Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells. ...
... there was no detectable functional interaction between their respective receptor subunits. By comparing the receptor action in ... The function of the receptor subunits was characterized in transiently transfected hepatoma cells and fibroblasts by the ... we analyzed the relationship between the receptor subunits for IL-3 and TPO and determined whether both receptors activate ... Although c-mpl and IL-3 receptor (IL-3R) reconstituted a qualitatively comparable gene regulatory response, ...https://www.semanticscholar.org/paper/Signal-transduction-by-the-receptors-for-%28c-mpL%29-in-Morella-Bruno/983a7e7c09d488c8fb512b8b6782ccee19e4bb7e
The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute...
Relapse in these diseases occurs at least in part due to the failure to eradicate leukemic stem cells or hematopoietic stem ... The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000; 14( ... Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies. Haematologica. 2001;86(12):1261- ... The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute ...http://www.haematologica.org/content/103/8/1288
Erythropoietin, Thrombopoietin and Leptin Receptors | SpringerLink
... through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3. J ... 1996 The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U ... they belong to the class I cytokine receptor family that includes most interleukin receptors involved in hematopoiesis as well ... 1993 Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. ...https://link.springer.com/chapter/10.1007/978-1-4757-3600-7_8
Phosphatases: The New Brakes for Cancer Development?
... in response to activation of hematopoietic cell surface receptors, such as erythropoietin, steel factor, interleukin-3 [55, 56 ... SHIP2 functions as a positive regulator of the epidermal growth factor receptor/Akt pathway, C-X-C chemokine receptor type 4 ... Keratinocytes not only express the epidermal growth factor (EGF) receptor but also produce ligands for this receptor, including ... SHIP2 is a positive regulator of the epidermal growth factor receptor/Akt pathway, C-X-C chemokine receptor type 4 expression, ...https://www.hindawi.com/journals/er/2012/659649/
Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease |...
The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor- ... Hematopoietic stem cell transplantation for pulmonary alveolar proteinosis associated with primary immunodeficiency disease. ... These patients may have underlying primary immunodeficiency (PID) and were successfully treated with allogeneic hematopoietic ... Pulmonary alveolar proteinosis Hematopoietic stem cell transplantation Primary immunodeficiency Granulocyte-macrophage colony ...https://rd.springer.com/article/10.1007/s12185-017-2375-1
The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling. - Semantic Scholar
... of the cytokine superfamily that promotes multi-potential hematopoietic cell growth by interacting with a cell surface receptor ... map to one side of the protein and form a putative binding site for the alpha subunit of the receptor. A model of the IL-3.IL-3 ... receptor complex based on the human growth hormone (hGH).hGH soluble receptor complex structure suggests that the interface ... likely to be required for interaction with the receptor. Ten important and solvent-exposed residues, Asp21, Gly42, Glu43, Gln45 ...https://www.semanticscholar.org/paper/The-receptor-binding-site-of-human-interleukin-3-d-Klein-Feng/54585dbe4f6528c4562475093b82b0d4a9502f54
Interleukin-3 receptor - Wikipedia
... induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell ... The receptor belongs to the type I cytokine receptor family and is a heterodimer with a unique alpha chain paired with the ... The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of ... The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. ...https://en.wikipedia.org/wiki/Interleukin-3_receptor
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size | JEM
Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or ... Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int. ... Primitive hematopoietic cells are increased in the bone marrow of OPN−/− mice, whereas mature cells are not. (A) Bone marrow ... Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. Sebastian Stier, Yon Ko ...http://jem.rupress.org/content/201/11/1781
Papers with the keyword KMT2 | Read by QxMD
Regulation of interleukin-3 receptor (IL-3R) gene expression by tumor necrosis factor alpha (TNF alpha) was investigated using ... a concave surface of the Ash2L SPIa and ryanodine receptor (SPRY) domain binds to a cluster of acidic residues, referred to as ... Tumor necrosis factor alpha-induced up-regulation of interleukin-3 receptor mRNA expression in a CD34-positive hematopoietic ... www.readbyqxmd.com/read/7545455/tumor-necrosis-factor-alpha-induced-up-regulation-of-interleukin-3-receptor-mrna-expression-in- ...https://www.readbyqxmd.com/keyword/21292
Regulation of interleukin 3 receptor alpha chain (IL-3R alpha)...
... on human monocytes by interleukin (IL)-4, IL-10, IL-13, and transforming growth factor beta (TGF- ... Regulation of interleukin 3 receptor alpha chain (IL-3R alpha) ... is constitutively expressed on committed haematopoietic stem ... This receptor is also expressed by monocytes and may induce functional activation. Interleukin (IL)-4, IL-10, IL-13, and ... Regulation of interleukin 3 receptor alpha chain (IL-3R alpha) on human monocytes by interleukin (IL)-4, IL-10, IL-13, and ...https://www.mysciencework.com/publication/show/regulation-interleukin-3-receptor-alpha-chain-il-3r-alpha-human-monocytes-interleukin-il-4-il-10-il-13-transforming-gro-701bcc94
The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial...
Neutrophil-activating peptide-1/interleukin-8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045. ... The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial ... The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial ... The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial ...http://www.bloodjournal.org/content/91/12/4523?ijkey=542c9e9f11b5384c3ee97316b5abdf7d07822b09&keytype2=tf_ipsecsha&sso-checked=true
The FLT3 ligand is a direct and potent stimulator of the growth of primitive and committed human CD34+ bone marrow progenitor...
IL-3 + SCF than to FL + IL-3 or SCF + IL-3. Similar findings were observed in serum-containing and serum-deprived cultures. ... IL-3 + SCF stimulated 2.3-fold and 2.5-fold more colonies than FL + IL-3 and SCF + IL-3, respectively. These additional ... 3, granulocyte colony-stimulating factor (G-CSF), CSF-1, granulocyte macrophage (GM) CSF stem cell factor (SCF), and IL-6. FL ... but synergistically and directly enhanced colony formation in combination with interleukin (IL) ...https://www.rdm.ox.ac.uk/publications/573533
Interleukin 3 - Wikipedia
Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined ... He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and ... "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3". Ann. N. Y. Acad. Sci. 554: ... Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene. Interleukin 3 is an interleukin, a type of ...https://en.wikipedia.org/wiki/Interleukin_3
The Carboxyl Terminus of the Granulocyte Colony- Stimulating Factor Receptor, Truncated in Patients with Severe Congenital...
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor β chain and down-regulates IL-3-induced ... IFN-αβ receptor (30), B cell Ag receptor (31), T cell Ag receptor (32, 33), killer cell inhibitor receptor (34), and CD22 (35 ... Likewise, Akt activation by G-CSF is significantly prolonged as a result of receptor truncation in hematopoietic cells ... 293T cells were transiently transfected with the wild-type G-CSF receptor (lanes 1 and 2), the D715 receptor (lanes 3 and 4), ...http://www.jimmunol.org/content/167/11/6447
CD123-PC7 - Beckman Coulter
... belongs to the cytokine receptor family. It is constitutively expressed by committed hematopoietic stem / progenitor cells, by ... The CD123 antigen, alias Interleukin-3 alpha receptor (IL-3Rα), ... CD123, IL-3Ralpha, Interleukin-3 receptor alpha chain. UNSPSC ...https://www.beckman.com/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/B13647?loopPrevention=1
4nkq - Proteopedia, life in 3D
IL3RB_HUMAN] High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. [ ... CSF2_HUMAN] Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, ... Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling., ... Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling. ...http://proteopedia.org/wiki/index.php/3cxe
CD131 / CSF2RB antibody | acris-antibodies.com
Interleukin 3 (IL3), originally called Colony Forming Unit-Stimulating Activity (CFU-SA) is a multifunctional cytokine produced ... The IL3 receptor complex contains two distinct cytokine receptor subunits, ligand binding IL3 Ralpha and IL3 Rbeta. Recombinant ... Interleukin 3 binds specifically and with high affinity to cell-surface receptors. Interleukin 3 receptors are members of the ... IL3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. It ...https://www.acris-antibodies.com/target/cd131-antibody-csf2rb-antibody.htm
Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells | PNAS
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors ... Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo ... mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem ... Interleukin 3 or interleukin 1 abrogates the reconstituting ability of hematopoietic stem cells. Y Yonemura, H Ku, F Hirayama, ...http://www.pnas.org/content/93/9/4040
Human IL-3 32-Tests - Aimplex Biosciences, Inc.
Interleukin-3 (IL-3) is an interleukin, a type cytokine that can improve the body's natural response to disease as part of the ... both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage- ... identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3". Cell 47 (1): 3-10. doi: ... It acts by binding to the interleukin-3 receptor. IL-3 stimulates the differentiation of multipotent hematopoietic stem cells ...https://www.aimplexbio.com/hil3-2
Most recent papers with the keyword fourts b | Read by QxMD
FDCP-1 cells are hematopoietic progenitor cells which require interleukin-3 for survival and proliferation. FDCP-1 cells stably ... Transfected cells expressing either the long form of the PRL receptor or the EPO receptor were used. We demonstrated that IL-3 ... Functional analysis of prolactin receptor and prolactin-erythropoietin receptor chimera expressed in lymphoid cells. ... induces-interleukin-6-and-cyclooxygenase-2-expression-in-human-vascular-smooth-muscle-cells-synergy-with-interleukin-1beta ...https://www.readbyqxmd.com/keyword/91320
Interleukin 11 - Wikipedia
1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): ... As a signaling molecule, interleukin 11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; ... Sims NA, Jenkins BJ, Nakamura A, Quinn JM, Li R, Gillespie MT, Ernst M, Robb L, Martin TJ (July 2005). "Interleukin-11 receptor ... 1999). "Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis". Eur. J. Biochem ...https://en.wikipedia.org/wiki/Interleukin_11
Get to know the Ozgene team - Ozgene
Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte ... Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation. [ ... Adult mice with targeted mutation of the interleukin 11 receptor (IL11Ra) display normal hematopoiesis. [Read] ... EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. [Read] ...https://www.ozgene.com/about-us/our-team
Characterization of a Novel Nonsense Mutation in the Interleukin-7 Receptor α Gene in a Korean Patient with Severe Combined...
Although it has been suggested that defective interleukin 7 receptor (IL-7R) signaling is one of the principal causes of severe ... Hematopoietic stem cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med. 1999:340:508-516. ... The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu ... Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell. 1993:73:147-157. ...https://link.springer.com/article/10.1532/IJH97.04026
Interleukin 8 receptor, beta - Wikipedia
"Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic ... Interleukin 8 receptor, alpha Interleukin 8 Interleukin Interleukin receptor Cluster of differentiation G protein-coupled ... "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to ... "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to ...https://en.wikipedia.org/wiki/Interleukin_8_receptor,_beta
Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones | Journal of Hematology & Oncology...
... hematopoietic stem cells. It has not been demonstrated whether CD123-positive (CD34+/CD38−) subpopulation is enriched for any ... LSCs are reported to overexpress the alpha subunit of the IL-3 receptor (CD123) compared to normal CD34+/CD38− ... Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10(4):588-99.PubMedGoogle Scholar. ... CD123 (interleukin 3 receptor alpha chain). J Biol Regul Homeost Agents. 2001;15(1):98-100.PubMedGoogle Scholar. ...https://jhoonline.biomedcentral.com/articles/10.1186/s13045-016-0292-z