*  Patente US5348876 - IgG3 antibodies with shortened hinge region and a complement activation test - Google Patentes
... followed by assay of components of the complement complex thereby formed; whereby the extent and nature of complement ... Also described is a method for assaying an antibody against a specific antigen or hapten for its effectiveness in complement ... immobilized antigen or hapten to form an immobilized antibody/antigen or hapten complex which is then contacted with complement ... Other groups have shown that it is possible to "humanize" murine antibodies in this way, and that chimeric antibodies secreted ...
  http://www.google.es/patents/US5348876?dq=flatulence
*  Patent US6664052 - Genetic polymorphism in a complement receptor - Google Patents
Complement receptors CR1 and CR2 are active in the immune response and autoimmune diseases. The susceptibility and severity of ... A method and a package for identifying single nucleotide polymorphisms in complement receptor is useful in identifying ... autoimmune disease is determined by genotyping or phenotyping an individual for complement receptor. ... The complement system involves a group of proteins that play a role in host defense against infection. Complement is active in ...
  http://www.google.com/patents/US6664052?dq=6,073,142
*  CR1 polyclonal antibody - (PAB30270) - Products - Abnova
C3-binding protein,C3b/C4b receptor,CD35 antigen,Knops blood group antigen,complement component receptor 1,complement receptor ... The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to ... This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of ... particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB30270
*  Table of Contents - January 01, 2016, 196 (1) | The Journal of Immunology
The Group B Streptococcus-Secreted Protein CIP Interacts with C4, Preventing C3b Deposition via the Lectin and Classical ... Complement Pathways Author Choice Article. Giampiero Pietrocola, Simonetta Rindi, Roberto Rosini, Scilla Buccato, Pietro ... Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production Maryam Salimi, Luzheng Xue ...
  http://www.jimmunol.org/content/196/1/
*  The Complement Inhibitors Crry and Factor H Are Critical for Preventing Autologous Complement Activation on Renal Tubular...
Tickover generates C3b, which can bind to amino and hydroxyl groups on the surface of cells. Bound C3b then catalyzes further ... Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous ... Recent studies examined complement regulation in Crry−/− mice (39, 40). Although maternal complement proteins injure the ... Complement is spontaneously activated on the apical surface of TECs. It was reported that the alternative pathway of complement ...
  http://www.jimmunol.org/content/185/5/3086.long
*  Professor Paul Turner - Nuffield Department of Medicine
Antibody-mediated complement C3b/iC3b binding to group B Streptococcus in paired mother and baby serum samples in a refugee ... Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known ... In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS ... Sheppard AE, Vaughan A, Jones N, Turner P, Turner C, Efstratiou A, Patel D, Modernising Medical Microbiology Informatics Group ...
  https://www.ndm.ox.ac.uk/principal-investigators/researcher/paul-turner
*  AlzGene
Knops blood group) (C3-binding protein; C3b/C4b receptor; CD35 antigen; Knops blood group antigen; complement component ...
  http://www.alzgene.org/polydetail.asp?geneID=635&studyID=1495ðnicDataID=4138
*  The Role of Complement System in Septic Shock
However, two clinical studies from Eisen's group in Australia showed more complicated patterns of lectin complement activation ... "Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 ... 2. Pathophysiology of Complement Involvement in Septic Shock. 2.1. Involvement of Complement Common Cascade in Septic Shock. A ... Involvement of Complement Lectin Pathway in Septic Shock. Specific factors in complement lectin pathway include MBL and ficolin ...
  https://www.hindawi.com/journals/jir/2012/407324/
*  Frontiers | The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct...
Stabilization of the C3b-B complex to prevent C3 convertase formation (C3b-Bb formation) is a novel mechanism that differs from ... Stabilization of the C3b-B complex to prevent C3 convertase formation (C3b-Bb formation) is a novel mechanism that differs from ... experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination ... experiments demonstrated that Lufaxin stabilizes the C3b-B proconvertase complex when passed over a C3b surface in combination ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01065/full
*  Evolving Immunity
This complex induces the cleavage of another factor, C3, into C3a and C3b. C3b can group with the C4b/C2b complex to form a C5 ... C5b attracts the complement proteins C6, C7, C8 and C9. This group of proteins, C5b through C9, forms a membrane attack complex ... In fact, complement proteins are believed to comprise a higher percentage of blood plasma proteins than any other group of ... The origin and evolution of the complement system. *The evolution of complement begins with an ancestor to protease inhibitor a ...
  http://www.talkdesign.org/faqs/Evolving_Immunity1.2.html
*  C3b - Wikipedia
Furthermore, if C3b does bind to a host-cell surface, regulators of complement activity (RCAs), a group of genetically-, ... where the C3b-tagged immune complex is then destroyed. In both cases C3b interacts with the C3b receptor, complement receptor 1 ... C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the ... The key to the success of the complement system in clearing antigens is regulating the effects of C3b to pathogens alone and ...
  https://en.wikipedia.org/wiki/C3b
*  Browse - AMA Manual of Style
M. K. Liszewski and J. P. Atkinson(p922) The term complement refers to a group of serum proteins activated sequentially and ... It is estimated that one C3b deposited on an organ- ism can become four million in about 4 min. M. K. Liszewski and J. P. ... Atkinson(p922) The term complement refers to a group of serum proteins ... More ... Historically, the letters T and B reflected the anatomic sites of maturation of the 2 groups of cells, the thymus Less ...
  http://www.amamanualofstyle.com/browse?btog=chap&pageSize=10&sort=title&t1=AMAMOS_SECTIONS%3Amed-9780195176339-div1-166&t2=AMAMOS_SECTIONS:med-9780195176339-chapter-15
*  CD35 / CR1 (Follicular Dendritic Cell Marker) Antibody - With BSA and Azide - Mouse Monoclonal Antibody [Clone CR1/802 ] IHC,...
... the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group ... The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, ... Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This MAb does not block CR1 ... Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv. Immunol. 46: 183-219 ...
  http://www.abgent.com/products/AH11125-CD35--CR1-Follicular-Dendritic-Cell-Marker-Antibody-With-BSA-and-Azide
*  Complement - AMA Manual of Style
M. K. Liszewski and J. P. Atkinson(p922) The term complement refers to a group of serum proteins activated sequentially and ... It is estimated that one C3b deposited on an organ- ism can become four million in about 4 min. ... It is estimated that one C3b deposited on an organ- ism can become four million in about 4 min. M. K. Liszewski and J. P. ... 15.1 Blood Groups, Platelet Antigens, and Granulocyte Antigens*15.1.1 Blood Groups ...
  http://www.amamanualofstyle.com/view/10.1093/jama/9780195176339.001.0001/med-9780195176339-div2-429?rskey=lo9aL2&result=1&q=
*  HER2 Expression Beyond Breast Cancer: Therapeutic Implications for Gynecologic Malignancies
Santin et al as well as multiple other research groups have shown that HER2 receptor is overexpressed in USC (scores 2+ and 3+ ... Membrane Complement Regulatory Proteins. One mechanism by which tumors escape immune surveillance is through antigen evolution ... mCRPs upregulation lead to inactivation of C4b/C3b, dissociation of C3/C5-convertases and prevention of membrane-attack complex ... Expression of CD46, CD55, and CD59 on renal tumor cell lines and their role in preventing complement-mediated tumor cell lysis ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3660991/?lang=en-ca
*  C3 receptors on macrophages | Journal of Cell Science
... the natural product of C3b from cleavage by the complement control protein factor I and its cofactors. CR1 belongs to a group ... The complement receptors on macrophage are responsible for their binding and ingestion of opsonized targets. The two ... This structural unit is called SCR (short consensus repeat) and is found in the complement proteins Clr, Cls, C2, factor B, ... established receptors are CR1, which recognizes C3b, and CR3, which recognizes iC3b, ...
  http://jcs.biologists.org/content/1988/Supplement_9/67
*  Anti-CR1 / CD35 Antibody (clone E11, RPE) for WB/Western, Flow LS-C134403
CR1 Antibody, C3b/C4b receptor Antibody, C3-binding protein Antibody, CD35 Antibody, C3BR Antibody, Knops blood group antigen ... Complement receptor 1 (CD35) molecule of about 220 kd.. Usage:. The applications listed have been tested for the unconjugated ... The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to ... CR1 / CD35 is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of ...
  https://www.lsbio.com/antibodies/anti-cr1-antibody-cd35-antibody-clone-e11-rpe-flow-wb-western-ls-c134403/138084
*  Acute inflammation on model biomaterial surfaces : studies on proteins, neutrophils and platelets
However, the complement deposition was apparendy not a result of true or prolonged complement activation, and immobilized actin ... This strongly suggests that the prevalent covalent linkage model between solid artificial surfaces and C3b is not accurate. ... a common belief has evolved that charged nucleophilic surface groups such as amine (-NH2) and hydroxyl (-OH) react with and ... indicating that complement factors enhance the neutrophil activation. We propose that the complement factors C3, C5a, and C1q ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:247225
*  Lecture 2 & 3 010908 011108 - MMG 461 Molecular Pathogenesis Prokaryotic Structure and Function M H Mulks Lectures 2& 3 January...
... because inhibits binding of complement component C3b to surface Resistance to specific host immunity Poor antibody response to ... phosphate group, E = ethanolamine, GlcN = glucosamine, ~~~~ = fatty acid side chains, Hep = heptose KDO = 2-keto-3-deoxy ... chromosome complement no meiosis Rare Often in plasmids Common In organelles Introns in genes Extrachromosomal DNA Comparison ... complement-mediated killing Bacterial capsule Functions of capsule Prevention of dessication Adherence Resistance to non- ...
  https://www.coursehero.com/file/27212/Lecture-2-3-010908-011108/
*  A Region of the N-terminal Domain of Meningococcal Factor H Binding Protein that Elicits Bactericidal Antibody across Antigenic...
1B), was specific for fHbps within individual variant groups. JAR 4 individually was not bactericidal with human complement but ... the mAb activated C3b deposition on strains expressing fHbp in the variant 1 or 2 groups (Welsch et al., 2004) and elicited ... Strains H44/76 and NZ98/254 had fHbp in the variant 1 group and strains 8047 and BuFa 1/03 had fHbp in the variant 2 group. The ... which cross-reacted with fHbps in variant groups 1 or 2 (95% of strains), and elicited human complement-mediated, cooperative ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2673115/
*  anti-CD55 antibody | GeneTex
Cromer blood group)) for WB. Anti-CD55 pAb (GTX82412) is tested in Human samples. 100% Ab-Assurance. ... This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b ... the amplification convertases of the complement cascade. Also acts as the receptor for echovirus 7 and related viruses ( ... Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 ...
  http://www.genetex.com/CD55-antibody-GTX82412.html
*  Sushi domain - Wikipedia
Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and is associated with Kn( ... Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a ... Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the ... Complement components may activate B cells through CD21. CD21 is part of a large signal-transduction complex that also involves ...
  https://en.wikipedia.org/wiki/Sushi_domain
*  Complement Cascade Flashcards by Paul Joshua Barcelona | Brainscape
Study Complement Cascade flashcards from Paul Joshua Barcelona ... Binds to C3b to prevent binding of factor B and cofactors ... Refers to a group of glycoproteins that promotes inflammation and serves important role in host defense ... Complement from 1 sp will react w/ immunoglobulin of another sp from the same taxonomic order ... Coating of antigen w/ specific complement peptide by specificreceptor on phagocytes for ingestion ...
  https://www.brainscape.com/flashcards/complement-cascade-6594651/packs/10367502
*  Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement | The Journal of Immunology
C3b,Bb cleaves C3, depositing C3b on and near itself. Some of the newly deposited C3b molecules will form C3b-C3b complexes, ... on the present kinetic analysis of the natural surface-bound C5 convertases together with results published by other groups on ... 10) have suggested the formation of C4b-C3b and C3b-C3b dimers as high-affinity C5 binding sites within the C3b clusters ... High C5 convertase activity was associated with the formation of C3b-C3b or C3b-C4b dimers in which the additional C3b molecule ...
  http://www.jimmunol.org/content/166/4/2635
*  Nonexudative (Dry) Age-Related Macular Degeneration (AMD): Practice Essentials, Background, Pathophysiology
... in that it protects host cells from complement-mediated damage by binding to the activated complement component C3b. ... In 2005, four separate groups reported that a common variation in the CFH (complement factor H) gene increased susceptibility ... The complement system is an alternative system (ie, independent of antibodies) of defense against infection. Complement factor ... as well as the complement-related proteins C3a, C5a, C5, C5b-9, CFH, CD35, and CD46. Inappropriate activation of the complement ...
  https://emedicine.medscape.com/article/1223154-overview