JCVI: Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection.
... although several hemagglutinin substitutions required an epistatic substitution in the neuraminidase glycoprotein to maximize ... Defining Influenza A Virus Hemagglutinin Antigenic Drift by Sequential Monoclonal Antibody Selection. ... Human influenza A virus (IAV) vaccination is limited by 'antigenic drift,' rapid antibody-driven escape reflecting amino acid ... Since each hemagglutinin mutation potentially sculpts future mutation space, drift can follow many stochastic paths, ...http://www.jcvi.org/cms/index.php?id=629&no_cache=1&tx_ttnews%5Btt_news%5D=3272/
HE - Hemagglutinin-esterase-fusion glycoprotein precursor - Influenza C virus (strain C/Kyoto/41/1982) - HE gene & protein
Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed ... These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell (By similarity ... bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range ... virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing ...http://www.uniprot.org/uniprot/P17004
CiNii 論文 - Identification of Amino Acids of Influenza Virus HA Responsible for Resistance to...
Fusion mutants of the influenza virus hemagglutinin glycoprotein DANIELS R. S. Cell 40, 431-439, 1985 ... Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion SKEHEl J. J. ... Dextran sulfate inhibits the fusion of influenza virus with model membranes, and suppresses influenza virus replication in vivo ... Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid STASCHKE K. A. ...https://ci.nii.ac.jp/naid/10004891620
An Early Stage of Membrane Fusion Mediated by the Low pH Conformation of Influenza Hemagglutinin Depends upon Membrane Lipids |...
1987) The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem 56:365-394, ... 1981) Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature (Lond) 289:366-373, ... 1985) Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell 40:431-439, pmid:3967299.. ... Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin ...http://jcb.rupress.org/content/136/1/81
Influenza Viral Proteins: Identification and Synthesis | SpringerLink
So much has been learnt about the proteins of influenza virus during the last three years that most of the gene products can ... Eckert, E. A.: Properties of an antigenic glycoprotein isolated from influenza virus hemagglutinin. J. Virol. 11, 183-192 (1973 ... Electrophoretic distribution of the proteins and glycoproteins of influenza virus and Sendai virus. J. Virol. 6, 707-716 (1970 ... Stanley, P. M., Gandhi, S. S., White, D. O.: The polypeptides of influenza virus. VII. Synthesis of the hemagglutinin. Virology ...https://link.springer.com/chapter/10.1007/978-3-642-65775-7_1
Defective Ribosomal Products Are the Major Source of Antigenic Peptides Endogenously Generated from Influenza A Virus...
... and intracellular transport of the influenza virus hemagglutinin glycoprotein. Cell 52: 843-852. ... hemagglutinin. IAV. influenza A virus. insOVA. PR8 containing inserted SIINFEKL peptide in NA. MDCK. Madin-Darby canine kidney ... In this study, we show that insertion of the SIINFEKL peptide into the stalk of influenza A virus neuraminidase (NA) does not ... when expressed in its natural context of influenza A virus infection. Using the 25-D1.16 mAb specific for Kb-SIINFEKL to ...http://www.jimmunol.org/content/184/3/1419.long
Conserved Synthetic Peptides from the Hemagglutinin of Influenza Viruses Induce Broad Humoral and T-Cell Responses in a Pig...
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature. 1981;289:366-373. [PubMed] ... Cross-protective immunity to influenza pH1N1 2009 viruses induced by seasonal A(H3N2) virus is mediated by virus-specific T ... Influenza virus vaccine based on the conserved hemagglutinin stalk domain. MBio 1. 2010. [PMC free article] [PubMed] ... Conserved Synthetic Peptides from the Hemagglutinin of Influenza Viruses Induce Broad Humoral and T-Cell Responses in a Pig ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3398042/?lang=en-ca
Analysis of activation of OVA-specific T cells. (A) Var | Open-i
Hemagglutinin Glycoproteins, Influenza Virus/immunology. *Male. *Mice. *Mice, Inbred BALB C. *Models, Immunological ... we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and ... we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195981_011167f4c&req=4
Flu virus, illustration - Stock Image F017/2475 - Science Photo Library
Illustration showing influenza virus with surface glycoprotein spikes hemagglutinin (HA, trimer) and neuraminidase (NA, ... tetramer). Hemagglutinin takes part in attachment of a virus to human respiratory cells and neuraminidase participate in a ... release of virus from a cell. - Stock Image F017/2475 ... influenza virus with surface glycoprotein spikes hemagglutinin ... glycoprotein, h1n1, ha, health, healthcare, hemagglutinin, illustration, infection, infectious, influenza, influenza virus, ...http://www.sciencephoto.com/media/802581/view
Cholesterol Supplementation During Production Increases the Infectivity of Retroviral and Lentiviral Vectors Pseudotyped with...
Two major transmembrane glycoproteins in influenza viruses, hemagglutinin and neuraminidase, are raft-associated proteins . ... 4. Keller P, Simons K. Cholesterol is required for surface transport of influenza virus hemagglutinin. J Cell Biol. 1998;140: ... as has been reported for influenza virus hemagglutinin and neuraminidase .. In our experiments, cholesterol was delivered ... Lipid rafts have been shown to be involved in the assembly of several enveloped viruses including influenza, Ebola, and HIV-1 [ ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2663912/
"Role of different lymphoid tissues in the initiation and maintenance o" by Christine Margaret Boyle, Merribeth J. Morin et al.
Antibody responses in mice immunized by a single gene gun inoculation of plasmid expressing the influenza virus H1 ... hemagglutinin and in mice immunized by a sublethal H1 influenza virus infection have been compared. Both immunizations raised ... Hemagglutinin Glycoproteins, Influenza Virus; Humans; Immunoglobulin G; Influenza A virus; Influenza Vaccines; Influenza, Human ... inoculation of plasmid expressing the influenza virus H1 hemagglutinin and in mice immunized by a sublethal H1 influenza virus ...https://escholarship.umassmed.edu/gsbs_sp/122/
"Th1 genetic adjuvants modulate immune responses in neonates" by Tamera Marie Pertmer, Alp E. Oran et al.
... of DNA encoding Th1 cytokines to bias the isotype of antibody raised by neonatal or adult immunization with an influenza ... hemagglutinin expressing DNA (HA-DNA). Neonatal mice coimmunized with HA-DNA and either IL-12 or IFN-gamma-expressing DNA ... Hemagglutinin Glycoproteins, Influenza Virus; Immunoglobulin G; Immunoglobulin Isotypes; Interferon Type II; Interleukin-12; ... encoding Th1 cytokines to bias the isotype of antibody raised by neonatal or adult immunization with an influenza hemagglutinin ...https://escholarship.umassmed.edu/gsbs_sp/980/
Don Craig Wiley - Wikipedia
Wilson, I. A.; Skehel, J. J.; Wiley, D. C. (1981). "Structure of the haemagglutinin membrane glycoprotein of influenza virus at ... Skehel, J. J.; Wiley, D. C. (2000). "Receptor Binding and Membrane Fusion in virus entry: The Influenza Hemagglutinin". Annual ... "Binding of the influenza a virus to cell-surface receptors: Structures of five hemagglutinin-sialyloligosaccharide complexes ... Eisen, Michael Bruce (1996). Structural Studies of Influenza A Virus Proteins (PhD thesis). Harvard University. OCLC 48938206. ...https://en.wikipedia.org/wiki/Don_Craig_Wiley
"DNA immunization: effect of secretion of DNA-expressed hemagglutinins " by Celia Aurora Tiglao Torres, Kejian Yang et al.
At low doses of DNA, the plasma membrane form of the influenza virus HA raised higher titers of antibody than the secreted form ... The raising of predominantly IgG1 by i.m. delivery of the secreted form of the influenza hemagglutinin was IL-4 dependent ... Following intramuscular injections, DNAs expressing membrane bound forms of the influenza and measles HAs raised predominantly ... DNA vaccines expressing plasma membrane and secreted forms of the influenza and measles virus hemagglutinins (HAs) have been ...http://escholarship.umassmed.edu/gsbs_sp/1261/
Viruses | Free Full-Text | Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane...
... approaches will be reviewed with a focus on the well-characterized influenza virus hemagglutinin fusion glycoprotein system. ... In combination, the approaches provide a significantly richer portrait of viral fusion glycoprotein structural variation and ... to understand mechanistically how these fusion glycoproteins perform their structural calisthenics and drive membrane fusion ... The fusion glycoproteins that decorate the surface of enveloped viruses undergo dramatic conformational changes in the course ...http://www.mdpi.com/1999-4915/8/1/15
Protection against lethal challenge of control and vacc | Open-i
Hemagglutinin Glycoproteins, Influenza Virus/chemistry. *Hemolysis. *Humans. *Immunoglobulin E/chemistry. *Immunoglobulin G/ ... Herein we report that alum-adjuvanted plant-made VLPs containing the hemagglutinin (HA) protein of H5N1 influenza (A/Indonesia/ ... Herein we report that alum-adjuvanted plant-made VLPs containing the hemagglutinin (HA) protein of H5N1 influenza (A/Indonesia/ ... Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3008737_pone.0015559.g002&req=4
Development of hyper IgE can be prevented by normal TCR | Open-i
Hemagglutinin Glycoproteins, Influenza Virus/immunology. *Male. *Mice. *Mice, Inbred BALB C. *Models, Immunological ... we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and ... we generated mice bearing monoclonal populations of B and T lymphocytes specific for influenza virus hemagglutinin (HA) and ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2195981_011167f3c&req=4
HA antibody | Western, Immunofluorescence, Immunoprecipitation | H6908 | Sigma-Aldrich
Hemagglutinin (HA) is an influenza-virus glycoprotein that regulates membrane fusion and receptor-binding functions during ... synthetic peptide corresponding to amino acid residues 98-106 (YPYDVPDYA) of human Influenza virus hemagglutinin (HA) known as ... This sequence corresponds to amino acids 99-107 of human influenza virus X47 (classified as an H3N2 strain) referred to in ... What strain of influenza hemagglutinin does Product H6908, Anti-HA antibody, recognize? ...https://www.sigmaaldrich.com/catalog/product/sigma/h6908?lang=en®ion=US
ASMscience | Committing the Oldest Sins in the Newest Kind of Ways-Antibodies Targeting the Influenza Virus Type A...
Increasing the immunogenicity of the RBD of other HA subtypes may be a step toward a universal influenza vaccine. The germ line ... The globular head of the trimeric influenza hemagglutinin (HA) contains the receptor-binding domain (RBD) and is the target of ... infrequently display cross-neutralizing activity against antigenic drift variants or even against HA molecules from viruses of ... Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature 289:366-373. [PubMed][ ...http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.AID-0021-2014
William Weis | Stanford Medicine Profiles
The haemagglutinin glycoprotein (HA) of influenza virus specifically mediates fusion of the viral and host cell endosomal ... Haemagglutinin glycoproteins are the components of influenza virus membranes against which infectivity-neutralizing antibodies ... IMMUNE RECOGNITION OF INFLUENZA-VIRUS HEMAGGLUTININ PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B- ... REFINEMENT OF THE INFLUENZA-VIRUS HEMAGGLUTININ BY SIMULATED ANNEALING JOURNAL OF MOLECULAR BIOLOGY Weis, W. I., Brunger, A. T ...https://med.stanford.edu/profiles/william-weis
Genetic content of Influenza H3N2 vaccine seeds
Enami M, Enami K. Influenza virus hemagglutinin and neuraminidase glycoproteins stimulate the membrane association of the ... Influenza virus assembly: effect of influenza virus glycoproteins on the membrane association of M1 protein. J Virol. 2000 Sep; ... Cooperation between the hemagglutinin of avian viruses and the matrix protein of human influenza A viruses. J Virol. 2002 Feb; ... Reference viruses for seasonal and pandemic influenza vaccine preparation. Influenza Other Respi Viruses. 2007 Jan;1(1):5-9. ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2928332/
... by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin. ... Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site pp667 - 671 ...http://links.ealert.nature.com/servlet/MailView?ms=NTQ0Nzc5ODIS1&r=ODkwMTM2NjI1NQS2&j=MTIwMTg3NjAyNAS2&mt=1&rt=0
Retrovirus Attachment and Entry | Overview of Retrovirus Infection | HubPages
The virus attaches to a host cell via its surface glycoproteins which then undergo conformational changes to allow entry. ... For the influenza viruses, interactions between the viral hemagglutinin glycoprotein and the cellular receptor are not ... Several enveloped viruses such as influenza and VSV require the increasingly acidic compartments of the endosome to initiate ... Influenza attaches to host cells via interactions between sialic acid containing glycoproteins or glycolipids and the viral ...https://hubpages.com/health/Retrovirus-Attachment-and-Entry-Overview-of-Retrovirus-Infection
Potential recombinant vaccine against influenza A virus based on M2e d | IJN
However, high mutation rates of influenza virus hemagglutinin (H) and neuraminidase (N) glycoproteins give rise to vaccine ... Currently available vaccines employ inactivated viruses of different strains to provide protection against influenza virus ... Thus, an effective vaccine providing protection against all strains of influenza virus would be a valuable asset. The ... Influenza A virus poses a major threat to human health, causing outbreaks from time to time. ...https://www.dovepress.com/potential-recombinant-vaccine-against-influenza-a-virus-based-on-m2e-d-peer-reviewed-article-IJN
Avian flu virus needs only minor adaptations to infect humans
Receptor specificity for the influenza virus is controlled by the glycoprotein hemagglutinin (HA) on the virus surface. These ... The hemagglutinin (HA) structure from the Viet04 virus was found to be closely related to the 1918 virus HA, which caused some ... Analysis of a critical protein produced by the 2009 H1N1 influenza A virus. ... RxPG] The H5N1 avian influenza virus, commonly known as "bird flu," is a highly contagious and deadly disease in poultry. So ...http://www.rxpgnews.com/Influenza_60/Avian_flu_virus_needs_only_minor_adaptations_to_in_3675_3675.shtml