Elevated Polymorphism and Divergence in the Class C Scavenger Receptors of Drosophila melanogaster and D. simulans | Genetics
In contrast to the extreme specificity exhibited by most receptor-ligand systems, individual scavenger receptors have high ... 2000). Although SR-CI and SR-A share ligand affinity and may have similar three-dimensional structures, they are unrelated in ... the one functionally characterized class C scavenger receptor (SR-C), shares with mammalian class A scavenger receptors (SR-As ... Krieger, M., and J. Herz, 1994 Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors ...http://www.genetics.org/content/169/4/2023?ijkey=2e575054260eb138a383193891c628d094777c69&keytype2=tf_ipsecsha
Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein-Stimulated Sphingosine 1-Phosphate-Dependent Signaling...
Signaling by the high-affinity HDL receptor scavenger receptor B type I. Arterioscler Thromb Vasc Biol. 2010;30:144-150. ... Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. Br J ... High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density ... S1P signals through distinct S1P receptor subtypes. We used S1P receptor subtype-selective antagonists to assess the role of ...http://atvb.ahajournals.org/content/33/8/1788
Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin
Hb complex exhibits higher functional affinity for the macrophage scavenger receptor CD163 than the Hp1-1:Hb complex . In ... neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors ... Recent studies have revealed that the elimination of oxidized Hb species via both high-affinity and low-affinity pathways can ... Hx-heme complexes are taken up via the scavenger receptor LDL receptor-related protein 1/CD91 . Although CD91 is expressed ...https://www.hindawi.com/journals/omcl/2013/703571/
ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level
Two receptor types have been identified, one is a high affinity receptor-scavenger receptor class B type I (SR-BI)  and the ... B. L. Trigatti, "Hepatic high-density lipoprotein receptors: roles in lipoprotein metabolism and potential for therapeutic ... "Identification of scavenger receptor SR-BI as high density lipoprotein receptor," Science, vol. 271, no. 5248, pp. 518-520, ... "A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I ...https://www.hindawi.com/journals/ije/2014/356432/
Evidence for Prolonged Cell-Surface Contact of Acetyl-LDL Before Entry Into Macrophages | Arteriosclerosis, Thrombosis, and...
... with a high affinity for the scavenger receptors.22 The ability of fucoidin to displace acetyl-LDL bound to scavenger receptors ... Surface location and high affinity for calcium of 500-kD liver membrane protein closely related to LDL receptor suggest a ... Characterization of Scavenger Receptors in Macrophages. The class A macrophage scavenger receptors bind a wide variety of ... Structure and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J ...http://atvb.ahajournals.org/content/17/7/1421
BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2 | Archivio Istituzionale...
ACKR2, previously referred to as D6, is a scavenger receptor that binds with high affinity to 13 inflammatory CC chemokines. ... Beyond conventional chemokine receptors, which directly induce cell migration through heterotrimeric Gαi-mediated signalling ... chemokine ; atypical chemokine receptor ; sytoskeleton ; actin ; microtubules ; myosin ; beta-arrestin. Settore Scientifico ... BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2 ; tutor: M. Locati ; ...https://air.unimi.it/handle/2434/229565
In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple...
We have shown previously that SCH354909 and SCH58235 bind to scavenger receptor class B, type I (SR-BI) with relatively high ... Strader CD, Fong TM, Graziano MP, and Tota MR (1995) The family of G protein coupled receptors. FASEB J 9: 745-754. ... Higher affinity is observed at monkey, dog, and rat NPC1L1 and lower affinity at human and rabbit NPC1L1 with affinity for ... with higher affinity for NPC1L1. Similar metabolism may affect related compounds. The ability to generate metabolites with high ...http://molpharm.aspetjournals.org/content/71/1/19
Frontiers | Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications | Physiology
... increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4. It is therefore likely that the ... Interestingly, CD36, a scavenger receptor that modulates the uptake of long chain fatty acid (LCFA) in high affinity tissues ... multiple receptors (Yang et al., 2011; Liu et al., 2012; Lu and Roche, 2012; Oddi et al., 2012; Zheng et al., 2012), receptor ... Indeed, it has been recently shown that cancer cells that express high levels of the fatty acid receptor CD36 and lipid ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00902/full
MSR1 - Wikipedia
"Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors". J ... Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also ... Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic ... Gough PJ, Greaves DR, Gordon S (1998). "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene ...https://en.wikipedia.org/wiki/MSR1
C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...
C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G ... In our study, we did not assess specific binding to scavenger receptors and we did not analyze scavenger receptors on U937 ... this results from blockade of oxidized LDL-binding to scavenger receptors by CRP in addition to inhibition of CRP-Fcγ receptor ... oxidized LDL binds to scavenger receptors; in the presence of CRP, binding of oxidized LDL represents mainly CRP-Fcγ receptor ...http://atvb.ahajournals.org/content/25/4/717
Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream...
Oxidized LDL can then bind and inactivate cathepsins with high affinity,30 inactivate other proteases including the Naβ Gases, ... Oxidized LDL is taken up by macrophage scavenger receptors and is trafficked to the endolysosomal compartment. ... NOD-like receptor family, pyrin domain containing 3) inflammasome by disrupting lysosomal integrity.13,14 Thus, the notion that ... At high pH (,6.0), the dye fluoresces at a peak wavelength of 460 nm, whereas at low pH, the peak emission is 530 nm. ...http://atvb.ahajournals.org/content/34/9/1942
Theodorus van Berkel - Universiteit Leiden
Selective targeting of liposomes to macrophages using a ligand with high affinity for the macrophage scavenger receptor class A ... Oosten M. van, Bilt E. van de, Berkel T.J.C. van & Kuiper J. (1998), New scavenger receptor-like receptors for the binding of ... Berkel T.J.C. van (1998), The importance of scavenger-receptor class A and B for the metabolism of modified LDL and HDL by ... Novel glycolipids with high affinity for the hepatic asialoglycoprotein receptor are potent cholesterol-lowering agents, ...https://www.universiteitleiden.nl/medewerkers/theodorus-van-berkel/publicaties
In Vitro-Differentiated Embryonic Stem Cell Macrophages | Arteriosclerosis, Thrombosis, and Vascular Biology
14 15 share the common property of binding a broad array of ligands with high affinity.16 Unlike the LDL receptor, however, ... Four specific receptors for modified forms of LDL, all members of the broad family of scavenger receptors, have been implicated ... Hughes DA, Fraser IP, Gordon S. Murine macrophage scavenger receptor: in vivo expression and function as receptor for ... including the expression of modified LDL receptors (scavenger receptor [SR]-A, CD36, and CD68), capacity for foam cell ...http://atvb.ahajournals.org/content/18/10/1647
SR-BI | Arteriosclerosis, Thrombosis, and Vascular Biology
2 Scavenger receptor class A types I and II, the class B scavenger receptors (CD36 and CD68), LOX-1, and possible others are ... 10 SR-BI binds HDL with high affinity11 and represents a physiologically relevant cell surface receptor for HDL.12-14⇓⇓ There ... Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science. 1996; 271: 518-520. ... Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the ...http://atvb.ahajournals.org/content/23/9/1486
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development | Development
Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271,518 -520. ... and displays high affinity for cholesterol in vitro (Acton et al., 1996). Although forced Scarb1 expression in heterologous ... including the class B scavenger receptors Scarb1 and CD36. Scarb1 is required to absorb β-carotene and vitamin E in mice ( ... Nuclear receptor (NR), homeodomain (HD) and high-mobility group (HMG) factors have the highest degree of temporal modulation. ...http://dev.biologists.org/content/133/20/4119
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
... on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors ... serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPAR. ... agonists also markedly induce hepatic expression of the fatty acid transporter/scavenger receptor Cd36, which is expressed in ... "The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ...https://www.hindawi.com/journals/ppar/2010/612089/
Trypanosoma brucei - Wikipedia
The first step in the killing mechanism is the binding of TLF to high affinity receptors-the haptoglobin-hemoglobin receptors- ... hemolysis Hp forms a complex with the Hb and these are removed from the circulation by the CD163 scavenger receptor. In ... It has a high affinity for phosphatidic acid and cardiolipin and can be induced by interferon gamma and tumor necrosis factor ... Hpr is 91% identical to haptoglobin (Hp), an abundant acute phase serum protein, which possesses a high affinity for ...https://en.wikipedia.org/wiki/Trypanosoma_brucei
Biology of microglia - Multiple Sclerosis - Derick Mussen Healthcare
... are a class of heterogeneous macrophage receptors that bind acetylated or other modified lipoproteins with high affinity and ... 3. Activation of Microglia through Scavenger Receptors. Scavenger receptors (SR) ... The IL-1 receptor complex is composed of the type 1 receptor (IL-1RI) and the receptor accessory protein (IL-1RAcp). LPS/LBP ... The IL-1 receptor complex is composed of the type 1 receptor (IL-1RI) and the receptor accessory protein (IL-1RAcp). LPS/LBP ...https://www.mussenhealth.us/multiple-sclerosis-3/ii-biology-of-microglia.html
MCB II Block 4
LDLs only bind to scavenger receptors secondarily because the receptors have a Km that is 7 to 8 times higher (lower affinity) ... A: on heparan sulfate proteoglycans and lipoprotein receptors.. Q: What apoprotein is required for hepatocyte receptor binding ... A: Scavenger receptors.. Q: When are scavenger receptors the most useful?. A: When plasma LDL levels are the highest… have lots ... A: most is taken up by scavenger receptors on macrophages.. Q: Cholesterol controls ACAT, HMG-CoA reductase, and LDL receptors ...http://www.caribbeanmedstudent.com/notes/mcb-ii-block-4/
Hepatitis C virus - wikidoc
"DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.". J Biol Chem. 278 (22): 20358-66 ... "The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.". EMBO J. 21 (19): 5017-25 ... by acting as ligands for cellular receptors, such as tetraspanin CD81, scavenger receptor class B type I (SR-BI), and mannose ... entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor." ...https://www.wikidoc.org/index.php/Hepatitis_C_virus
IJMS | Free Full-Text | Deleted in Malignant Brain Tumors-1 Protein (DMBT1): A Pattern Recognition Receptor with Multiple...
All these proteins belong to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins: a superfamily of secreted or ... which leads to conformational changes in gp120 allowing high affinity interaction with chemokine receptors [105,106]. DMBT1SAG ... receptors was suggested since this organism also has a high number of innate immune receptors such as Toll-like receptors. ... Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of ...http://www.mdpi.com/1422-0067/11/12/5212/htm
Odorant-binding protein 2A - Wikipedia
The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for ... volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly ... 2003). "Porcine odorant-binding protein selectively binds to a human olfactory receptor". Chem. Senses. 27 (8): 691-701. doi: ...https://en.wikipedia.org/wiki/Odorant-binding_protein_2A
MicroRNAs as stress regulators in pancreatic beta cells and diabetes
... surface membrane receptors such as the scavenger receptor BI for high-density lipoproteins and low-density lipoprotein receptor ... Their mode of action is through high-affinity base pairing with miRNAs, which prevents the binding of miRNAs to their target ... The discrepancy between the in vitro and in vivo overexpression data may be explained by the higher expression of miR-375 in ... For example, high dose STZ administration leads to increased circulating miR-375 levels prior to the onset of hyperglycemia. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5605735/
The Role of the Anaphylatoxins in Health and Disease
The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but ... 2.1 Anaphylatoxin receptors. The ATs bind to a family of three receptors, so-called AT receptors, which belong to the ... On the one hand, it has been described as a non-signaling scavenger receptor for C5a and C5a-desArg. In contrast, at least two ... The AT receptor family comprises the C3a receptor (C3aR), C5a receptor (C5aR) and C5a receptor-like 2 (C5L2). They share high ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2725201/?lang=en-ca
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps | JEM
There are two functional classes of cell-associated PRRs: endocytic PRRs (i.e., scavenger receptors and mannose receptors) ... With high affinity, PTX3 binds the complement component C1q, the extracellular matrix TNF-inducible protein 6, and selected ... Innate immunity receptors, also called pattern recognition receptors (PRRs), recognize a few highly conserved structures, ... pattern recognition receptor; PTX, pentraxin; SAP, serum amyloid P component; TLR, Toll-like receptor. ...http://jem.rupress.org/content/204/4/793
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