*  Facio-Genital Dysplasia-5 Regulates Matrix Adhesion and Survival of Human Endothelial Cells | Arteriosclerosis, Thrombosis, and...
49 The Rho GTP-binding protein, RhoB has been identified as a regulator of the Akt signal transduction pathway.50 However, in ... Rho guanine nucleotide exchange factor domain and similar to other subfamily members has been shown to mediate GDP to GTP ... The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF- ... of the extracellular matrix and subsequent cell remodeling to form tubes is regulated by Rho family GTP-binding proteins in the ...
  http://atvb.ahajournals.org/content/32/11/2694
*  RHOB - Wikipedia
... is a protein which in humans is encoded by the RHOB gene. RHOB is a member of the Rho GTP-binding protein family. RHOB has been ... a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. United States. 277 (45): 42964-72. doi: ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ...
  https://en.wikipedia.org/wiki/RHOB
*  RHOC ras homolog family member C [Homo sapiens (human)] - Gene - NCBI
Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five ... RTKN binds to GTP-bound RHOA, RHOB and RHOC and .... *RHO GTPases activate CIT, organism-specific biosystem (from REACTOME) RHO ... mRNA and Protein(s) * NM_001042678.1 → NP_001036143.1 rho-related GTP-binding protein RhoC precursor ... NM_175744.4 → NP_786886.1 rho-related GTP-binding protein RhoC precursor. See identical proteins and their annotated locations ...
  https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=389&ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
*  Angiotensin II Signal Transduction Through Small GTP-Binding Proteins | Hypertension
... the growth factor receptor on activation recruits a Ras guanine nucleotide exchange factor (GEF), Sos, via adaptor proteins Shc ... The Rho family consists of RhoA, RhoB, and RhoC. RhoA is a prototype for most studies. In general, Rho is activated by GPCR ... Small GTP-binding proteins (G proteins) are monomeric G proteins with a low molecular weight of 20 to 40 kDa. A small G protein ... Also, eIF4E is released from eIF4E binding protein/PHAS-I on phosphorylation of eIF4E binding protein/PHAS-I regulated through ...
  http://hyper.ahajournals.org/content/48/4/534
*  RAS Pathway v2.0 - National Cancer Institute
ral guanine nucleotide dissociation stimulator-like 3. [none]. RHEB. Ras Homolog Enriched In Brain, GTP-binding protein Rheb. ... RHOB. Ras homolog family member B. ARH6, ARHB, MST081, MSTP081, RHOH6. RHOC. Ras homolog family member C. ARH9, ARHC, H9, RHOH9 ... RAS protein activator like-3 [none]. RASGRF1. Ras protein-specific guanine nucleotide-releasing factor 1. CDC25, CDC25L, GNRP, ... Ras protein-specific guanine nucleotide-releasing factor 2. GRF2, RAS-GRF2. RASGRP1. RAS guanyl-releasing protein 1. CALDAG- ...
  https://www.cancer.gov/research/key-initiatives/ras/ras-central/blog/2015/ras-pathway-v2
*  Biomolecules | Free Full-Text | The TORC2‐Dependent Signaling Network in the Yeast Saccharomyces cerevisiae | HTML
Pkc1 is also regulated by Pkh1‐ and TORC2‐dependent phosphorylation, but, in addition, by interaction with Rho1‐GTP and lipids ... In Saccharomyces cerevisiae, a plasma membrane‐localized protein kinase complex, Target of Rapamicin (TOR) complex‐2 (TORC2) ( ... associated protein kinase Pkh1 (mammalian ortholog is PDK1) and a paralog (Pkh2). For cell survival under various stresses, ... Ypk1 is a central regulator of pathways and processes required for plasma membrane lipid and protein homeostasis, and requires ...
  http://www.mdpi.com/2218-273X/7/3/66/htm
*  List of MeSH codes (D12.776.476) - Wikipedia
... rac1 gtp-binding protein MeSH D12.776.476.525.700.200 -- rhoa gtp-binding protein MeSH D12.776.476.525.700.300 -- rhob gtp- ... ral guanine nucleotide exchange factor MeSH D12.776.476.325.300.700 -- ras guanine nucleotide exchange factors MeSH D12.776. ... rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp-binding protein MeSH D12.776.476.525.400.100 -- rab3 gtp- ... rab3a gtp-binding protein MeSH D12.776.476.525.400.150 -- rab4 gtp-binding proteins MeSH D12.776.476.525.400.200 -- rab5 gtp- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.476)
*  Gene Report for G00002322 - Genes2Cognition Neuroscience Research Programme
... the light chain of the microtubule-associated protein MAP1A, as a novel binding partner for RhoB. GTP binding and the 18-amino ... In addition to protein kinase cascades, the targets of reversible phosphorylation include ubiquitin ligases, guanine nucleotide ... and in vitro binding studies showed that NXF proteins bound to brain-specific microtubule-associated proteins (MAP) such as ... Microtubule associated protein MAP1A is an actin-binding and crosslinking protein.. Pedrotti B, Colombo R and Islam K ...
  http://www.genes2cognition.org/db/Gene/G00002322
*  List of MeSH codes (D08) - Wikipedia
... rhoa gtp-binding protein MeSH D08.811.277.040.330.300.400.700.300 --- rhob gtp-binding protein MeSH D08.811.277.040.465 --- ... cyclic nucleotide-regulated protein kinases MeSH D08.811.913.696.620.682.700.150.125 --- cyclic amp-dependent protein kinases ... gtp cyclohydrolase MeSH D08.811.277.151.350 --- guanine deaminase MeSH D08.811.277.151.418 --- methenyltetrahydrofolate ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 --- gtp-binding protein alpha subunits, gq-g11 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
*  Rho family of GTPases - Wikipedia
NHE1-mediated H+ efflux is required for guanine nucleotide exchange factor (GEF)-catalyzed GTP binding to Cdc42, suggesting a ... Rho proteins sometimes denote some members of the Rho family (RhoA, RhoB, and RhoC), and sometimes refers to all members of the ... guanine nucleotide exchange factor (GEFs), GTPase-activating proteins (GAPs) and guanine nucleotide dissociation inhibitors ( ... Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in ...
  https://en.wikipedia.org/wiki/Rho_family_of_GTPases
*  The power and promise of "rewiring" the mitogen-activated protein kinase network in prostate cancer therapeutics | Molecular...
... the guanine-nucleotide exchange factor Sos potentiates Ras, by catalyzing the replacement of GDP for GTP. GTP-bound Ras ... a protein that regulates Rec, which in turn activates various proteins such as RhoB and nuclear factor-κB (11). RhoB is ... GTP-bound Ras interacts with Raf and mobilizes the inactive protein from the cytoplasm. Once the Ras-Raf complex is ... Stimulation of this pathway results in activation of the GTP-bound protein RAC, which then interacts with the NAC-PAK complex, ...
  http://mct.aacrjournals.org/content/6/3/811
*  Rho-Kinase Is an Important Therapeutic Target in Cardiovascular Medicine | Arteriosclerosis, Thrombosis, and Vascular Biology
Cytoskeletal effects of Rho-like small guanine nucleotide-binding proteins in the vascular system. Arterioscler Thromb Vasc ... The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy ... RhoB, and RhoC (collectively referred to here as Rho) have the same amino acid sequence, and these G proteins appear to have ... Rho-kinase has been identified as one of the effectors of the small GTP-binding protein Rho. Accumulating evidence has ...
  http://atvb.ahajournals.org/content/25/9/1767
*  Angiotensin II Activates RhoA in Cardiac Myocytes | Circulation Research
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J Biol Chem. 1994;269:31674-31679 ... RhoA but Not RhoB Is Expressed in Cardiac Myocytes. Since Rho-family small GTP-binding proteins play an important role in actin ... Lfc, and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J Biol Chem. ... Since Rho is a member of the small GTP-binding proteins, activation of Rho could be shown by its increased binding of GTP. ...
  http://circres.ahajournals.org/content/82/6/666
*  RhoG - Wikipedia
Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of ... Three classes of protein interact with RhoG to regulate GTP/GDP loading. The first are known as Guanine nucleotide exchange ... Other proteins known to bind RhoG in its GTP-bound state include the microtubule-associated protein kinectin, Phospholipase D1 ... RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein (G protein), and is an ...
  https://en.wikipedia.org/wiki/RhoG
*  NOVEL INHIBITORS OF RHO KINASE - Patent application
... converted to active GTP-bound Rho by membrane-localized guanine-nucleotide exchange factors. GTP-bound Rho then binds and ... proteins, converts Rho back to the inactive, GDP-bound form, whereupon GDP-bound Rho can be extracted from the plasma membrane ... The Rho subfamily of GTPases (consisting of RhoA, RhoB, and RhoC) transmits signals, frequently from cell surface receptors, to ... the GDI may extract GTP-bound Rho to extinguish a signal, or redirect GTP-bound Rho to a different compartment) [Sasaki T., and ...
  http://www.patentsencyclopedia.com/app/20090318485
*  List of MeSH codes (D12.644) - Wikipedia
... rac1 gtp-binding protein MeSH D12.644.360.525.700.200 --- rhoa gtp-binding protein MeSH D12.644.360.525.700.300 --- rhob gtp- ... p120 gtpase activating protein MeSH D12.644.360.325.150.750 --- rgs proteins MeSH D12.644.360.325.225 --- guanine nucleotide ... rab5 gtp-binding proteins MeSH D12.644.360.525.450 --- ral gtp-binding proteins MeSH D12.644.360.525.462 --- ran gtp-binding ... rab gtp-binding proteins MeSH D12.644.360.525.400.025 --- rab1 gtp-binding proteins MeSH D12.644.360.525.400.050 --- rab2 gtp- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
*  RHOA - Wikipedia
Cachero TG, Morielli AD, Peralta EG (June 1998). "The small GTP-binding protein RhoA regulates a delayed rectifier potassium ... a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964-72. doi:10.1074/jbc. ... RhoA contains both inactive GDP-bound and active GTP-bound conformational states; these states alternate between the active and ... "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". J. Biol ...
  https://en.wikipedia.org/wiki/RHOA
*  Patent US6180597 - Upregulation of Type III endothelial cell nitric oxide synthase by rho ... - Google Patents
A rho GTPase is a small, membrane-bound, Ras-related GTP-binding protein that functions by binding and hydrolyzing GTP. Rho ... proteins which repress expression of a rho GTPase-specific guanine nucleotide exchange factor gene locus, proteins, peptides ( ... GTP-bound state), we immunoprecipitated [35S]GTP S-labeled RhoA and RhoB from the membrane and cytosol of endothelial cells ... Assay for Rho GTP-binding Activity. The Rho GTP-binding activity was determined by immunoprecipitation of [35S]GTP S-labeled ...
  http://www.google.ca/patents/US6180597
*  RhoC - Wikipedia
2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964-72. doi: ... It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction ... Here is a list of the ones found so far: IQGAP1 (IQ-domain GTP-ase Activating Protein): an effector of RhoC to enhance ... Wheeler AP, Ridley AJ (2004). "Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility". Exp. Cell Res. 301 (1): 43-9. doi: ...
  https://en.wikipedia.org/wiki/RhoC
*  Frontiers | ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration | Frontiers in Molecular...
... consists in the prevention of the GDP to GTP exchange of RhoA through integrin membrane complex binding of guanine nucleotide ... RhoB, and RhoC proteins on asparagine residue 41, rendering them inactive. It is available as a cell permeable recombinant ... The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy ... results in the transformation of GDP-bound RhoA GTPase into the GTP-bound form, which is the active one. After binding to the ...
  https://www.frontiersin.org/articles/10.3389/fnmol.2011.00039/full
*  ARHGDIB - Wikipedia
Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... "Prediction of translocation and cleavage of heterogeneous ribonuclear proteins and Rho guanine nucleotide dissociation ... a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation". FEBS Lett. 467 (1): 75- ... a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation". FEBS Lett. 467 (1): 75- ...
  https://en.wikipedia.org/wiki/ARHGDIB
*  A, Binding affinities of two chosen scFvs (A5 and E3) for 6xHis-RhoAL63 (AL63), 6xHis-RhoBL63 (BL63) have been calculated by...
ScFvE3 preferentially binds to RhoB energetic conformation. Kd values have been identified by nonlinear regression and outlined ... on HeLa cells transiently expressing the Myc-tagged XPLN that stimulates guanine nucleotide exchange on RhoA and RhoB, but not ... As demonstrated in Determine 6B, the scFvE3 only interacted with GTP-bound RhoB while RhoA was also activated as unveiled by ... True-time binding of scFvs F7, D10 and E3 by Surface Plasmon Resonance on immobilized GST fusion Rho energetic mutant proteins ...
  http://www.sgkinhibitor.com/2016/03/24/a-binding-affinities-of-two-chosen-scfvs-a5-and-e3-for-6xhis-rhoal63-al63-6xhis-rhobl63-bl63-have-been-calculated-by-aggressive-elisa-on-dilution-of-6his-rhol63-exhibited-in-molar-logarithmic/
*  Plus it
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but ... GST fusion protein containing the Rho-binding domain of Rhotekin) bound to glutathione-Sepharose beads. Samples were washed in ... shuttle between inactive GDP-bound and active GTP-bound form and exhibit intrinsic GTPase activities. Activation of the Rho ... B, Rho activity assay was done to analyze the GTP-bound form of RhoC GTPases induced by ATX. The concentration of ATX in serum- ...
  http://clincancerres.aacrjournals.org/content/14/21/6804
*  Plus it
2002) XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem 277:42964-42972. ... During an EMT, cells may acquire new mesenchymal markers such as vimentin, α smooth muscle actin, S100 calcium binding protein ... Rhophilin 1 interacts strongly with GTP-bound RhoA, but its exact role in cytoskeletal organization remains elusive (Watanabe ... including Snai2 and the Rho GTPase proteins Rhophilin and Rho guanine nucleotide exchange factor 3 (ARHGEF3). Pharmacological ...
  http://molpharm.aspetjournals.org/content/84/1/128
*  Computational Analysis of Rho GTPase Cycling
... bind to the active GTPases and promote conversion of the nucleotide GTP into GDP, inactivating the GTPase. Binding to GDI ... 3. Bustelo XR, Sauzeau V, Berenjeno IM (2007) GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions ... Rac guanine nucleotide exchange factor, and GTP. J Biol Chem 283: 22257-22271. [PMC free article] [PubMed] ... Huang M, Satchell L, Duhadaway JB, Prendergast GC, Laury-Kleintop LD (2011) RhoB links PDGF signaling to cell migration by ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3542069/?lang=en-ca