*  ATM1 protein (Saccharomyces cerevisiae) - STRING interaction network
Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved ... Required for biogenesis a [...] Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins ... Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein ... Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein ...
  https://string-db.org/network/4932.YMR301C
*  A new cellular model to follow Friedreich's ataxia development in a time-resolved way | Disease Models & Mechanisms
... mitochondrial protein that is involved in the regulation of iron-sulfur cluster biogenesis and that is highly conserved from ... and animal models all revealed that FXN deficiency primarily leads to defects in iron-sulphur cluster-containing proteins, but ... It has also the potential to use available markers, e.g. indicators of iron-sulphur cluster biogenesis, to characterize and ... It is made of highly conserved protein 'modules' of 33-34 amino acids with just two repeat variable di-residues (RVDs, ...
  http://dmm.biologists.org/content/8/7/711
*  Most recent papers with the keyword Parallel evolution | Read by QxMD
... ribosome biogenesis and translation. Fe-S cluster biogenesis is performed by multiple enzymes that are highly conserved ... Iron sulfur (Fe-S) clusters are cofactors in hundreds of proteins involved in multiple cellular processes, including ... For the G-protein receptor kinases (GRKs), the GRK1 and GRK7 divisions arose prior to the divergence of tunicates, with further ... Cytosolic HSC20 integrates de novo iron-sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients. ...
  https://www.readbyqxmd.com/keyword/4792
*  Iron-sulfur cluster biosynthesis protein family - Wikipedia
... the iron-sulfur cluster biosynthesis protein family of includes proteins involved in biogenesis of Fe-S clusters (iron-sulfur ... is highly conserved in evolution". J. Mol. Evol. 43 (5): 536-40. doi:10.1007/BF02337525. PMID 8875867. This article ... binds iron and [2Fe-2S] clusters, and participates in the biosynthesis of iron-sulfur proteins. IscA is able to bind at least 2 ... cluster insertion protein, Fe/S biogenesis protein). This family includes IscA, HesB, YadR and YfhF-like proteins. The hesB ...
  https://en.wikipedia.org/wiki/Iron-sulfur_cluster_biosynthesis_protein_family
*  Transcription factor HTH, IscR (IPR010242) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... iron-sulphur cluster), SUF (sulphur assimilation), and NIF (nitrogen fixation) systems.. The ISC system is conserved in ... the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. It is ...
  http://www.ebi.ac.uk/interpro/entry/IPR010242
*  Ferredoxin-NADP(+) reductase - Wikipedia
... and iron-sulfur protein biogenesis. FNR is a soluble protein that is found both free in the chloroplast stroma and bound to the ... The glutamate residue is highly conserved; because, it both stabilizes the semiquinone form of FAD and is a proton donor/ ... This enzyme belongs to the family of oxidoreductases, that use iron-sulfur proteins as electron donors and NAD+ or NADP+ as ... However, these proteins belong to two unrelated protein families and are an example of convergent evolution. The plant-type ...
  https://en.wikipedia.org/wiki/Ferredoxin%E2%80%94NADP(+)_reductase
*  Shaping the dynamic mitochondrial network | BMC Biology | Full Text
... iron-sulfur cluster biogenesis, pyrimidine biosynthesis and the storage and release of apoptotic factors (reviewed in [1]). TCA ... Adaptor proteins mediate the interactions between these cytoskeletal motors and mitochondria. The adaptor protein Milton/TRAK ... Mitochondria are not discrete or autonomous but form highly dynamic, interconnected networks whose biogenesis and structure are ... The conserved MOM Rho-like GTPase Miro and its binding partner Milton function as a mitochondrial receptor for kinesin. In ...
  https://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-12-35
*  Structural Basis for Fe-S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein-Protein Interactions - Semantic Scholar
... and rhodanese RhdA are sulfur acceptors. Other proteins, such as CyaY/frataxin and IscX, also bind to IscS, but their ... Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters. ... the first member of a sulfur relay leading to sulfur incorporation into the wobble uridine of several tRNAs; ThiI, involved in ... The sulfur acceptors can only bind to IscS one at a time, while frataxin and IscX can form a ternary complex with IscU and IscS ...
  https://www.semanticscholar.org/paper/Structural-Basis-for-Fe%E2%80%93S-Cluster-Assembly-and-tRNA-Shi-Proteau/99095ddea16d5a3f29a65d8b07e9cbeac312d531
*  Homeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila Ferritin | Genetics
1998 Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species-characterization of IRP-1 homologues in ... Rouault, T. A., and W. H. Tong, 2005 Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat. Rev. Mol. Cell ... Translation of ferritin proteins is regulated by the binding of either of the two iron regulatory proteins (IRPs) to an iron ... iron region, control diet; (G) anterior midgut, iron diet; (H) iron region, iron diet. (I and J) Fer1HCHG188/+ larvae were ...
  http://www.genetics.org/content/177/1/89.full
*  Protocols and Video Articles Authored by Rebecca A. Wingert
Aug, 2005 , Pubmed ID: 16110529 Iron is required to produce haem and iron-sulphur (Fe-S) clusters, processes thought to occur ... Nephron composition is highly conserved across species, and an increasing appreciation of the similarities between zebrafish ... In contrast to yeast, vertebrates use iron regulatory protein 1 (IRP1) to sense intracellular iron and regulate mRNA stability ... causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesis. Murine Mfrn rescues the defects in frs zebrafish, ...
  https://www.jove.com/author/Rebecca+A._Wingert
*  Three hydrophobic amino acids in Escherichia coli HscB make the greatest contribution to the stability of the HscB-IscU complex...
... structure of the iron-sulfur cluster cochaperone HscB and its binding surface for the iron-sulfur assembly scaffold protein ... Of the three highly conserved acidic residues (E97, E100, E104), only the E100A substitution perturbed the affinity of HscB for ... Beinert H: Iron-sulfur proteins: ancient structures, still full of surprises. J Biol Inorg Chem. 2000, 5: 2-15. 10.1007/ ... the scaffold for Fe-S cluster biogenesis. J Biol Chem. 2006, 281: 14580-14587. 10.1074/jbc.M600842200.PubMedView ArticleGoogle ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/1471-2091-12-3
*  serine Dehydratase (SDS) ELISA Kits
The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur ... protein 22A3 , ribosome maturation protein SBDS , shwachman-Bodian-Diamond syndrome protein homolog , iron-sulfur subunit of ... Deficiency of the ribosome biogenesis gene Sbds (show SBDS ELISA Kits) in hematopoietic stem and progenitor cells causes ... Additionally we are shipping serine Dehydratase Antibodies (53) and serine Dehydratase Proteins (6) and many more products for ...
  http://www.antibodies-online.com/ribonucleoprotein-complex-subunit-organization-pathway-73/sds-elisa-kit-18803/
*  NDUFA4 - Wikipedia
The highly conserved two-domain structure suggests that this feature is critical for the protein function and that the ... The electrons are transferred through a series of iron-sulfur (Fe-S) clusters in the prosthetic arm and finally to coenzyme Q10 ... NDUFA4 has many protein-protein interactions, including ubiquitin proteins such as ubiquitin C and UBL4A, as well as CUL3 and ... It has been demonstrated that NDUFA4 plays a role in Complex IV function and biogenesis, however, with some authors suggesting ...
  https://en.wikipedia.org/wiki/NDUFA4
*  POLD1 - Wikipedia
Paul VD, Lill R (June 2015). "Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability". ... In this process, the highly conserved C-terminal domain (CTD) of POLD1/p125 interacts with the CTD domain of PolĪ¶, and the iron ... cluster added through Cytosolic Iron-sulfur protein Assembly (CIA), which requires the function of the mitochondrial Iron ... "MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity". Science. 337 (6091): 195-9. doi: ...
  https://en.wikipedia.org/wiki/POLD1
*  Frontiers | Novel, Deep-Branching Heterotrophic Bacterial Populations Recovered from Thermal Spring Metagenomes | Microbiology
Analysis of conserved phylogenetic marker genes indicated that two of the phylotypes represent separate groups of an ... Analysis of conserved phylogenetic marker genes indicated that two of the phylotypes represent separate groups of an ... fumarate reductase iron-sulfur protein; fumC, fumarase C; mdh, malate dehydrogenase; amtB, ammonium transporter; gdh, glutamate ... "conserved" bacterial housekeeping genes (Garcia Martin et al., 2006) and 40 "conserved" prokaryotic universal markers (Wu et al ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.00304/full
*  Preliminary comparative genomics revealed pathogenic potential and international spread of Staphylococcus argenteus | BMC...
1). Further analysis suggested that agrA was highly conserved within species and had no common sequence differences among agr ... Cell wall/membrane/envelope biogenesis; N, Cell motility; O, Posttranslational modification, protein turnover, chaperones; P, ... Skaar EP, Schneewind O. Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes ... Of the 19 (17.1%) genes absent in S. argenteus or S. schweizeri, 11 encode enterotoxins or related superantigen-like proteins, ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4149-9
*  Most recent papers in the journal Journal of Biological Inorganic Chemistry: JBIC | Read by QxMD
Iron-sulfur clusters (Fe-S) are amongst the most ancient and versatile inorganic cofactors in nature which are used by proteins ... Domain 6 of these ribozymes contains a highly conserved adenosine whose 2'-OH acts as a nucleophile during self-cleavage via ... Iron-sulfur clusters biogenesis by the SUF machinery: close to the molecular mechanism understanding. ... putatively delivering cluster from the Isu scaffold protein to target proteins. The tripeptide glutathione is intimately ...
  https://www.readbyqxmd.com/journal/32648
*  Genetic dissection of cyclic pyranopterin monophosphate biosynthesis in plant mitochondria | Biochemical Journal
2014) Mitochondrial iron-sulfur protein biogenesis and human disease. Biochimie 100, 61-77 doi:10.1016/j.biochi.2014.01.010. ... superfamily of proteins. The cysteines co-ordinate the proximal Fe4S4 cluster and SAM. Arginine 88 is highly conserved among ... iron-sulfur; GSSG, glutathione disulfide; GS-S-SG, glutathione trisulfide; ISU/ISCU, iron-sulfur cluster assembly protein 1; ... 2009) An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis ...
  http://www.biochemj.org/content/475/2/495
*  NMR Spectroscopy in the Analysis of Protein-Protein Interactions | SpringerLink
Protein-protein interactions are a central aspect of biology and NMR spectroscopy is one of the most powerful and versatile ... Prischi F, Pastore A. Hybrid methods in iron-sulfur cluster biogenesis. Front Mol Biosci. 2017;4:12.CrossRefGoogle Scholar ... Characterization of the conserved interaction between GATA and FOG family proteins. J Biol Chem. 2002;277:35720-9.CrossRef ... a nuclear magnetic resonance study of a highly dynamic protein complex. Biochemistry. 2002;41:11721-30.CrossRefGoogle Scholar ...
  https://link.springer.com/referenceworkentry/10.1007/978-3-319-28275-6_121-1
*  Session Listing | 2017 Drosophila Research Conference
Function of the Iron-sulfur Cluster Assembly Protein Ciao1 in Growth Regulation in Drosophila Jean Jung. 232A Differential ... is highly conserved for proper RAS signal transduction Robert Van Sciver. 219C Sequential Activation of Pointed Initiates ... De novo recruitment of PcG proteins at giant Jumana AlHaj Abed. 677B The recognition of target gene transcriptional state by ... Understanding phased primary-piRNA biogenesis in Drosophila Daniel Tianfang Ge. 694A The interplay of Piwi and heterochromatin ...
  http://www.genetics-gsa.org/drosophila/2017/pages/sessionlisting/Posters.shtml
*  Mutation analysis of Chinese sporadic congenital sideroblastic anemia by targeted capture sequencing | Journal of Hematology &...
... iron-sulfur cluster biogenesis, or mitochondrial solute transport or metabolism. However, approximately 40 % of patients with ... Iron-sulfur cluster biogenesis and human disease. Trends Genet. 2008;24:398-407.View ArticlePubMed CentralPubMedGoogle Scholar ... Among these proteins, the TRNG tRNA-Gly protein plays a role in mitochondrial glycine transport. Therefore, the deletion of ... The mutated amino acid may be located in the middle of a highly conserved hydrophobic region of ALAS2, and its side chain may ...
  https://jhoonline.biomedcentral.com/articles/10.1186/s13045-015-0154-0
*  Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities...
... proteins in bioenergetics, intermediary metabolism, and redox regulation of cellular, mitochondrial, and nuclear processes, ... Despite the prominence of iron-sulfur cluster (ISC) ... proteins involved in ISC biogenesis is heat shock protein ... Jac1 interacts with the iron-sulfur scaffold protein Isu1p [27] and this interaction appears to be conserved in evolution [21, ... Moreover, biosynthesis and delivery of ISCs to target proteins requires a highly regulated molecular network that spans ...
  https://link.springer.com/article/10.1007/s00775-013-0988-2
*  Comparative transcriptomics analysis reveals difference of key gene expression between banana and plantain in response to cold...
... probable cytosolic iron-sulfur protein assembly protein 1 (C), zinc finger protein 1 (D), U-box domain- containing protein 25 ( ... three novel MYB proteins (MYBS1, MYBS2 and MYBS3) containing one highly conserved DNA-binding domain mediate sugar and hormone ... protein modification, nucleosome assembly, cell wall organization and biogenesis, signal transduction, oxidation reduction, RNA ... Probable cytosolic iron-sulfur protein assembly protein 1), GSMUA_Achr6G32910_001 (Zinc finger CCCH domain-containing protein ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1551-z
*  Protocols and Video Articles Authored by Peter-Leon Hagedoorn
A conserved iron-binding site, the ferroxidase center, regulates the vital iron storage role of the ubiquitous protein ferritin ... The uncharacterized proteins YgfK and XdhD were found to be significant iron containing proteins under elevated iron conditions ... A highly conserved tyrosine residue of unknown function is present in the vicinity of the di-iron catalytic center of the ... Nov, 2006 , Pubmed ID: 16924554 Formaldehyde oxidoreductase (FOR) is one of the tungstopterin iron-sulfur enzymes of the five- ...
  https://www.jove.com/author/Peter-Leon_Hagedoorn
*  Frontiers | Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives | Physiology
Ma, C., Agrawal, G., and Subramani, S. (2011). Peroxisome assembly: matrix and membrane protein biogenesis. J. Cell Biol. 193, ... Autophagy is a highly conserved intracellular pathway that delivers cytoplasmic substrates to lysosomes for subsequent ... non-sulfur iron dioxygenases, which catalyze the conversion of poly-unsaturated fatty acids (PUFAs) into conjugated ... Thoms, S., and Erdmann, R. (2005). Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation. FEBS J ...
  https://www.frontiersin.org/articles/10.3389/fphys.2013.00145/full