PSYC Call for Commentators: BIOCHEMICAL BASIS OF COMA (969 lines)
General anaesthetics are mainly GABA agonists but some (such as ketamine) are glutamate antagonists. They also affect other ... This effectively shuts down the glutamate synapse and the functional effect is akin to the effect of ketamine, although the ... the general anaesthetic ketamine, like nitrous oxide ('laughing gas'), is a glutamate NMDA receptor blocker, and acts ... Ketamine-like agents inhibit glutamate-mediated conduction at the receptor level, while nitrous oxide affects both systems. ...http://www.bio.net/bionet/mm/neur-sci/1999-September/040643.html
Addiction Inbox: What is Drug Craving?
Dissociative drugs like PCP and ketamine are glutamate antagonists.. However, drugs that play off receptors for glutamate are ... Glutamate is the most common neurotransmitter in the brain. (In sodium salt form, as monosodium glutamate, it is a potent food ... The glutamate receptor is ... NMDA'. ONE of the glutamate receptors is NMDA. There are also AMPA, Kainate (the ionotropic ones ... One glutamate receptor' or 'The glutamate receptor most relevant to this issue is'. Just a nit-pick. I gotta use my 'Drugs of ...http://addiction-dirkh.blogspot.com/2007/12/what-is-drug-craving.html
Is Topical Ketamine Ready For Prime Time?
A literature review reveals limited evidence of efficacy of topical ketamine for neuropathic pain, but larger studies are ... There are multiple mechanisms through which ketamine provides analgesia (See Figure 1). Ketamine is a glutamate NMDA antagonist ... Ketamine is a N-methyl-D-aspartate (NMDA) antagonist used for general anesthesia that has been formulated and studied as a ... Kapur S, Seeman P. NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT (2) ...https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/topical-ketamine-ready-prime-time
Ketamine, Transcranial Magnetic Stimulation, and Depression Specific Yoga and Mindfulness Based Cognitive Therapy in Management...
Of note, ketamine, although a glutamate antagonist, can actually increase glutamate transmission in PFC. Ketamine decreases the ... "ketamine in TRD," "ketamine in treatment resistant depression," "ketamine and TRD," "ketamine and depression," and "ketamine ... Ketamine, working primarily as a glutamate receptor (NMDA) antagonist, suppresses excitatory effects of glutamate, promotes ... Ketamine is primarily known to be an antagonist of the excitatory glutamate receptors: it directly blocks the NMDA subtype of ...https://www.hindawi.com/journals/drt/2015/842817/
Addiction Inbox: A Few Words About Glutamate
Dissociative drugs like PCP and ketamine are glutamate antagonists.) Dextromethorphan, the compound found in cough medicines ... The receptor for glutamate is called the N-methyl-D-aspartate (NMDA) receptor. Unfortunately, NMDA antagonists, which might ... Drugs that boost glutamate levels in the brain can cause seizures. Glutamate does most of the damage when people have strokes. ... Drug companies have been working on new glutamate-modulating antianxiety drugs, and a glutamate-active drug called acamprosate ...https://addiction-dirkh.blogspot.com/2012/01/few-words-about-glutamate.html
Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia....
Studies of the effects of the N-methyl-d-aspartate (NMDA) glutamate receptor antagonist, ketamine, have suggested similarities ... AK: Acute ketamine; CK: Chronic ketamine; EC-SZ: Early course of schizophrenia; C-SZ: chronic schizophrenia. ... Comparison of each PANSS item in acute ketamine (AK), chronic ketamine (CK), early course of schizophrenia (EC-SZ), and chronic ... The factors in the chronic ketamine group were more similar to the factors in the two schizophrenia groups rather than to the ...https://www.ncbi.nlm.nih.gov/pubmed?term=25560772
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential - Mony - 2009 - British...
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working ... Maeng S, Zarate CA Jr (2007). The role of glutamate in mood disorders: results from the ketamine in major depression study and ... Gogas KR (2006). Glutamate-based therapeutic approaches: NR2B receptor antagonists. Curr Opin Pharmacol 6: 68-74. *CrossRef, ... Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism. Mov Disord 23: 1860-1866. ...http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00304.x/references
Ralitza Gueorguieva, PhD | Yale School of Public Health
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working ... Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am J Psychiatry. ... Krystal JH, Madonick S, Perry E, Gueorguieva R, Brush L, Wray Y, Belger A, D'Souza DC: Potentiation of low dose ketamine ... preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors. Alcohol Clin Exp Res. 2008 Jan; ...http://medicine.yale.edu/ysph/about/contact/ralitza_gueorguieva-2.profile
John H. Krystal, MD > Psychiatry | Yale School of...
Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working ... Krystal JH: N-methyl-D-aspartate glutamate receptor antagonists and the promise of rapid-acting antidepressants. Arch Gen ... Chang F, Xu K, Huang MC, Krystal JH: Alcohol Triggers Reemergence of Ketamine-Like Experience in a Ketamine Ex-User. J Clin ... In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biol Psychiatry. 2015 Feb ...https://medicine.yale.edu/psychiatry/people/john_krystal-2.profile?source=news
... a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist. We aimed to assess the efficacy of ketamine in major depressive ... A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment ... Our meta-analysis suggests that single administrations ketamine are efficacious in the rapid treatment of unipolar and bipolar ... Data were synthesized from seven RCTs employing an intravenous infusion and one RCT employing intranasal ketamine, representing ...https://www.cambridge.org/core/search?filters%5BauthorTerms%5D=R.%20W.%20Lam&eventCode=SE-AU
Intraoperative Awareness:From Neurobiology to Clinical Practice | Anesthesiology | ASA Publications
... methyl-d-aspartate glutamate receptor antagonist ketamine.14,17 It is also becoming clear on the behavioral level that ... methyl-d-aspartate glutamate receptor antagonists.173,177,178 ... infusion of a GABAAreceptor antagonist into the basolateral ... including enhanced activity of AMPA-subtype glutamate receptors, insertion of new AMPA receptors into the postsynaptic membrane ... such as opioids and ketamine, are part of the anesthetic regimen.138 ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2034780
References for Schizophrenia and Glutamate: An Update
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Arch Gen Psychiatry 1994;51:199-214. ... Ketamine symposium comments by moderator. Anesth Analg 1971;50:471-479. 7. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali ... Glutamate receptor subtype in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res 1995;674:82-90. ... Hammer RP, Jr, Herkenham M. Altered metabolic activity in the cerebral cortex of rats exposed to ketamine. J Comp Neurol 1983; ...http://www.acnp.org/g4/GN401000116/114R.htm
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids - Full Text View - ClinicalTrials.gov
Experimental: Ketamine plus dexmedetomidine Ketamine infusion plus dexmedetomidine. Drug: Dexmedetomidine Ketamine plus ... glutamate receptor. NMDA receptor hypofunction can disinhibit excitatory (cholinergic/glutamatergic) projections in key areas ... Visual Analog Scale (VAS) Pain Intensity [ Time Frame: Before Ketamine, During Ketamine, Post Ketamine and 1 Week Follow up ]. ... Visual Analog Scale (VAS) Anxiety Rating [ Time Frame: Before Ketamine, During Ketamine, Post Ketamine, 1 week follow up ]. ...https://clinicaltrials.gov/ct2/show/NCT00205712
Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD) - Full Text View - ClinicalTrials.gov
Understanding the Glutamate System in Adults With Obsessive-Compulsive Disorder With N-methyl-D Aspartate Antagonist Ketamine. ... In vivo effects of ketamine on glutamate-glutamine and gamma-aminobutyric acid in obsessive-compulsive disorder: Proof of ... Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD). This study has been completed. ... Ketamine. Analgesics. Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Anesthetics, ...https://clinicaltrials.gov/ct2/show/NCT01100255?recr=Open&cond=%22Obsessive-Compulsive+Disorder%22&rank=18
Glutamate Hypothesis of Schizophrenia | Schizophrenia Research Forum
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and ... Glutamate Hypothesis of Schizophrenia. Posted on 7 Nov 2005 The glutamate hypothesis of schizophrenia posits that the function ... Glutamate receptors are classified into two broad categories: ionotropic and metabotropic receptors. Ionotropic glutamate ... our limited knowledge of the glutamate system at the time suggested that disruptions in glutamate neurotransmission would ...http://www.schizophreniaforum.org/forums/glutamate-hypothesis-schizophrenia
Schizophrenia: Practice Essentials, Background, Pathophysiology
... subclass of glutamate receptors because NMDA antagonists, such as phencyclidine and ketamine, can lead to psychotic symptoms in ... Clozapine, perhaps the most effective antipsychotic agent, is a particularly weak dopamine D2 antagonist. Thus, other ...https://emedicine.medscape.com/article/288259-overview
Review and update of the Hong Kong Epilepsy Guideline on status epilepticus | HKMJ
Ketamine, a non-competitive antagonist of the NMDA glutamate receptor, has demonstrated its antiepileptic properties in ... Response to ketamine was shown to be better when used as a third- or fourth-line agent rather than late in the course of SRSE ... Ketamine is also increasingly used in this challenging condition. There are also reports of potential use of a ketogenic diet ... Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia 2013;54: ...http://hkmj.org/abstracts/v23n1/67.htm
Psycho-Babble Medication Thread 1086241
Because Lamictal and benzos are targeting glutamate and GABA, and then ketamine is mucking around with that system as well, ... is an nmda antagonist and works on glutamate (as well as almost all other receptors). though i've had to tweak the dose over ... Because Lamictal and benzos are targeting glutamate and GABA, and then ketamine is mucking around with that system as well, ... Because Lamictal and benzos are targeting glutamate and GABA, and then ketamine is mucking around with that system as well, ...https://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20161215/msgs/1093903.html
The importance of integrating basic and clinical research toward the development of new therapies for Huntington disease
... lowering glutamate receptor activation with NMDA receptor antagonists (ketamine and memantine; Supplemental Table 1), ... The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a ... modulating the interplay of glutamate and dopamine on MSNs (72), and recently with mGluR5 antagonists (43). Currently there is ... Dopamine and glutamate in Huntington's disease: A balancing act. CNS Neurosci Ther. 2010;16(3):163-178. doi: 10.1111/j.1755- ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3026740/
Regional Dysregulation and Aberrant Functional Connectivity in ADHD | Journal of Neuroscience and Neuropsychology | Scholarena...
Ketamine and other glutamate antagonists have been applied as animal models for ADHD (Fredriksson and Archer, 2002, 2003, 2004 ... 2015) Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ... 2015) Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ... Miller EM, Pomerleau F, Huettl P, Gerhardt GA, Glaser PE (2014) Aberrant glutamate signaling in the prefrontal cortex and ...http://fulltext.scholarena.co/Regional-Dysregulation-and-Aberrant-Functional-Connectivity-in-ADHD.php
Glutamate and psychiatric disorders | BJPsych Advances
In the study by Anand et al (2000), lamotrigine potentiated the mood-elevating effects of the NMDA antagonist ketamine, thus ... Thus, a reduced glutamate function, for example as induced by ketamine, may cause some elevation of dopamine release. If, ... Lamotrigine attenuation of ketamine-induced effects in humans. In addition to metabotropic glutamate receptor agonists and ... Grotta, J., Clark, W., Coull, B., et al (1995) Safety and tolerability of the glutamate antagonist CGS 19755 (Selfotel) in ...http://apt.rcpsych.org/content/8/3/189
Most recent papers with the keyword Ketamine neuron | Read by QxMD
Ketamine is a noncompetitive glutamate N-methyl-D-aspartic acid receptor antagonist. When acutely administered to rodents, it ... Ketamine, a non-competitive N-methyl D-aspartate (NMDA) receptor antagonist, is widely used in pediatric clinical practice. ... The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing ... We investigated effects of anesthetic ketamine on neuroapoptosis and further explored role of NMDA receptors in ketamine- ...https://www.readbyqxmd.com/keyword/62139
DUJS 16W by Dartmouth Undergraduate Journal of Science - issuu
... antagonist. In other words, ketamine prevents glutamate from binding to its receptor on certain neurons, blocking its effect (9 ... Ketamine One drug currently being developed using the glutamate hypothesis is ketamine, also known as the party drug "Special K ... The Glutamate Hypothesis The glutamate hypothesis is one theory currently being researched that may help to supplement the ... Much of this research is directed toward the excitatory amino acid glutamate; high concentrations of glutamate correlate to MDD ...https://issuu.com/dartmouth_science/docs/16w_dujs_print_issue?e=0/34538453
Dizocilpine - Wikipedia
Dissociative Dextromethorphan (DXM) Ketamine Phencyclidine (PCP) Glutamate NMDA receptor NMDA antagonists Olney's lesions ... Herberg LJ, Rose IC (1989). "The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation ... Ellison G (February 1995). "The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and ... a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The ...https://en.wikipedia.org/wiki/Dizocilpine
Philosophical Transactions of the Royal Society B: Biological Sciences
If synaptic glutamate levels are very low, then a presynaptic mGlu2/3 antagonist would not be expected to enhance glutamate ... The ability of ketamine and NMDA receptor antagonists to rapidly increase synaptogenesis represents a fundamental shift in our ... metabotropic glutamate receptor type II antagonists and AMPA receptor potentiating agents.. (a) Enhancing glutamate-AMPA ... 2011 Glutamate N-methyl-d-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic ...http://rstb.royalsocietypublishing.org/content/367/1601/2475.full
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