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Extracellular loop C of NPC1L1 is important for binding to ezetimibe | PNAS
2007) Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush ... 2007) Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the ... The amino acid sequence of NPC1L1 (residues 510-571) corresponding to high-affinity (dog, rat, and human) or low-affinity ( ... AS to high-affinity dog NPC1L1 and low-affinity mouse NPC1L1. Under equilibrium-binding conditions, [3H]AS binds to dog NPC1L1 ...http://www.pnas.org/content/105/32/11140
Elevated Polymorphism and Divergence in the Class C Scavenger Receptors of Drosophila melanogaster and D. simulans | Genetics
In contrast to the extreme specificity exhibited by most receptor-ligand systems, individual scavenger receptors have high ... 2000). Although SR-CI and SR-A share ligand affinity and may have similar three-dimensional structures, they are unrelated in ... the one functionally characterized class C scavenger receptor (SR-C), shares with mammalian class A scavenger receptors (SR-As ... Krieger, M., and J. Herz, 1994 Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors ...http://www.genetics.org/content/169/4/2023?ijkey=2e575054260eb138a383193891c628d094777c69&keytype2=tf_ipsecsha
Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein-Stimulated Sphingosine 1-Phosphate-Dependent Signaling...
Signaling by the high-affinity HDL receptor scavenger receptor B type I. Arterioscler Thromb Vasc Biol. 2010;30:144-150. ... Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. Br J ... High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density ... S1P signals through distinct S1P receptor subtypes. We used S1P receptor subtype-selective antagonists to assess the role of ...http://atvb.ahajournals.org/content/33/8/1788
Natural History of the Bruise: Formation, Elimination, and Biological Effects of Oxidized Hemoglobin
Hb complex exhibits higher functional affinity for the macrophage scavenger receptor CD163 than the Hp1-1:Hb complex . In ... neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors ... Recent studies have revealed that the elimination of oxidized Hb species via both high-affinity and low-affinity pathways can ... Hx-heme complexes are taken up via the scavenger receptor LDL receptor-related protein 1/CD91 . Although CD91 is expressed ...https://www.hindawi.com/journals/omcl/2013/703571/
ATP Synthase β-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level
Two receptor types have been identified, one is a high affinity receptor-scavenger receptor class B type I (SR-BI)  and the ... B. L. Trigatti, "Hepatic high-density lipoprotein receptors: roles in lipoprotein metabolism and potential for therapeutic ... "Identification of scavenger receptor SR-BI as high density lipoprotein receptor," Science, vol. 271, no. 5248, pp. 518-520, ... "A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I ...https://www.hindawi.com/journals/ije/2014/356432/
MSR1 : Wikis (The Full Wiki)
"Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors.". J ... receptor activity. • scavenger receptor activity. • lipid transporter activity. Cellular component. • cytoplasm. • integral to ... Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. ... Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic. ...http://www.thefullwiki.org/MSR1
Evidence for Prolonged Cell-Surface Contact of Acetyl-LDL Before Entry Into Macrophages | Arteriosclerosis, Thrombosis, and...
... with a high affinity for the scavenger receptors.22 The ability of fucoidin to displace acetyl-LDL bound to scavenger receptors ... Surface location and high affinity for calcium of 500-kD liver membrane protein closely related to LDL receptor suggest a ... Characterization of Scavenger Receptors in Macrophages. The class A macrophage scavenger receptors bind a wide variety of ... Structure and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J ...http://atvb.ahajournals.org/content/17/7/1421
BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2 | Archivio Istituzionale...
ACKR2, previously referred to as D6, is a scavenger receptor that binds with high affinity to 13 inflammatory CC chemokines. ... Beyond conventional chemokine receptors, which directly induce cell migration through heterotrimeric Gαi-mediated signalling ... chemokine ; atypical chemokine receptor ; sytoskeleton ; actin ; microtubules ; myosin ; beta-arrestin. Settore Scientifico ... BETA-ARRESTIN DEPENDENT REGULATION OF CYTOSKELETON DYNAMICS AND SIGNALLING OF CHEMOKINE RECEPTOR ACKR2 ; tutor: M. Locati ; ...https://air.unimi.it/handle/2434/229565
In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple...
We have shown previously that SCH354909 and SCH58235 bind to scavenger receptor class B, type I (SR-BI) with relatively high ... Strader CD, Fong TM, Graziano MP, and Tota MR (1995) The family of G protein coupled receptors. FASEB J 9: 745-754. ... Higher affinity is observed at monkey, dog, and rat NPC1L1 and lower affinity at human and rabbit NPC1L1 with affinity for ... with higher affinity for NPC1L1. Similar metabolism may affect related compounds. The ability to generate metabolites with high ...http://molpharm.aspetjournals.org/content/71/1/19
Frontiers | Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications | Physiology
... increased ectopic fat accumulation and increased inflammatory tone via toll-like receptor 4. It is therefore likely that the ... Interestingly, CD36, a scavenger receptor that modulates the uptake of long chain fatty acid (LCFA) in high affinity tissues ... multiple receptors (Yang et al., 2011; Liu et al., 2012; Lu and Roche, 2012; Oddi et al., 2012; Zheng et al., 2012), receptor ... Indeed, it has been recently shown that cancer cells that express high levels of the fatty acid receptor CD36 and lipid ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00902/full
MSR1 - Wikipedia
"Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors". J ... Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene. MSR1 has also ... Macrophage scavenger receptor has been shown to mediate adhesion of macrophages and other cell lines to tissue culture plastic ... Gough PJ, Greaves DR, Gordon S (1998). "A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene ...https://en.wikipedia.org/wiki/MSR1
Frontiers | SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin,...
Internalized HDL partially co-localized with the scavenger receptor BI (SR-BI) and knockdown of SR-BI significantly attenuated ... Internalized HDL partially co-localized with the scavenger receptor BI (SR-BI) and knockdown of SR-BI significantly attenuated ... High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it ... High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00841/full
C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...
C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G ... In our study, we did not assess specific binding to scavenger receptors and we did not analyze scavenger receptors on U937 ... this results from blockade of oxidized LDL-binding to scavenger receptors by CRP in addition to inhibition of CRP-Fcγ receptor ... oxidized LDL binds to scavenger receptors; in the presence of CRP, binding of oxidized LDL represents mainly CRP-Fcγ receptor ...http://atvb.ahajournals.org/content/25/4/717
Phagocytosis - Creative Diagnostics
... including C-type lectins and scavenger receptors. Phagocytes also have high-affinity receptors for certain opsonins, including ... Binding of several IgG molecules to Fc receptors on macrophages or polymorphs triggers receptor activation, and activates ... Once a microbe or particle binds to receptors on a phagocyte, the plasma membrane in the region of the receptors begins to ... Pattern-recognition receptors: Phagocytic cells have surface and phagosomal receptors that recognize complementary molecular ...https://www.creative-diagnostics.com/phagocytosis.htm
Induction of Lysosomal Biogenesis in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream...
Oxidized LDL can then bind and inactivate cathepsins with high affinity,30 inactivate other proteases including the Naβ Gases, ... Oxidized LDL is taken up by macrophage scavenger receptors and is trafficked to the endolysosomal compartment. ... NOD-like receptor family, pyrin domain containing 3) inflammasome by disrupting lysosomal integrity.13,14 Thus, the notion that ... At high pH (,6.0), the dye fluoresces at a peak wavelength of 460 nm, whereas at low pH, the peak emission is 530 nm. ...http://atvb.ahajournals.org/content/34/9/1942
Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells |...
... alternate receptors may be overexpressed as a compensatory adaptation and that these receptors bind PS with a higher affinity. ... Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J. ... The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids. J. Biol. Chem. 270:16221-16224. ... A heavily glycosylated mutiligand receptor belonging to the class B scavenger receptor group, CD36 is reported to mediate ...http://jem.rupress.org/content/203/12/2613
Theodorus van Berkel - Universiteit Leiden
Selective targeting of liposomes to macrophages using a ligand with high affinity for the macrophage scavenger receptor class A ... Oosten M. van, Bilt E. van de, Berkel T.J.C. van & Kuiper J. (1998), New scavenger receptor-like receptors for the binding of ... Berkel T.J.C. van (1998), The importance of scavenger-receptor class A and B for the metabolism of modified LDL and HDL by ... Novel glycolipids with high affinity for the hepatic asialoglycoprotein receptor are potent cholesterol-lowering agents, ...https://www.universiteitleiden.nl/medewerkers/theodorus-van-berkel/publicaties
SCD163 elisa kit | Bovine sCD163/Soluble Haemoglobin Scavenger Receptor ELISA Kit-NP 004235.4
Bovine sCD163/Soluble Haemoglobin Scavenger Receptor ELISA Kit-NP_004235.4 (MBS044938) product datasheet at MyBioSource, ELISA ... Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of ... Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies. Binding And Uptake Of Ligands By Scavenger Receptors ... scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen ...https://www.mybiosource.com/prods/ELISA-Kit/Bovine/sCD163-Soluble-Haemoglobin-Scavenger-Receptor/SCD163/datasheet.php?products_id=44938
Regulation of blood vascular permeability in the skin | Inflammation and Regeneration | Full Text
Under crosslinking of high-affinity IgE receptors on their surface by specific antigens, mast cells are activated and release ... Pardridge WM, Kang YS, Buciak JL, Yang J. Human insulin receptor monoclonal antibody undergoes high affinity binding to human ... Potential role of gp30 and gp18 as novel scavenger receptors. J Biol Chem. 1993;268:7562-70.PubMedGoogle Scholar. ... In addition, low-affinity IgE receptors (CD23) or polymeric Ig receptors in epithelial cells have been reported responsible for ...https://inflammregen.biomedcentral.com/articles/10.1186/s41232-017-0042-9
In Vitro-Differentiated Embryonic Stem Cell Macrophages | Arteriosclerosis, Thrombosis, and Vascular Biology
14 15 share the common property of binding a broad array of ligands with high affinity.16 Unlike the LDL receptor, however, ... Four specific receptors for modified forms of LDL, all members of the broad family of scavenger receptors, have been implicated ... Hughes DA, Fraser IP, Gordon S. Murine macrophage scavenger receptor: in vivo expression and function as receptor for ... including the expression of modified LDL receptors (scavenger receptor [SR]-A, CD36, and CD68), capacity for foam cell ...http://atvb.ahajournals.org/content/18/10/1647
SR-BI | Arteriosclerosis, Thrombosis, and Vascular Biology
2 Scavenger receptor class A types I and II, the class B scavenger receptors (CD36 and CD68), LOX-1, and possible others are ... 10 SR-BI binds HDL with high affinity11 and represents a physiologically relevant cell surface receptor for HDL.12-14⇓⇓ There ... Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science. 1996; 271: 518-520. ... Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the ...http://atvb.ahajournals.org/content/23/9/1486
Scavenger Receptor Class B Proteins Mediate Carotenoid Uptake into the Primate Retina | IOVS | ARVO Journals
Surface plasmon resonance experiments were conducted to determine the binding affinity of carotenoids with scavenger receptor ... Expression of scavenger receptors in the primate eye sections showed no overlap in their pattern, suggestive of non-redundant ... Relative abundance of SCARB2 transcripts and protein was higher than that observed for SCARB1 and CD36. ... In this study, we undertook a systematic approach to study the presence and function of all three Class B scavenger receptor ...https://iovs.arvojournals.org/article.aspx?articleid=2640851
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development | Development
Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271,518 -520. ... and displays high affinity for cholesterol in vitro (Acton et al., 1996). Although forced Scarb1 expression in heterologous ... including the class B scavenger receptors Scarb1 and CD36. Scarb1 is required to absorb β-carotene and vitamin E in mice ( ... Nuclear receptor (NR), homeodomain (HD) and high-mobility group (HMG) factors have the highest degree of temporal modulation. ...http://dev.biologists.org/content/133/20/4119
Trypanosoma brucei - Wikipedia
The first step in the killing mechanism is the binding of TLF to high affinity receptors-the haptoglobin-hemoglobin receptors- ... hemolysis Hp forms a complex with the Hb and these are removed from the circulation by the CD163 scavenger receptor. In ... It has a high affinity for phosphatidic acid and cardiolipin and can be induced by interferon gamma and tumor necrosis factor ... Hpr is 91% identical to haptoglobin (Hp), an abundant acute phase serum protein, which possesses a high affinity for ...https://en.wikipedia.org/wiki/Trypanosoma_brucei
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
... on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors ... serves as a molecular target for hypolipidemic fibrates drugs which bind the receptor with high affinity. Furthermore, PPAR. ... agonists also markedly induce hepatic expression of the fatty acid transporter/scavenger receptor Cd36, which is expressed in ... "The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ...https://www.hindawi.com/journals/ppar/2010/612089/