*  Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats |...
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem ... Glucose transporters in insulin sensitive tissues of lean and obese mice. Effects of the thermogenic agent BRL 26830A*. ... Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and ... Muscle glucocorticoids insulin resistance glucose transport glucose transporter glucose fatty-acid cycle lipid oxidation ...
  https://link.springer.com/article/10.1007/BF02374470
*  JCI - Hypothalamic inflammation in obesity and metabolic disease
... were sufficient to impair the ability of hypothalamic insulin to suppress white adipose tissue lipolysis and hepatic glucose ... but not in other tissues, leads to protection against insulin resistance, hyperinsulinemia, and glucose intolerance (56, 57). ... Prolonged HFD feeding leads to metabolic inflammation in peripheral organs such as white adipose tissue, liver, and skeletal ... Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech. 2012;5(5):583-587.. View this article via: PubMed ...
  https://jci.org/articles/view/88878
*  Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding. - Semantic...
Expression of proinflammatory cytokines was increased in adipose tissue of eNOS-/- mice. Conversely, enhancement of signaling ... increased cGMP signaling can block adipose tissue inflammation induced by HF feeding. METHODS AND RESULTS Relative to mice fed ... whether reduced NO contributes to adipose tissue inflammation is unknown. We sought to determine whether (1) obesity induced by ... diet reduces endothelial nitric oxide signaling in adipose tissue, (2) reduced endothelial nitric oxide synthase (eNOS) ...
  https://www.semanticscholar.org/paper/Reduced-vascular-nitric-oxide-cGMP-signaling-to-Handa-Tateya/cc5b848d66de045bb816c9b80a759a7f6296ac61
*  Anti-UCP1抗体(ab23841)参考文献| Abcam中国官方网站
Weiner J et al. Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice. Sci ... Mössenböck K et al. Browning of white adipose tissue uncouples glucose uptake from insulin signaling. PLoS One 9:e110428 (2014 ... a phenotype distinguishing brown adipocytes from interscapular brown adipose tissue and white adipose tissue. J Biol Chem 290: ... Bi P et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20:911-8 ( ...
  http://www.abcam.cn/ucp1-antibody-ab23841-references.html
*  Effect of Angiotensin II Type 2 Receptor-Interacting Protein on Adipose Tissue Function via Modulation of Macrophage...
Glucose uptake and cytokines levels in white adipose tissue and serum levels of TNF-α and adiponectin in each chimeric mouse. ... CCR2− monocytes accumulate in noninflamed tissues and are termed "resident", while CCR2+ monocytes are potent inflammatory ... Glucose Uptake in Adipose Tissue. Glucose uptake in WAT was measured as the rate constant of 2-[3H]deoxy-d-glucose (2-[3H]DG) ... Inflammation in white adipose tissue (WAT) is known to contribute to the pathogenesis of insulin resistance and type 2 diabetes ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3614946/?lang=en-ca
*  JCI - FGF19 action in the brain induces insulin-independent glucose lowering
Although activation of FGFR1 in peripheral tissues, such as brown and white adipose tissue, may contribute to glucose lowering ... FGFR1 activation exerts glucose-lowering effects in liver as well as both brown and white adipose tissue (11), and the ... A and C) Glucose tolerance (0.5 g/kg) and (B and D) the integrated area under the glucose curve (AUCglucose) in leptin- ... i.p. glucose tolerance testing. i.p. glucose tolerance tests (ipgtt; 30% d-glucose; 0.5 or 1.5 g/kg) were conducted in 5-hour ...
  https://www.jci.org/articles/view/70710
*  Plus it
Insulin-stimulated glucose metabolic index (. ) in red quadriceps (A) and white adipose tissue (B) during hyperinsulinemic ... Estimation of individual muscle glucose metabolic index.. Frozen tissues (50-100 mg) were homogenized in 10-20 vol of ice-cold ... and white quadriceps muscle, white adipose tissue (epididymal fat pads), liver, heart, and interscapular brown adipose tissue ... muscle and white adipose tissue insulin-mediated glucose uptake was enhanced, as indicated by . Significant enhancement of net ...
  http://ajpendo.physiology.org/content/273/5/E859
*  Most recent papers with the keyword stress hormones; diabetes | Read by QxMD
Irisin induces browning of the white adipose tissue and has been shown to regulate glucose and lipid homeostasis. Keeping its ... inducing a neovascularization process that finally increases flow in ischemic tissues... ... ABA stimulates insulin independent glucose uptake in myocytes and adipocytes via LANCL2 binding in vitro, improves glucose ... The emerging role of the ABA/LANCL2 system in glucose and lipid metabolism makes it an attractive target for pharmacological ...
  https://www.readbyqxmd.com/keyword/76551
*  JCI Insight - Welcome
... white adipose tissue expansion, and impaired glucose homeostasis. Pharmacological blockade of SGK1 in high-fat diet-fed Akt3- ... Membrane lipid composition is central to the highly specialized functions of neurological tissues. In the retina, abnormal ... NK cells are a subset of innate effector cells, which play an important role in the regulation of adipose tissue and antitumor ... We directly tested this hypothesis using tissue-specific ChREBP deletion. HFrD increased adiposity and impaired glucose ...
  https://insight.jci.org/tags/28?content=articles&page=1
*  Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism | Diabetes
Gender- and site-related effects on lipolytic capacity of rat white adipose tissue. Cell Mol Life Sci 60: 1982- 1989, 2003. ... Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev 5: 197- 216, 2004. ... Similar results were observed in adipose tissue weight. Male PG adipose tissue was double the size of female PG adipose tissue ... 0.47 ± 0.03 g, respectively; P , 0.05). In contrast, male SC adipose tissue was only 25% bigger than female SC adipose tissue ( ...
  http://diabetes.diabetesjournals.org/content/58/4/803
*  JCI - A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution
Tissue glucose uptake rates of mice treated as in J. pgWAT, perigonadal white adipose tissue; scWAT, subcutaneous white adipose ... which was caused by enhanced glucose disposal in tissues such as brown and inguinal white adipose and perhaps heart (Figure 2M ... pgWAT, perigonadal white adipose tissue; scWAT, subcutaneous white adipose tissue; GCM, gastrocnemius complex muscle; BAT, ... B) Brown adipose tissue (BAT) UCP1 protein expression in mice treated as in Figure 3A. (C) Subcutaneous white adipose tissue ( ...
  https://www.jci.org/articles/view/85946
*  Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation | Endocrinology and Metabolism
... the lipolytic response in white adipose tissue and subsequent transport to target tissues may take some time and therefore may ... During short-term fasting, a robust increase in lipolytic fluxes from white adipose tissue to liver and muscle tissue occurs. ... 1) (13, 14a, 30). KB synthesis is controlled by white adipose tissue lipolysis, entry of FAs into hepatic mitochondria, and ... that the ratio between white adipose tissue lipolysis and FA reesterification modulates glycerol availability for glucose ...
  http://ajpendo.physiology.org/content/303/12/E1397
*  Quantification in vivo of the effects of insulin on glucose utilization in individual tissues of warm- and cold-acclimated rats...
... skeletal muscle made the largest contribution to whole-body glucose utilization. White and brown adipose tissue had low glucose ... Tissue sites of glucose utilization were investigated by using a tracer dose of 2-deoxy-D-[14C]glucose and a glucose metabolic ... cold-acclimation produced a significant increase in the glucose metabolic index of brown adipose tissue, but not of white ... insulin treatment of cold-acclimated rats resulted in a marked increase in the glucose metabolic index of brown adipose tissue ...
  http://www.biochemj.org/content/237/3/789
*  TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle | Diabetes
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem ... For example, whereas AS160 is expressed in multiple tissues at similar levels, TBC1D1 is several-fold higher in skeletal muscle ... Impairment of glucose transport in muscle could lead to increased fat accumulation in adipose tissue, and subsequent obesity. ... For the glucose treatment, mice were anesthetized and administered a 20% glucose bolus (1.0 g of glucose/kg of body wt). For ...
  http://diabetes.diabetesjournals.org/content/59/6/1358
*  Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation | JCB
Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues. Am. J. Physiol. 266:R914-R920. ... 2-deoxy-d-[1-3H]-glucose. 8-Br-cAMP. 8-bromoadenosine-cAMP. BAT. brown adipose tissue. GLUT4. glucose transporter 4. hMADS. ... depressing insulin-stimulated glucose uptake in adipose tissue and impairing glucose tolerance in vivo (Kumar et al., 2010). ... Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J. Clin. Invest. 123:215-223. doi:10.1172/JCI62308 ...
  http://jcb.rupress.org/content/207/3/365
*  JCI - Skeletal muscle inflammation and insulin resistance in obesity
... amounts of intermuscular adipose tissue and a greater acute insulin response to glucose in African American than in white ... Increased influx of fatty acids and inflammatory molecules from other tissues, particularly visceral adipose tissue, can also ... Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes. ... Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance ...
  https://www.jci.org/articles/view/88880
*  Decreased Transcription of ChREBP-α/β Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes...
Glucose stimulation of lipogenic enzyme gene expression in cultured white adipose tissue. A role for glucose 6-phosphate. J ... Insulin resistance associated with altered fat partitioning in liver and adipose tissues is a prediabetic condition in obese ... Altered adipose tissue glucose metabolism also is a cause of insulin resistance, and adipose-tissue glucose transporter type 4 ... is highly regulated by GLUT4 in adipose tissue and that ChREBP in adipose tissue is required for the improved glucose ...
  http://diabetes.diabetesjournals.org/content/62/3/837
*  Asprosin - Wikipedia
... white adipose) tissues that stimulates the liver to release glucose into the blood stream. In these tissues, asprosin is ... Asprosin is a protein hormone that has been found to be produced by white adipose tissue in mammals; it is transported to the ... "Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis". primary. Data in Brief. 8: 851- ... Glucose released by the liver into the blood stream is required for the normal function of the brain and other organs, as well ...
  https://en.wikipedia.org/wiki/Asprosin
*  CL-316,243, a β3-Specific Adrenoceptor Agonist, Enhances Insulin-Stimulated Glucose Disposal in Nonobese Rats | Diabetes
A particularly interesting observation was that the tissues responsible for this effect were white and brown adipose tissue, ... while interscapular brown adipose tissue (IBAT) weight doubled. Basal and insulin-stimulated whole-body glucose disposal rates ... This antiobesity effect is attributed to an increase in the thermogenic activity of brown adipose tissue (BAT). The ... Plasma glucose and insulin excursions in response to an oral glucose load (2 g/kg) on day 11 were unaltered. CL-316,243 ...
  http://diabetes.diabetesjournals.org/content/46/8/1257
*  Mechanistic target of rapamycin - Wikipedia
... white adipose tissue, and pancreatic beta cells is systemic glucose intolerance and insulin resistance in one or more tissues. ... with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain, and is ... Some studies have suggested that mTOR signaling may increase during aging, at least in specific tissues like adipose tissue, ... Baar EL, Carbajal KA, Ong IM, Lamming DW (February 2016). "Sex- and tissue-specific changes in mTOR signaling with age in C57BL ...
  https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin
*  Brown adipose tissue - Wikipedia
Brown adipose tissue (BAT) or brown fat makes up the adipose organ together with white adipose tissue (or white fat). Brown ... Additionally research has shown: Brown adipose tissue activation improves glucose homeostasis and insulin sensitivity in humans ... it is actually a collection of adipose tissues lying between the scapulae of rodentine mammals. Composed of brown adipose ... These adipocytes are found interspersed in white adipose tissue and are also named 'beige' or 'brite'. Brown adipose tissue is ...
  https://en.wikipedia.org/wiki/Brown_adipose_tissue
*  Glyceroneogenesis - Wikipedia
... brown and white adipose tissue are brown adipose tissues have higher activity in glyceroneogenesis than white adipose tissues ... However, when the glucose level of in the cell drops in situations like fasting, white adipose tissue generates glycerol 3- ... White adipose tissue, also known as white fat, is one of the 2 types of adipose tissue in mammals. White adipose tissue stores ... Brown adipose tissue is another type of adipose tissue which stores free fatty acids. Brown adipose tissue is especially ...
  https://en.wikipedia.org/wiki/Glyceroneogenesis
*  KLF15 - Wikipedia
The data indicates an example of cross talk between white adipose tissue and pancreatic β cells mediated through modulation of ... Klf15 concentrations are markedly reduced in failing human hearts and in human aortic aneurysm tissues. Mice deficient in Klf15 ... However, they also exhibit improved glucose tolerance as a result of enhanced insulin secretion. The enhancement of insulin ... in white adipose tissue and a consequent reduced level of oxidative stress. This is supported by the findings that restoration ...
  https://en.wikipedia.org/wiki/KLF15
*  Adipose tissue - Wikipedia
"Brown and white adipose tissues: Intrinsic differences in gene expression and response to cold exposure in mice". American ... This explains to a large degree why central obesity is a marker of impaired glucose tolerance and is an independent risk factor ... The two types of adipose tissue are white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which ... The layer of brown adipose tissue in this depot is often covered by a "frosting" of white adipose tissue; sometimes these two ...
  https://en.wikipedia.org/wiki/Adipose_tissue
*  FGF21 - Wikipedia
While FGF21 is expressed in numerous tissues, including liver, brown adipose tissue, white adipose tissue and pancreas, ... FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. ... FGF21 expression is also induced in white adipose tissue by PPAR-gamma, which may indicate it also regulates metabolism in the ... FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced ...
  https://en.wikipedia.org/wiki/FGF21