*  Chimerin 1 - Wikipedia
Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may ... This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular ... Kozma R, Ahmed S, Best A, Lim L (September 1996). "The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs ... Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P (February 2006). "The diacylglycerol-binding protein α1-chimaerin ...
  https://en.wikipedia.org/wiki/Chimerin_1
*  Recombinant Human Bcr protein (ab72493) | Abcam
Ab72493 is a protein fragment produced in Baculovirus infected Sf9 cells and has been validated in WB, SDS-PAGE. Abcam… ... GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. ... Proteins and Peptides. Proteomics tools. Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By ... The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to ...
  http://www.abcam.com/recombinant-human-bcr-protein-ab72493.html
*  Ponatinib - DrugBank
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. ... Protein binding. , 99% bound to plasma proteins. Metabolism. At least 64% of a ponatinib dose undergoes phase I and phase II ... Syntaxin binding. Specific Function. Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to ... Sh2 domain binding. Specific Function. Non-receptor tyrosine-protein kinase that plays an essential role in the selection and ...
  https://www.drugbank.ca/drugs/DB08901
*  Plus it
GTP loading requires the guanine exchange factors (GEF), whereas inactivation is facilitated by the GTPase-activating proteins ... the most common cause of Rac hyperactivation is the deregulation of upstream molecules (6). Rac is active when bound to GTP and ... 6C). Downregulation of Rap1a/b further reduced Rac-GTP levels without affecting total Rac protein levels (Fig. 6D), supporting ... We, therefore, investigated Rac activation by GLISA and found that increased miR149 expression resulted in reduced Rac-GTP ...
  http://cancerres.aacrjournals.org/content/74/18/5256
*  Anti-Bcr 抗体 (ab86173) | アブカム
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. ... PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated ... The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to ... The Universal Protein Resource (UniProt) in 2010. Nucleic Acids Res. 38:D142-D148 (2010) . ...
  http://www.abcam.co.jp/bcr-antibody-ab86173.html
*  Platelet-neutrophil interactions under thromboinflammatory conditions
Since GTPases are activated and inactivated by binding of GTP and GDP, respectively, they are regulated by GTPase activating ... proteins (GAPs) and guanine nucleo-tide exchange factors (GEFs) [162]. It is known that Cdc42 and Rac control the formation of ... Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001;81(1):153-208. [PubMed] ... Mitogen-activated protein kinases (MAPKs). Activated MAPKs are crucial for regulating thromboxane A2 production, granule ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4480154/
*  RALA - Wikipedia
"Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". The Journal of ... As a Ras GTPase, RalA functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. ... "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". The Journal of ... "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of ...
  https://en.wikipedia.org/wiki/RALA
*  RACGAP1 - Wikipedia
RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and ... stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also ... Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of ... "Entrez Gene: RACGAP1 Rac GTPase activating protein 1". Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, ...
  https://en.wikipedia.org/wiki/RACGAP1
*  Academic Excellence in Biomedical Research at Semmelweis University Budapest, Hungary - PDF
... small GTPases GTPase activating proteins (GAPs) We have demonstrated that the active, GTP-bound state of the small GTPase Rac ... Hydrolysis of.- GTP to GDP reduces O 2 production instantanously. In vivo this is achieved by GTPase activating proteins (GAPs ... 1. What is a ligand? a. An integral membrane protein associated with G proteins b. A DNA-binding protein that alters gene ... Phospholipids can switch the GTPase substrate preference of a GTPase activating protein. J. Biol. Chem. 279: Rada, B.K., Geiszt ...
  http://docplayer.net/180835-Academic-excellence-in-biomedical-research-at-semmelweis-university-budapest-hungary.html
*  Neuronal Chemorepellent Slit2 Inhibits Vascular Smooth Muscle Cell Migration by Suppressing Small GTPase Rac1 Activation |...
Slit/Robo GTPase activating proteins (srGAPs) bind to the intracellular domain of Robo and promote the hydrolysis of GTP-Cdc42. ... also bind to the intracellular domains of Robo receptors, and they promote hydrolysis of GTP-Rac.19 Therefore, Vilse's human ... was used to selectively bind GTP-Rac1 and GTP-Cdc42 in HASMC lysates. GTP-Rac1 and GTP-Cdc42 bound to GST-PBD were immobilized ... roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell. 2001; 107: 209-221. ...
  http://circres.ahajournals.org/content/98/4/480
*  SMART: RhoGAP domain annotation
... are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases). A ... The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. ... The Rho family small GTP-binding proteins are subjected to regulation by Rho GTPase-activating proteins (GAPs) in the course of ... active in their GTP-bound form but inactive when GDP-bound. The Rho family of G proteins, which includes Cdc42Hs, activate ...
  http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00324
*  Angiotensin II Activates RhoA in Cardiac Myocytes | Circulation Research
Nobes CD, Hawkins P, Stephens L, Hall A. Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J ... whereas hydrolysis of GTP is stimulated by GTPase-activating proteins (reviewed in Reference 11 ). Recent studies have shown ... The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T ... Since Rho is a member of the small GTP-binding proteins, activation of Rho could be shown by its increased binding of GTP. ...
  http://circres.ahajournals.org/content/82/6/666
*  Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control of plant growth and development...
Role of rop proteins in the control of plant growth and development, Russian Journal of Plant Physiology" on DeepDyve, the ... "Superfamily of monomeric GTP-binding proteins in plants: 1. ... of Rho GTPase-Activating Proteins That Require the Cdc42/Rac- ... Rac-Related GTP-Binding Protein in Elicitor-Induced Reactive Oxygen Generation by Suspension-Cultured Soybean Cells ... Superfamily of monomeric GTP-binding proteins in plants: 1. Role of rop proteins in the control... Novikova, G.; Moshkov, I. ...
  https://www.deepdyve.com/lp/springer_journal/superfamily-of-monomeric-gtp-binding-proteins-in-plants-1-role-of-rop-bJUCGEA0QQ
*  Dock4 - Dedicator of cytokinesis protein 4 - Mus musculus (Mouse) - Dock4 gene & protein
Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP ... Rac GTPase binding Source: MGI. *receptor tyrosine kinase binding Source: MGI. *SH3 domain binding Source: UniProtKB-KW ... Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 10090. ...
  http://www.uniprot.org/uniprot/P59764
*  Frontiers | The alternative Medicago truncatula defense proteome of ROS-defective transgenic roots during early microbial...
... while in MtROP9i the majority of proteins were involved in alternative defense pathways such as cell wall and protein ... indicating a dual function of ROS in defense signaling as well as alternative response patterns activated during microbial ... 213 spots comprising 984 proteins (607 unique) were identified after S. meliloti infection, 230 spots comprising 796 proteins ( ... 213 spots comprising 984 proteins (607 unique) were identified after S. meliloti infection, 230 spots comprising 796 proteins ( ...
  https://www.frontiersin.org/articles/10.3389/fpls.2014.00341/full
*  Plus it
... the GTPase-activating proteins facilitate conversion of the GTP-bound to the GDP-bound form by activating the intrinsic GTPase ... Amounts of activated (GTP-bound) Rac were determined by a pull-down assay (see research design and methods). Data are expressed ... after which Rac1 attains its GTP-bound active conformation via GTP/GDP exchange. ARF6.GTP singly, or in concert with Rac1.GTP, ... Second, they appear to inhibit the intrinsic and GTPase-activating protein-catalyzed hydrolysis of GTP. The third biochemical ...
  http://diabetes.diabetesjournals.org/content/54/12/3523
*  Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix | The EMBO Journal
... bound and GTPbound states (Boguski and McCormick, 1993). Rho family proteins, such as Cdc42 and Rac, are activated by a number ... a G protein‐coupled receptor kinase‐associated ADP ribosylation factor GTPaseactivating protein. Proc Natl Acad Sci USA 95: ... bound Cdc42 or Rac and the Cool‐2 monomer. The βγ subunit complex of large GTPbinding proteins, by interacting with PAK, ... 1 has been shown to bind preferentially to activated (GTPbound) Cdc42 and to act as a target/scaffold protein in mediating the ...
  http://emboj.embopress.org/content/23/17/3492.long
*  G-protein signaling - Regulation of CDC42 activity Pathway Map - PrimePCR | Life Science | Bio-Rad
A group of proteins called GTPase-activating proteins (GAPs) inactivates CDC42 by catalyzing the hydrolysis of GTP to GDP. Main ... Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. The Journal of ... GAP activity is abrogated by RAS p21 protein activator (GTPase activating protein) 1 (p120GAP) binding [25], [26]. Fibroblast ... Rho GTPase activating protein 17 (Rich1) [18], CDC42 GTPase-activating protein (CDGAP) [19], Breakpoint cluster region (BCR) [ ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/g-protein-signaling-regulation-cdc42-activity
*  A Novel Role for p21-Activated Protein Kinase 2 in T Cell Activation | The Journal of Immunology
... which cycle between the active GTP-bound form and the inactive GDP-bound form. Binding of GTP-loaded Cdc42 or Rac to PAK family ... Although Cdc42/Rac binding results in PAK activation, there is a report of PAK1 mediating GTPase function independent of PAK ... mitogen-activated protein kinase; PAK, p21-activated serine/threonine protein kinase; CRIB, Cdc42/Rac interactive binding ... A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:29071. ...
  http://www.jimmunol.org/content/172/12/7324.long
*  GTPase-activator protein for Ras-like GTPase - Wikipedia
... or GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down- ... Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that ... GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. Ras proteins are membrane- ... associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic GTPase activity of ras is ...
  https://en.wikipedia.org/wiki/GTPase-activator_protein_for_Ras-like_GTPase
*  The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration | Journal of...
... which serve to activate the GTPases by promoting the exchange of GDP for GTP, and GTPase-activating proteins (GAPs) that ... Ren, X. D., Kiosses, W. B. and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the ... Ridley, A. J. and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress ... RAC siRNA #1 and RAC siRNA #2 decreased endogenous expression of Rac by approximately 75% compared with empty pSUPER vector or ...
  http://jcs.biologists.org/content/122/24/4535
*  Plus it
The RHO-family proteins RAC1, CDC42, and RHOA are small GTP-binding proteins that act as molecular switches, shifting between ... p21-activated kinases (PAK), the most extensively studied CDC42 and RAC effector proteins, consist of two subgroups containing ... This process is regulated by guanine nucleotide-exchange factors, GTPase-activating proteins, and guanine nucleotide- ... Upon activation, RHO proteins recruit and activate a number of cytoplasmic protein kinases, indicated in green. These protein ...
  http://clincancerres.aacrjournals.org/content/21/1/24
*  Frontiers | Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders...
... bound states. These transitions are dynamically regulated by GTPase activating proteins (GAPs), guanine nucleotide exchange ... Brain-derived neurotrophic factor (BDNF), involved in synaptic maturation, activates Rac/RhoA-GEF proteins via TrkB tyrosine ... inhibiting the conversion to the active GTP-bound state (Sasaki and Takai, 1998). In syndromic OPHN1 ID, changes in spine ... a Ras GTPase-activating protein implicated in ID and ASD but this also normalizes at the end of the first postnatal week ( ...
  https://www.frontiersin.org/articles/10.3389/fnsys.2013.00075/full
*  Interactive Fly, Drosophila
These two proteins form a complex. Tuberin, which has a region of homology to Rap1 GTPase-activating proteins (GAPs), has been ... TSC2 was found to bind to Rheb-GTP in vitro and to reduce Rheb GTP levels in vivo. Over-expression of Rheb but not Rap1 ... Tuberin does not stimulate the GTPase activity of Rap2, Ha-Ras, Rac, or Rho. These results suggest that the loss of tuberin ... TSC2 is a GTPase-activating protein (GAP) toward Rheb, a Ras family GTPase. Rheb stimulates phosphorylation of S6K and 4EBP1. ...
  http://www.sdbonline.org/sites/fly/newgene/gigas2.htm
*  Contribution of Guanine Nucleotide Exchange Factor Vav2 to Hyperhomocysteinemic Glomerulosclerosis in Rats | Hypertension
GDP-bound Rac under resting condition may be converted into GTP-Rac through the action of a guanine nucleotide exchange factor. ... Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. Kidney Int. ... Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell. 2007; 129: 865- ... Rac GTPase Activation Assay. A pull-down experiment was performed to determine Rac GTPase activity using a Rac activation assay ...
  http://hyper.ahajournals.org/content/53/1/90