The only curative therapy for sickle cell disease (SCD) is allogeneic hematopoietic stem cell (HSC) transplantation. Gene ... Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. ... Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. ... The frequency of ML-ICs also correlated with increases in stem cell factor, GCSF, and IL-8 levels in AC-SCD compared with ...https://www.jci.org/111/6
Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis | Haematologica
Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis ... Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis ... Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis ... no significant difference in the distribution of mature blood cells, progenitors or stem cells were observed in Cdx4-deficient ...http://www.haematologica.org/content/early/2010/05/21/haematol.2010.023168
Climb For Life - 4. What is bone marrow hematopoietic stem cell transplant used for?
4. What is bone marrow hematopoietic stem cell transplant used for?. Published on 5 September 2012 in Information about ... Indications for hematopoietic stem cell transplant are acute leukimias, chronic leukimias, different forms of bone marrow ... With the expression "bone marrow hematopoietic stem cell transplant" we intend a complex procedure used especially, but not ... Stem cells can be obtained not only from bone marrow but also from peripheral blood after a specific preconditioning of the ...http://www.climbforlife.it/4-what-is-bone-marrow-hematopoietic-stem-cell-transplant-used-for/
Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
... cell survival, enzyme activation, extracellular signal-regulated map kinases/metabolism, flow cytometry, hematopoietic stem ... survival and differentiation of haematopoietic stem cells (HSCs). To further understand the mechanisms underlying these events ... Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Edling ... stem cell factor/metabolism/pharmacology Identifiers. URN: urn:nbn:se:umu:diva-5916DOI: 10.1111/j.1365-2141.2006.06434.x ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:145584
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. - Semantic Scholar
... two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell ... endothelial and perivascular cells. Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression ... cell depletion significantly reduces bone marrow homing of haematopoietic progenitors. These results uncover an unprecedented ... Whereas parathormone administration doubles the number of bone marrow nestin(+) cells and favours their osteoblastic ...https://www.semanticscholar.org/paper/Mesenchymal-and-haematopoietic-stem-cells-form-a-u-M%C3%A9ndez-Ferrer-Michurina/4c008d7f62d031755b291dbde076d4c86c8e9671
Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit...
... cells. Thus, whereas KL appears crucial for recruitment of FL + IL-7-unresponsive candidate (c-kit(+)flt3(-)) murine stem cells ... Here we show that most if not all murine Lin(-/lo)Sca1(+)c-kit(+) bone marrow (BM) cells generating B220(+)CD19(+) proB-cells ... In contrast to FL + IL-7, KL + IL-7 could not promote proB-cell formation from Lin(-/lo)Sca1(+)c-kit(+) cells. However, KL ... long-term repopulating stem cell population, whereas KL had no effect on FL + IL-7-stimulated recruitment of Lin(-/lo)Sca1(+)c- ...https://www.rdm.ox.ac.uk/publications/573551
Download Predicting The Lineage Choice Of Hematopoietic Stem Cells A Novel Approach Using Deep Neural Networks
Van de Laar M, Van der Korst J. Food download predicting the lineage choice of hematopoietic stem cells a novel approach in 0) ... Holker U, Hofer M, Lenz J( 2004) auriferous books of 10mW download predicting the lineage choice of hematopoietic stem cells a ... Eifel download predicting the lineage choice of hematopoietic stem cells, Axelson JA, Costa J et al. Goldhirsch A, Glick JH, ... download predicting the lineage choice of hematopoietic stem cells a novel approach using deep neural in the health of active ...http://harveyphillipsfoundation.org/img/library/download-predicting-the-lineage-choice-of-hematopoietic-stem-cells%3A-a-novel-approach-using-deep-neural-networks.htm
Smurf2 regulates hematopoietic stem cell self-renewal and agin...
The age-dependent decline in the self-renewal capacity of stem cells plays a critical role in ... Smurf2 regulates hematopoietic stem cell self-renewal and aging.: ... Smurf2 regulates hematopoietic stem cell self-renewal and aging.. Authors * Ramkumar, Charusheila ... In this study, we found that mice deficient in Smurf2 had an expanded hematopoietic stem cell (HSC) compartment in bone marrow ...https://www.mysciencework.com/publication/show/smurf2-regulates-hematopoietic-stem-cell-self-renewal-aging-efb689c1
Fetal liver hematopoietic stem cell niches associate with portal vessels | Science
Fetal liver hematopoietic stem cell niches associate with portal vessels. By Jalal A. Khan, Avital Mendelson, Yuya Kunisaki, ... Fetal liver hematopoietic stem cell niches associate with portal vessels. By Jalal A. Khan, Avital Mendelson, Yuya Kunisaki, ... Fetal liver hematopoietic stem cell niches associate with portal vessels Message Subject. (Your Name) has forwarded a page to ... Hematopoietic stem cells (HSCs) undergo dramatic expansion in the fetal liver before migrating to their definitive site in the ...http://science.sciencemag.org/content/351/6269/176
N4BP2L2 - NEDD4-binding protein 2-like 2 - Homo sapiens (Human) - N4BP2L2 gene & protein
... negative regulation of hematopoietic stem cell differentiation, negative regulation of transcription from RNA polymerase II ... promoter, positive regulation of hematopoietic stem cell proliferation ... negative regulation of hematopoietic stem cell differentiation Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p> ... positive regulation of hematopoietic stem cell proliferation Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p> ...http://www.uniprot.org/uniprot/Q92802
Translational Research: The CD34+ Cell Is Crucial for Large-Volume Bone Regeneration from the Milieu of Bone Marrow Progenitor...
The history and current concepts of bone marrow hematopoietic stem cells and mesenchymal stem cells are reviewed as they relate ... The CD34+ cell functions as a central signaling cell to mesenchymal stem cells and osteoprogenitor cells in bone regeneration. ... Purpose: This study investigated the role of the bone marrow derived CD34+ cell in a milieu of osteoprogenitor cells, bone ... Group B received the same graft, except the CD34+ cell concentration was 1,012 752 cells/mL. The results were analyzed ...http://www.quintpub.com/journals/omi/abstract.php?iss2_id=1221&article_id=14314&article=32&title=Translational%20Research:%20The%20CD34+%20Cell%20Is%20Crucial%20for%20Large-Volume%20Bone%20Regeneration%20from%20the%20Milieu%20of%20Bone%20Marrow%20Progenitor%20Cells%20in%20Craniomandibular%20Reconstruction
Identification and characterization of genes specifically expressed in hematopoietic progenitor/stem cells immortalized by Lhx2
Developmental biology, LIM-homeobox gene, Lhx2, fetal liver, hepatic stellate cells, hematopoietic stem cells, septum ... As the liver becomes a distinct organ it is colonized by hematopoietic cells and serves as hematopoietic organ until birth. The ... including the hematopoietic stem cells (HSCs). Liver development in Lhx2-/- embryos is disrupted leading to a lethal anemia due ... The putative role of Lhx2 in the expansion of the HS was examined by introducing Lhx2 cDNA into embryonic stem cells ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:143023
Development and aging of primitive hematopoietic stem cells in BALB/c" by J Chen, C M. Astle et al.
Concentrations of HSC that engrafted and functioned were similar among 16-day fetal liver cells and bone marrow cells (BMC) ... The functional ability per HSC, as well as the HSC concentration, was measured with minimal disruption to the cells in vivo ... Relative HSC functional ability per cell declined during development, so that a fetal HSC had 1.6 to 3.0 times the functional ... They were either 10 or 4 HSC per million cells when tested in BALB or CByB6F1 recipients, respectively. All HSC were ...https://mouseion.jax.org/stfb1990_1999/1218/
Inflammation-Mediated Notch Signaling Skews Fanconi Anemia Hematopoietic Stem Cell Differentiation | The Journal of Immunology
hematopoietic stem cell. HSPC. hematopoietic stem progenitor cell. LSK. Lin−Sca1+c-kit+. MPP. multipotential progenitor. SLAM. ... Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2: 356-366. ... SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell ... double-positive T cells, and T cells bearing αβTCR+ or γδRCT+ cells derived from hematopoietic stem progenitor cells (HSPCs) at ...http://www.jimmunol.org/content/191/5/2806.long
Aged Hematopoietic Stem Cells Rejuvenated To Be Functionally Younger - Redorbit
HSCs are stem cells that originate in the bone marrow and generate all of the body's red and white blood cells and platelets. ... Researchers have rejuvenated aged hematopoietic stem cells to be functionally younger, offering intriguing clues into how ... countering what used to be broad consensus that the aging of hematopoietic stem cells (HSCs) was locked in by nature and not ... Pharmacologic inhibition of Cdc42 reversed HSC aging and restored function similar to that of younger stem cells, explained ...http://www.redorbit.com/news/health/1112528128/aged-hematopoietic-stem-cells-rejuvenated-to-be-functionally-younger/
Extended in vitro expansion of adult, mobilized CD34+ cells without significant cell senescence using a stromal cell coculture...
... is known to support hematopoietic stem cell (HSC) expansion as well as hematopoietic differentiation of embryonic stem cells. ... OP9/TPO system provides extensive stem cell expansion without concomitant telomere erosion for both CB and adult CD34(+) cells ... cells. Maximum cell expansion was attained during the first 4 weeks of coculture. At the same time, the maximum progenitor cell ... cells showed termination of cultures after 8 weeks, independent of the cell expansion rates attained. The evaluation of cell ...https://www.semanticscholar.org/paper/Extended-in-vitro-expansion-of-adult-mobilized-CD3-Weisel-Moore/183c53319b0509f5b80b576c1af92b24cfaa753b
"Effect of cyclophosphamide on the murine hematopoietic stem cell compa" by S Hellman and H E. Grate
Hellman, S and Grate, H E., "Effect of cyclophosphamide on the murine hematopoietic stem cell compartment as measured by ... Effect of cyclophosphamide on the murine hematopoietic stem cell compartment as measured by different assay techniques. ...https://mouseion.jax.org/ssbb1971/1381/
Stem Cells for Myocardial Regeneration | Circulation Research
These cells, referred to as hematopoietic stem cells (HSCs), are rare, perhaps as few as 1:10 000 bone marrow cells.28 However ... Embryonic and Fetal Stem Cells. The most primitive of all stem cell populations are the embryonic stem cells (ES cells) that ... Adult Hematopoietic Stem/Progenitor Cells. Two categories of blood-forming stem cells exist in adult bone marrow. One ... Hematopoietic stem cells: rare adult stem cells present in blood and bone marrow; they give rise to several distinct ...http://circres.ahajournals.org/content/91/12/1092
CFU-GEMM - Wikipedia
... hematopoietic stem cell). In current terminology, CFU-S refers to the pluripotent stem cells that can differentiate into all ... CFU-GEMM cells are the multipotential progenitor cells for myeloid cells; they are thus also called common myeloid progenitor ... researchers were in search of molecules to stimulate the proliferation of long-term hematopoietic stem cells (LT-HSC). They ... "Pyrimido-Indole Derivatives Are Novel Agonists of Human Cord Blood Hematopoietic Stem Cell Self-Renewal". Blood. 124 (21). ...https://en.wikipedia.org/wiki/CFU-GEMM
Hematopoietic stem cells
Suppliers of: Hematopoietic stem cells. Found 4 Companies HOW TO USE BSN RAPID REQUEST. To send a request for quote/information ...http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=5799
Mobilizing Hematopoietic Stem Cells | Science Signaling
Cell Host Microbe 15, 792-798 (2014). [PubMed] J. H. Fritz, NOD-like receptors have a grip on stem cells. Cell Host Microbe 15 ... Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. Cell Host ... Although most hematopoietic stem cells (HSCs) reside in the bone marrow, some are located in the spleen, and some are even ... Pathogen-induced signaling through Toll-like and NOD-like receptors mobilizes hematopoietic stem cells to the spleen. ...http://stke.sciencemag.org/content/7/331/ec168
Researchers Parse The Origins Of Hematopoietic Stem Cells - Redorbit
... it is not possible to create HSCs from converted embryonic stem cells or induced pluripotent stem cells "" pluripotent cells ... HSCs are multipotent stem cells that give rise to all blood cell types, including red blood and immune cells. Existing medical ... both critical for making the first hematopoietic stem cells (HSCs) in developing vertebrate embryos. The discovery has ... dimpled red blood cells and several types of white blood cells, including lymphocytes, a monocyte and a neutrophil, and many ...http://www.redorbit.com/news/health/2061626/researchers_parse_the_origins_of_hematopoietic_stem_cells/
Bioengineered rat limbs, rare hematopoietic stem cells, and more
Rare subset of hematopoietic stem and progenitor cells control white blood cell production after a myocardial infarction. (Cell ... Cell stress regulation driving resident progenitor cell function: a potential pan-stem cell mechanism? ... Arnaout Lab: Stem cell antigen-1 helps maintain renal epithelial cell homeostasis and promotes recovery of renal function ... A team at MGH decellularized a donor rat limb and repopulated it with vascular cells and muscle progenitor cells. "We have ...http://archive.constantcontact.com/fs112/1101555263867/archive/1121402491752.html
BBC - Homepage
Breaking news, sport, TV, radio and a whole lot more. The BBC informs, educates and entertains - wherever you are, whatever your age.http://www.bbc.com
JCI - Welcome
Thrombopoietin expands hematopoietic stem cells after transplantation. Norma Fox, Greg Priestley, Thalia Papayannopoulou, ... β cell regeneration from islet cell precursors might reverse this disease, but factors that can induce β cell neogenesis and ... β cell mass increased in parallel as a result of neogenesis and β cell replication. Thus, our results indicate that local ... Furthermore, adiponectin failed to block fat cell generation when bone marrow cells were derived from B6,129SPtgs2tm1Jed (COX- ...https://www.jci.org/tags/20?content=articles&page=17