Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice -...
Treatment with H7 increased basal glucose uptake in white and brown adipose tissues (WAT and BAT respectively), the brain and ... Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice ... Treatment with H7 decreased triglyceride content and increased adipose triglyceride lipase content in white adipose tissue, ... Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice. ...http://eprints.nottingham.ac.uk/45718/
Involvement of non-esterified fatty acid oxidation in glucocorticoid-induced peripheral insulin resistance in vivo in rats |...
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem ... Glucose transporters in insulin sensitive tissues of lean and obese mice. Effects of the thermogenic agent BRL 26830A*. ... Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and ... Muscle glucocorticoids insulin resistance glucose transport glucose transporter glucose fatty-acid cycle lipid oxidation ...https://link.springer.com/article/10.1007/BF02374470
JCI - Hypothalamic inflammation in obesity and metabolic disease
... were sufficient to impair the ability of hypothalamic insulin to suppress white adipose tissue lipolysis and hepatic glucose ... but not in other tissues, leads to protection against insulin resistance, hyperinsulinemia, and glucose intolerance (56, 57). ... Prolonged HFD feeding leads to metabolic inflammation in peripheral organs such as white adipose tissue, liver, and skeletal ... Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech. 2012;5(5):583-587.. View this article via: PubMed ...https://jci.org/articles/view/88878
Robert Farese | Harvard Catalyst Profiles | Harvard Catalyst
Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA: ... Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null ... Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking ... diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 2002 Nov; 51(11):3189-95. PMID: 12401709. ...https://connects.catalyst.harvard.edu/Profiles/display/Person/124877
Reduced vascular nitric oxide-cGMP signaling contributes to adipose tissue inflammation during high-fat feeding. - Semantic...
Expression of proinflammatory cytokines was increased in adipose tissue of eNOS-/- mice. Conversely, enhancement of signaling ... increased cGMP signaling can block adipose tissue inflammation induced by HF feeding. METHODS AND RESULTS Relative to mice fed ... whether reduced NO contributes to adipose tissue inflammation is unknown. We sought to determine whether (1) obesity induced by ... diet reduces endothelial nitric oxide signaling in adipose tissue, (2) reduced endothelial nitric oxide synthase (eNOS) ...https://www.semanticscholar.org/paper/Reduced-vascular-nitric-oxide-cGMP-signaling-to-Handa-Tateya/cc5b848d66de045bb816c9b80a759a7f6296ac61
Weiner J et al. Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice. Sci ... Mössenböck K et al. Browning of white adipose tissue uncouples glucose uptake from insulin signaling. PLoS One 9:e110428 (2014 ... a phenotype distinguishing brown adipocytes from interscapular brown adipose tissue and white adipose tissue. J Biol Chem 290: ... Bi P et al. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med 20:911-8 ( ...http://www.abcam.cn/ucp1-antibody-ab23841-references.html
Marine Drugs | Free Full-Text | Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids | HTML
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose ... In this pathology, phytanic acid accumulates in serum and other tissues due to a defect of the metabolic pathway for phytanic ... Dietary diacylglycerol prevents high-fat diet-induced lipid accumulation in rat liver and abdominal adipose tissue. Lipids 2004 ... Reproduction, blood, and tissue studies. Am. J. Vet. Res. 1954, 15, 643-646. [Google Scholar] ...http://www.mdpi.com/1660-3397/11/9/3425/htm
Uncoupling Protein 1 Is Necessary for Norepinephrine-Induced Glucose Utilization in Brown Adipose Tissue | Diabetes
In BAT, as in white adipose tissue (WAT) and other insulin-sensitive tissues, glucose utilization is activated by insulin. ... WAT, white adipose tissue. Brown adipose tissue (BAT) is a tissue specified for metabolic heat production, at least in small ... Liu X, Perusse F, Bukowiecki LJ: Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues. ... deoxyglucose in vivo by brown adipose tissue and other glucose-utilising tissues of the mouse. FEBS Lett188 :257 -261,1985. ...http://diabetes.diabetesjournals.org/content/54/5/1385
Effect of Angiotensin II Type 2 Receptor-Interacting Protein on Adipose Tissue Function via Modulation of Macrophage...
Glucose uptake and cytokines levels in white adipose tissue and serum levels of TNF-α and adiponectin in each chimeric mouse. ... CCR2− monocytes accumulate in noninflamed tissues and are termed "resident", while CCR2+ monocytes are potent inflammatory ... Glucose Uptake in Adipose Tissue. Glucose uptake in WAT was measured as the rate constant of 2-[3H]deoxy-d-glucose (2-[3H]DG) ... Inflammation in white adipose tissue (WAT) is known to contribute to the pathogenesis of insulin resistance and type 2 diabetes ...http://pubmedcentralcanada.ca/pmcc/articles/PMC3614946/?lang=en-ca
anti-Stanniocalcin 1 Primary Antibodies
C from glucose into lipids in the white retroperitoneal adipose tissue (WRAT). STC1 is one of the hormonal factors that control ... This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or ... storage in brown adipose tissue (BAT (show BAAT Antibodies)). The decrease of TG capacity synthesis from glucose by hSTC-1 ... Glycolysis from glucose is regulated by hSTC-1, decreasing the adequate supply of glycerol-3-phosphate (G3P) needed for fatty ...https://www.antibodies-online.com/hormone-activity-pathway-42/stanniocalcin-1-antibody-6772/
Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice | Microbiome | Full Text
c White adipose tissue (WAT) weight. d Glucose tolerance test (GTT). e GTT area under curve (AUC). f Homeostatic model ... and white adipose tissues accumulation) (Additional file 1: Figure S1a-c). Noticeably, although there were no differences in ... and white adipose tissue (WAT) weight (c), glucose tolerance test curves with area under the curve (AUC) (d, e) and insulin ... The mice were then euthanized and white adipose tissue (WAT), which includes visceral (vWAT), subcutaneous (sWAT), and ...https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0587-0
JCI - FGF19 action in the brain induces insulin-independent glucose lowering
Although activation of FGFR1 in peripheral tissues, such as brown and white adipose tissue, may contribute to glucose lowering ... FGFR1 activation exerts glucose-lowering effects in liver as well as both brown and white adipose tissue (11), and the ... A and C) Glucose tolerance (0.5 g/kg) and (B and D) the integrated area under the glucose curve (AUCglucose) in leptin- ... i.p. glucose tolerance testing. i.p. glucose tolerance tests (ipgtt; 30% d-glucose; 0.5 or 1.5 g/kg) were conducted in 5-hour ...https://www.jci.org/articles/view/70710
Insulin-stimulated glucose metabolic index (. ) in red quadriceps (A) and white adipose tissue (B) during hyperinsulinemic ... Estimation of individual muscle glucose metabolic index.. Frozen tissues (50-100 mg) were homogenized in 10-20 vol of ice-cold ... and white quadriceps muscle, white adipose tissue (epididymal fat pads), liver, heart, and interscapular brown adipose tissue ... muscle and white adipose tissue insulin-mediated glucose uptake was enhanced, as indicated by . Significant enhancement of net ...http://ajpendo.physiology.org/content/273/5/E859
Most recent papers with the keyword stress hormones; diabetes | Read by QxMD
Irisin induces browning of the white adipose tissue and has been shown to regulate glucose and lipid homeostasis. Keeping its ... inducing a neovascularization process that finally increases flow in ischemic tissues... ... ABA stimulates insulin independent glucose uptake in myocytes and adipocytes via LANCL2 binding in vitro, improves glucose ... The emerging role of the ABA/LANCL2 system in glucose and lipid metabolism makes it an attractive target for pharmacological ...https://www.readbyqxmd.com/keyword/76551
Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis | Signal Transduction...
Brown Adipose Tissue Improves Whole Body Glucose Homeostasis and Insulin Sensitivity in Humans. . Diabetes 2014; 63: 4089-4099. ... catecholamine released from sympathetic nerves are considered major stimulating factors for browning of white adipose tissues. ... Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis. *Aung Than1. *, ... The excess white adipose tissue (WAT) that characterizes obesity is a major risk factor for the development of many diseases, ...https://www.nature.com/articles/sigtrans201722?error=cookies_not_supported&code=e9eb300c-2774-48c4-92a8-0f416b0c1191
JCI Insight - Welcome
... white adipose tissue expansion, and impaired glucose homeostasis. Pharmacological blockade of SGK1 in high-fat diet-fed Akt3- ... Membrane lipid composition is central to the highly specialized functions of neurological tissues. In the retina, abnormal ... NK cells are a subset of innate effector cells, which play an important role in the regulation of adipose tissue and antitumor ... We directly tested this hypothesis using tissue-specific ChREBP deletion. HFrD increased adiposity and impaired glucose ...https://insight.jci.org/tags/28?content=articles&page=1
Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism | Diabetes
Gender- and site-related effects on lipolytic capacity of rat white adipose tissue. Cell Mol Life Sci 60: 1982- 1989, 2003. ... Direct effects of sex steroid hormones on adipose tissues and obesity. Obes Rev 5: 197- 216, 2004. ... Similar results were observed in adipose tissue weight. Male PG adipose tissue was double the size of female PG adipose tissue ... 0.47 ± 0.03 g, respectively; P , 0.05). In contrast, male SC adipose tissue was only 25% bigger than female SC adipose tissue ( ...http://diabetes.diabetesjournals.org/content/58/4/803
JCI - Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically...
... and white adipose tissue, and systemic glucose tolerance and insulin sensitivity were restored in ob/ob mice after a 7-day ... targeting SCD1 in both liver and adipose tissues) also prevents many of the HF/HC-diet metabolic complications, including ... and lipolysis in white adipose tissue is not suppressed. Therefore peripheral fats stored in adipose tissue flow to the liver ... It should also be noted that SREBP-1c expression was not only inhibited in liver but also in white adipose tissue of ob/ob mice ...https://www.jci.org/articles/view/34275
Current Advances in the Biochemical and Physiological Aspects of the Treatment of Type 2 Diabetes Mellitus with...
... mainly those genes involved in glucose homeostasis and adipogenesis, specifically within white adipose tissue (WAT) by inducing ... PPAR β/δ is expressed in all kinds of tissues and has a crucial role in fatty acid oxidation, mainly in skeletal muscle, liver ... and carotenoids in preadipocytes obtained from bovine white adipose tissue," Journal of Animal Science, vol. 88, no. 5, pp. ... I. J. Lodhi, L. Yin, A. P. L. Jensen-Urstad et al., "Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ ...https://www.hindawi.com/journals/ppar/2016/7614270/
Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses...
Background The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. ... a pivotal transcriptional mediator of glucose-related stimulation of lipogenic genes, were elevated in the adipose tissue of ... Subcutaneous adipose tissues sampled from 4 fetal genotypes on d 90 or d 110 of development were analyzed (n = 6 per age and ... Lipid content in adipose tissue. Triglycerides content in subcutaneous fetal adipose tissue was determined using the method ...https://link.springer.com/article/10.1186/s40104-018-0244-2
JCI - Interplay between FGF21 and insulin action in the liver regulates metabolism
... but rather to increased glucose metabolism in brown adipose tissue (BAT), browning of white adipose tissue (WAT), and ... FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26(3):271-281.. View ... Samples of liver, skeletal muscle, perigonadal adipose tissue, s.c. adipose tissue, and iBAT were taken at the end of the ... adipose tissue, and may thereby contribute to an overall improvement in blood glucose levels (not shown). Increased glucose ...https://www.jci.org/articles/view/67353
Asprosin - Wikipedia
... white adipose) tissues that stimulates the liver to release glucose into the blood stream. In these tissues, asprosin is ... Asprosin is a protein hormone that has been found to be produced by white adipose tissue in mammals; it is transported to the ... "Datasets of genes coexpressed with FBN1 in mouse adipose tissue and during human adipogenesis". primary. Data in Brief. 8: 851- ... Glucose released by the liver into the blood stream is required for the normal function of the brain and other organs, as well ...https://en.wikipedia.org/wiki/Asprosin
Mechanistic target of rapamycin - Wikipedia
... white adipose tissue, and pancreatic beta cells is systemic glucose intolerance and insulin resistance in one or more tissues. ... with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain, and is ... Some studies have suggested that mTOR signaling may increase during aging, at least in specific tissues like adipose tissue, ... Baar EL, Carbajal KA, Ong IM, Lamming DW (February 2016). "Sex- and tissue-specific changes in mTOR signaling with age in C57BL ...https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin
Glyceroneogenesis - Wikipedia
... brown and white adipose tissue are brown adipose tissues have higher activity in glyceroneogenesis than white adipose tissues ... However, when the glucose level of in the cell drops in situations like fasting, white adipose tissue generates glycerol 3- ... White adipose tissue, also known as white fat, is one of the 2 types of adipose tissue in mammals. White adipose tissue stores ... Brown adipose tissue is another type of adipose tissue which stores free fatty acids. Brown adipose tissue is especially ...https://en.wikipedia.org/wiki/Glyceroneogenesis
KLF15 - Wikipedia
The data indicates an example of cross talk between white adipose tissue and pancreatic β cells mediated through modulation of ... Klf15 concentrations are markedly reduced in failing human hearts and in human aortic aneurysm tissues. Mice deficient in Klf15 ... However, they also exhibit improved glucose tolerance as a result of enhanced insulin secretion. The enhancement of insulin ... in white adipose tissue and a consequent reduced level of oxidative stress. This is supported by the findings that restoration ...https://en.wikipedia.org/wiki/KLF15