*  111(6)
The only curative therapy for sickle cell disease (SCD) is allogeneic hematopoietic stem cell (HSC) transplantation. Gene ... Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. ... Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. ... The frequency of ML-ICs also correlated with increases in stem cell factor, GCSF, and IL-8 levels in AC-SCD compared with ...
  https://www.jci.org/111/6
*  Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation
... cell survival, enzyme activation, extracellular signal-regulated map kinases/metabolism, flow cytometry, hematopoietic stem ... survival and differentiation of haematopoietic stem cells (HSCs). To further understand the mechanisms underlying these events ... Haematopoietic progenitor cells utilise conventional PKC to suppress PKB/Akt activity in response to c-Kit stimulation. Edling ... stem cell factor/metabolism/pharmacology Identifiers. URN: urn:nbn:se:umu:diva-5916DOI: 10.1111/j.1365-2141.2006.06434.x ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:145584
*  Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit...
... cells. Thus, whereas KL appears crucial for recruitment of FL + IL-7-unresponsive candidate (c-kit(+)flt3(-)) murine stem cells ... Here we show that most if not all murine Lin(-/lo)Sca1(+)c-kit(+) bone marrow (BM) cells generating B220(+)CD19(+) proB-cells ... In contrast to FL + IL-7, KL + IL-7 could not promote proB-cell formation from Lin(-/lo)Sca1(+)c-kit(+) cells. However, KL ... long-term repopulating stem cell population, whereas KL had no effect on FL + IL-7-stimulated recruitment of Lin(-/lo)Sca1(+)c- ...
  https://www.rdm.ox.ac.uk/publications/573551
*  Smurf2 regulates hematopoietic stem cell self-renewal and agin...
The age-dependent decline in the self-renewal capacity of stem cells plays a critical role in ... Smurf2 regulates hematopoietic stem cell self-renewal and aging.: ... Smurf2 regulates hematopoietic stem cell self-renewal and aging.. Authors * Ramkumar, Charusheila ... In this study, we found that mice deficient in Smurf2 had an expanded hematopoietic stem cell (HSC) compartment in bone marrow ...
  https://www.mysciencework.com/publication/show/smurf2-regulates-hematopoietic-stem-cell-self-renewal-aging-efb689c1
*  Fetal liver hematopoietic stem cell niches associate with portal vessels | Science
Fetal liver hematopoietic stem cell niches associate with portal vessels. By Jalal A. Khan, Avital Mendelson, Yuya Kunisaki, ... Fetal liver hematopoietic stem cell niches associate with portal vessels. By Jalal A. Khan, Avital Mendelson, Yuya Kunisaki, ... Fetal liver hematopoietic stem cell niches associate with portal vessels Message Subject. (Your Name) has forwarded a page to ... Hematopoietic stem cells (HSCs) undergo dramatic expansion in the fetal liver before migrating to their definitive site in the ...
  http://science.sciencemag.org/content/351/6269/176
*  N4BP2L2 - NEDD4-binding protein 2-like 2 - Homo sapiens (Human) - N4BP2L2 gene & protein
... negative regulation of hematopoietic stem cell differentiation, negative regulation of transcription from RNA polymerase II ... promoter, positive regulation of hematopoietic stem cell proliferation ... negative regulation of hematopoietic stem cell differentiation Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p> ... positive regulation of hematopoietic stem cell proliferation Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p> ...
  http://www.uniprot.org/uniprot/Q92802
*  Identification and characterization of genes specifically expressed in hematopoietic progenitor/stem cells immortalized by Lhx2
Developmental biology, LIM-homeobox gene, Lhx2, fetal liver, hepatic stellate cells, hematopoietic stem cells, septum ... As the liver becomes a distinct organ it is colonized by hematopoietic cells and serves as hematopoietic organ until birth. The ... including the hematopoietic stem cells (HSCs). Liver development in Lhx2-/- embryos is disrupted leading to a lethal anemia due ... The putative role of Lhx2 in the expansion of the HS was examined by introducing Lhx2 cDNA into embryonic stem cells ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:143023
*  Development and aging of primitive hematopoietic stem cells in BALB/c" by J Chen, C M. Astle et al.
Concentrations of HSC that engrafted and functioned were similar among 16-day fetal liver cells and bone marrow cells (BMC) ... The functional ability per HSC, as well as the HSC concentration, was measured with minimal disruption to the cells in vivo ... Relative HSC functional ability per cell declined during development, so that a fetal HSC had 1.6 to 3.0 times the functional ... They were either 10 or 4 HSC per million cells when tested in BALB or CByB6F1 recipients, respectively. All HSC were ...
  https://mouseion.jax.org/stfb1990_1999/1218/
*  Aged Hematopoietic Stem Cells Rejuvenated To Be Functionally Younger - Redorbit
HSCs are stem cells that originate in the bone marrow and generate all of the body's red and white blood cells and platelets. ... Researchers have rejuvenated aged hematopoietic stem cells to be functionally younger, offering intriguing clues into how ... countering what used to be broad consensus that the aging of hematopoietic stem cells (HSCs) was locked in by nature and not ... Pharmacologic inhibition of Cdc42 reversed HSC aging and restored function similar to that of younger stem cells, explained ...
  http://www.redorbit.com/news/health/1112528128/aged-hematopoietic-stem-cells-rejuvenated-to-be-functionally-younger/
*  Demonstration of early functional compromise of bone marrow derived hematopoietic progenitor cells during bovine neonatal...
Stemcell technologies, UK). On one occasion (calf Y day 6) insufficient cell numbers were obtained for 2 dishes and a single ... This supports the hypothesis that the main target cell is the pluripotent hematopoietic progenitor cell. In addition, this ... Clonogenic assay of hematopoietic progenitor cells. A protocol based on a previously described method [20] was followed with ... γδT cell and B cell percentages to drop and subsequently fail to rise when compared to control animals. B-cell lymphopoesis ...
  https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-599
*  Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell...
Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell ... The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid ... The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid ... article{99c2b32e-f9cf-4afb-8052-6d71d776ad00, abstract = {The first lineage commitment step of hematopoietic stem cells (HSC) ...
  https://lup.lub.lu.se/search/publication/110578
*  Stem Cells for Myocardial Regeneration | Circulation Research
These cells, referred to as hematopoietic stem cells (HSCs), are rare, perhaps as few as 1:10 000 bone marrow cells.28 However ... Embryonic and Fetal Stem Cells. The most primitive of all stem cell populations are the embryonic stem cells (ES cells) that ... Adult Hematopoietic Stem/Progenitor Cells. Two categories of blood-forming stem cells exist in adult bone marrow. One ... Hematopoietic stem cells: rare adult stem cells present in blood and bone marrow; they give rise to several distinct ...
  http://circres.ahajournals.org/content/91/12/1092
*  Autologous Hematopoietic Progenitor Cell Transplantation | The MD Anderson Manual of Medical Oncology, 3e | AccessHemOnc |...
Stem Cell Collection. ++. Bone marrow is collected via multiple aspirations from the posterior-superior iliac crest in a ... "Autologous Hematopoietic Progenitor Cell Transplantation." The MD Anderson Manual of Medical Oncology, 3e Kantarjian HM, Wolff ... Hematopoietic progenitor cells are normally infrequent in the blood but are mobilized into the blood during the recovery after ... Fakih R, Shah N, Nieto Y. Fakih R, Shah N, Nieto Y Fakih, Riad El, et al.Autologous Hematopoietic Progenitor Cell ...
  http://hemonc.mhmedical.com/content.aspx?bookid=1772§ionid=121897865
*  Hematopoietic stem cells
Suppliers of: Hematopoietic stem cells. Found 4 Companies HOW TO USE BSN RAPID REQUEST. To send a request for quote/information ...
  http://www.biosupplynet.com/cfdocs/products/prod_supp.cfm?prod_id=5799
*  Mobilizing Hematopoietic Stem Cells | Science Signaling
Cell Host Microbe 15, 792-798 (2014). [PubMed] J. H. Fritz, NOD-like receptors have a grip on stem cells. Cell Host Microbe 15 ... Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. Cell Host ... Although most hematopoietic stem cells (HSCs) reside in the bone marrow, some are located in the spleen, and some are even ... Pathogen-induced signaling through Toll-like and NOD-like receptors mobilizes hematopoietic stem cells to the spleen. ...
  http://stke.sciencemag.org/content/7/331/ec168
*  Researchers Parse The Origins Of Hematopoietic Stem Cells - Redorbit
... it is not possible to create HSCs from converted embryonic stem cells or induced pluripotent stem cells "" pluripotent cells ... HSCs are multipotent stem cells that give rise to all blood cell types, including red blood and immune cells. Existing medical ... both critical for making the first hematopoietic stem cells (HSCs) in developing vertebrate embryos. The discovery has ... dimpled red blood cells and several types of white blood cells, including lymphocytes, a monocyte and a neutrophil, and many ...
  http://www.redorbit.com/news/health/2061626/researchers_parse_the_origins_of_hematopoietic_stem_cells/
*  Bioengineered rat limbs, rare hematopoietic stem cells, and more
Rare subset of hematopoietic stem and progenitor cells control white blood cell production after a myocardial infarction. (Cell ... Cell stress regulation driving resident progenitor cell function: a potential pan-stem cell mechanism? ... Arnaout Lab: Stem cell antigen-1 helps maintain renal epithelial cell homeostasis and promotes recovery of renal function ... A team at MGH decellularized a donor rat limb and repopulated it with vascular cells and muscle progenitor cells. "We have ...
  http://archive.constantcontact.com/fs112/1101555263867/archive/1121402491752.html
*  BBC - Homepage
Breaking news, sport, TV, radio and a whole lot more. The BBC informs, educates and entertains - wherever you are, whatever your age.
  http://www.bbc.com
*  Gene Editing in Adult Hematopoietic Stem Cells | IntechOpen
Gene Editing in Adult Hematopoietic Stem Cells , IntechOpen, Published on: 2016-05-18. Authors: Sergio López-Manzaneda, Sara ... Cell Stem Cell. 2012;10:120-36.. 4 - Stolfi JL, Pai CS, Murphy WJ. Preclinical modeling of hematopoietic stem cell ... such as immortalized cell lines or pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells). However, ... Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 2014;15:643-52. ...
  https://www.intechopen.com/books/modern-tools-for-genetic-engineering/gene-editing-in-adult-hematopoietic-stem-cells/
*  Transplanted Hematopoietic Stem Cells Reverse Damage Caused by Neuro-Muscular Disorder
Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic ... stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by ... hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) ... Human hematopoietic stem and progenitor cells (HSPCs), derived from bone marrow, have become a primary vehicle for efforts to ...
  http://www.newswise.com/articles/transplanted-hematopoietic-stem-cells-reverse-damage-caused-by-neuro-muscular-disorder
*  Human Hematopoietic Stem Cells Can Survive In Vitro for Several Months
... Taro Ishigaki,1,2 Kazuhiro Sudo,1 Takashi Hiroyama,1 ... 1Cell Engineering Division, RIKEN BioResource Center, Tsukuba, Ibaraki 305-0074, Japan. 2Division of Hematology, Institute of ... Supplementary Figure S1 shows that the majority of detached cells had the morphological characteristics of granulocyte/ ...
  https://www.hindawi.com/journals/ah/2009/936761/sup/
*  JCI - BRPF1 is essential for development of fetal hematopoietic stem cells
Hematopoietic stem cells (HSCs) serve as a life-long reservoir for all blood cell types and are clinically useful for a variety ... Here, we investigated the function of BRPF1 in hematopoiesis by selectively deleting its gene in murine blood cells. Brpf1. - ... The mutant bone marrow and fetal liver exhibited severe deficiency in HSCs and hematopoietic progenitors, along with elevated ...
  https://www.jci.org/articles/view/80711/figure/1
*  Mini-symposium on hematopoietic stem cells | Event | News | Karolinska Institutet
Identification of novel hematopoietic stem- and progenitor populations: implications for the hierarchical organization of ... 16.00 17.00: 'Shaping a Hemtopoietic lineage: Lessons from B-cell development' Mikael Sigvardsson, Linköping University. ... Unraveling the stem and progenitor cell hierarchies of normal and malignant hematopoiesis' Sten Eirik Jacobsen, University of ... Mini-symposium on hematopoietic stem cells. 2013-10-0713:30 to 17:00 Birkeaulan , F51, KI hospital in Huddinge. ...
  http://ki.se/en/news/calendar/mini-symposium-on-hematopoietic-stem-cells
*  CSHLPress.com - hematopoietic stem cells intergenic noncoding RNAs
investigated how the Wnt/β-catenin and PTEN/PI3K/Akt pathways cooperate in hematopoietic stem cells (HSC) to regulate self- ... Cooperation between both Wnt/β-catenin and PTEN/PI3K/Akt Signaling is Necessary to Promote Primitive Hematopoietic Stem Cell ... The expansion of stem cell populations AND A large part of the human genome codes for noncoding RNA (ncRNA).. 09/01/2011. ... The expansion of stem cell populations depends upon a dynamic balance between active proliferation and the suppression of both ...
  https://www.cshlpress.com/press.tpl?pag=hematopoietic%20_stem%20cells_intergenic_noncoding_%20RNAs
*  JCI - Welcome
Thrombopoietin expands hematopoietic stem cells after transplantation. Norma Fox, Greg Priestley, Thalia Papayannopoulou, ... β cell regeneration from islet cell precursors might reverse this disease, but factors that can induce β cell neogenesis and ... β cell mass increased in parallel as a result of neogenesis and β cell replication. Thus, our results indicate that local ... Furthermore, adiponectin failed to block fat cell generation when bone marrow cells were derived from B6,129SPtgs2tm1Jed (COX- ...
  https://www.jci.org/tags/20?content=articles&page=17