IJMS | Free Full-Text | Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic...
In EAE, DMF ameliorates the disease course and improves preservation of myelin, axons and neurons. Finally, Nrf2 is also up- ... Furthermore, application of FAE involves direct modification of the inhibitor of Nrf2, Kelch-like ECH-associated protein 1. On ... cellular levels, the application of FAE enhances neuronal survival and protects astrocytes against oxidative stress. Increased ... activation of Nrf2-dependent transcriptional activity and abundant synthesis of detoxifying proteins. ...http://www.mdpi.com/1422-0067/13/9/11783/htm
Protocols and Video Articles Authored by Patrick Doherty (Translated to Arabic)
... motor function, muscle contractile characteristics, motor unit and motor neuron survival. These results therefore strongly ... enhances laminin-dependent extension of axonal processes in hippocampal neurons, whereas knockdown of PITPalpha protein by ... retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (cerebellar granule cells). The neurite ... SW4 supported the survival of rat postnatal cerebellar granule neurons plated in serum-free medium and limited the death of ...https://www.jove.com/author/Patrick_Doherty?language=Arabic
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies |...
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol Dis 8: 479 ... Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell ... Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a ... Decreased hippocampal cell proliferation in R6/1 Huntington's mice. Neuroreport 15: 811-813, 2004.PubMedGoogle Scholar ...https://link.springer.com/article/10.1602%2Fneurorx.2.3.447
Journal Artikel - Zentrum für Neuropathologie und Prionforschung - LMU München
Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in ... Loss of the cellular prion protein affects the Ca(2+) homeostasis in hippocampal CA1 neurons. J Neurochem 98 (6), 1876-85. ... Loss of the cellular prion protein affects the Ca2+ homeostasis in hippocampal CA1 neurons. J. Neurochem. 98:1876-85. ... Effects of copper on survival of prion protein knockout neurons and glia. J. Neurochem. 70, 1686-1693 ...http://www.neuropathologie.med.uni-muenchen.de/publikationen/publikationen/index.html
Neurotrophic factors - Wikipedia
CNTF prevents degeneration of motor neurons in rats and mice which increases survival time and motor function of the mice. ... dorsal root ganglion sensory neurons, and ciliary neuron hippocampal neurons. It is structurally related to leukemia inhibitory ... Neurotrophic factors are polypeptides or small proteins that support the growth, differentiation, and survival of neurons. They ... survival, and differentiation of both developing and mature neurons. Most NTFs exert their trophic effects on neurons by ...https://en.wikipedia.org/wiki/Neurotrophic_factors
PI3K/AKT/mTOR pathway - Wikipedia
This is better for survival of the neurons as a whole but is at the expense of generating motor neurons. Therefore, it can be ... "Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons". Neuron ... Additionally, AKT localizes PtdIns-3Ps in the post synapse, which recruits docking proteins such as tSNARE and Vam7. This ... "Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons". Neuron ...https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult...
... survival, or BrdU labeling of new hippocampal neurons. None of the latter effects have been described, but in principle they ... 1994) Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell ... Cell-specific markers used were: β-tubulin-III for neurons (Easter, et al., 1993), glial fibrillary acidic-protein (GFAP) ( ... Thus, external stimulators of the number of new neurons in the hippocampal formation, such as exercise may modulate hippocampal ...http://www.jneurosci.org/content/21/5/1628.long
Protocols and Video Articles Authored by Baljit S. Khakh
Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels', 'Imaging Intracellular Ca2+ Signals in ... Using Lck-GCaMP2 in rat hippocampal astrocyte-neuron cocultures, we measured near-membrane calcium signals that were evoked ... some aspects of motor dysfunction and increased survival time in a HD mouse model. Overall, the data show that aspects of ... Here, we report that neuronal depolarization in hippocampal slices induces a calcium and protein phosphatase 1/2A-dependent ...https://www.jove.com/author/Baljit+S._Khakh
Neurotrophic Factors and Neurodegeneration | Springer for Research & Development
... are molecules which act to promote the differentiation of neurons and to maintain their phenotype. The discovery by Hamburger ... Eagleson KL, Bennett MR (1983) Survival of purified motor neurons in vitro: effects of skeletal muscle conditioned medium. ... Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite-extension. Proc Natl Acad ... Halegoua S, Patrick J (1980) Nerve growth factor mediates phosphorylation of specific proteins. Cell 22: 571-581PubMedGoogle ...https://rd.springer.com/chapter/10.1007/978-1-4471-1871-8_12
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC...
doi: 10.1016/j.neuron.2016.04.006. Epub 2016 Apr 21. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't ... Immunoblot demonstrating the levels of the 54 kD mouse C9ORF72 protein. GAPDH was used as a loading control. (D) Survival curve ... No motor neuron loss and motor deficits in C9ORF72 transgenic mice with 450 repeats ... accompanied by loss of hippocampal neurons, increased anxiety, and impaired cognitive function. Single-dose injection of ...https://www.ncbi.nlm.nih.gov/pubmed/27112497?access_num=27112497&link_type=MED&dopt=Abstract
Most recent papers with the keyword Christopher C Thompson | Read by QxMD
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive, fatal motor neuron disease with a variable ... Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake ... The Adverse Survival Implications of Bland Thrombus in Renal Cell Carcinoma with Venous Tumor Thrombus. ... with hippocampal abnormalities from an exome sequencing study of 10 cases of SIDS but no history of seizures. One harbored ...https://www.readbyqxmd.com/keyword/79154
Association of the Kinesin Superfamily Motor Protein KIF1Bα with Postsynaptic Density-95 (PSD-95), Synapse-Associated Protein...
C-F, Overlapping subcellular distribution of KIF1Bα with PSD-95, SAP97, and S-SCAM in cultured hippocampal neurons (at 6 d in ... In a previous study, culturedkif1B−/− neurons exhibiting reduced survival and differentiation were rescued only by KIF1Bβ, but ... enabling motors to interact with a large number of proteins. Second, PDZ proteins may help the cargo-PDZ protein-motor complex ... Association of the Kinesin Superfamily Motor Protein KIF1Bα with Postsynaptic Density-95 (PSD-95), Synapse-Associated Protein- ...http://www.jneurosci.org/content/22/13/5253
Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation |...
1997) under the prion protein promoter. The phenotype of this line is represented by the onset of motor symptoms (also ... In previous studies, DFP treatment increased the survival of dopaminergic neurons in the SNpc in toxin-induced animal models of ... From each brain region, namely cortex (CX), hippocampal CA3 region (CA3), hippocampal dentate gyrus (DG), deep mesencephalic ... 2012). Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of ...https://link.springer.com/article/10.1007/s12017-017-8447-9
Succinic semialdehyde dehydrogenase deficiency - Wikipedia
... simultaneously releasing excitatory neurotransmitters onto motor neurons. Because the number and function of GABAB receptors ... Taurine is a non-protein sulfur amino acid that is found in high concentrations in human milk. It has been shown to have ... Although vigabatrin has not been consistently successful in patients with SSADH deficiency, it has shown enhanced survival of ... "Gamma-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices". European Journal of Pharmacology ...https://en.wikipedia.org/wiki/Succinic_semialdehyde_dehydrogenase_deficiency
Protocols and Video Articles Authored by Junling Gao (Translated to Japanese)
The increased motor neuron differentiation was accompanied by a decrease in the number of glial fibrillary acidic protein (GFAP ... The therapeutic efficacy of stem cell therapy depends greatly on the survival of grafted stem cell-derived motor neurons in the ... To explore the correlation between cognition disorder and morphologic change of hippocampal neurons after traumatic brain ... motor neurons in vitro. More importantly, blocking PI3K not only enhances motor neuron differentiation from hNSCs grafted into ...https://www.jove.com/author/Junling_Gao?language=Japanese
Cytoplasmic polyadenylation element binding protein regulates neurotrophin 3-dependent β-catenin mRNA translation in developing...
... along with its binding partner survival motor neuron (SMN), are thought to regulate β-actin synthesis in growth cones (Zhang et ... NT3-mediated increase in β-catenin protein in growth cones is protein synthesis dependent. A, Cultured hippocampal neurons (1 ... CPEB1 localizes to hippocampal growth cones. A, Rat hippocampal neurons (1 DIV) were processed for immunocytochemistry (ICC) ... and translation in neurons and represent possible stimuli to elicit CPEB1-mediated protein synthesis in hippocampal neurons. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2789487/
IJMS | Free Full-Text | Neuroprotective Effects of Psychotropic Drugs in Huntington's Disease | HTML
... and extended survival (lithium, valproate, sertraline, melatonin) have been documented. Upregulated CREB binding protein (CBP; ... motor improvement (tetrabenazine, lithium, valproate, imipramine, nortriptyline, trazodone, sertraline, venlafaxine), ... or huntingtin protein expression, psychotropic neuroprotective effects include upregulated huntingtin autophagy (lithium), ... hippocampal, or cortical neurons . Similarly, a trial of 5-20 mg/kg/day sertraline (about 6 times human therapeutic doses) ...http://mdpi.com/1422-0067/14/11/22558/htm
Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic Localization | Journal of...
Ferreira A, Niclas J, Vale RD, Banker G, Kosik KS (1992) Suppression of kinesin expression in cultured hippocampal neurons ... The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain. FEBS Lett 470 ... Liu Q, Dreyfuss G (1996) A novel nuclear structure containing the survival of motor neurons protein. EMBO J 15: 3555-3565. ... Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic Localization. Honglai L. Zhang, ...http://www.jneurosci.org/content/23/16/6627.long
Exposure of Neurons to Excitotoxic Levels of Glutamate Induces Cleavage of ADAR2 and Loss of GluR2 Editing
The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study. Eur J ... Edited GluR2, a gatekeeper for motor neurone survival? Bioessays. 2008;30:1185-1192. [PubMed] ... For hippocampal neurons in 6 well plates, the neurons were plated at a density of 150,000 per well on cover slips precoated ... has been shown to contribute to motor neuron toxicity and late onset motor neuron disease, suggesting that the increased Ca2+ ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3150305/?lang=en-ca
1998) RPE secreted proteins and antibody influence photoreceptor cell survival and maturation. Brain Res Dev Brain Res 107:57- ... 1999) Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J ... and hippocampal neurons (DeCoster et al., 1999). In addition, PEDF differentially protects immature, but not mature, cerebellar ... Moreover, it has been demonstrated that RPE-secreted proteins positively influence photoreceptor survival (Gaur et al., 1992; ...http://www.jneurosci.org/content/20/19/7149
IJMS | Free Full-Text | Oxidative Stress and Neurodegenerative Disorders | HTML
... weakly antioxidative systems and the terminal-differentiation characteristic of neurons. Thus, oxidative stress elicits various ... a transmembrane protein amyloid-β precursor protein (AβPP) is critical to neuron growth, survival and post-injury repair [67,68 ... Duan, W.; Li, X.; Shi, J.; Guo, Y.; Li, Z.; Li, C. Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron- ... Modulation of protein kinases and protein phosphatases by reactive oxygen species: Implications for hippocampal synaptic ...http://www.mdpi.com/1422-0067/14/12/24438/htm
Protocols and Video Articles Authored by Junmin Peng
... is caused by low levels of survival motor neuron (SMN) protein. Currently it is not clear how the SMN protein levels are ... N40K expression led to substantial degeneration of rat primary hippocampal neurons. In summary, we combined multiple approaches ... Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-survival Motor Neuron The ... A liposome pull-down screen identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein. In ...https://www.jove.com/author/Junmin_Peng
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor ... Protein-protein interaction, High-throughput screening, Luminescence, Yeast two-hybrid, HT-GPCA, Network, protein, yeast, cell ... Neuromodulation and Mitochondrial Transport: Live Imaging in Hippocampal Neurons over Long Durations ... neurons results in rapid degeneration of the 5-HT system and suggests that the 5-HT system is important for postnatal survival. ...https://www.jove.com/visualize/abstract/22140524/deletion-munc18-1-5-ht-neurons-results-rapid-degeneration-5-ht-system
The survival rate of TH-positive neurons of each midbrain was calculated by dividing the number of TH-positive neurons on the ... 2005) Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to ... 1988) Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8:2804-2815. ... It has been shown that overexpression of α-syn impairs the neurotransmitter release in cortical and hippocampal neurons ( ...http://www.jneurosci.org/content/32/27/9248
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C....
1995). The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of ... 2007). MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J. Exp. Med. 204, 2063- ... Hippocampal neurons from SARM-deficient mice are protected from death during deprivation of oxygen and glucose, suggesting an ... Many proteins are transported by dynein/dynectin and kinesin motor proteins along microtubules to different locations within ...http://dev.biologists.org/content/138/16/3509.long
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