*  A new cellular model to follow Friedreich's ataxia development in a time-resolved way | Disease Models & Mechanisms
... mitochondrial protein that is involved in the regulation of iron-sulfur cluster biogenesis and that is highly conserved from ... and animal models all revealed that FXN deficiency primarily leads to defects in iron-sulphur cluster-containing proteins, but ... It has also the potential to use available markers, e.g. indicators of iron-sulphur cluster biogenesis, to characterize and ... It is made of highly conserved protein 'modules' of 33-34 amino acids with just two repeat variable di-residues (RVDs, ...
  http://dmm.biologists.org/content/8/7/711
*  Most recent papers with the keyword Parallel evolution | Read by QxMD
... ribosome biogenesis and translation. Fe-S cluster biogenesis is performed by multiple enzymes that are highly conserved ... Iron sulfur (Fe-S) clusters are cofactors in hundreds of proteins involved in multiple cellular processes, including ... For the G-protein receptor kinases (GRKs), the GRK1 and GRK7 divisions arose prior to the divergence of tunicates, with further ... Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. ...
  https://www.readbyqxmd.com/keyword/4792
*  Iron-sulfur cluster biosynthesis protein family - Wikipedia
... the iron-sulfur cluster biosynthesis protein family of includes proteins involved in biogenesis of Fe-S clusters (iron-sulfur ... is highly conserved in evolution". J. Mol. Evol. 43 (5): 536-40. doi:10.1007/BF02337525. PMID 8875867. This article ... binds iron and [2Fe-2S] clusters, and participates in the biosynthesis of iron-sulfur proteins. IscA is able to bind at least 2 ... cluster insertion protein, Fe/S biogenesis protein). This family includes IscA, HesB, YadR and YfhF-like proteins. The hesB ...
  https://en.wikipedia.org/wiki/Iron-sulfur_cluster_biosynthesis_protein_family
*  Ferredoxin-NADP(+) reductase - Wikipedia
... and iron-sulfur protein biogenesis. FNR is a soluble protein that is found both free in the chloroplast stroma and bound to the ... The glutamate residue is highly conserved; because, it both stabilizes the semiquinone form of FAD and is a proton donor/ ... This enzyme belongs to the family of oxidoreductases, that use iron-sulfur proteins as electron donors and NAD+ or NADP+ as ... However, these proteins belong to two unrelated protein families and are an example of convergent evolution. The plant-type ...
  https://en.wikipedia.org/wiki/Ferredoxin%E2%80%94NADP(+)_reductase
*  Transcription factor HTH, IscR (IPR010242) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... iron-sulphur cluster), SUF (sulphur assimilation), and NIF (nitrogen fixation) systems.. The ISC system is conserved in ... the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. It is ...
  http://www.ebi.ac.uk/interpro/entry/IPR010242
*  Phylogenetic analysis of fungal ABC transporters | BMC Genomics | Full Text
... is an essential iron-sulfur protein required for ribosome biogenesis and translation initiation [88, 89]. A single ... The function of Atm1p in the biogenesis of Fe/S clusters is highly conserved in the evolution, as homologous proteins of plants ... the biogenesis of iron-sulfur proteins to fatty acid metabolism and cell protection against different classes of toxic ... Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J. 2005, 24: 589-598 ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-11-177
*  Shaping the dynamic mitochondrial network | BMC Biology | Full Text
... iron-sulfur cluster biogenesis, pyrimidine biosynthesis and the storage and release of apoptotic factors (reviewed in [1]). TCA ... Adaptor proteins mediate the interactions between these cytoskeletal motors and mitochondria. The adaptor protein Milton/TRAK ... Mitochondria are not discrete or autonomous but form highly dynamic, interconnected networks whose biogenesis and structure are ... The conserved MOM Rho-like GTPase Miro and its binding partner Milton function as a mitochondrial receptor for kinesin. In ...
  https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-12-35
*  Protocols and Video Articles Authored by Rebecca A. Wingert
Aug, 2005 , Pubmed ID: 16110529 Iron is required to produce haem and iron-sulphur (Fe-S) clusters, processes thought to occur ... Nephron composition is highly conserved across species, and an increasing appreciation of the similarities between zebrafish ... In contrast to yeast, vertebrates use iron regulatory protein 1 (IRP1) to sense intracellular iron and regulate mRNA stability ... causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis. Murine Mfrn rescues the defects in frs zebrafish, ...
  https://www.jove.com/author/Rebecca+A._Wingert
*  Homeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila Ferritin | Genetics
1998 Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species-characterization of IRP-1 homologues in ... Rouault, T. A., and W. H. Tong, 2005 Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat. Rev. Mol. Cell ... Translation of ferritin proteins is regulated by the binding of either of the two iron regulatory proteins (IRPs) to an iron ... iron region, control diet; (G) anterior midgut, iron diet; (H) iron region, iron diet. (I and J) Fer1HCHG188/+ larvae were ...
  http://www.genetics.org/content/177/1/89.full
*  NDUFA4 - Wikipedia
The highly conserved two-domain structure suggests that this feature is critical for the protein function and that the ... The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 ... NDUFA4 has many protein-protein interactions, including ubiquitin proteins such as ubiquitin C and UBL4A, as well as CUL3 and ... It has been demonstrated that NDUFA4 plays a role in Complex IV function and biogenesis, however, with some authors suggesting ...
  https://en.wikipedia.org/wiki/NDUFA4
*  POLD1 - Wikipedia
Paul VD, Lill R (June 2015). "Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability". ... In this process, the highly conserved C-terminal domain (CTD) of POLD1/p125 interacts with the CTD domain of PolĪ¶, and the iron ... cluster added through Cytosolic Iron-sulfur protein Assembly (CIA), which requires the function of the mitochondrial Iron ... "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity". Science. 337 (6091): 195-9. doi: ...
  https://en.wikipedia.org/wiki/POLD1
*  serine Dehydratase (SDS) ELISA Kits
The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur ... protein 22A3 , ribosome maturation protein SBDS , shwachman-Bodian-Diamond syndrome protein homolog , iron-sulfur subunit of ... Deficiency of the ribosome biogenesis gene Sbds (show SBDS ELISA Kits) in hematopoietic stem and progenitor cells causes ... Additionally we are shipping serine Dehydratase Antibodies (53) and serine Dehydratase Proteins (6) and many more products for ...
  http://www.antibodies-online.com/ribonucleoprotein-complex-subunit-organization-pathway-73/sds-elisa-kit-18803/
*  FARA - Grant Program
Structural Dynamics and the Consolidation of Protein Function in Protein Complexes Involved in the Biosynthesis of Iron-Sulfur ... Frataxin, like many of the proteins involved in mitochondrial Fe-S cluster synthesis is highly conserved among eukaryotes. The ... those that increase mitochondrial iron-sulfur cluster biogenesis. The goal of the project is to identify the most potent in ... ISCU and FXN as a protein complex. Iron, sulfur, and electrons are transferred to a protein scaffold (ISCU); the second step is ...
  http://www.curefa.org/grant
*  Three hydrophobic amino acids in Escherichia coli HscB make the greatest contribution to the stability of the HscB-IscU complex...
... structure of the iron-sulfur cluster cochaperone HscB and its binding surface for the iron-sulfur assembly scaffold protein ... Of the three highly conserved acidic residues (E97, E100, E104), only the E100A substitution perturbed the affinity of HscB for ... Beinert H: Iron-sulfur proteins: ancient structures, still full of surprises. J Biol Inorg Chem. 2000, 5: 2-15. 10.1007/ ... the scaffold for Fe-S cluster biogenesis. J Biol Chem. 2006, 281: 14580-14587. 10.1074/jbc.M600842200.PubMedView ArticleGoogle ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-12-3
*  Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria | Biochemical Journal
2014) Mitochondrial iron-sulfur protein biogenesis and human disease. Biochimie 100, 61-77 doi:10.1016/j.biochi.2014.01.010. ... superfamily of proteins. The cysteines co-ordinate the proximal Fe4S4 cluster and SAM. Arginine 88 is highly conserved among ... iron-sulfur; GSSG, glutathione disulfide; GS-S-SG, glutathione trisulfide; ISU/ISCU, iron-sulfur cluster assembly protein 1; ... 2009) An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis ...
  http://www.biochemj.org/content/475/2/495
*  Frontiers | Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives | Physiology
Ma, C., Agrawal, G., and Subramani, S. (2011). Peroxisome assembly: matrix and membrane protein biogenesis. J. Cell Biol. 193, ... Autophagy is a highly conserved intracellular pathway that delivers cytoplasmic substrates to lysosomes for subsequent ... non-sulfur iron dioxygenases, which catalyze the conversion of poly-unsaturated fatty acids (PUFAs) into conjugated ... Thoms, S., and Erdmann, R. (2005). Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation. FEBS J ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00145/full
*  Comparative transcriptomics analysis reveals difference of key gene expression between banana and plantain in response to cold...
... probable cytosolic iron-sulfur protein assembly protein 1 (C), zinc finger protein 1 (D), U-box domain- containing protein 25 ( ... three novel MYB proteins (MYBS1, MYBS2 and MYBS3) containing one highly conserved DNA-binding domain mediate sugar and hormone ... protein modification, nucleosome assembly, cell wall organization and biogenesis, signal transduction, oxidation reduction, RNA ... Probable cytosolic iron-sulfur protein assembly protein 1), GSMUA_Achr6G32910_001 (Zinc finger CCCH domain-containing protein ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1551-z
*  Marine Drugs | Free Full-Text | Proteomic Analysis of Anti-Tumor Effects of 11-Dehydrosinulariolide on CAL-27 Cells | HTML
Some of the differential proteins are associated with cell proliferation, apoptosis, protein synthesis, protein folding, and ... A total of 28 differential proteins (12 up-regulated and 16 down-regulated) in CAL-27 cells treated with 11- ... to investigate the effects of 11-dehydrosinulariolide on CAL-27 cells at the molecular level by comparison between the protein ... It is a member of the highly conserved Hsp70 family and is involved in polypeptide translation, protein folding, and protein ...
  http://www.mdpi.com/1660-3397/9/7/1254/htm
*  NMR Spectroscopy in the Analysis of Protein-Protein Interactions | SpringerLink
Protein-protein interactions are a central aspect of biology and NMR spectroscopy is one of the most powerful and versatile ... Prischi F, Pastore A. Hybrid methods in iron-sulfur cluster biogenesis. Front Mol Biosci. 2017;4:12.CrossRefGoogle Scholar ... Characterization of the conserved interaction between GATA and FOG family proteins. J Biol Chem. 2002;277:35720-9.CrossRef ... a nuclear magnetic resonance study of a highly dynamic protein complex. Biochemistry. 2002;41:11721-30.CrossRefGoogle Scholar ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-319-28275-6_121-1
*  Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities...
... proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, ... Despite the prominence of iron-sulfur cluster (ISC) ... proteins involved in ISC biogenesis is heat shock protein ... Jac1 interacts with the iron-sulfur scaffold protein Isu1p [27] and this interaction appears to be conserved in evolution [21, ... Moreover, biosynthesis and delivery of ISCs to target proteins requires a highly regulated molecular network that spans ...
  https://link.springer.com/article/10.1007/s00775-013-0988-2
*  ABCE1 - Wikipedia
"Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria". The EMBO Journal. 24 (3 ... and highly conserved protein that is required for both eukaryotic translation initiation as well as ribosome biogenesis. The ... RLI belongs to the ABCE family of ATP-binding cassette (ABC) proteins. ABC proteins typically also contain a transmembrane ... The protein sequences between species is very well conserved, for example Pixie and yeast Rli1p are 66% identical, and Rli1p ...
  https://en.wikipedia.org/wiki/ABCE1
*  Most recent papers in the journal Journal of Biological Inorganic Chemistry: JBIC | Read by QxMD
Iron-sulfur clusters (Fe-S) are amongst the most ancient and versatile inorganic cofactors in nature which are used by proteins ... Domain 6 of these ribozymes contains a highly conserved adenosine whose 2'-OH acts as a nucleophile during self-cleavage via ... Iron-sulfur clusters biogenesis by the SUF machinery: close to the molecular mechanism understanding. ... putatively delivering cluster from the Isu scaffold protein to target proteins. The tripeptide glutathione is intimately ...
  https://www.readbyqxmd.com/journal/32648
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Among the best-characterized cytosolic RNA-binding proteins are iron regulatory proteins, IRP1 and IRP2. They bind to iron ... In C. elegans, exposure to moderate hypoxia elicits a transcriptional response mediated largely by hif-1, the highly-conserved ... A crude protein lysate containing an RNA-binding protein, or a purified preparation of this protein, is incubated with an ... Biochemistry, Issue 93, Redox titration, electron paramagnetic resonance, Nar1, cofactor, iron-sulfur cluster, mononuclear iron ...
  https://www.jove.com/visualize/abstract/23555700/copper-deficiency-leads-to-anemia-duodenal-hypoxia-upregulation-hif-2
*  Frontiers | Multilevel Regulation of Abiotic Stress Responses in Plants | Plant Science
Ubiquitin (Ub), a small protein with 76-amino acids that are conserved across all eukaryotic organisms, functions as a protein ... 2006). A protein kinase, interacting with two calcineurin B-like proteins, regulates K+ transporter AKT1 in Arabidopsis. Cell ... 2011). Monoubiquitin-dependent endocytosis of the IRON-REGULATED TRANSPORTER 1 (IRT1) transporter controls iron uptake in ... outside of the highly conserved domains-APETALA2 and N-Terminus) have played an important role in the evolution of ERF-VII ...
  https://www.frontiersin.org/articles/10.3389/fpls.2017.01564/full
*  Diseases | Free Full-Text | Pathological Mutations of the Mitochondrial Human Genome: the Instrumental Role of the Yeast S....
However, some extragenic nuclear suppressors were also obtained and turned out to be mutations of the Iron-Sulfur protein. They ... These mutations, in conserved regions of subunit a, all impair the ATP synthase. Examination of the same mutations in yeast has ... Highly developed genetics with a diverse and well-adapted toolbox. Thousands of mutations exist in practically every nuclear ... that support the fact that these suppression effects are not linked to the catalytic activity of these two proteins in protein ...
  http://www.mdpi.com/2079-9721/2/1/24/htm