*  Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously...
In toxicological research, immortalized human hepatocytes provide a useful alternative to primary hepatocytes because ... The purpose of this study was to characterize a novel spontaneously immortalized human hepatocyte cell line, HC-04, with ... HC-04 cells retained hepatocyte-specific function including albumin production and ornithine transcarbamoylase and glucose-6- ... at a rate similar to primary human hepatocytes. Furthermore, the major human sulfotransferase and UDP-glucuronosyltransferase ...
  http://scholarbank.nus.edu.sg/handle/10635/28873
*  Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile...
Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Hepatocyte transplantation in bile salt export pump-deficient mice: selective growth advantage of donor hepatocytes under bile ... Modulation of rat hepatocyte proliferation by bile salts: in vitro and in vivo studies. Hepatology. 1996; 23: 1159-66.. *PubMed ... Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I. Nat Genet. 1996 ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01586.x/references?globalMessage=0
*  In Vitro Metabolism of Thyroxine by Rat and Human Hepatocytes | Science Inventory | US EPA
Rat hepatocytes had as much as 13-times higher concentrations of metabolites in the media compared to human hepatocytes. ... Rat hepatocytes had as much as 13-times higher concentrations of metabolites in the media compared to human hepatocytes. ... Rat hepatocytes, human hepatocytes, Phase II metabolic enzymes, ISTD-STICS-12-081, thyroid hormone, thyroxine, ORD-003013, ... The hepatocytes were fed daily with William's E media containing 0.1% DMSO. Up to five days after plating, cell culture media ...
  https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=275394
*  A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes. | JCB
A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes.. A ... We have identified the liver-regulating protein (LRP), a cell surface protein involved in the maintenance of hepatocyte ... mAb L8 specifically detected two polypeptides of 85 and 73 kD in immunoprecipitation of both hepatocyte- and RLEC-iodinated ... A plasma membrane protein is involved in cell contact-mediated regulation of tissue-specific genes in adult hepatocytes. ...
  http://jcb.rupress.org/content/115/2/505
*  Human extracellular matrix simultaneously enhances proliferation and function in 3-D spheroids of human hepatocyte cell lines ...
Human extracellular matrix simultaneously enhances proliferation and function in 3-D spheroids of human hepatocyte cell lines. ... Human extracellular matrix simultaneously enhances proliferation and function in 3-D spheroids of human hepatocyte cell lines ... Human extracellular matrix simultaneously enhances proliferation and function in 3-D spheroids of human hepatocyte cell lines. ...
  http://discovery.ucl.ac.uk/1325507/
*  Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the...
Hepatocytes were grown in chemically defined hepatocyte growth medium (HGM) containing hepatocyte growth factor (HGF) and ... Many single, long plates of hepatocytes were seen, suggesting progressive linear assembly guided by hepatocyte specific ... Desmin-positive cells surrounded hepatocytes. Collagen types I and III were deposited in a diffuse manner whereas collagen type ... Morphogenetic events in mixed cultures of rat hepatocytes and nonparenchymal cells maintained in biological matrices in the ...
  http://onlinelibrary.wiley.com/doi/10.1002/hep.510290149/abstract
*  Plus it
Since there is still a debate on whether GLP-1 receptor (GLP-1R) is expressed in hepatocytes (12, 13, 36, 76), it has not been ... In mouse hepatocytes, GLP-128-36 treatment activated protein kinase A (PKA) and the Wnt signaling pathway effector β-catenin (β ... A few studies have supported the notion that GLP-1R is also expressed in hepatocytes (26, 36, 77, 84), whereas a number of ... GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes. Horm Metab Res 42: 657-662, 2010 ...
  http://ajpendo.physiology.org/content/311/3/E620
*  Assay-Ready Expanded (ARE) Hepatocytes, CYP2D6 Overexpressing | ax3702 (5,000,000 cells) | Axol Bioscience
Easy to plate primary hepatocyte cell line overexpressing CYP2D6 enzyme. Cryopreserved plateable primary human hepatocyte cell ... Axol Assay-Ready Expanded (ARE) Hepatocytes are primary human hepatocytes that have been expanded in vitro so large batch sizes ... Axol Assay-Ready Expanded (ARE) Hepatocytes are primary human hepatocytes that have been expanded in vitro so large batch sizes ... ARE Hepatocytes express CYP enzymes, are metabolically functional, are polarized and can be infected by the Hepatitis C virus. ...
  https://www.axolbio.com/shop/product/assay-ready-expanded-are-hepatocytes-cyp2d6-overexpressing-4384
*  Primary Hepatocytes | Human and Animal Hepatocytes | Corning
Primary Animal Hepatocytes Primary Animal Hepatocytes Learn More *Characterized for platability and many metabolic enzyme ... High Quality Primary Human Hepatocytes High Quality Primary Human Hepatocytes Learn More *Pre-screened and characterized for ... Cyropreserved hepatocytes from common pre-clinical animal species are also available. All primary hepatocyte products are pre- ... Need to Outsource Your Hepatocyte Studies? Need to Outsource Your Hepatocyte Studies? Utilize Corning Expertise to get the ...
  https://www.corning.com/in/en/products/life-sciences/products/adme-tox-research/primary-hepatocytes.html
*  Stem Cells Speaker Biography
Ostrowska has conducted hepatocyte research for >15 years, and has broad expertise relevant to this research program. She ... She also coordinated protocol development for a multicenter hepatocyte transplantation clinical trial. She was on the ISCO team ... the leading providers of hepatocytes used in pharmaceutical research. Though most of her work was in industry with significant ... management responsibilities, she has published numerous peer reviewed papers on human hepatocyte biology, cell transplantation ...
  http://selectbiosciences.com/PastConferences/biographies.aspx?speaker=793120&conf=SC2012
*  Hepatotoxicity Cytotoxicity Assays | China-Mainland | Sigma-Aldrich
Apart from human hepatocytes, HepaRG cells are the most metabolically active liver cell line described to date and have the ... Primary human hepatocytes are the gold standard for these types of studies, but limited availability, high cost, donor-to-donor ...
  https://www.sigmaaldrich.com/china-mainland/zh/life-science/adme-tox-assays/hepatotoxicity-cytotoxicity-assays.html
*  iPS Cell to Hepatocyte Differentiation System
iPS cell-derived hepatocytes resemble primary hepatocytes and express mature hepatocyte markers. To evaluate the robustness and ... iPS cell-derived hepatocytes reflect maturing hepatocyte mRNA expression profiles. mRNA expression of several hepatocyte ... fetal-like hepatocyte and mature hepatocyte. This process takes another two weeks. At the end of this process, hepatocyte ... The iPS-derived hepatocytes express markers typical of mature hepatocytes such as HNFα, albumin, PXR, and Phase I metabolizing ...
  http://www.clontech.com/US/Products/Stem_Cell_Research/Resources/Technical_Notes/iPSC-derived-hepatocytes?sitex=10020:22372:US&PEBCL1=q8DIRG9bPvMbTPhbC49c9ONqG5&PEBCL1_pses=ZG7AFC907621D7D9B47296560AA304D443226DB8FD4546DE161C4122758BE6DAF83AA0A21DAD20AEFF0C559D6E161D0F78B40BF35311019719
*  Isolation and culture of adult human liver progenitor cells: i...
... in vitro differentiation to hepatocyte-like cells.: Highly differentiated normal human hepatocytes ... Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.. Authors * ... Under appropriate conditions, these cells differentiate in vitro in hepatocyte-like cells and therefore appear to behave as ... Highly differentiated normal human hepatocytes represent the gold standard cellular model for basic and applied research in ...
  https://www.mysciencework.com/publication/show/isolation-culture-adult-human-liver-progenitor-cells-vitro-differentiation-hepatocyte-like-cells-179b7954
*  iPS Cell to Hepatocyte Differentiation System
... functional hepatocytes from human induced pluripotent stem cells. ... The Cellartis iPS Cell to Hepatocyte Differentiation System ... Hepatocytes obtained with the Cellartis iPS Cell to Hepatocyte Differentiation System express major hepatic markers and show ... Hepatocytes derived from human induced pluripotent stem (hiPS) cells using the Cellartis iPS Cell to Hepatocyte Differentiation ... Cellartis Hepatocyte Differentiation Kit (Y30050). References. *Asplund, A., et al. (2015) Stem Cell Rev. and Rep. Advance ...
  http://www.clontech.com/US/Products/Stem_Cell_Research/Pluripotency_and_Differentiation/iPS_Cell_to_Hepatocyte_Differentiation_System?sitex=10020:22372:US&PEBCL1=6du0l11nLZ1hFC5C84u1YrXpqn&PEBCL1_pses=ZG82761168F143A8A140B60F080A7AE7551D2F5C575A3ABD2EBEA2D6F7EE892B24FE15697F39EBB3405C5C15F3CB91E2EF3D1E2D13697095F3
*  Plus it
Immunocytochemistry. Hepatocytes were cultured on glass coverslips coated with rat-tail collagen (25 μg/cm2). Mouse hepatocytes ... Regulation of CYP2B6 and CYP3A4 in primary human hepatocyte cultures. Human hepatocytes were exposed for 16 h to PB, Rif, or ... AICAR and metformin induce CYP2B6 and CYP3A4 in primary human hepatocyte cultures. Primary human hepatocytes were exposed for ... Measurement of ATP Concentration in Primary Hepatocytes. Primary human hepatocytes were seeded in a 96-well plate as described ...
  http://molpharm.aspetjournals.org/content/70/6/1925
*  Hepatocyte | Encyclopedia.com
hepatocyte* A specialized epithelial cell that is the most abundant type of cell in the liver [1]. Hepatocytes are arranged ... hepatocyte A specialized epithelial cell that is the most abundant type of cell in the liver. Hepatocytes are arranged around a ... hepatocyte (hip-at-oh-syt) n. the principal cell type in the liver: a large cell with many metabolic functions, including ... hepatocyte A Dictionary of Biology © A Dictionary of Biology 2004, originally published by Oxford University Press 2004. ...
  https://www.encyclopedia.com/medicine/anatomy-and-physiology/anatomy-and-physiology/hepatocyte
*  Hepatocytes | Gastrointestinal and Liver Physiology
Role of apoptotic hepatocytes in HCV dissemination: regulation by acetaldehyde Murali Ganesan, Sathish Kumar Natarajan, Jinjin ... Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes Margaret L. ... Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice Abigael Muchenditsi ... Follistatin attenuates early liver fibrosis: effects on hepatic stellate cell activation and hepatocyte apoptosis Shane Patella ...
  http://ajpgi.physiology.org/keyword/hepatocytes
*  Metabolism of rT3 by Isolated Rat Hepatocytes | SpringerLink
Rooda S.J.E., van Loon M.A.C., Visser T.J. (1986) Metabolism of rT3 by Isolated Rat Hepatocytes. In: Medeiros-Neto G., Gaitan E ...
  https://link.springer.com/chapter/10.1007/978-1-4684-5260-0_76
*  Hepatocyte Growth Factor | SpringerLink
... was originally detected in the circulation of hepatectomized animals on the basis of its ability to stimulate hepatocyte ... Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 1992;89:373-7.PubMedCrossRef ... Hepatocyte growth factor enhances B-cell activity. Life Sci 1993;53:PL89-93.PubMedCrossRefGoogle Scholar ... Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995;373:699-702.PubMedCrossRefGoogle ...
  https://link.springer.com/chapter/10.1007/978-1-4612-1876-0_18
*  Stem Cell-Derived Hepatocytes
Enhanced hiPS-HEP cells are a highly homogenous population of hepatocytes derived from human induced pluripotent stem (iPS) ... Hepatocyte long-term maintenance medium. Additional Information. Please see the product's Certificate of Analysis for ... Cellartis enhanced hiPS-HEP iPSC-derived hepatocytes. Cellartis enhanced hiPS-HEP v2 kits provide an inexhaustible supply of ... Cells express key hepatocyte proteins, including α1AT, Alb, CK18, HNF4α, and E-cadherin ...
  http://www.clontech.com/US/Products/Stem_Cell_Research/Cells/Human_Stem_Cell_Derived_Hepatocytes?sitex=10020:22372:US&PEBCL1=6du0l11nLZ1hFC5C84u1YrXpqn&PEBCL1_pses=ZG82761168F143A8A140B60F080A7AE7551D2F5C575A3ABD2EBEA2D6F7EE892B24FE15697F39EBB3405C5C15F3CB91E2EF3D1E2D13697095F3
*  The Preparation and Culturing of Rat Hepatocytes | SpringerLink
... cultured hepatocytes would seem at first sight to be an ideal model system for the study of hepatocarcinogenesis and the ... Isolated, cultured hepatocytes would seem at first sight to be an ideal model system for the study of hepatocarcinogenesis and ... Paine A (1990).The maintenance of cytochrome P$%) in rat hepatocyte cultures: Some applications of liver cell cultures to the ... Guillouzo A., Morel F.,Fardel O., and Meunier B. (1993) Use of human hepatocyte cultures for drug metabolism studies.Toxicology ...
  https://link.springer.com/chapter/10.1007/978-3-642-79215-1_23
*  Intracytoplasmic Crystalline Inclusions in the Hepatocytes of an Antelope
... Sanjeev Gumber,1 Eric Lombardini,2 Bruce Williams,2 ... This case report describes intracytoplasmic crystalline inclusions in the hepatocytes of a 13-year-old female Thomson's gazelle ... Von Kossa staining showed the presence of calcium within cytoplasm, mainly in the inclusions, of hepatocytes. Transmission ... Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale ...
  https://www.hindawi.com/journals/vmi/2010/373698/abs/
*  Human Stem Cell-derived Hepatocytes Regenerate Liver Function: Study
Functional hepatocytes from human stem cells were found to increase the survival of mice with acute liver injury, say ... Human Stem Cell-derived Hepatocytes Regenerate Liver Function: Study. by Sheela Philomena on July 28, 2013 at 10:18 AM Genetics ... Functional hepatocytes from human stem cells were found to increase the survival of mice with acute liver injury, say ... The researchers "developed a system for mass manufacture of stem cell derived hepatocytes in numbers that would be useful for ...
  https://www.medindia.net/news/human-stem-cell-derived-hepatocytes-regenerate-liver-function-study-122716-1.htm
*  Gene expression profiling of human hepatocytes grown on differing substrate stiffness | SpringerLink
Objective To study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology ... Transforming growth factor-beta signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte- ... Differentially expressed gene Hepatocyte RNA-sequencing Substrate stiffness Tingting Xia and Runze Zhao contributed equally to ... You J et al (2013) Characterizing the effects of heparin gel stiffness on function of primary hepatocytes. Tissue Eng A 19:2655 ...
  https://link.springer.com/article/10.1007/s10529-018-2536-1