*  Lowering Uric Acid in Live Kidney Donors - Full Text View - ClinicalTrials.gov
... systolic and diastolic Office blood pressure.. *Estimated insulin sensitivity, metabolic clearance rate of glucose [ Time Frame ... Accepts Healthy Volunteers: No. Criteria. Inclusion Criteria:. *Kidney donor ≥ 6 months after donor nephrectomy ... Change in blood pressure [ Time Frame: Nine months ]. Change from baseline to 9 months in the allopurinol group compared to ... compared to placebo in insulin sensitivity using an orgal glucose tolerance test to measure estimated metabolic clearance rate ...
  https://clinicaltrials.gov/ct2/show/NCT03353298
*  Cardiovascular Risk Factors After Single Pancreas Transplantation - Full Text View - ClinicalTrials.gov
Blood pressure [ Time Frame: 1 year post-transplant ]. Blood pressure will be measured seated after ten minutes rest by Dyna ... A control group of healthy volunteers (non-diabetic, non-transplanted), frequency-matched for age and gender with regards to ... Renal function, defined as glomerular filtration rate, will be evaluated by measuring iohexol clearance. The concentration of ... Metabolic Diseases. Endocrine System Diseases. Autoimmune Diseases. Immune System Diseases. Pancrelipase. Pancreatin. ...
  https://clinicaltrials.gov/ct2/show/NCT02066350?recr=Open&intr=%22pancreas+transplantation%22&rank=1
*  3,4-Dehydrodebrisoquine, a Novel Debrisoquine Metabolite Formed from 4-Hydroxydebrisoquine That Affects the CYP2D6 Metabolic...
... sitting blood pressures of 123 ± 2/79 ± 2 (male) and 115 ± 4/69 ± 4 (female). The volunteers were nonsmokers, with the ... Creatinine clearance (milliliters per second) and glomerular filtration rate (milliliters per second) were calculated using the ... All volunteers gave their written informed consent to participate in the study. The volunteers comprised 14 healthy Caucasians ... Thirteen healthy young volunteers, nine CYP2D6*1 homozygotes [extensive metabolizers (EMs)] and four CYP2D6*4 homozygotes [poor ...
  http://dmd.aspetjournals.org/content/34/9/1563
*  Twynsta (Telmisartan Amlodipine Tablets): Side Effects, Interactions, Warning, Dosage & Uses
These decreases in blood pressure are not accompanied by a significant change in heart rate or plasma catecholamine levels with ... Erythromycin co-administration in healthy volunteers did not significantly change amlodipine systemic exposure. However, strong ... Total plasma clearance of telmisartan is , 800 mL/min. Terminal half-life and total clearance appear to be independent of dose. ... Metabolic: gout, hypercholesterolemia, diabetes mellitus; Musculoskeletal: arthritis, arthralgia, leg cramps; Psychiatric: ...
  https://www.rxlist.com/twynsta-drug.htm
*  Mifepristone for Metabolic Syndrome - Full Text View - ClinicalTrials.gov
These risk factors include central obesity (extra weight around the middle of the body) and high blood pressure and blood sugar ... Whole-body rate of regenerating cortisol response to mifepristone of glucose insulin sensitivity, free fatty acid clearance, ... Accepts Healthy Volunteers: Yes. Criteria. * INCLUSION CRITERIA:. *Men and women 35 - 70 years of age ... Day 1: Body measurements (height, weight, waist, hip, and neck) and blood pressure tests. Also, 24 hours of regular blood draws ...
  https://clinicaltrials.gov/ct2/show/NCT01419535?term=Prediabetes&lup_s=04%2F18%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
*  Pharmacokinetics of Empagliflozin (BI 10773) in Patients With Impaired Liver Function - Full Text View - ClinicalTrials.gov
... systolic blood pressure , 100 or , 160 mm Hg, diastolic blood pressure , 60 or , 100 mm Hg, pulse rate , 50 or , 100 1/min. ... Healthy subjects (group 1). *Significant gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, ... Renal Clearance After Extravascular Administration (CL R) [ Time Frame: Pre-dose and 20minutes (min), 40min, 1h, 1.5h, 2h, 2.5h ... Accepts Healthy Volunteers: Yes. Criteria. Inclusion criteria:. Healthy males and females. Hepatically impaired male and female ...
  https://clinicaltrials.gov/ct2/show/NCT01111318
*  Pharmacokinetic Study of Vildagliptin in Patients With Renal Impairment - Tabular View - ClinicalTrials.gov
C systolic blood pressure, 100-140 mm Hg diastolic blood pressure, 60-110 mm Hg pulse rate, 45-90 bpm ... Sex and Weight-Matched Healthy Volunteers Following Daily Doses of 50 mg Vildagliptin for 14 Days. ... A history of type 1 diabetes, diabetes that is a result of pancreatic injury, or secondary forms of diabetes, acute metabolic ... Serum creatinine with a calculated creatinine clearance (CrCl) of ,80 ml/min. ...
  https://clinicaltrials.gov/ct2/show/record/NCT00567047
*  Ginkgo Biloba Uses, Benefits & Dosage - Drugs.com Herbal Database
88 The clearance of midazolam was decreased 26% in an experiment in 10 healthy volunteers who were also administered G. biloba ... EGb 761 was hypothesized to increase the rate of insulin metabolic clearance. 44 In a follow-up study, EGb 761 increased ... 39 Similarly, ginkgo did not reduce blood pressure in hypertensive or normotensive participants in the GEM study. 40 A Cochrane ... In 12 healthy volunteers, 14 days of pretreatment with G. biloba extract 60 mg twice daily decreased the AUC of alprazolam 17% ...
  https://www.drugs.com/npp/ginkgo-biloba.html
*  Corvert - FDA prescribing information, side effects and uses
In healthy male volunteers, about 82% of a 0.01 mg/kg dose of [14C] ibutilide fumarate was excreted in the urine (about 7% of ... Ibutilide has a high systemic plasma clearance that approximates liver blood flow (about 29 mL/min/kg), a large steady-state ... Patients with more recent onset of arrhythmia had a higher rate of conversion. Response rates were 42% and 50% for patients ... mean pulmonary arterial pressure, or pulmonary capillary wedge pressure at doses of Corvert up to 0.03 mg/kg. ...
  https://www.drugs.com/pro/corvert.html
*  Theomar GG and Alcohol / Food Interactions - Drugs.com
In six healthy male volunteers (all smokers), serum concentrations of theophylline (administered as aminophylline 400 mg single ... High Blood Pressure (Hypertension). Moderate Potential Hazard, Moderate plausibility. methylxanthines - tachyarrhythmias. The ... The proposed mechanism involves competitive inhibition of theophylline metabolism via CYP450 1A2, as well as metabolic ... and reduced its total body clearance by 23%. In another study, steady-state concentration and area under the concentration-time ...
  https://www.drugs.com/food-interactions/guaifenesin-theophylline,theomar-gg.html
*  Delapril and Manidipine for Nephroprotection in Diabetes (DEMAND) - Full Text View - ClinicalTrials.gov
Blood pressure, blood glucose concentrations and urinary albumin excretion rate will be monitored every three months. Serum ... Accepts Healthy Volunteers: No. Criteria. Inclusion Criteria:. *Age ≥ 40 years. *History of diabetes mellitus type 2 for at ... AIMS The primary aim of this study is to assess whether at comparable levels of optimal blood pressure and metabolic control, ... lipid concentrations and GFR (estimated with the iohexol plasma clearance) will be measured every six months. ...
  https://clinicaltrials.gov/ct2/show/NCT00157586
*  Flomax - FDA prescribing information, side effects and uses
Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position ... healthy male volunteers. Intrinsic clearance is independent of tamsulosin hydrochloride binding to AAG, but diminishes with age ... Incubations with human liver microsomes showed no evidence of clinically significant metabolic interactions between tamsulosin ... 0.4 mg QD to healthy. volunteers; n=23. (age range 18-32 years). 0.8 mg QD to healthy volunteers; n=22. (age range 55-75 years) ...
  https://www.drugs.com/pro/flomax.html
*  Case-Cohort Study of Styrene Exposure and Ischemic Heart Disease Investigators| Research Project Database | Grantee...
R828112C083 Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure ... R828112C118 Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los ... blood pressure or type of job within the industry. Although the results are statistically significant, uncertainties regarding ... R828112C077 Metabolic Studies in Monkeys Exposed to Methanol Vapors. R828112C078 Effects of Ozone on Pulmonary Function and ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/10042
*  Sex-Based Differences in Drug Activity - American Family Physician
For example, because renal clearance is slower in women, some renally-excreted medications, such as digoxin, may require a ... should receive lower dosages of digoxin and have lower serum concentration targets than men because of higher mortality rates. ... and slower glomerular filtration rate. Because of delayed gastric emptying, women may need to extend the interval between ... Enhanced lowering of blood pressure and heart rate when exercising in women ...
  http://www.aafp.org/afp/2009/1201/p1254.html
*  Frontiers | Perioperative acute hypertension-role of Clevidipine butyrate | Pharmacology
Clevidipine butyrate has obvious advantages and can be safely used for perioperative control of elevated blood pressure (BP) in ... The drug is metabolized by plasma and tissue esterases to inactive metabolites with a mean blood clearance rate of 0.121 lit. ... 1999b). Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion. Eur. J. Clin. ... The systolic blood pressure (SBP) in normotensive patients may increase by up to 20-30 mm Hg, while hypertensive patients may ...
  https://www.frontiersin.org/articles/10.3389/fphar.2014.00197/full
*  Zofran (Ondansetron Hydrochloride Tablets and Solution): Side Effects, Interactions, Warning, Dosage & Uses
The extent and rate of ondansetron's absorption is greater in women than men. Slower clearance in women, a smaller apparent ... labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, ... Table 1: Pharmacokinetics in Normal Volunteers: Single 8-mg ZOFRAN Tablet Dose. Age-group (years). Mean Weight (kg). n. Peak ... The primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation. ...
  https://www.rxlist.com/zofran-drug.htm
*  GUARANA: Uses, Side Effects, Interactions and Warnings - WebMD
Taking guarana along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. ... metabolic, and cardiovascular effects in healthy volunteers. Am.J.Clin.Nutr. 1990;51(5):759-767. View abstract. ... Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol 1985 ... High blood pressure: Taking guarana might raise blood pressure in people with high blood pressure due to its caffeine content. ...
  https://www.webmd.com/vitamins-supplements/ingredientmono-935-guarana.aspx?activeingredientid=935&activeingredientname=guarana
*  Halcion (Triazolam): Side Effects, Interactions, Warning, Dosage & Uses
As in all cases of drug overdosage, respiration, pulse, and blood pressure should be monitored and supported by general ... Drugs which inhibit this metabolic pathway may have a profound effect on the clearance of triazolam (see CONTRAINDICATIONS and ... Tolerance may occur to both the desired and undesired effects of drugs and may develop at different rates for different effects ... Laboratory tests are not ordinarily required in otherwise healthy patients.. Carcinogenesis, Mutagenesis, Impairment Of ...
  https://www.rxlist.com/halcion-drug.htm
*  Qbrelis - FDA prescribing information, side effects and uses
... systemic vascular resistance and blood pressure accompanied by an increase in cardiac output and no change in heart rate. ... The oral bioavailability of lisinopril in patients with acute myocardial infarction is similar to that in healthy volunteers. ... The typical value of lisinopril oral clearance (systemic clearance/absolute bioavailability) in a child weighing 30 kg is 10 L/ ... Metabolic: Gout.. Skin: Urticaria, alopecia, photosensitivity, erythema, flushing, diaphoresis, cutaneous pseudolymphoma, toxic ...
  https://www.drugs.com/pro/qbrelis.html
*  Micardis HCT - FDA prescribing information, side effects and uses
What is high blood pressure (hypertension)?. Blood pressure is the force in your blood vessels when your heart beats and when ... glomerular filtration rate, filtration fraction, renovascular resistance, or creatinine clearance. ... Electrolytes and Metabolic Disorders [see Warnings and Precautions (5.4)]. Clinical Trials Experience. Because clinical studies ... In normal volunteers, a dose of telmisartan 80 mg inhibited the pressor response to an intravenous infusion of angiotensin II ...
  https://www.drugs.com/pro/micardis-hct.html
*  Verelan PM (Verapamil Hydrochloride): Side Effects, Interactions, Warning, Dosage & Uses
Variable results on clearance have been obtained in acute studies of healthy volunteers; clearance of verapamil was either ... to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily stokes ... The rate of absorption was not affected by whether the volunteers were supine two hours after night-time dosing or non-supine ... Verapamil was not mutagenic in the Ames test in 5 test strains at 3 mg per plate, with or without metabolic activation. Studies ...
  https://www.rxlist.com/verelan-pm-drug.htm
*  IRAPs (Secreted Insulin Regulated AminoPeptidase): a New Insulin Sensitivity Biomarker - Full Text View - ClinicalTrials.gov
Blood pressure , 140/90mmHg. *Tea and coffee consumption more than 5 cups per day ... Accepts Healthy Volunteers: Yes. Criteria. Inclusion Criteria:. *Men and women (sex ratio = 1) ... Glucose Infusion Rate (GIR) [ Time Frame: at T90, T100, T110, T120 minutes and T210, T220, T230, T 240 minutes ]. It is an ... Medical history of metabolic disease (diabetes, dyslipidemia), endocrine disease, renal insufficiency. *Drug use that could ...
  https://clinicaltrials.gov/ct2/show/NCT01648478?recr=Open&cond=%22Insulins%22&rank=7
*  Final Report | The National Morbidity, Mortality, and Air Pollution Study: Morbidity and Mortality from Air Pollution in the...
R828112C083 Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure ... R828112C118 Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los ... R828112C077 Metabolic Studies in Monkeys Exposed to Methanol Vapors. R828112C078 Effects of Ozone on Pulmonary Function and ... R828112C101 Penetration of Lung Lining and Clearance of Particles Containing Benzo[a]pyrene. R828112C102 Metabolism of Ether ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2399/report/F
*  Changes in Complex Carbohydrate Content and Structure in Rat Lungs Caused by Prolonged Ozone Inhalation| Research...
R828112C083 Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure ... R828112C118 Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los ... R828112C077 Metabolic Studies in Monkeys Exposed to Methanol Vapors. R828112C078 Effects of Ozone on Pulmonary Function and ... R828112C101 Penetration of Lung Lining and Clearance of Particles Containing Benzo[a]pyrene. R828112C102 Metabolism of Ether ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2330
*  Metabolism of Ether Oxygenates Added to Gasoline| Research Project Database | Grantee Research Project | ORD | US EPA
Blood samples from human volunteers who reported that they were sensitive to the health effects of MTBE were examined by Hong ... R828112C083 Daily Changes in Oxygen Saturation and Pulse Rate Associated with Particulate Air Pollution and Barometric Pressure ... He also exposed human volunteers by ingestion to MTBE or TAME to compare metabolic pathways after inhalation and ingestion of ... R828112C118 Controlled Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Particles in Metropolitan Los ...
  https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/2407