*  Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from...
glucose metabolism. *fructose-2,6-bisphosphate. the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase ( ... glucose-6-phosphate (glucose 6-P), and fructose-2,6-bisphosphate (fructose-2,6-P2). Rates of glucose metabolism (A) and ... Payne VA, Arden C, Wu C, Lange AJ, Agius L. Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the ... Pilkis SJ, Claus TH, Kurland IJ, Lange AJ. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. ...
  http://ajpregu.physiology.org/content/293/2/R618
*  Fructose 2,6-bisphosphate - Wikipedia
Fru-2,6-P2 is synthesized and broken down by the bifunctional enzyme phosphofructokinase 2/fructose-2,6-bisphosphatase (PFK-2/ ... "Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatase:glucokinase ... Fructose 2,6-bisphosphatase Fructose 1,6-bisphosphate Lange AJ. "fructose-2,6-bisphosphate". University of Minnesota. Archived ... 6-bisphosphatase: insights into autoregulation of a bifunctional enzyme". Protein Sci. 4 (6): 1023-37. doi:10.1002/pro. ...
  https://en.wikipedia.org/wiki/Fructose_2,6-bisphosphate
*  PFKFB4 - Wikipedia
The bifunctional 6-phosphofructo-2-kinase (EC 2.7.1.105)/fructose-2,6-bisphosphatase (EC 3.1.3.46) (PFKFB) regulates the steady ... concentration of fructose 2,6-bisphosphate, an activator of a key regulatory enzyme of glycolysis, phosphofructokinase. Latest ... Almut Schulze, said: "Our study suggests that PFKFB4 acts to fine-tune the process by which cells convert glucose into energy. ... "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta ...
  https://en.wikipedia.org/wiki/PFKFB4
*  Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity | Journal of the American...
... limiting enzyme of glycolysis.12, 13 The bifunctional enzyme, 6‐phosphofructo‐2‐kinase/fructose 2,6‐bisphosphatase (PFK‐2), ... Ery‐4‐P indicates erythrose 4‐phosphate; Fru‐1,6‐P2, fructose 1,6‐bisphosphate; Fru‐6‐P, fructose 6‐phosphate; Glu‐1‐P, glucose ... 6‐Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase: head‐to‐head with a bifunctional enzyme that controls glycolysis. Biochem ... AKT indicates protein kinase B; Fru‐1,6‐P, fructose 1,6‐bisphosphate; Fru‐6‐P, fructose 6‐phosphate; Glu‐6‐P, glucose 6‐ ...
  http://jaha.ahajournals.org/content/6/12/e007159
*  Phosphofructokinase 2 - Wikipedia
"The crystal structure of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase reveals distinct domain ... On the other hand, when the glucose level increases, the level of fructose 6-phosphate (F6P) subsequently rises and the ... Phosphofructokinase 2 (PFK2) or fructose bisphosphatase 2 (FBPase2), is an enzyme responsible for regulating the rates of ... Van Schaftingen E, Hers HG (August 1981). "Phosphofructokinase 2: the enzyme that forms fructose 2,6-bisphosphate from fructose ...
  https://en.wikipedia.org/wiki/Phosphofructokinase_2
*  Frontiers | Novel, Deep-Branching Heterotrophic Bacterial Populations Recovered from Thermal Spring Metagenomes | Microbiology
C. nevadense) indicating the potential to oxidize glucose. The presence of an archaeal-like fructose 1,6-bisphosphatase (fbp) ... also indicated that gluconeogenesis may occur via a bacterial variant of the bifunctional enzyme that is conserved in Archaea ... 6-phosphofructokinase I; fba/p, fructose bisphosphate aldolase/phosphatase; tpi, triose phosphate isomerase; gapA, ... Say, R. F., and Fuchs, G. (2010). Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme. ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.00304/full
*  Metabolic processes of Methanococcus maripaludis and potential applications
... and fructose-bisphosphatase (FBP)]. In other words, all the steps leading to glucose-6-phosphate from pyruvate are reversible ... ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus ... glucose-6-phosphate to glucose-1-phosphate via phosphoglucomutase (MMP1372), 2) glucose-1-phosphate to UDP-glucose via UTP- ... via glucose phosphomutase, glucose-6-phosphate isomerase, and fructose-bisphosphate aldolase) and triose phosphate conversions ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4902934/
*  Tumor hypoxia - Wikipedia
6-Phosphofructo-2-kinases/fructose 2,6-bisphosphatases (PFKFBs) belong to a family of bifunctional ATP-dependent enzymes ... is the first enzyme in the glycolytic pathway converting glucose to glucose-6-phosphate through an ATP-dependent ... Along with phospho-fructokinase 1, pyruvate kinase is also allosterically activated by fructose-2,6-bisphosphate. In cancer ... HIF-1-induced expression of these enzymes (PFK-2/FBPase-2) subsequently alters the balance of fructose-2,6-bisphosphate which ...
  https://en.wikipedia.org/wiki/Tumor_hypoxia
*  Glucokinase - Wikipedia
... "bifunctional enzyme" (phosphofructokinase-2/fructose-2,6-bisphosphatase), which also plays a role in the regulation of ... Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in ... Phosphorylation of glucose to glucose-6-phosphate by GK facilitates storage of glucose as glycogen and disposal by glycolysis. ... of the curve describing enzyme activity as a function of glucose concentration at about 4 mmol/L. In other words, at a glucose ...
  https://en.wikipedia.org/wiki/Glucokinase
*  Glucagon (medication) - Wikipedia
This regulates the reaction catalyzing fructose-2,6-bisphosphate (a potent activator of phosphofructokinase-1, the enzyme that ... will also phosphorylate a single serine residue of the bifunctional polypeptide chain containing both the enzymes fructose-2,6- ... bisphosphatase and phosphofructokinase-2. This covalent phosphorylation initiated by glucagon activates the former and inhibits ... Phosphorylase a is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. Additionally, the ...
  https://en.wikipedia.org/wiki/Glucagon_(medication)
*  Glucagon - Wikipedia
This regulates the reaction catalyzing fructose-2,6-bisphosphate (a potent activator of phosphofructokinase-1, the enzyme that ... will also phosphorylate a single serine residue of the bifunctional polypeptide chain containing both the enzymes fructose-2,6- ... High blood-glucose levels, on the other hand, stimulate the release of insulin. Insulin allows glucose to be taken up and used ... bisphosphatase and phosphofructokinase-2. This covalent phosphorylation initiated by glucagon activates the former and inhibits ...
  https://en.wikipedia.org/wiki/Glucagon
*  Plus it
2014). The Pfkfb1 gene produces a class of "bifunctional" enzymes that maintain levels of fructose‐2,6‐bisphosphatase (F‐2,6‐BP ... 2001). Fructose‐2,6‐BP is the most powerful activator of the Pfk enzymes (Pilkis et al. 1995), which regulate glucose through ... 2014). For example, phosphofructokinase, liver, type B (Pfkl - P = 0.04) was a target gene of miR‐466b‐3p, and 6‐phosphofructo‐ ... 6‐Phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 64:799-835. ...
  http://physreports.physiology.org/content/3/7/e12469
*  Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in...
... glucose phosphate isomerase, 2 - phosphofructokinase, 3 - fructose bisphosphate aldolase, 4 - triose phosphate isomerase, 5 - ... Genes for sugar metabolism are extensive, including those encoding enzymes involved in the utilization of fructose, galactose, ... fructose-1,6-bisphosphatase I, 11 - pyruvate carboxylase, 12 - PEP carboxykinase, 13 - RE-citrate synthase, 14 - aconitate ... bifunctional methenyltetrahydrofolate cyclohydrolase/methelynetetrahydrofolate dehydrogenase, 23 - methylenetetrahydrofolate ...
  https://0-microbiomejournal-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/2049-2618-1-22
*  Gluconeogenesis - Wikipedia
... and pyruvate kinase enzymes of glycolysis are replaced with glucose-6-phosphatase, fructose-1,6-bisphosphatase, and PEP ... phosphofructokinase 1 converts F6P and ATP to F1,6BP and ADP). This is also the rate-limiting step of gluconeogenesis. Glucose- ... Liu F, Thatcher JD, Barral JM, Epstein HF (1995). "Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a ... However, fructose 1,6-bisphosphatase converts fructose 1,6-bisphosphate to fructose 6-phosphate, using one water molecule and ...
  https://en.wikipedia.org/wiki/Gluconeogenesis
*  Methods and compositions for producing solvents - Patent application
Fructose bisphosphatase 3818 Propionate-CoA transferase 3820 Crotonase 3821 Fructose-1,6-bisphosphate aldolase 3828 ... Enzymes of particular interest include alcohol dehydrogenase, phosphofructokinase, glucokinase, galactokinase, aldehyde ... Malic enzyme 2425 Predicted aldo/keto reductase, YTBE/YVGN B. subtilis ortholog 2496 Phosphoenolpyruvate synthase 2500 Glucose ... tyrosine-phosphatase family enzyme 1422 Spore coat peptide assembly protein CotJB 1434 Transketolase 1450 Bifunctional D- ...
  http://www.patentsencyclopedia.com/app/20090047718
*  Fructose | definition of fructose by Medical dictionary
... fructose explanation free. What is fructose? Meaning of fructose medical term. What does fructose mean? ... Looking for online definition of fructose in the Medical Dictionary? ... fructose 2,6-bisphosphatase. part of multifunctional enzyme that regulates the concentration of the key positive allosteric ... Fructose is sweeter than glucose, but has the same energy value. It is readily absorbed. Fructose provides direct energy for ...
  http://medical-dictionary.thefreedictionary.com/fructose
*  Glucokinase regulatory protein - Wikipedia
"Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase ... where much of it associates with the bifunctional enzyme. In hepatocytes of various mammals, GKRP has always been found in ... GKRP competes with glucose to bind with GK, but inactivates it when bound. In conditions of low glucose, GKRP then pulls the GK ... Fructose and sorbitol can both be converted to fructose-1-phosphate, which inhibits GKRP and frees GK. Fructose 6-phosphate ...
  https://en.wikipedia.org/wiki/Glucokinase_regulatory_protein
*  The big picture: exploring the metabolic cross-talk in cancer | Disease Models & Mechanisms
One example for this is the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB3), a bifunctional enzyme that generates ... the gluconeogenic enzyme fructose bisphosphatase 1, which is frequently depleted in clear cell renal cancer, binds to and ... such as the binding of the glycolytic enzyme phosphofructokinase 1 to the transcription factor TEAD, which leads to the ... instead of fully oxidising glucose to CO2, switch to aerobic glycolysis and ferment glucose to lactate (Warburg, 1924). ...
  http://dmm.biologists.org/content/11/8/dmm036673?utm_source=Editorial&utm_campaign=DMM_Snippet&utm_content=dmm036673
*  glucose 6-phosphate
On the other hand, the binding of fructose 2,6-bisphosphate to fructose 1,6-bisphosphatase inhibits the enzyme, even in the ... Phosphofructokinase 1 or PFK-1 (EC 2.7.1.11) catalyzes the phosphorylation of fructose 6-phosphate at C-1 to form fructose 1,6- ... 6-bisphosphatase or FBPasi-2 (EC 3.1.3.46). These two enzymatic activities are located on a single bifunctional enzyme or ... Glucose 6-phosphatase. Unlike pyruvate carboxylase and fructose-1,6-bisphosphatase, the catalytic subunit of glucose-6- ...
  http://www.tuscany-diet.net/tag/glucose-6-phosphate/
*  Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells | JEM
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis. Biochem ... 2 µl glucose probe, and 2 µl glucose enzyme mix. After 30 min of incubation, absorbance was measured at 570 nm. Glucose ... 6BP are essentially set by the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB), which ... Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer. Exp. Mol. Pathol. 86:174- ...
  http://jem.rupress.org/content/early/2013/09/11/jem.20130252
*  PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2), Authors: Ana Rodríguez-García, Pere Fontova, Helga Simon, Anna Manzano ... 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.. ... Regulation of phosphofructokinase in perfused rat heart. Requirement for fructose 2,6-bisphosphate and a covalent modification. ... 6-bisphosphate metabolic process fructose 2,6-bisphosphate metabolic process glucose catabolic process lactate metabolic ...
  http://atlasgeneticsoncology.org/Genes/PFKFB2ID52100ch1q32.html
*  When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation | Molecular...
Mazon MJ, Gancedo JM, Gancedo C (1982) Phosphorylation and inactivation of yeast fructosebisphosphatase in vivo by glucose and ... where glucose triggers the specific inactivation and proteolysis of many proteins, including the gluconeogenic enzymes fructose ... limiting phosphofructokinase activity (Theobald et al, 1997). However, the constant increase of the F1,6‐P2/F6P concentration ... encoding a bifunctional IMP cyclohydrolase-phosphoribosyl‐amino imidazole carboxamide formyltransferase, was expressed ...
  http://msb.embopress.org/content/2/1/49
*  SAUSA300 1490 - AureoWiki
putative fructose-1,6-bisphosphatase [1] (data from MRSA252). SAUSA300_2484. hydroxymethylglutaryl-CoA synthase [1] (data from ... bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase [1] (data from ... glucose-6-phosphate isomerase [1] (data from MRSA252). SAUSA300_0757. (pgk). phosphoglycerate kinase [1] (data from MRSA252). ... 6-phosphofructokinase [1] (data from MRSA252). SAUSA300_0220. (pflB). formate acetyltransferase [1] (data from MRSA252). ...
  http://aureowiki.med.uni-greifswald.de/SAUSA300_1490
*  Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity | Life Science Alliance
1994) Effect of thioltransferase on the cystamine-activated fructose 1,6-bisphosphatase by its redox regulation. Biochem Mol ... phosphofructokinase, glucose-3-phosphate dehydrogenase, and pyruvate kinase) was reversibly inhibited by cystamine thiolation, ... A master reaction mix containing 46 μl lactate assay buffer, 2 μl lactate enzyme mix, and 2 μl lactate probe was added on 50 μl ... and the bifunctional CoASy in the mitochondria (the subcellular location of PPCS and PPCDC remains to be confirmed, but ...
  http://www.life-science-alliance.org/content/1/4/e201800073