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*  Study: Directly observed HIV therapy for children is promising | EurekAlert! Science News
The first study in the developing world of directly observed antiretroviral therapy for HIV-infected children shows this form ... "We know that a high degree of adherence reduces the chances of drug resistance - which can lead to treatment failure and the ... David Pugatch and colleagues at Brown University have shown that directly observed therapy increases adherence to treatment ... Study: Directly observed HIV therapy for children is promising. Brown University. Journal. American Journal of Public Health. ...
  https://www.eurekalert.org/pub_releases/2007-05/bu-sdo053107.php
*  Adolescents and Young Adults with HIV | Considerations for Antiretroviral Use in Special Patient Populations | Adult and...
Virologic response using directly observed therapy in adolescents with HIV: an adherence tool. J Assoc Nurses AIDS Care. Mar- ... Sexually transmitted infections among HIV infected and HIV uninfected high-risk youth in the REACH study. Reaching for ... the adolescent's degree of independence/autonomy and decisional capacity; patient confidentiality; and informed consent. Also, ... Enhancing adherence to HAART: a pilot program of modified directly observed therapy. AIDS Read. Jun 2001;11(6):317-319, 324-318 ...
  https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/21/hiv-infected-adolescents-and-young-adults?source=govdelivery
*  Oral Antimyeloma Therapy: Barriers to Patient Adherence and Tips for Improvement | Volume 15 Issue 3 (2018) | HOPA News |...
Direct methods include directly observed therapy, and indirect methods include use of patient questionnaires, patient self- ... In addition, current treatment regimens are highly complex, and oral chemotherapy regimens require from patients a high degree ... Oral Antimyeloma Therapy: Barriers to Patient Adherence and Tips for Improvement. Karen Sweiss, PharmD BCOP. Clinical ... Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly ...
  http://hoparx.org/hopa-news/volume-15-issue-3-2018/oral-antimyeloma-therapy-barriers-to-patient-adherence-and-tips-for-improvement
*  Tuberculosis treatment abandonment and comprehensive health care to patients in the family healthcare strategy
In order to control TB, the Brazilian Ministry of Health has adopted the Directly Observed Therapy, Short-course (DOTS). This ... without generating higher or lower degrees of importance among them.10 By overcoming reductionisms of a biologicist practice ... turning the adherence to therapy into a difficult process. The second meaning unit deals with the articulation between the ... This study observed that the care is provided directly by the healthcare professional; the contents of the interviews did not ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072012000300021&lng=en&nrm=iso&tlng=en
*  HIV and People Who Use Illicit Drugs | Adult and Adolescent ARV | AIDSinfo
... the use of adherence support mechanisms such as modified directly observed therapy (mDOT), which has shown promise among people ... The association between club drugs and high-risk sexual behavior in men who have sex with men (MSM) is strongest for ... therapeutic failure in this population generally correlates with the degree that drug use disrupts daily activities rather than ... Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: a ...
  https://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/22/hiv-and-illicit-drug-users
*  Plus it
Early passage cell strains showed high consistency in response to cancer therapy between tumorgraft and cell strain. ... Significant diversity in tumorgraft tumor differentiation was observed with good agreement in degree of differentiation between ... Tumor was transported directly from the operating room to the laboratory in ice-cold culture media [Dulbecco's Modified Eagle ... the tremendous selection pressure required to grow human tumor cells in artificial tissue culture systems with adherence to ...
  http://clincancerres.aacrjournals.org/content/19/4/855
*  Treatment Support Program
The TAC staff provide directly observed therapy (DOT) for patients in need of our highest level of support. ... Treatment Adherence Center. The JACQUES Initiative Treatment Adherence Center (TAC) provides adherence support for over 300 ... This may include pursuing healthy relationships, returning to school or completing a more advanced degree, employment, or ... This support model evaluates medication adherence and client wellness on a daily, weekly, and monthly basis through meetings ...
  http://www.jacques.ihv.org/Patient-Care/Treatment-Support-Program/
*  Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised...
Adherence to therapy. Adherence to therapy was high in all treatment arms (mean (SD) adherence 95%,13 93%,20 96%11 and 95%9 for ... This is the first trial to directly compare the effects of different antibiotic classes on airway bacterial load in stable COPD ... We have also demonstrated an increase in the degree and rate of resistance of cultured airway bacteria following administration ... The reduction in exacerbation frequency observed elsewhere is therefore likely to be mediated by other mechanisms. These may ...
  https://thorax.bmj.com/content/70/10/930
*  Chronic Subdural Hematoma Associated with Thrombocytopenia in a Patient with Human Immunodeficiency Virus Infection in Cameroon
... therapy for many years had a very low CD4+ cell count and thrombocytopenia suggesting suboptimal therapy or adherence to ... Major bleeding is unusual unless the platelet count is less than 50 × 103 per μL. Risk factors for bleeding at higher platelet ... Thrombocytopenia is correlated with low CD4 cell count and older age as observed in our patient [8]. Although the pathogenesis ... Though cotrimoxazole has been shown to directly affect thrombopoiesis, it may be difficult to determine its contribution to the ...
  https://www.hindawi.com/journals/crinm/2017/5395829/
*  Breast density change as a predictive surrogate for response to adjuvant endocrine therapy in hormone receptor positive breast...
... high preoperative MD, and long interval between start of ET to follow-up mammogram were significantly associated with larger ... Anti-estrogen therapy has been shown to reduce mammographic breast density (MD). We hypothesized that a short-term change in ... MDR (p < 0.05). In a survival analysis, tumor size, lymph node positivity, high Ki-67 (≥ 10%), and low MDR were independent ... breast density may be a surrogate biomarker predicting response to adjuvant endocrine therapy (ET) in breast cancer. We ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3221
*  Overview, Vol 13, Issue 3 | International Osteoporosis Foundation
Curtis et al report that in 13,444 postmenopausal women observed for 106,066 person-years, high placebo adherence was ... Degree of mineralization of bone (DMB) and its distribution did not differ from placebo. Hardness (Hv) was higher in the ... Placebo adherence, clinical outcomes, and mortality in the women's health initiative randomized hormone therapy trial. Med Care ... WT mice engrafted with db/db bone marrow (BM) are not capable of directly responding to leptin and did not differ in energy ...
  https://www.iofbonehealth.org/volume-13-issue-3
*  Dog ownership supports the maintenance of physical activity during poor weather in older English adults: cross-sectional...
... directly observed activities undertaken in six public parks over 12-week period and recorded visitors' types of physical ... 17 The other study used therapy dogs as an intervention in a walking programme and suggested a positive effect on adherence ... High levels of physical inactivity in older adults present a challenge to active ageing. In the UK, for example, it is ... Education was divided into four levels: less than O level, O level (age 14-16), A level (age 16-18) and university degree or ...
  https://jech.bmj.com/content/71/9/905
*  Challenge of phosphorus control in hemodialysis patients: a problem of adherence? - PDF
... the highest levels of compliance are observed in treatments that require directly supervised medication (e.g., chemotherapy) ... Adherence to insulin therapy at a tertiary care diabetes center in South India Original Article: Adherence to insulin therapy ... the degree of adherence to the drugs prescribed was studied using the Simplified Medication Adherence Questionnaire. Results: ... Promoting Adherence to HIV Antiretroviral Therapy Promoting Adherence to HIV Antiretroviral Therapy New York State Department ...
  http://docplayer.net/318189-Challenge-of-phosphorus-control-in-hemodialysis-patients-a-problem-of-adherence.html
*  Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy, JNCI: Journal of the...
"Prognostic Value of Clinical vs Pathologic Stage in Rectal Cancer Patients Receiving Neoadjuvant Therapy, JNCI: Journal of the ... Further, our definition of downstaging assumes a high degree of accuracy in clinical staging. At this time, the NCDB does not ... These data will be invaluable for advocating consistency in guideline adherence to the use of neoadjuvant therapy and providing ... No statistically significant survival difference was observed between clinical (cT2, cT1: HR = 0.87, 95% CI = 0.75 to 1.01, P ...
  https://www.deepdyve.com/lp/ou_press/prognostic-value-of-clinical-vs-pathologic-stage-in-rectal-cancer-JO04E0lS6s
*  Pharmaceutical composition based on a hepatoprotector and a prebiotic, and production and application thereof - Dikovskiy...
Moreover, they also do not make it possible to control to the necessary degree the adequacy and effectiveness of the therapy of ... It is well known that in liver diseases and cholelithiasis with mainly cholesterol stones, one observes a higher content of ... In addition to directly affecting the liver tissue, ademethionine has a number of additional pharmacological effects, such as ... Prebiotic galactooligosaccharides reduce the adherence of Enteropathogenic Escherichia coli to tissue culture cells. Infect ...
  http://www.freepatentsonline.com/9446058.html
*  Maternal Phenylketonuria | FROM THE AMERICAN ACADEMY OF PEDIATRICS | Pediatrics
Poor dietary adherence leads to blood Phe concentrations above the current recommended therapeutic range.4 High blood Phe ... Recommendations for dietary therapy have evolved as experience with different regimens and durations of therapy have ... The best observed outcomes occur when strict control of maternal blood Phe concentration is instituted before pregnancy or by 8 ... Achieving this degree of control requires a major commitment by the woman and support by her treating professionals. The ...
  http://pediatrics.aappublications.org/content/122/2/445
*  Children with HIV in low-income countries more adherent to treatment: IU News Room: Indiana University
... in children who live in low income countries is as high as or higher than adherence by children living in high income countries ... the Regenstrief Institute and Moi University School of Medicine are the first to report that adherence to antiretroviral ... therapy (ART) to fight human immunodeficiency virus (HIV) ... and directly observed therapy. Neither electronic drug ... strongly suggests that children in low-income countries are able to maintain at least a comparable degree of ART adherence, if ...
  http://newsinfo.iu.edu/web/page/normal/8656.html
*  Cell therapy for severe burn wound healing, Burns & Trauma | 10.1186/s41038-018-0117-0 | DeepDyve
"Cell therapy for severe burn wound healing, Burns & Trauma" on DeepDyve, the largest online rental service for scholarly ... "Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with ... CEAs sample could be taken for growing CEAs, a 3-week wait- could be transplanted directly to the wound area [8, 73] ing time ... Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a ...
  https://www.deepdyve.com/lp/springer_journal/cell-therapy-for-severe-burn-wound-healing-0ITdhv3Tkx
*  Mycobacterium tuberculosis | Pediatric Opportunistic Infection | AIDSinfo
If adherence with daily isoniazid cannot be ensured, then consider twice-weekly isoniazid by directly observed therapy (DOT) by ... In high-TB-burden settings, screening for TB exposure and for signs or symptoms suggestive of TB disease is universally ... HIV infection and the degree of immune alteration diminish the utility of these tests and change interpretation of results. A ... Key to Acronyms: cART = combined antiretroviral therapy; CNS = central nervous system; DOT = directly observed therapy; FDA = ...
  https://aidsinfo.nih.gov/guidelines/html/5/pediatric-opportunistic-infection/414/mycobacterium-tuberculosis
*  Minimally Invasive Therapy for Neurogenic Detrusor Overactivity: A Review
... there was a high degree of correlation between 1-year and 5-year success rates [115]. Surgical revision is a relatively common ... Continence was observed at the 6-week follow-up. No side effects were reported. Mean reflex volume and mean maximum cystometric ... Recent trials have focused on injection of botulinum toxin A (BoNT-A) directly into the detrusor, and there is a good body of ... with antimuscarinic therapy are problematic in patients with NDO and can result in drug discontinuation and reduced adherence ...
  https://www.urotoday.com/volume-2-2009/vol-2-issue-6/32880-minimally-invasive-therapy-for-neurogenic-detrusor-overactivity-a-review-2225796.html
*  1997 USPHS/IDSA Guidelines for the Prevention of Opportunistic Infections in Persons Infected with Human Immunodeficiency Virus
Directly observed therapy required for isoniazid (INH), 900 mg b.i.w.; INH regimens should include pyridoxine to prevent ... Most clinicians favor lifelong therapy for the mother, given the high likelihood that disease will recur promptly if therapy is ... IVIG should also involve consideration of adherence, ease of intravenous access, and cost. If IVIG is used, RSV-IVIG may be ... and the degree to which precautions are taken to prevent the transmission of tuberculosis in the workplace (BIII). Whether the ...
  https://www.cdc.gov/mmwr/preview/mmwrhtml/00048226.htm
*  Lancet Series Showcases Challenges, Promise in the Fight Against TB | Science Speaks: Global ID News
... in association with directly observed therapy, short-course (DOTS) for TB, form the basis of prevention and control of HIV- ... and the degree to which access to appropriate therapy follows access to diagnosis. Translation of scientific progress in ... Treatment success rates in MDR TB can be as high as 83%, and 60% in patients with XDR TB, in treatment programmes that function ... with drug selection and patient adherence correctly managed, is also essential to prevent resistance to new regimens developing ...
  https://sciencespeaksblog.org/2010/05/18/lancet-series-showcases-challenges-promise-in-the-fight-against-tb/
*  Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies
... the technique is less effective in defining structures due to high degree of backscatter, and finally it requires the prolonged ... the LESCs were cultivated directly on the contact lens [171]. Gore et al. investigated cultivation of LESCs on contact lenses ... biocompatibility of SF and SF-CS films has been observed in rabbit corneas for up to six months [183, 188]. However, membranes ... 4-diaminobutane has been shown to improve LESC adherence and proliferation [202]. ...
  https://www.hindawi.com/journals/sci/2016/9798374/
*  Explanation and elaboration of the Standards for UNiversal reporting of patient Decision Aid Evaluations (SUNDAE) guidelines:...
Example 2 discusses how the characteristics of the sample (eg, chronic condition) may have contributed to the high observed ... music therapy was listed among the treatment options, but no music therapy was currently offered because of absence of a music ... These examples also directly address interactivity and tailoring, and other factors that might moderate the PDA effect (eg, ... There is a risk that strict adherence to guidelines of any sort may be counterproductive.8 While we recommend that authors pay ...
  https://qualitysafety.bmj.com/content/27/5/389
*  Hormone replacement therapy (menopause) - Wikipedia
The WHI trial was limited by low adherence, high attrition, inadequate power to detect risks for some outcomes, and evaluation ... but no association has been observed in women with a high body mass index. A recent randomized controlled trial recently showed ... These have the ability to significantly impact sexual functioning, either directly or indirectly through the various side ... and somatic symptoms of surgically menopausal women to a greater degree than ERT. In various placebo-controlled studies, ...
  https://en.wikipedia.org/wiki/Hormone_replacement_therapy_(menopause)