*  Cangitoxin - Wikipedia
... which most likely acts by prolonging the inactivation of voltage-gated sodium channels (NaV channels). Cangitoxin is a ... NaV1.2, NaV1.4, NaV1.5, NaV1.6, NaV1.7) and depending on their affinity to a specific isoform, they mainly act on cardiac or ... Higher doses of cangitoxin (12-16 µg) induce severe tonic-clonic convulsions, leading to death. Cunha, RB; Santana, ANC; Amaral ... III on the NaV1.1 channel was investigated. Intrahippocampal injection of 8 µg of cangitoxin in rats has strong behavioral ...
  https://en.wikipedia.org/wiki/Cangitoxin
*  Frank Bosmans | Hopkins BCMB
Voltage-activated sodium (Nav) channels are found throughout the human body where they form the cornerstones of fast electrical ... Animal toxins influence voltage-gated sodium channel function. Handb Exp Pharmacol. 2014 ... cardiac arrhythmias and pain syndromes. Despite their physiological importance, our understanding of these channels is hampered ... Das, S., Gilchrist, J.,Bosmans, F.*, Van Petegem, F.* (*Co-corresponding authors). Binary architecture of the Nav1.2/?2 ...
  http://bcmb.bs.jhmi.edu/people/faculty/frank-bosmans
*  Neosaxitoxin - Wikipedia
"Voltage gated", also called "voltage sensitive" and "voltage dependant" sodium channel also known as "VGSCs" or "Nav channel" ... and high specificity for Nav channels. The action of NSTX produces minimal effect on cardiac Nav, where it exhibits about 20-60 ... In fact, when Phe 385 near the selectivity filter of Nav1.2 is mutated to Cys, the channel's affinity for TTX is reduced 3,000- ... Invertebrates possess two Nav channels (Nav1 and Nav2), whereas vertebrate Nav channels are of the Nav1 family. Sodium-channel ...
  https://en.wikipedia.org/wiki/Neosaxitoxin
*  DERIVATIVES FOR MODULATION OF ION CHANNELS - Patent application
0005]In general, voltage-gated sodium channels (NaVs) are responsible for initiating the rapid upstroke of action potentials in ... Accordingly, there remains a need to develop additional Na channel and Ca channel antagonists, preferably those with higher ... 0218]24 hours before the assay on VIPR, CHO cells endogenously expressing a NaV1.2 type voltage-gated NaV are seeded in 96-well ... life threatening cardiac arrhythmias and cardiac failure. Accordingly, there remains a need to develop additional Na channel ...
  http://www.patentsencyclopedia.com/app/20110077269
*  calcium - How intracellular Calcium signaling, gradient and its role as a universal intracellular regulator points to design
Voltage-gated sodium (NaV) and calcium (CaV) channels are involved in electrical signaling, contraction, secretion, synaptic ... a) Two-dimensional schematic map of NaV channel structure and function. The α subunit of NaV1.2 channels is illustrated as a ... Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher ... These channels are central to cardiac action potential propagation, neurotransmitter and hormone release, muscle contraction ...
  http://reasonandscience.heavenforum.org/t2448-howintracellular-calcium-signaling-gradient-and-its-role-as-a-universal-intracellular-regulator-points-to-design?highlight=calcium
*  Equilibrative Nucleoside Transporters
Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable. 8 May 2017 ovarian ... human prostate cancer cell lines and explored the clinical relevance of a particular voltage gated sodium channel Nav1.8 in ... CNS Nav1.1-Nav1.2 Nav1.6; PNS Nav1.7-Nav1.9) [5]. Navs mediate sodium influx to generation action potentials which are critical ... 11 0 includes a high HIV endemicity and presumptively high exposure. A lot of the area is normally rural and drinking water ...
  http://www.ovarian-cancersymptoms.com/category/equilibrative-nucleoside-transporters/
*  ModelDB: Models that contain the Modeling Application : NEURON
A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017) ... Calculating the consequences of left-shifted Nav channel activity in sick cells (Joos et al 2017) ... Cardiac sarcomere dynamics (Negroni and Lascano 1996) 171.. Cell splitting in neural networks extends strong scaling (Hines et ... High frequency oscillations induced in three gap-junction coupled neurons (Tseng et al. 2008) ...
  https://senselab.med.yale.edu/ModelDB/ModelList.cshtml?id=1882
*  Channelpedia
All L-type voltage gated Ca channels are characterized by high sensitivity to dihydropyridine (DHP) Ca2+ channel modulators, ... Sodium channels in CNS are sensitive to nanomolar concentration of TTX.. - Sodium channels expressed in cardiac muscle cells ... There are 15 phosphorylation sites on Nav1.2. Extensive modulation of Nav channel activity by phosphorylation in rat brain was ... KCNE channel alters KCNQ5 channel gating. The proteins KCNE1 and KCNE3 alter the gating of the Kv7.5 channel in Xenopus oocytes ...
  http://channelpedia.epfl.ch/reports/interaction
*  ModelDB: Models that contain the Modeling Application : MATLAB
for stochastic ion channels (Orio & Soudry 2012) 273.. Simulating ion channel noise in an auditory brainstem neuron model ( ... approximation of ion channel gating models (Bruce 2009) 101.. Excessive beta oscillations in Parkinson's disease (Pavlides et ... State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013) ... Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) 270.. Self-influencing synaptic plasticity (Tamosiunaite et ...
  https://senselab.med.yale.edu/ModelDB/ModelList.cshtml?id=36835&allsimu=true