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*  The integrin β tail is required and sufficient to regulate adhesion signaling to Rac1 | Journal of Cell Science
... or guanine nucleotide dissociation inhibitors (GDIs) ( Kjoller and Hall, 1999). Recent studies have demonstrated that integrin ... Rac1 can be regulated by signaling pathways that activate guanine nucleotide exchange factors (GEFs), and/or inhibit GTPase ... Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat. Cell Biol. 4, 232-239. ... Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell ...
  http://jcs.biologists.org/content/115/22/4285
*  Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix | The EMBO Journal
... guanine nucleotide dissociation inhibitors (GDIs), and guanine nucleotide exchange factors (GEFs), regulate the cycling of ... 2 as indicated by the fact that little dissociation of [3H]GDP from Cdc42 (i.e. the rate‐limiting step for guanine nucleotide ... Hart MJ, Eva A, Zangrilli D, Aaronson SA, Evan T, Cerione RA, Zheng Y (1994) Cellular transformation and guanine nucleotide ... Gao Y, Xing J, Streuli M, Leto TL, Zheng Y (2001) Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide ...
  http://emboj.embopress.org/content/23/17/3492.long
*  rho guanine nucleotide dissociation inhibitors Summary Report | CureHunter
rho guanine nucleotide dissociation inhibitors: amino acid sequence given in first source; MW=27 kDa; specifically regulates ... rho guanine nucleotide dissociation inhibitors. Subscribe to New Research on rho guanine nucleotide dissociation inhibitors ... GDP dissociation inhibitor; Rho GDIalpha; Rho guanidine nucleotide dissociation inhibitor 1; Rho-GDI; Rho-GDIs; RhoGDI; rho GDI ... the GDP dissociation inhibitor Arhgdib, and the metalloprotease inhibitors Timp1 and Timp2. ". 04/20/2012 - "We further ...
  http://www.curehunter.com/public/keywordSummaryC066667-rho-guanine-nucleotide-dissociation-inhibitors.do
*  Superfamily of plant monomeric GTP-binding proteins: 2. Rab proteins are the regulators of vesicles trafficking and plant...
guanine nucleotide dissociation inhibitor. GEP. guanine nucleotide exchange protein. GFP. green fluorescent protein ... a Novel Arabidopsis Gene Encoding a Rab GDP Dissociation Inhibitor, Gene, 1998, vol. 206, pp. 137-143.CrossRefPubMedGoogle ...
  https://link.springer.com/article/10.1134%2FS1021443708010159
*  Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection | The...
guanine nucleotide dissociation inhibitor. GPCR. G-protein-coupled receptor. iBMDM. immortalized BMDM. LDH. lactate ... AGS3 was originally identified as a guanine nucleotide dissociation inhibitor (GDI) in a yeast-based functional screen of ... Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J. Biol. Chem. 271 ... Ligand-activated GPCR trigger Gα nucleotide exchange and the functional dissociation of GTP-Gα and Gβγ, both of which activate ...
  http://www.jimmunol.org/content/196/2/846
*  Untying the Gordian Knot of Cytokinesis | JCB
... guanine nucleotide dissociation inhibitors; GEFs, guanine nucleotide exchange factors; MLC, myosin light chain. ... 1999). In addition, inactive Rho proteins are complexed in the cytosol with guanine nucleotide dissociation inhibitors (GDIs), ... 1999) The guanine-nucleotide-exchange factor Cdc24p is targeted to the nucleus and polarized growth sites. Curr. Biol. 9:1183- ... Small G proteins are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP ...
  http://jcb.rupress.org/content/148/5/843
*  Neutrophil Functional Disorders
GDI, guanine nucleotide dissociation inhibitor; GDP, guanosine diphosphate; GTP, guanosine triphosphate; NADP, nicotinamide- ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0002182.html
*  2jhu - Proteopedia, life in 3D
Guanine nucleotide dissociation inhibitor References *↑ Cooper DR, Boczek T, Grelewska K, Pinkowska M, Sikorska M, Zawadzki M, ... Categories: Human , Cooper, D R , Derewenda, Z S , Pinkowska, M , Crystal engineering , Gtpase activation , Inhibitor , Surface ...
  http://proteopedia.org/wiki/index.php/2jhu
*  Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation | JCB
guanine nucleotide dissociation inhibitor. GEF. guanine nucleotide exchange factor. GSH. glutathione. MMP. matrix ... that inactivate them as well as the inhibitory guanine nucleotide dissociation inhibitor (GDI; Hall, 2005). In nonpathological ... These guanine nucleotide exchange factors regulate the spatiotemporal dynamics of Rac3 activity, impacting GIT1 localization. ... Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is ...
  http://jcb.rupress.org/content/216/12/4331
*  Super toxins from a super bug: structure and function of Clostridium difficile toxins | Biochemical Journal
... guanine-nucleotide-dissociation inhibitor; GEF, guanine-nucleotide-exchange factor; LCT, large clostridial toxin; PaLoc, ...
  http://www.biochemj.org/content/436/3/517
*  Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease | Biochemical Society...
... guanine nucleotide dissociation inhibitor; GEF, guanine nucleotide exchange factor; LRRK2, leucine-rich repeat kinase 2; NAADP ...
  http://www.biochemsoctrans.org/content/43/3/390
*  Inflammatory breast cancer: Relationship between growth factor signaling and motility in aggressive cancers | Breast Cancer...
... guanine nucleotide dissocation inhibitors (GDIs), GDI-dissociation factors (GDFs), and guanine nucleotide exchange factors ( ... guanine nucleotide dissociation inhibitor; GDP = guanosine diphosphate ; GEF = guanine nucleotide exchange factor; GTP = ... Treatment with either a PI3K inhibitor (LY294002) or a MEK1 inhibitor (PD98059), alone or in combination, decreases cellular ... RhoGDIs (1) sequester Rho GTPases in the cytoplasm and prevent GDP dissociation until released by RhoGDFs (2). The Rho protein ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr598
*  JCI - p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell. 2014;159(1): ... an inhibitor for mTORC1 signaling, or a COX2 inhibitor, celecoxib, prevented PTB in p53d/d females (5, 6). PTB in these ... Treatment with the mTORC1 inhibitor rapamycin reduced the incidence of PTB in the p53d/d mice. Decidual senescence with ... Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010;327(5970):1223-1228.. View this ...
  https://www.jci.org/articles/view/87715
*  Gene Report for G00001754 - Genes2Cognition Neuroscience Research Programme
These data suggest that TCTP has guanine nucleotide dissociation inhibitor activity, and, moreover, implicate TCTP in the ... Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation ... The guanine nucleotide-binding subunit of EF-1, EF-1 alpha, shows a more diffuse distribution throughout the cytoplasm and is, ... EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both ...
  http://www.genes2cognition.org/db/Gene/G00001754
*  Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics
Short Talk: Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. ... PI3K and mTOR Inhibitors in Breast Cancer. Jerry Y. Hsu, Genentech, Inc., USA Clinical Development of PI3K Inhibitors at ... Design and Development of New Class of PI3K-p110beta/delta Inhibitors for the Treatment of Immune-Inflammatory Disease. ... The Role of Nucleotide Deficiency in the Transcriptional Regulation of Neural Crest Differentiation and Melanoma. ...
  http://keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=1312
*  RHOC ras homolog family member C [Homo sapiens (human)] - Gene - NCBI
These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the... ... Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five ... PubMed(nucleotide/PMC) Citations in PubMed identified from shared sequence and PMC links. ... Full text in PMC_nucleotide Full text in PubMedCentral identified from shared sequence links ...
  https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=389&ordinalpos=2&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum
*  Expression Profile in Rice Panicle: Insights into Heat Response Mechanism at Reproductive Stage
The guanine nucleotide dissociation inhibitor (GDI) negatively regulated the GTPases activity [103]. In our case, the 9 HR ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3498232/?lang=en-ca
*  Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein | PNAS
This includes guanine nucleotide dissociation inhibitors (GDIs) (2, 3), which bind Gα and lock it in an inactive GDP-bound ... 2001) RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor activity. J ... guanine nucleotide dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), or the chaperone/GEF Ric-8A], while ... 2008) Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J Biol Chem ...
  http://www.pnas.org/content/114/48/E10319
*  Sestrin 2 attenuates neonatal rat cardiomyocyte hypertrophy induced by phenylephrine via inhibiting ERK1/2, Molecular and...
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling ... Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer ...
  https://www.deepdyve.com/lp/springer_journal/sestrin-2-attenuates-neonatal-rat-cardiomyocyte-hypertrophy-induced-by-dfa69mhvMj
*  What's hot today: Current papers in developmental biology and gene function
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 159: 122-133 ... and function as guanine nucleotide dissociation inhibitors (GDIs) for RagA/B. Sestrin overexpression inhibits amino-acid- ... Bj1 is the guanine-nucleotide exchange factor for Ran GTPase, which regulates nuclear import/export. Bj1 transcripts are highly ... induced Rag guanine nucleotide exchange and mTORC1 translocation to the lysosome. Mutation of the conserved GDI motif creates a ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-november2014.htm
*  The Ming Li Lab | Gerstner Sloan Kettering Graduate School of Biomedical Sciences
Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Peng M, Yin N, Li ...
  https://www.sloankettering.edu/research-areas/labs/ming-li/publications
*  WikiGenes - OXSR1 - oxidative stress responsive 1
Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. Wakasugi, K., ...
  https://www.wikigenes.org/e/gene/e/9943.html
*  Identification of Process-Localized mRNAs from Cultured Rodent Hippocampal Neurons | Journal of Neuroscience
2003) Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation ... and Protease Inhibitor Cocktail. A small aliquot of beads was removed for protein analysis. The RNA on the remaining beads was ... and Protease Inhibitor Cocktail (Sigma) with a Dounce homogenizer. The lysate was precleared with anti-rabbit IgG-Sepharose ( ...
  http://www.jneurosci.org/content/26/51/13390.long
*  Viruses | Free Full-Text | Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions | HTML
Nevins, A.K.; Thurmond, D.C. Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic beta ... a Rac/Cdc42 guaninenucleotide activating protein, targets the AP-2 complex and regulates endocytosis [60]. REPS1 and REPS2 ... PI3K inhibitors [97] and filamentous actin depolymerizing agents can block phagocytosis but their inhibitory effects are not ... Several chemical agents such as dimethyl amiloride [96], cytochalasin D and PI3K inhibitors [97] have been shown to block ...
  http://mdpi.com/1999-4915/4/12/3647/htm
*  A systematic comparative and structural analysis of protein phosphorylation sites based on the mtcPTM database | Genome Biology...
b) Structure of the α isoform of the guanine nucleotide dissociation inhibitor [86] (PDB: 1gnd). (c) Structure of mouse Sec1 ... and the α isoform of the human guanine nucleotide dissociation inhibitor (ENSP00000369538; Figure 9b). On the other hand, ... a) Structure of the Rho GDP-dissociation inhibitor 2 in complex with RAC [81] (Protein Data Bank [PDB]: 1ds6). (b) Structure of ... Two examples of human proteins exhibiting this behavior were the Rho GDP-dissociation inhibitor 2 (ENSP00000228945) and the ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-5-r90