*  Acrylamide - Wikipedia
Acrylamide is easily absorbed by the skin and distributed throughout the organism; the highest levels of acrylamide post- ... The discovery of acrylamide in some cooked starchy foods in 2002 prompted concerns about the carcinogenicity of those foods. As ... Food industry workers exposed to twice the average level of acrylamide do not exhibit higher cancer rates. Acrylamide is also a ... The European Chemical Agency added acrylamide to the list of substances of very high concern in March 2010. The Heat-generated ...
  https://en.wikipedia.org/wiki/Acrylamide
*  Abstract 4692: Comparison of dietary exposure to acrylamide and acrolein: monitoring mercapturic acids in human urine after...
On the basis of the AUC values of MAs excreted in urine, the total excretion of 3-HPMA was about 15 times higher than that of ... Acrolein (AC) is an α,ß-unsaturated aldehyde, classified by the IARC in group 3B (not classifiable as to its carcinogenicity to ... Thus, the exposure to AC from the test meal was at least one order of magnitude higher than exposure to AA. The question as to ... Analytical determination of AC in foodstuffs is difficult, due to its high volatility and reactivity. Data on exposure and ...
  http://cancerres.aacrjournals.org/content/70/8_Supplement/4692
*  Opinion on the results of Risk Assessment | Scientific Committees
In the case of germ cells, Acrylamide has been demonstrated to induce heritable mutations. Carcinogenicity Acrylamide is ... exposure to Acrylamide. A surprisingly high vapour pressure (2500 Pa) is given for aqueous solutions (50%) of Acrylamide as ... Acrylamide as a high-potency carcinogen (K1), any preparation containing greater than 0.01% W/W Acrylamide would require ... Acrylamide is produced at 80,000 - 100,000 tonnes per year in the EU. Approximately 99.9 % of Acrylamide is used in the ...
  http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/sctee/sct_out88_en.htm
*  Molecular Mri for Sensitive and Specific Detection of Lung Metastases - Toxicologic Pathology
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... its value must eventually derive from very high specificity combined with high detection sensitivity. For example, if a patient ... High-resolution 3D HP 3He images (156-μm isotropic resolution) were then acquired with a 2-cm field of view (FOV) in both the ... Combined with the high spatial resolution and signal-to-noise ratio (SNR) with which the lung can be imaged using HP gases, ...
  https://focusontoxpath.com/molecular-mri-for-sensitive-and-specific-detection-of-lung-metastases/
*  Liver Hypertrophy: A Review of Adaptive (Adverse and Non-adverse) Changes-Conclusions from the 3rd International ESTP Expert...
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... FIGURE 3.-H&E stained high-power photomicrograph of a male B6C3F1 mouse liver chronically (2-year carcinogenicity study) ... may also lead to higher ALT levels in both the liver and the serum. In this scenario, moderately higher serum ALT levels, ... Comb Chem High Throughput Screen 13, 135-44.. Fromm, M. F., Kauffmann, H. M., Fritz, P, Burk, O., Kroemer, H. K., Warzok, R. W ...
  https://focusontoxpath.com/liver-hypertrophy-a-review-of-adaptive-adverse-and-non-adverse-changes-conclusions-from-the-3rd-international-estp-expert-workshop/
*  Prediction of Rodent Carcinogenesis: An Evaluation of Prechronic Liver Lesions as Forecasters of Liver Tumors in NTP...
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... These include the high cost of a full 2-year bioassay in both sexes of rats and mice, and the time interval between a ... Rodent carcinogenicity bioassay data were obtained for 111 technical reports (TR) produced by the NTP over a 10-year period, ... Despite the high number of false positives, the correlation between the grouped strategy (including increased liver weight) and ...
  https://focusontoxpath.com/prediction-of-rodent-carcinogenesis-an-evaluation-of-prechronic-liver-lesions-as-forecasters-of-liver-tumors-in-ntp-carcinogenicity-studies/
*  Measurement of Cell Replication and Apoptosis in Mice - Toxicologic Pathology
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. ... An Evaluation of Prechronic Liver Lesions as Forecasters of Liver Tumors in NTP Carcinogenicity Studies. ...
  https://focusontoxpath.com/measurement-cell-replication-apoptosis-mice/
*  Evaluation Of The Genotoxicity Of The Food Additive, Gum Ghatti - Toxicologic Pathology
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... The highest dose (2000 mg/kg) conforms to OECD guidelines for limit dose (OECD, 1997c). No treatment related clinical or cage- ... However, one animal in the vehicle control group had an exceptionally high percentage (20%) of type II cells and the diameter ... Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. ...
  https://focusontoxpath.com/evaluation-of-the-genotoxicity-of-the-food-additive-gum-ghatti/
*  Recommendations from the INHAND Apoptosis/Necrosis Working Group - Toxicologic Pathology
Two-year Carcinogenicity Study of Acrylamide in Wistar Han Rats with In Utero Exposure. ... Practical Applications of in Vivo and ex Vivo MRI in Toxicologic Pathology Using a Novel High-performance Compact MRI System. ... High mobility group protein 2 [HMG2]). Factors that determine which apoptotic pathway is activated include the stage of the ... An Evaluation of Prechronic Liver Lesions as Forecasters of Liver Tumors in NTP Carcinogenicity Studies. ...
  https://focusontoxpath.com/recommendations-from-the-inhand-apoptosisnecrosis-working-group/
*  Mutagen - Wikipedia
2002). "Analysis of acrylamide, a carcinogen formed in heated foodstuffs". J. Agric. Food Chem. 50 (17): 4998-5006. doi:10.1021 ... In 1775, Sir Percivall Pott wrote a paper on the high incidence of scrotal cancer in chimney sweeps, and suggested chimney soot ... Excessive alcohol consumption has also been linked to cancer; the possible mechanisms for its carcinogenicity include formation ... Aromatic amines and amides have been associated with carcinogenesis since 1895 when German physician Ludwig Rehn observed high ...
  https://en.wikipedia.org/wiki/Mutagen
*  Acrylamide and Cancer Risk: What Do Human Studies Say?
There's been much debate over whether acrylamide can really cause cancer in humans. Here's a summary of the available research ... and that the findings that did show a link between acrylamide and cancer risk were simply based on higher levels of acrylamide ... to carry out research on the carcinogenicity of acrylamide and to assess the overall health risks associated with acrylamide. ... If you are worried about the levels of acrylamide in your food, you may want to check out this list of foods that are high in ...
  https://www.healwithfood.org/studies/acrylamide-cancer-risk.php
*  Genotoxic carcinogens | definition of genotoxic carcinogens by Medical dictionary
... acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the ... Although the in vitro test battery demonstrates a high degree of sensitivity in detecting genotoxic carcinogens, it is poor at ... The ready quantifiable nature of sister chromatid exchanges with high sensitivity for revealing toxicant-DNA interaction and ... Estimating the extent of the health hazard posed by high-production volume chemicals. (Articles) ...
  http://medical-dictionary.thefreedictionary.com/genotoxic+carcinogens
*  List of IARC Group 2A carcinogens - Wikipedia
In some cases, an agent may be classified in this group when there is inadequate evidence of carcinogenicity in humans along ... Acrylamide Adriamycin Androgenic (anabolic) steroids Azacitidine BCNU (Bischloroethyl nitrosourea) Captafol Chloral Chloral ... High-temperature frying, emissions from Household combustion of biomass fuel (primarily wood), indoor emissions from Non- ... Exceptionally, an agent may be classified in this group solely on the basis of limited evidence of carcinogenicity in humans. ...
  https://en.wikipedia.org/wiki/List_of_IARC_Group_2A_carcinogens
*  Taking a new look at enzymes part 2 | Baking Business | Baking Industry Features and Reports
... asparagine-reducing enzyme technology is an area of interests due to increased concern about the carcinogenicity of acrylamide ... replaced papain as a source of protease in bakery products as it is typically much more functional at similar but high price ... Asparagine is the precursor responsible for formation of Acrylamide in bread crust or in bread that has been toasted as a ... they can also pave the way to better control over moisture and prevention of acrylamide formation. Bill McKeown, vice-president ...
  http://www.bakingbusiness.com/Features/Formulations/2014/4/Taking-a-new-look-at-enzymes-part-2.aspx
*  Research on environmental mutagenesis from young scientists - the open symposium of the Japanese Environmental Mutagen Society ...
These analogs exhibited higher anti-breast cancer potential and no DNA-adduct formation activity in animal studies, thereby ... He reported the cases of madder color, estragole, and acrylamide.. Dr. Naoki Koyama reported on a colon cancer model in mice. ... Based on the mechanisms of carcinogenicity with estrogenic activity and DNA adduct formations of the metabolite, new tamoxifen ... The detection of such chemical modifications of proteins requires sensitive and high-throughput techniques, suggesting some ...
  https://genesenvironment.biomedcentral.com/articles/10.1186/s41021-017-0086-8
*  Monitoring of acrylamide carcinogen in selected heat-treated foods from Saudi Arabia | Springer for Research & Development
The present study reports the outcomes of assessment on acrylamide levels in selected heat-treated foods of diverse brands and ... Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure. Food Chem. Toxicol. 51: ... In chips, acrylamide level was detected from 28 to 954 µg/kg, sample 7 (salted) contained higher amount (954 μg/kg) whereas, ... Acrylamide carcinogenicity. J. Agric. Food Chem. 56: 5984-5989 (2008).CrossRefGoogle Scholar ...
  https://rd.springer.com/article/10.1007/s10068-018-0358-5
*  Mercola Skin Care | Organic Skin Care Product
Acrylamide. Found in many facial creams.. A potential carcinogen.. Propylene glycol. Common cosmetic moisturizer and carrier ... It also offers high levels of essential fatty acids. These fatty acids, plus its rich phytosterols, give it the ability to ... Its carcinogenicity was first reported in 1965, and later confirmed in other studies in 1978. Nasal passages are considered ... Out of Stock Notice: Due to high demand, these products are temporarily out of stock. We expect to have a supply soon, so ...
  http://healthyskin.mercola.com/home.aspx
*  Velvet Glove, Iron Fist: The year of acrylamide
The highest acrylamide level found in the survey was 670 µg/kg, over six times higher than the lowest at 100 µg/kg, followed by ... They found 'inadequate evidence in humans for the carcinogenicity of acrylamide'. The FSA has gone way beyond its remit by ... The highest acrylamide levels were found in Little Dish biscuits, with levels almost 5 times higher than the European benchmark ... I haven't seen either of these studies (if they are studies), but if the highest acrylamide level in french fries is only 10 ...
  https://velvetgloveironfist.blogspot.co.uk/2017/03/the-year-of-acrylamide.html
*  DailyMed - EPIDUO- adapalene and benzoyl peroxide gel
Carcinogenicity studies with adapalene have been conducted in mice at topical doses of 0.4, 1.3, and 4.0 mg/kg/day (1.2, 3.9, ... Patients with high levels of sun exposure and those with inherent sensitivity to sun should exercise particular caution. Use of ... Each gram contains Active: adapalene 0.1% and benzoyl peroxide 2.5% in an aqueous gel consisting of Inactive: acrylamide/sodium ... No carcinogenicity, photocarcinogenicity, genotoxicity, or fertility studies were conducted with EPIDUO gel. ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a0610f87-3b39-458a-afa3-66be1fefd1de
*  TOBACCO SMOKING AND TOBACCO SMOKE (IARC Summary & Evaluation, Volume 83, 2002)
5.3 Animal carcinogenicity data. Cigarette smoke has been tested for carcinogenicity by inhalation studies in rodents, rabbits ... In many studies the levels of carcinogen-DNA adducts have been shown to be higher in tissues of smokers than in tissues of ... acrylamide and acrylonitrile. ... 5.2 Human carcinogenicity data. In the previous 1986 IARC ... There is evidence suggesting lack of carcinogenicity of tobacco smoking in humans for cancers of the female breast and ...
  http://inchem.org/documents/iarc/vol83/01-smoking.html
*  Fluoride Action Network | Fluoride's Mutagenicity: In vitro Studies
There is a high correlation between carcinogenicity and mutagenicity of pollutants, and fluoride has been one of the major ... acrylamide, hydrogen peroxide. In addition, two complex genotoxic agents (water samples) existing in the environment were ... A potential for carcinogenicity of this chemical, which is widely used by humans, is suggested. However, the carcinogenic risk ... This week NTP plans to release data showing that lab rats given fluoridated water had a higher rate of a rare bone cancer ...
  https://fluoridealert.org/studies/cancer01/
*  Acrylamide (HSG 45, 1991)
1.3.5 High pressure liquid chromatography (HPLC) Reverse phase HPLC can be used to determine the concentration of acrylamide or ... No epidemiological data are available to evaluate the carcinogenicity of acrylamide for human beings. On the basis of ... Acrylamide (ICSC) Acrylamide (WHO Food Additives Series 55) ACRYLAMIDE (JECFA Evaluation) Acrylamide (PIM 652) Acrylamide (IARC ... 49: Acrylamide, Geneva, World Health Organization. See Also: Toxicological Abbreviations Acrylamide (EHC 49, 1985) ...
  http://www.inchem.org/documents/hsg/hsg/hsg045.htm
*  Don't Drop That Cup, Coffee Is Safe According To Cancer Experts | Tech Times
"A cup of coffee a day, exposure probably is not that high. If you drink a lot of cups a day, this is one of the reasons you ... The human neurotoxin acrylamide, which is classified by WHO as a possible 2A carcinogen, is present in coffee and other highly- ... "Coffee is not classifiable as to carcinogenicity," says Dana Loomis, an expert on disease patterns at the University of ... Sitting Too Much Linked To Memory Problems And Higher Dementia Risk. Atlantic Ocean Current Slowing Down Due To Global Warming ...
  http://www.techtimes.com/articles/224136/20180401/dont-drop-that-cup-coffee-is-safe-according-to-cancer-experts.htm
*  What Carcinogens Are You Avoiding? - Cancer - LONGECITY
When a compound is tested for carcinogenicity, it's given at high dose in order to see if there's an effect from it. The ... Acrylamide is in coffee...which drink a lot of. Also abundant in chips and french fries, which I try to avoid. ... That means at high enough doses, the compounds manufactured by plants to fend off pests cause cancer in rodent studies. Is that ... That means at high enough doses, the compounds manufactured by plants to fend off pests cause cancer in rodent studies. Is that ...
  http://www.longecity.org/forum/topic/84323-what-carcinogens-are-you-avoiding/
*  Carcinogen - Wikipedia
... the incidence of stomach cancer is high. Preserved meat such as bacon, sausages, and ham increases the risk while a diet high ... It assesses carcinogenicity as part of a wider assessment of the occupational hazards of chemicals. Group A1: Confirmed human ... Acrylamide Asian Dust History of cancer Industrial Union Department v. American Petroleum Institute International Agency for ... though there are some documented cases of radar technicians with prolonged high exposure experiencing significantly higher ...
  https://en.wikipedia.org/wiki/Carcinogen