*  Medifocus Guidebook on Hereditary Hemochromatosis
The role of important iron-regulating proteins, such as ferritin, transferrin, and hepcidin, in the origin and progression of ...
  http://abdominalaneurysm-info.com/landing.php?gid=GS020&a=a
*  Hereditary Hemochromatosis - American Family Physician
Ashrafian H. Hepcidin: the missing link between hemochromatosis and infections. Infect Immun. 2003;71(12):6693-6700. ... Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol. 2009;122(2-3):78-86. ... causes decreased hepcidin expression in response to elevated iron levels and subsequent unregulated control of iron levels.15, ... hepatocytes secrete hepcidin, which decreases intestinal iron absorption by enterocytes and decreases iron release by ...
  https://www.aafp.org/afp/2013/0201/p183.html
*  Iron Disorders Institute:: Juvenile Hemochromatosis
B autosomal recessive hepcidin mutation chromosome 19. Hemojuvelin (HJV) positively modulates the iron regulator hepcidin, and ... Defective HJV reduces hepcidin up-regulation both in humans and in HJV-deficient mice.. There are some early signs or symptoms ...
  http://www.irondisorders.org/juvenile-hemochromatosis1
*  hepcidin - The BMJ
Tag: hepcidin. Peter Labib and Jeremy Jordan: Conducting research in developing countries can be as challenging as climbing ... Guest writers, Studentsbase camp, hepcidin, Mount Everest, Nepal, research2 Comments ...
  http://blogs.bmj.com/bmj/tag/hepcidin/
*  Hepcidin agonists as therapeutic tools | Blood Journal
Hepcidin agonists as therapeutic tools. Carla Casu, Elizabeta Nemeth and Stefano Rivella ... Hepcidin agonists are a new class of compounds that regulate blood iron levels and limit iron absorption, and could improve the ... Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron ... This review highlights the preclinical studies that support the development of hepcidin agonists for the treatment of these ...
  http://www.bloodjournal.org/content/early/2018/03/08/blood-2017-11-737411?sso-checked=true
*  Search of: hepcidin | 'hemochromatosis' - List Results - ClinicalTrials.gov
Correlation between Hepcidin / ferritin plasma ratio and IRI.. *Correlation between Hepcidin / Ferritin ratio before and after ... Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential ... Distribution of inter-individual Hepcidin / Ferritin ratio according to the stage of liver fibrosis ... distribution of values of Hepcidin / ferritin plasma ratio. * ... Change of hepcidin concentration in serum. *Change of non- ...
  https://clinicaltrials.gov/ct2/results?term=hepcidin&cond=%22hemochromatosis%22
*  hepcidin Summary Report | CureHunter
hepcidin: a urinary antimicrobial peptide synthesized in the liver; may play a role in the regulation of iron metabolism; amino ... hepcidin 1, mouse; hepcidin antimicrobial peptide 1, mouse; hepcidin antimicrobial peptide, human; hepcidin antimicrobial ... hepcidin. Subscribe to New Research on hepcidin a urinary antimicrobial peptide synthesized in the liver; may play a role in ... 06/05/2014 - "Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic ...
  http://www.curehunter.com/public/keywordSummaryC428463-hepcidin.do
*  Biology Seminar: "Iron and infection - hepcidin BMPs us off"
Biology Seminar: "Iron and infection - hepcidin BMPsus off" The Departments of Biological Sciences are hosting a seminar named ... Iron and infection - hepcidin BMPs us off' from 12:45pm to 1:45pm on Friday 15 January. The seminar will take place in room ...
  https://warwick.ac.uk/insite/events/events/bio_seminar_150110/
*  Hepcidin Antimicrobial Peptide Lysates: Novus Biologicals
Browse our Hepcidin Antimicrobial Peptide Lysate catalog backed by our Guarantee+. ... Hepcidin Antimicrobial Peptide Lysates available through Novus Biologicals. ... Our Hepcidin Antimicrobial Peptide Lysates can be used in a variety of model species. Use the list below to choose the Hepcidin ... Hepcidin Antimicrobial Peptide Lysates. We offer Hepcidin Antimicrobial Peptide Lysates for use in common research applications ...
  https://www.novusbio.com/lysates/hepcidin-antimicrobial-peptide
*  Hepcidin Antimicrobial Peptide Research Products: Novus Biologicals
Browse our Hepcidin Antimicrobial Peptide product catalog backed by our Guarantee+. ... Hepcidin Antimicrobial Peptide products available through Novus Biologicals. ... PTMs for Hepcidin Antimicrobial Peptide. Learn more about PTMs related to Hepcidin Antimicrobial Peptide.. Cleavage. ... Diseases related to Hepcidin Antimicrobial Peptide. Discover more about diseases related to Hepcidin Antimicrobial Peptide.. ...
  https://www.novusbio.com/common-name/hepcidin-antimicrobial-peptide
*  JCI - Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
Hepcidin, a small polypeptide produced by hepatocytes, plays a central role in regulating iron uptake by promoting ... Hypoxia suppresses hepcidin, thereby enhancing intestinal iron uptake and release from internal stores. While HIF, a central ... the molecular basis of hypoxia/HIF-mediated hepcidin suppression in the liver remains unclear. Here, we used a genetic approach ... to disengage HIF activation from EPO synthesis and found that HIF-mediated suppression of the hepcidin gene (Hamp1) required ...
  https://www.jci.org/articles/view/63924/figure/1
*  RCSB PDB - 1M4E: Solution Structure of Hepcidin-20 Methods Report Page
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and ...
  http://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1M4E
*  RCSB PDB - 1M4F: Solution Structure of Hepcidin-25 Literature Report Page
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and ... Hepcidin A 25 Homo sapiens Fragment: Hepcidin-25 (residues 60-84) Gene Name(s): HAMP Gene View HEPC LEAP1 UNQ487/PRO1003 ...
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1M4F
*  GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance
... Mehmet Muhittin Yalcin,1 Alev Eroglu Altinova ... Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Mujde Akturk, et al., "GDF-15 and Hepcidin Levels in Nonanemic Patients with ...
  https://www.hindawi.com/journals/jdr/2016/1240843/cta/
*  JCI - A tincture of hepcidin cures all: the potential for hepcidin therapeutics
A tincture of hepcidin cures all: the potential for hepcidin therapeutics. Thomas B. Bartnikas and Mark D. Fleming Department ... Hepcidin-targeted therapeutics in other iron metabolism disorders. Altering hepcidin levels and/or activity has also proven ... These data led us to suggest that therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat ... As a negative regulator, hepcidin expression is inversely correlated with body iron stores. Importantly, hepcidin expression is ...
  https://www.jci.org/articles/view/45043
*  Obesity during pregnancy and fetal iron status: is Hepcidin the link?
We hypothesized that obese (Ob) pregnant women would have increased inflammation, hepcidin levels, and that their infants would ... IL-6 upregulates hepcidin expression through the Jak/STAT pathway. It has been recently shown that hepcidin is also upregulated ... cord blood hepcidin was approximately ten times higher than hepcidin levels in the mothers (14). Adjusting for mode of delivery ... and directly upregulates hepcidin through the bone morphogenic protein-hemojuvelin (BMP-HJV) pathway (13). Conversely, hepcidin ...
  http://www.biomedsearch.com/nih/Obesity-during-pregnancy-fetal-iron/22722675.html
*  Hepcidin - Wikipedia
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the ... The structure of hepcidin has been determined through solution NMR. NMR studies showed a new model for hepcidin: at ambient ... Hepcidin is a regulator of iron metabolism. Hepcidin inhibits iron transport by binding to the iron export channel ferroportin ... Hepcidin was first discovered in human urine and serum in 2000. Soon after this discovery, researchers discovered that hepcidin ...
  https://en.wikipedia.org/wiki/Hepcidin
*  Hepcidin levels in blood donors - Research and Development - NHS Blood and Transplant
This study aims to measure hepcidin levels in blood donors and obtain information about how hepcidin is controlled in different ... Hepcidin is the hormone that controls iron levels. When iron is needed and/or when iron levels are low, hepcidin levels fall ... This study aims to measure hepcidin levels in blood donors and obtain information about how hepcidin is controlled in different ... Study of the significance and genetic determinants of hepcidin levels in blood donors ...
  http://www.nhsbt.nhs.uk/research-and-development/current-research/trust-fund-research/hepcidin-levels-in-blood-donors/
*  hepcidin-20 | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
hepcidin-20 ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...
  http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=5379
*  Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
To determine whether these rapid effects of hepcidin were also evident in vivo we injected mice with a synthetic hepcidin ... The in vivo effects of hepcidin were also investigated in mice injected with a synthetic hepcidin peptide. Results: Exposure to ... Upon its release, hepcidin initially targets macrophage iron recycling. The duodenum appears to be less sensitive to this ... The aim of this study was to investigate the regulatory actions of the hormone hepcidin on ferroportin expression in these two ...
  http://connection.ebscohost.com/c/articles/31301023/evidence-differential-effects-hepcidin-macrophages-intestinal-epithelial-cells
*  Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin | Haematologica
For the hepcidin treatment, chemically synthesized hepcidin/LEAP-1 (human) was used (Peptide Institute Inc., Osaka, Japan). ... Mutations that lead to decreased production of hepcidin or that reduce the sensitivity of ferroportin to hepcidin lead to ... Ferroportin Q248H is less sensitive to hepcidin than WT ferroportin. (A) Effect of hepcidin on ferroportin Q248H expression. ... Compared to ferroportin WT, ferroportin Q248H had reduced sensitivity to 0.03 μM hepcidin but not to 0.3 μM hepcidin. ...
  http://www.haematologica.org/content/98/3/455
*  Hepcidin Expression in Iron Overload Diseases Is Variably Modulated by Circulating Factors
Hepcidin in serum and urine Urinary hepcidin concentration was assessed in 8 C-NAFLD, 28 DIOS and 15 HFE-HH patients. Urine ... The correction of hepcidin data according to serum ferritin level is supposed to better assess the adequateness of hepcidin ... Urinary hepcidin immunodot assay was performed as previously described [14]. Urinary hepcidin was normalized to urinary ... mRNA, Serum and Urinary Hepcidin. HFE-HH and THAL had the lowest mRNA, serum and urinary hepcidin among groups, whereas DIOS ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3346721/
*  Hepcidin Market Research Analysis by Application Analysis and Global Forecast to 2025
EMAILWIRE.COM, June 13, 2018 ) The study begins with a detailed overview of the market for Global hepcidin market professional ... survey report 2018, including the definition, classification, and industry chain structure of Global hepcidin market ... 1 Hepcidin Market Overview. 2 Global Hepcidin Market Competition by Manufacturers. 3 Global Hepcidin Market Production, Revenue ... Table Hepcidin Raw Material and Suppliers. Table Manufacturing Cost Structure Analysis of Hepcidin in 2017. (Note: If you have ...
  http://emailwire.com/release/764290-Hepcidin-Market-Research-Analysis-by-Application-Analysis-and-Global-Forecast-to-2025.html
*  Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
... and IL-6 induces the transcription of hepcidin, leading to increased serum hepcidin. Hepcidin, by binding to Fpn, leads to Jak2 ... Hepcidin has two functions. First, iron homeostasis in vertebrates is regulated by the binding of hepcidin to the cell surface ... Hepcidin suppresses acute inflammation in vivo.. These results led us to examine whether hepcidin pretreatment modulated the ... Hepcidin expression is altered in response to inflammation and iron loading (4). LPS induces hepcidin transcription directly ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2898601/