Plasma B-Type Natriuretic Peptide Levels in Ambulatory Patients With Established Chronic Symptomatic Systolic Heart Failure |...
Changes in gene expression in the intact human heart: downregulation of alpha-myosin heavy chain in hypertrophied, failing ... Plasma BNP is considered a direct counterregulatory response to myocardial stress and increased left ventricular filling ... Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentration. Lancet. 2000; 355: ... Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med. 2002; 347: 161-167. ...http://circ.ahajournals.org/content/108/24/2964
Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure | UMIACS
Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure. ... Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure. ... More than 1800 genes displayed sexual dimorphism in the heart (adjusted P value ,0.05). A significant number of these genes ... The second goal of this study was to determine the effect of age on gene expression. Within the female cohort, ,140 genes were ...https://www.umiacs.umd.edu/publications/sex-and-age-dimorphism-myocardial-gene-expression-nonischemic-human-heart-failure
Endomyocardial Nitric Oxide Synthase and Left Ventricular Preload Reserve in Dilated Cardiomyopathy | Circulation
Myocardial NOS Gene Expression in Heart Failure. Experimental evidence on endomyocardial NOS3 expression and activity in heart ... Low Myocardial NOS Gene Expression in Severe LV Dysfunction. In the present study, both NOS2 and NOS3 gene expression were ... Background-Patients with heart failure have modified myocardial expression of nitric oxide synthase (NOS), as is evident from ... gene expression to be assessed not only in patients with end-stage heart failure but also in patients with compensated heart ...http://circ.ahajournals.org/content/99/23/3009
Heart Failure and Cardiac Disease | Circulation: Genomic and Precision Medicine
Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure David R. Fermin, Ana Barac, Sangjin Lee ... Time-Warped Comparison of Gene Expression in Adaptive and Maladaptive Cardiac HypertrophyCLINICAL PERSPECTIVE Sean P. Sheehy, ... Association and Functional Analyses of MEF2A as a Susceptibility Gene for Premature Myocardial Infarction and Coronary Artery ... 2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a ...http://circgenetics.ahajournals.org/collection/heart-failure-and-cardiac-disease?page=26
Impact of Cardiac Contractility Modulation on Left Ventricular Global and Regional Function and Remodeling | JACC:...
2008) Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure. J ... heart failure. LV. left ventricular. MLWHFQ. Minnesota Living with Heart Failure Questionnaire. Sm. peak systolic velocity. Te- ... Methods Thirty patients (60 ± 11 years, 80% male) with New York Heart Association (NYHA) functional class III heart failure, ... there was a switch in expression of a host of genes from a normal adult genotype to a fetal genotype indicative of myocardial ...http://imaging.onlinejacc.org/content/2/12/1341
Abstract 3250: Functional Myocardial Improvement With CRT Correlates With Normalization of Dyssynchrony-induced Regional Gene...
... global heart failure-related gene expression patterns, encompassing ~2400 and ~5300 transcripts in ventricles and atria, ... With CRT Correlates With Normalization of Dyssynchrony-induced Regional Gene Expression Rather Than Correction of Heart Failure ... With CRT Correlates With Normalization of Dyssynchrony-induced Regional Gene Expression Rather Than Correction of Heart Failure ... With CRT Correlates With Normalization of Dyssynchrony-induced Regional Gene Expression Rather Than Correction of Heart Failure ...http://circ.ahajournals.org/content/120/Suppl_18/S771.2
Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial...
Myocardial Gene Expression of HGF and c-Met after Cardiac Ischemia/Reperfusion.. Our results (Fig.1) are consistent with ... 2001) Effects of early angiotensin-converting enzyme inhibition on cardiac gene expression after acute myocardial infarction. ... Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial ... Early Treatment with Hepatocyte Growth Factor Improves Cardiac Function in Experimental Heart Failure Induced by Myocardial ...http://jpet.aspetjournals.org/content/304/2/654
The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure
However, total CSE gene expression was elevated in the heart failure models. These findings were in accordance with our ... We then investigated H2S in heart failure.. 4. Hydrogen Sulfide and Heart Failure. Heart failure is the heart's inability to ... coronary heart disease or heart failure). The discovery of H2S deficiency in heart failure patients led to our exploration of H ... 2S therapy for the treatment of heart failure. In our preliminary study to create a heart failure in the murine heart, ...https://www.hindawi.com/journals/scientifica/2014/768607/
Circulation Editors' Picks | Circulation
Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice. ... Hemodynamic load regulates myocardial function and gene expression. Increased load triggers molecular, structural, and ... Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. ... Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice ...http://circ.ahajournals.org/content/125/1/e221
Postmyocardial Infarct Remodeling and Heart Failure: Potential Contributions from Pro- and Antiaging Factors
... congestive heart failure, valvular heart disease, vascular disease, congenital heart disease, and cardiomyopathy. ... L. W. Stanton, L. J. Garrard, D. Damm et al., "Altered patterns of gene expression in response to myocardial infarction," ... in human myocardium age and promote heart failure . Age-related gene expression changes in human are described but the ... Gene expression changes with aging in mice is available  and changes in gene expression in all organs with age are noted ...https://www.hindawi.com/journals/crp/2011/836806/
Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial InfarctionNovelty and...
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007;26:745-752. ... Upregulation of 3 specific microRNAs in sera of the heart failure (HF) group. The expression levels of miR-192 (A) and of miR- ... Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction. J ... A number of patients survive acute myocardial infarction (AMI) but experience development of chronic ischemic heart failure (HF ...http://circres.ahajournals.org/content/113/3/322.long
Myocardial reverse remodeling after pressure unloading is associated with maintained cardiac mechanoenergetics in a rat model...
Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile. J Surg Res ... Myocardial matrix metalloproteinase activity and abundance with congestive heart failure. Am J Physiol Heart Circ Physiol 274: ... Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with ... and a TaqMan Gene Expression Assay (0.5 μl) (Applied Biosystems) for the following genes: myocardial fibrosis markers, such as ...http://ajpheart.physiology.org/content/311/3/H592
Abstract 791: Cardiac Dysfunction and Heart Failure are Associated with Decreased Levels of Non-Nuclear Oligomeric Muscle LIM...
... hemodynamic overload results in cardiac hypertrophy and failure with detrimental changes in myocardial gene expression and ... In conclusion, heart failure may result from impaired mechanosensing associated with reduced oligomeric MLP in the costamere ... In ventricles from aortic banded and myocardial infarcted rat hearts, nuclear MLP increased by 2 fold (p,0.01 n=7) along with a ... Abstract 791: Cardiac Dysfunction and Heart Failure are Associated with Decreased Levels of Non-Nuclear Oligomeric Muscle LIM ...http://circ.ahajournals.org/content/114/Suppl_18/II_138.2
Effects of Excessive Long-Term Exercise on Cardiac Function and Myocyte Remodeling in Hypertensive Heart Failure Rats |...
Arai M, Matsui H, Periasamy M. Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ Res. 1994 ... increased myocardial fibrosis, and accelerated signs of heart failure in aging SHHF rats. This study used methods of documented ... Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats. ... Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ...http://hyper.ahajournals.org/content/50/2/410
Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium | Circulation
Subsequent thinning and expansion of this non-elastic scar contributes to cardiac dilatation and congestive heart failure. We ... Myocardial birefringence determined by polarized light (linear retardance of the tissue structure) was significantly highest in ... Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium. Shu-Hong Li, ... Abstract 1604: Improved Cardiac Function after Expression of the Human Elastin Gene in the Infarcted Myocardium ...http://circ.ahajournals.org/content/118/Suppl_18/S_355.4
Gene expression profiles associated with acute myocardial infarction and risk of cardiovascular death | Genome Medicine | Full...
Neutrophilia and congestive heart failure after acute myocardial infarction. Am Heart J. 2000, 139: 94-100., 10.1016/S0002-8703 ... Gene expression profiling. Gene expression data have been deposited at the Gene Expression Omnibus archive under accession ... It is likely that the very high covariance of gene expression into axes of coordinated gene expression that explain over half ... One small study of 28 cases  documented a peripheral blood gene expression signature associated with acute myocardial ...https://genomemedicine.biomedcentral.com/articles/10.1186/gm560
Ralph DD[au] - PubMed - NCBI
... and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression ... Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, ... Gene Expression Omnibus (GEO) Database *Gene Expression Omnibus ... A Tale of Two Hearts: Patients with Decompensated Right Heart Failure in the Intensive Care Unit. ... Histamine H2 Receptor Antagonists, Left Ventricular Morphology, and Heart Failure Risk: The MESA Study. ...https://www.ncbi.nlm.nih.gov/pubmed?access_num=Ralph+DD&link_type=AUTHORSEARCH&cmd=search&term=Ralph+DD%5Bau%5D&dispmax=50
Joao Lima - Research Output - Johns Hopkins University
... and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression ... ALLogeneic heart STem cells to achieve myocardial regeneration (ALLSTAR) trial: Rationale and design. Chakravarty, T., Makkar, ... Ideal Cardiovascular Health, Cardiovascular Remodeling, and Heart Failure in Blacks: The Jackson Heart Study. Spahillari, A., ... Electrocardiographic predictors of heart failure with reduced versus preserved ejection fraction: The multi-ethnic study of ...https://jhu.pure.elsevier.com/en/persons/joao-lima/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
Identifying pathogenic processes by integrating microarray data with prior knowledge | BMC Bioinformatics | Full Text
Applied to a microarray heart failure dataset the method found one large cluster with several genes important for the structure ... Specifically, our method makes use of Bayesian statistics to identify groups of co-regulated genes based on the microarray data ... We present a novel method for identifying groups of connected molecules from a set of differentially expressed genes. These ... where the main cluster was dominated by genes related to keratinocyte differentiation. Our method found clusters overlapping ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-15-115
ACE inhibition prevents diastolic Ca2+ ... Ca2+ sensitivity after myocardial infarction
... and gene expression in congestive heart failure due to myocardial infarction . Can J Physiol Pharmacol . 2004 ; 82 : (12 ) 1118 ... Partial prevention of changes in SR gene expression in congestive heart failure due to myocardial infarction by enalapril or ... Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction . Am J Physiol Heart Circ ... Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure . Circ Res . 1994 ; 75 : (3 ) 443 - 53 47 ...http://spotidoc.com/doc/9000/ace--inhibition--prevents--diastolic--ca2--...-ca2--sensi..
Effect of acute and chronic zofenopril administration on cardiac gene expression | Springer for Research & Development
... may modulate the expression of genes which are involved in the pathophysiology of... ... may modulate the expression of genes which are involved in the pathophysiology of myocardial ischemia and heart failure. We ... We conclude that zofenopril can produce heart-specific effects on gene expression. Persistent changes were detected with regard ... Effect of imidapril on myocardial remodeling in L-NAME-induced hypertensive rats is associated with gene expression of NOS and ...https://rd.springer.com/article/10.1007/s11010-011-0766-9
Arginine:glycine amidinotransferase - Wikipedia
"Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failure and normalized after ... gene expression during the late-stage heart failure. This suggests that the reduced AGAT may correlate with loss of heart ... Increase of AGAT expression in the myocardium after heart failure due to increase in creatine synthesis was associated with ... GATM expression wishing the mouse placenta as been shown to be imprinted meaning only the maternal copy of the GATM gene is ...https://en.wikipedia.org/wiki/Arginine:glycine_amidinotransferase
Circulation Editors' Picks | Circulation
... epigenomic patterns may control the expression of specific genes with critical functions in the progression of heart failure. ... The epigenome may control the expression of local or distal genes with critical functions in myocardial stress response. If ... Distinct Epigenomic Features in End-Stage Failing Human Hearts. Summary. Molecular research in heart failure points to the ... This cardiac genomic stress response is typified by the re-expression of fetal genes, upregulation of fibrosis-related genes, ...http://circ.ahajournals.org/content/126/11/e163
Molecular regulation of cardiac hypertrophy - UCL Discovery
CHRONIC HEART-FAILURE, LEFT-VENTRICULAR MASS, GUANYLYL CYCLASE-A, PRESSURE-INDEPENDENT ENHANCEMENT, MYOCARDIAL GENE-EXPRESSION ... Heart failure is one of the leading causes of mortality in the western world and encompasses a wide spectrum of cardiac ... signalling modulators in the vasculature milieu are known to regulate heart mass including those that influence gene expression ... obesity or drug abuse promotes cardiac myocyte hypertrophy and subsequent heart failure. A number of ...http://discovery.ucl.ac.uk/141011/
Mark Sussman, San Diego State University, San Diego (USA) | Telethon
... and persistence of expression have hampered implementation of myocardial gene therapy for treatment of heart failure. Recent ... many practical aspects of gene therapy such as delivery and targeted expression in the myocardium, regulation of gene ... by scientists and clinicians has advanced the use of gene therapy as an alternative approach to treatment of heart failure. ... Current therapeutic interventions rely predominantly upon pharmacologic strategies to slow the progression of heart failure, or ...http://www.telethon.it/node/4559