*  p21WAF1/CIP1 expression in primary lung adenocarcinomas: heterogeneous expression in tumor tissues and correlation with p53...
We also observed heterogeneous expression of p21 in lung adenocarcinomas, i.e. in about two-thirds of the tumors, the tumor ... These results suggest that p21 is involved in tumor cell differentiation and the physiological mechanism that protects against ... In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of ... In order to elucidate the significance of p21 expression in lung adenocarcinomas, we performed immunohistochemical analysis of ...
  http://oxfordindex.oup.com/view/10.1093/carcin/19.10.1755
*  Adenocarcinoma of the lung classification - wikidoc
... and variants of invasive adenocarcinoma. Classification. * Adenocarcinomas are highly heterogeneous tumors. Several major ... adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive adenocarcinoma, ... American Roentgen Ray Society Images of Adenocarcinoma of the lung classification All Images. X-rays. Echo & Ultrasound. CT ... Adenocarcinoma of the lung may be classified according to WHO into mixed, acinar, papillary, bronchioloalveolar carcinoma, and ...
  http://www.wikidoc.org/index.php/Adenocarcinoma_of_the_lung_classification
*  Adenocarcinoma of the lung - Wikipedia
Adenocarcinomas are highly heterogeneous tumors. Several major histological subtypes are currently recognized by the WHO and ... The current theory is that the scar probably occurred secondary to the tumor, rather than causing the tumor. The adenocarcinoma ... adenocarcinoma of the lung Invasive adenocarcinoma Acinar predominant adenocarcinoma Papillary predominant adenocarcinoma ... Similar to other adenocarcinoma, if this tumor is well differentiated (low grade) it will resemble the normal glandular ...
  https://en.wikipedia.org/wiki/Adenocarcinoma_of_the_lung
*  Histologic Subtype in NSCLC: Does It Matter? | Cancer Network | The Oncology Journal
Adenocarcinoma includes a morphologically heterogeneous group of tumors that are less frequently associated with tobacco ... with conventional acinar or papillary adenocarcinoma associated with mixed areas of BAC in the same tumor. Such tumors are ... They found a better prognosis for women and adenocarcinoma, with a 67% 5-year survival for adenocarcinoma vs 53% for SCC. In ... gene mutation-positive tumors (mainly adenocarcinomas). In addition, histology has been recently recognized as a potential ...
  http://www.cancernetwork.com/articles/histologic-subtype-nsclc-does-it-matter
*  Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for...
Periampullary adenocarcinoma, including pancreatic cancer, is a heterogeneous group of tumors with dismal prognosis, partially ... Periampullary adenocarcinoma, including pancreatic cancer, is a heterogeneous group of tumors with dismal prognosis, partially ... is a heterogeneous group of tumors with dismal prognosis, partially due to lack of reliable targetable and predictive ... Herein, we examined the prognostic value of RBM3 in periampullary adenocarcinoma, as well as the effects following RBM3 ...
  https://lup.lub.lu.se/search/publication/5c3ea6ec-fb9b-4569-9173-7627ce441fbc
*  Nitroglycerin Treatment May Enhance Chemosensitivity to Docetaxel and Carboplatin in Patients with Lung Adenocarcinoma |...
... had heterogeneous subtype components including papillary and acinar components of adenocarcinoma in a tumor tissue. ... We could not estimate the long-term effects of nitroglycerin on tumor growth and metastasis in advanced lung adenocarcinoma ... 1C and D, HIF-1α immunostaining in center area of tumor; Fig. 1E and F, HIF-1α immunostaining in peripheral area in tumor; Fig ... The HIF-1α immunostaining-positive cell rate in the tumor center (Fig. 1D) was higher than that in the tumor periphery (Fig. 1F ...
  http://clincancerres.aacrjournals.org/content/12/22/6748
*  Plus it
Tumor cell clones isolated from a rat 13762NF mammary adenocarcinoma and its spontaneous metastases were heterogeneous in their ... Heterogeneity in Induced Heat Resistance and Its Relation to Synthesis of Stress Proteins in Rat Tumor Cell Clones. Stephen P. ... Heterogeneity in Induced Heat Resistance and Its Relation to Synthesis of Stress Proteins in Rat Tumor Cell Clones ... Heterogeneity in Induced Heat Resistance and Its Relation to Synthesis of Stress Proteins in Rat Tumor Cell Clones ...
  http://cancerres.aacrjournals.org/content/44/12_Part_1/5850
*  Endothelin B receptor gene hypermethylation in prostate adenocarcinoma | Journal of Clinical Pathology
The endothelin B receptor (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells ... Prostate adenocarcinoma is the second most common cause of cancer related death in men from North America and Western Europe.1 ... Gonzalez-Zulueta M, Bender CM, Yang AS, et al. Methylation of the 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal ... Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J Natl Cancer ...
  http://jcp.bmj.com/content/56/1/52
*  Plus it
This is certainly the case for pancreatic adenocarcinoma (PDAC), which consists of a heterogeneous population of tumor cells ... Likewise, the tumor microenvironment contributes critical support in this setting, including from tumor stromal cells and tumor ... the tumor-associated microenvironment of many solid tumors provides cues to a subpopulation of tumor-initiating cells, also ... While tumors efficiently formed in wild-type mice at dilutions of 105 (8 of 8), 104 (6 of 8), and 103 (5 of 6) cells, tumor ...
  http://cancerres.aacrjournals.org/content/74/24/7309
*  Evaluation of a New Anti-cancer Vaccine for Patients With Non-small Cell Lung Cancer, After Tumor Removal by Surgery
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ... ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy. ... Tumor-specific T Cells in Lung Cancer. Non-small cell lung cancer is characterized by aggressive growth and treatment ... Tumor Suppressor Protein P53. Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control ...
  https://www.bioportfolio.com/resources/trial/62995/Evaluation-of-a-New-Anti-cancer-Vaccine-for-Patients-With-Non-small.html
*  Patients harboring ALK rearrangement adenocarcinoma after acquired res | OTT
... a heterogeneous tumor may exist at the time of diagnosis and manifest during the course of disease. Keywords: lung cancer, ALK ... Herein, we report a 49-year-old man diagnosed with adenocarcinoma, who was negative for EGFR and ALK genes as detected by ... 2Department of Tumor Molecular Laboratory, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang, 3Department of Chemotherapy, Zhejiang ... Patients harboring ALK rearrangement adenocarcinoma after acquired resistance to crizotinib and transformation to small-cell ...
  https://www.dovepress.com/patients-harboring-alk-rearrangement-adenocarcinoma-after-acquired-res-peer-reviewed-article-OTT
*  Fetal adenocarcinoma - Wikipedia
Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation ... Synonyms for FA include well differentiated fetal adenocarcinoma, high-grade fetal adenocarcinoma, pulmonary adenocarcinoma of ... DiFurio MJ, Auerbach A, Kaplan KJ (2003). "Well-differentiated fetal adenocarcinoma: rare tumor in the pediatric population". ... Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell ...
  https://en.wikipedia.org/wiki/Fetal_adenocarcinoma
*  SurgPath4U Case Viewer
Although mucinous adenocarcinomas often demonstrates high-grade cytology, the tumor is often heterogeneous with foci of low- ... Tumors of the Intestines: Atlas of Tumor Pathology.Third Series, Fascicle 32. Washington DC; AFIP: 2002; 241-248. ... Patients with mucinous adenocarcinomas had 1 year, 3 year, 5 year, 10 year survival rates of 85%, 57%, 28% and ~0% (either lost ... Ovarian mucinous tumors may also cause pseudomyxoma peritonei, however, in most instances where both ovarian and appendiceal ...
  http://surgpath4u.com/caseviewer.php?case_no=288
*  Plus it
Although EMT and tumor immune rejection/evasion are continuous, heterogeneous, and potentially reversible processes, they ... bona fide and relatively simple EMT markers to test their predictive role in lung adenocarcinoma as well as in other tumor ... The balance between tumor inflammation and immune evasion is considered to be a dynamic process and solid tumors can display ... Adaptation of the tumor through upregulation of immune inhibitory signals and expansion of regulatory cells could support tumor ...
  http://clincancerres.aacrjournals.org/content/22/14/3422
*  Atypical presentation of renal cell carcinoma: a case report | Journal of Medical Case Reports | Full Text
Renal cell carcinoma represents a heterogenous group of tumors, the most common of which is clear cell adenocarcinoma. RCC ... Because of this unusual characteristic, RCC has been labelled the "internist's tumor"[1]. Today, most tumors are diagnosed ... Malignant neoplasms involving the kidney may be primary or secondary tumors. Although metastatic lesions outnumber primary ... It shows echo-dense area in the renal area, suggestive of a renal tumour. ...
  https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-1-26
*  MMR testing - Humpath.com - Human pathology
... on tumor samples has brought to light several heterogenous MMR staining patterns. Colorectal adenocarcinoma Universal testing ... for all patients with colorectal adenocarcinoma age 70 or younger. Testing surgical resection or biopsy specimen using IHC, PCR ...
  http://humpath.com/spip.php?rubrique507
*  Athena Cherry | Stanford Medicine Profiles
Of the 19 HER2-positive adenocarcinomas, 8 (42%) demonstrated heterogeneous HER2 protein expression by immunohistochemistry. ... are the imprecise histologic distinction between these tumors and those of the atypical lipoma/atypical lipomatous tumor/ well- ... it does not clearly eliminate other well-differentiated lipomatous tumors. Accordingly, without the aid of classic tumor ... Interestingly, the histiocytic tumor component has been shown to harbor BCL2 gene translocations that are identical to those ...
  https://med.stanford.edu/profiles/athena-cherry?tab=teaching
*  Translating Genomics to the Clinic: Implications of Cancer Heterogeneity | Clinical Chemistry
... "tumor cellularity" (Table 1). Bulk tumors of pancreatic ductal adenocarcinomas, for example, are highly heterogeneous, with up ... 2. Clonal evolution of heterogeneous tumor cells. A malignant parent tumor clone (blue) amid normal cells (beige) expands and ... TUMOR CELLULARITY. Lastly, bulk tumors almost always consist of tumor cells exclusively, but they are usually intermixed with ... Tumor Complexity and Heterogeneity from a Genomic Perspective. As tumor samples continue to be sequenced and mutations in ...
  http://clinchem.aaccjnls.org/content/59/1/127.long
*  The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by...
Periampullary adenocarcinoma, including pancreatic cancer, is a heterogenous group of tumours that originate in the area around ... The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by ... Medrek C, Ponten F, Jirstrom K, Leandersson K. The presence of tumor associated macrophages in tumor stroma as a prognostic ... have shown an intricate interplay between macrophages and tumour cells in vitro, where tumour derived factors drive the ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1256-y
*  Dictionary - pathology overview - The Human Protein Atlas
Epithelial tumors are the most common forms of cancer and include adenocarcinoma, representing tumors originating from ... progenitor cells in combination with a plethora of possible mutation spectra renders cancer a complex and highly heterogeneous ... For invasive cancer it is furthermore important to determine the stage of tumor growth, i.e. the extension of tumor growth in ... The accepted classification for determining stage of tumors is based on the TNM system, which defines criteria for each tumor ...
  http://www.proteinatlas.org/learn/dictionary/pathology
*  Metformin treatment caused cancer stem cell death in pancreatic cancer cell lines | EurekAlert! Science News
... a group of cells that are considered to be responsible for tumor initiation and, because they are resistant to standard ... which are capable of repopulating the entire heterogeneous populations of cancer cells in the tumor and, even more importantly ... Pancreatic ductal adenocarcinomas contain a subset of exclusively tumorigenic cancer stem cells (CSCs), ... "Intriguingly, in all tumors treated with metformin to date, relapse of disease was efficiently prevented and there were no ...
  https://www.eurekalert.org/pub_releases/2012-06/aafc-mtc061412.php
*  3-methylcholanthrene: Topics by WorldWideScience.org
The larger tumors, which exhibited features of adenocarcinomas, showed a marked reduction or almost complete absence of nuclear ... with the smaller adenomas showing moderate numbers of nuclei with heterogeneous staining for pRb in contrast with a highly ... Results showed a significant inhibition of stomach tumor burden (tumors per mouse) by cumin. Tumor burden was 7.33 +/- 2.10 in ... in tumor 23-1 and GGG-->GAG transition at base 350 (GLY90-->GLU90) in tumor 36-1. Northern blot analysis of the larger tumors ...
  https://worldwidescience.org/topicpages/0-9/3-methylcholanthrene.html
*  Plus it
Such heterogeneous results may reflect differing mechanisms of carcinogenesis in different tumor types and may be due to either ... Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer ... tumor progression. Translational Relevance. Tumor-based biomarkers that can indicate response to histone deacetylase (HDAC) ... Changes in histone H3 and H4 acetylation levels with tumor progression have been reported in other tumor types, although these ...
  http://clincancerres.aacrjournals.org/content/15/9/3163
*  Diagnostic value of MUC4 immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma - PDF
2004 USCAP, Inc All rights reserved /04 $ immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma ... In the deeper part of the tumor and at the front progression, the staining was more heterogeneous. In these cases, expression ... Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used? Dr. Anthony C.H. YING What are? Tumour markers are ... consisted of 10 breast adenocarcinomas, two ovarian adenocarcinomas, one colon adenocarcinoma, two gastric adenocarcinomas, one ...
  http://docplayer.net/1702548-Diagnostic-value-of-muc4-immunostaining-in-distinguishing-epithelial-mesothelioma-and-lung-adenocarcinoma.html
*  Optimal treatment and stochastic modeling of heterogeneous tumors | Biology Direct | Full Text
Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on ... and brain tumors [84]. The definition of CSC implies that an anticancer therapy can control a tumor, i.e. permanent local tumor ... If we show the tumor radius and number of tumor cells at time t by R t and n t , respectively, and we assume the density of ... Tumor geometry in the mathematical model by [94]. Tumor cells are insensitive to radiation at hypoxic core and die at rate γ N ...
  https://0-biologydirect-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s13062-016-0142-5