNA translation in developing...
... along with its binding partner survival motor neuron (SMN), are thought to regulate β-actin synthesis in growth cones (Zhang et ... NT3-mediated increase in β-catenin protein in growth cones is protein synthesis dependent. A, Cultured hippocampal neurons (1 ... CPEB1 localizes to hippocampal growth cones. A, Rat hippocampal neurons (1 DIV) were processed for immunocytochemistry (ICC) ... and translation in neurons and represent possible stimuli to elicit CPEB1-mediated protein synthesis in hippocampal neurons. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2789487/
Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy
... cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a ... X. Zhang, L. Li, S. Chen et al., "Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic ... This is the case of autophagy-linked FYVE protein (ALFY) that serves as a scaffold protein for p62 mediated labeling . ... M. Sandri, "FOXOphagy path to inducing stress resistance and cell survival," Nature Cell Biology, vol. 14, no. 8, pp. 786-788, ...https://www.hindawi.com/journals/omcl/2018/5010741/