*  Dendritic spike - Wikipedia
Nav1.1, Nav2.2, and Nav1.6 are three isoforms of the voltage-gated sodium channels that are present at high levels in the ... The density of voltage-gated sodium and calcium channels is similar in both dendrites and axons; however, the dendritic ... Nav1.6 has been identified in the dendrites of hippocampal CA1 neurons that generate dendritic spikes; the density of Nav1.6 in ... A variety of alpha subunit voltage-gated sodium channels have been identified. Voltage-gated sodium channels found in mammals ...
  https://en.wikipedia.org/wiki/Dendritic_spike
*  Plus it
Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... Mistargeting hippocampal axons by expression of a truncated Eph receptor. Proc Natl Acad Sci USA 99: 10777-10782, 2002. ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ... Ephrin-dependent growth and pruning of hippocampal axons. Proc Natl Acad Sci USA 96: 4073-4077, 1999. ...
  http://jn.physiology.org/content/105/5/2364
*  SCN8A - Wikipedia
Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at the nodes of Ranvier. The channels are ... immature Nav1.2 channels outnumber Nav1.6 in axons. However, mature Nav1.6 channels gradually replace the other channels as ... which reduce peak sodium currents. Dopamine and acetycholine reduce sodium currents in hippocampal pyramidal neurons through ... The voltage gated sodium channel is composed of 1980 residues. Like other sodium channels, Nav1.6 is a monomer composed of four ...
  https://en.wikipedia.org/wiki/SCN8A
*  Antagonism of Lidocaine Inhibition by Open-Channel Blockers That Generate Resurgent Na Current | Journal of Neuroscience
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium ... 2007) Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. J Neurosci 27:13552-13566. ... 1978) Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons. Biophys J 2:285-311. ... 2007a) Analysis of resurgent sodium current expression in rat parahippocampal cortices and hippocampal formation. Brain Res ...
  http://www.jneurosci.org/content/33/11/4976
*  Frontiers | The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional...
Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which ... review will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels ... review will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels ... molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels. ...
  https://www.frontiersin.org/articles/10.3389/fncel.2017.00115/full
*  Frontiers | Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment | Frontiers in...
... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... In rat cultured hippocampal neurons and cortical organotypic slices, we found that shRNA-mediated knockdown of ankG membrane ... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... In rat cultured hippocampal neurons and cortical organotypic slices, we found that shRNA-mediated knockdown of ankG membrane ...
  https://www.frontiersin.org/articles/10.3389/fncel.2017.00006/full
*  Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
... normal voltage-gated sodium channel currents, and normal accumulation of ankyrin G and the sodium channels Nav1.6 at NR. The ... Constitutively active IKK is enriched at axon initial segments and nodes of Ranvier (NR). We used mice with a Cre-loxP-mediated ... In addition, a dominant-negative form of PDZ-RhoGEF blocks semaphorin 4D-induced growth cone collapse in primary hippocampal ... Patch-clamp recordings revealed changes in voltage-dependent tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels ...
  https://www.jove.com/author/Rohini_Kuner?language=Italian
*  Physiologic Alterations in Ataxia | Movement Disorders | JAMA Neurology | The JAMA Network
... normally interacts with voltage-gated sodium channels and appears to regulate the expression of these channels at the axon ... Several ion channels help regulate Purkinje neuron firing. The sodium channel Nav1.6 is the major depolarizing conductance ... Nav1.1 is widely expressed in other neurons, including hippocampal neurons, which may explain the seizures seen in this ... Two major categories of ion channels exist: voltage-gated and ligand-gated. Voltage-gated channels on the cell surface generate ...
  https://jamanetwork.com/journals/jamaneurology/fullarticle/798137
*  Plus it
Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... In cells with successfully filled axons (n = 16/30), the axons projected densely to layer I (Fig. 1C), as Ma et al. (2006) also ... Oliva AA Jr, Jiang M, Lam T, Smith KL, Swann JW. Novel hippocampal interneuronal subtypes identified using transgenic mice that ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ...
  http://jn.physiology.org/content/100/5/2640
*  ModelDB: Models that contain the Modeling Application : NEURON
Fast sodium channel gating in mossy fiber axons (Schmidt-Hieber et al. 2010) ... A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017) ... Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) ... Hippocampal basket cell gap junction network dynamics (Saraga et al. 2006) 310.. Hippocampal CA1 NN with spontaneous theta, ...
  https://senselab.med.yale.edu/ModelDB/ModelList.cshtml?id=1882
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... Baclofen selectively inhibits transmission at synapses made by axons of CA3 yramidal cells in the hippocampal slice. Pharmacol ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ... voltage-gated calcium channels whereas postsynaptic GABAB receptors hyperpolarize the cell by activating potassium channels ( ...
  http://jn.physiology.org/content/100/1/8
*  Downregulation of Dendritic HCN Channel Gating in Epilepsy Is Mediated by Altered Phosphorylation Signaling | Journal of...
2005) Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase. J Neurosci 25:6621-6630. ... We then determined how upregulation of HCN channel gating by CaN inhibition affected the excitability of CA1 hippocampal ... 2009) Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a ... and p38 MAPK directly phosphorylates voltage-gated sodium channels (Wittmack et al., 2005), we cannot rule out the alternative ...
  http://www.jneurosci.org/content/30/19/6678
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... The Hodgkin and Huxley (1952) model of the squid axon action potential predicts that about 10% of the channels remain ... 2009), and hippocampal CA1 and cortical pyramidal neurons (Carter and Bean 2009), but incomplete inactivation in several types ... To assay sodium channel inactivation during and between action potentials, we measured sodium channel availability in voltage- ...
  http://jn.physiology.org/content/105/2/860
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. J Neurosci 14: 4613-4638 ... Contribution of noradrenaline-, dopamine- and adrenaline-containing axons to the innervation of different regions of the spinal ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ...
  http://jn.physiology.org/content/103/1/490
*  Sharpness of Spike Initiation in Neurons Explained by Compartmentalization
According to this standard theory, these channels should open gradually when the membrane potential increases, but spikes ... Since the pioneering work of Hodgkin and Huxley, it is known that spikes are generated by the opening of sodium channels with ... 3. Angelino E, Brenner MP (2007) Excitability constraints on voltage-gated sodium channels. PLoS Comput Biol 3: 1751-1760. * ... 3E, dashed curve, somatic Nav1.2 channels are also added, with the same total conductance as in the axon. In Fig. 4, Nav1.6 ...
  http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003338
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... The axon usually projected from a basal dendrite. In three of eight P14 cells the axon was preserved to at least layer VI and ... Both in hippocampal neurons (Harris et al. 1992; Kirov et al. 2004; Pokorný and Yamamoto 1981) and stellate cells in other ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ...
  http://jn.physiology.org/content/100/6/3144
*  Mechanics of the brain: perspectives, challenges, and opportunities | SpringerLink
... leaky voltage-gated sodium ion channels were observed after trauma. The degree of trauma of these Nav1.6 ion channels was ... Axons. Long slender projection of neurons, that transmit information in the form of electrical signals to other neurons and ... An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. J ... Wang JA, Lin W, Morris T, Banderali U, Juranka PF, Morris CE (2009) Membrane trauma and \(Na^+\) leak from Nav1.6 channels. Am ...
  https://link.springer.com/article/10.1007%2Fs10237-015-0662-4
*  Channelpedia
CAP-1A binds to a conserved motif present in NaV1.8 linking voltage-gated sodium channels to clathrin, which is involved in ... Ankyrins have an important role in clustering NaV1.6 into nodes of Ranvier and axon initial segments [1390]. ... mGluR regulate hippocampal CA1 pyramidal neuron excitability via activation of SK channels through regulation of intracellular ... KCNE channel alters KCNQ5 channel gating. The proteins KCNE1 and KCNE3 alter the gating of the Kv7.5 channel in Xenopus oocytes ...
  http://channelpedia.epfl.ch/reports/interaction
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... Whole cell patch recordings were made with an Axon Multiclamp 700A (Molecular Devices) for voltage clamp or a Dagan BVC700A for ... Garaschuk O, Yaari Y, Konnerth A. Release and sequestration of calcium by ryanodine-sensitive stores in rat hippocampal ... Three prominent sources of Ca2+ in many dendrites in general are voltage-gated Ca2+ channels (VGCCs), glutamate-gated channels ...
  http://jn.physiology.org/content/102/2/1218
*  Perlecan is recruited by dystroglycan to nodes of Ranvier and binds the clustering molecule gliomedin | JCB
Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron. 30:91-104. doi: ... Nodes of Ranvier are located at gaps in myelin, where the axolemma is endowed with high densities of voltage-gated Na+ channels ... H and I) Teased fibers were stained for Nav 1.6 and ERM-P, and the number of normal and abnormal clusters were correlated with ... Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and ...
  http://jcb.rupress.org/content/208/3/313
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Cover: Presence of sodium voltage-gated channel isoform 1.6 (NaV1.6) at the heminode and sensory terminals of a Ia afferent ... Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons. Nature 395: 900-905, ... All analysis and production of graphic presentations were performed using Clampfit (version 9.0, Axon Instruments), Mini ... Distribution of TTX-sensitive voltage-gated sodium channels in primary sensory endings of mammalian muscle spindles. J ...
  http://jn.physiology.org/content/104/1/200
*  FENS Forum 2004 - Abstracts
EXPRESSION OF THE NAV1.6 SODIUM CHANNEL IN THE NORMAL AND PATHOLOGIC NEUROMUSCULAR JUNCTION IN MICE.. A016.1. Poster 247 - Sun ... A SECOND ISOFORM OF VOLTAGE-DEPENDENT ANION CHANNEL (VDAC) IN DROSOPHILA MELANOGASTER: A FUNCTIONAL CHARACTERIZATION.. A057.1. ... SOLUBLE FORM OF TUBULIN IS TRANSPORTED AS A COMPLEX WITH CRMP-2 BY CONVENTIONAL KINESIN IN GROWING AXON.. A132.1. Poster 440 - ... BDNF PROTECTS HIPPOCAMPAL NEURONS FROM GLUTAMATE EXCITOTOXICITY THROUGH A PROTEIN SYNTHESIS DEPENDENT MECHANISM.. A020.1. ...
  http://fens2004.neurosciences.asso.fr/posters/Let/LetA.html