*  Treat-to-target Trial of Basal Insulin in Post-transplant Hyperglycemia - Full Text View - ClinicalTrials.gov
Glucose Metabolism Disorders. Metabolic Diseases. Insulin, Globin Zinc. Isophane insulin, beef. Insulin. Insulin, Long-Acting. ... capillary blood glucose profile in patients treated with long-acting insulin and in the control group, as evaluated by the ... To assess the amount of (long-acting) insulin (in IU) needed in order to obtain a target capillary blood glucose level in the ... In group No.1 (study arm 1 (=A)), patients will be treated with long-acting insulin (Insulatard) as soon as the glucose-level ...
  https://clinicaltrials.gov/ct2/show/study/NCT00830297?show_desc=Y
*  Long-Acting Insulin Analogs Versus Insulin Pump Therapy for the Treatment of Type 1 and Type 2 Diabetes | Diabetes Care
The prebreakfast increase in blood glucose concentration that occurs in many patients treated by isophane insulin-based MDI can ... insulin detemir and insulin aspart) versus traditional human insulins (NPH and regular human insulin) in basal-bolus therapy ... A 16-week comparison of the novel insulin analog insulin glargine (HOE 901) and NPH human insulin used with insulin lispro in ... 44) comparing CSII with aspart insulin versus MDI with basal NPH and mealtime aspart insulin reported a similar effectiveness ...
  http://care.diabetesjournals.org/content/31/Supplement_2/S140
*  Diabetic Kidney Disease: Hyperglycemia Management - ONA
Some patients may achieve goal glucose control with the combination of basal insulin and oral agents. Insulin may also be ... The available intermediate-acting insulin is isophane, or NPH (neutral protamine Hagedorn). It has an onset of action at 2 to 4 ... The two newer very long-acting basal insulins, insulin glargine U300 and insulin degludec have even less intra- and ... With the availability of insulin analogs, glargine has surpassed the use of NPH as a basal insulin. It can be given once daily ...
  https://www.oncologynurseadvisor.com/nephrology-hypertension/diabetic-kidney-disease-hyperglycemia-management/article/616119/
*  Drugs and Treatment for Type 2 Diabetes | LIVESTRONG.COM
Insulin comes in a variety of forms with different durations of action:. *Long-acting. insulins give baseline (or basal) ... insulins, or regular insulin (lispro, aspart, glulisine), are given in boluses. prior to meals to lower the post-meal glucose ... neutral protamine hagedorn, or insulin human isophane) is an. intermediate-acting insulin and is administered twice a day. ... It decreases liver glucose production and increases insulin sensitivity. Since it improves the body's use of insulin, overall ...
  https://www.livestrong.com/article/1011731-drugs-treatment-type-2-diabetes/
*  Continuous Subcutaneous Insulin Infusion at 25 Years | Diabetes Care
... lispro versus intensified injections using lispro and isophane insulin showed lower glycated hemoglobin and mean blood glucose ... with multiple daily insulin doses given in a basal-bolus mode (with or without an insulin pen), with adjustment according to ... The insulin of choice for CSII is now a monomeric insulin such as lispro (Humalog; Eli Lilly, Indianapolis, IN). Insulin aspart ... insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin ...
  http://care.diabetesjournals.org/content/25/3/593
*  Hypoglycaemia Causes & Risk Factors | IHSG Online
Dose of basal insulin too high. *Too much rapid-acting insulin to correct high glucose, particularly at bedtime, or to cover ... NPH insulin (isophane) in the evening. References. *UK Hypoglycaemia Study Group. Risk of hypoglycaemia in types 1 and 2 ... While this is a risk factor, it is important to note that hypoglycaemia can occur at any level of glucose control. ... Hypoglycaemia in diabetes typically occurs as a result of medical treatment, particularly with insulin, sulfonylureas (SUs) or ...
  http://ihsgonline.com/understanding-hypoglycaemia/causes-and-risk-factors/
*  Insulin (medication) - Wikipedia
No basal insulin is given, usually resulting in an elevated blood glucose each morning, which is then chased throughout the day ... "Insulin, isophane". International Drug Price Indicator Guide. Retrieved 8 December 2016. Jones K (March 2000). "Insulin coma ... Nasrallah SN, Reynolds LR (1 April 2012). "Insulin Degludec, The New Generation Basal Insulin or Just another Basal Insulin?". ... basal insulin), as well as short-acting insulin to cover meals (bolus insulin). Maintaining the basal rate and the bolus rate ...
  https://en.wikipedia.org/wiki/Insulin_(medication)
*  Free Pharmacology Flashcards about Endocrine Pharm
MOA: increased insulin sensitivity in target tissues; Liver: â glucose output. Muscle: â glucose uptake. Adipose: â glucose ... Isophane basally and one of the rapid actings to cover meals. Shortest duration of insulin stability at room temperature. 10 ... 15 Basal at the beginning of the day and 15/3 for each meal. ... Inadequate insulin to transfer glucose and amino acids into ... Surrogate for insulin?. C peptide. 2 things insulin does. 1) Inhibits hepatic glucose production 2) Stimulates hepatic, muscle ...
  https://www.studystack.com/flashcard-1889219
*  Exubera (Insulin Human [rDNA origin]): Side Effects, Interactions, Warning, Dosage & Uses
Insulin Human [rDNA origin]) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... The primary activity of insulin is regulation of glucose metabolism. Insulin lowers blood glucose concentrations by stimulating ... In both treatment arms, NPH human insulin was administered BID (in the morning and at bedtime) as the basal insulin. In this ... insulin (human insulin isophane suspension) (n = 132). In this study, the mean age was 38.2 years (range: 20-64) and 52% of the ...
  https://www.rxlist.com/exubera-drug.htm
*  PPT - INSULIN AND ORAL HYPOGLYCEMICS PowerPoint presentation | free to view - id: 559c9-ODZkY
Describe the metabolic effects of insulin and the major ... 2. Understand the physiology of circulating insulin, C-peptide and ... treatment with a basal insulin given before sleep, adjusting the dose to achieve a mean fasting glucose level of approximately ... Insulin Preparations - NPH Insulin - intermediate. NPH insulin - Neutral Protamine Hagedorn / Isophane - insulin treated with ... basal level of insulin 50. Insulin Preparations - Glargine Insulin. Long-Acting Insulin. Glargine Insulin (Lantus) - pH 4 ...
  http://www.powershow.com/view/559c9-ODZkY/INSULIN_AND_ORAL_HYPOGLYCEMICS_powerpoint_ppt_presentation
*  Actraphane | definition of Actraphane by Medical dictionary
Isophane Insulin injections: Insulatard, Humulin, Hypurin Bovine Isophane, Isuman Basal and Pork Insulatard. Insulin Zinc ... insulin:glucose ratio. a comparison of simultaneously obtained blood levels of immunoreactive insulin and plasma glucose. An ... NPH insulin isophane i. suspension.. prompt insulin zinc suspension a rapid-acting insulin consisting of porcine insulin with ... insulin injection site. See: site. insulin isophane suspension. Intermediate-acting insulin with onset in 1 2 to 1 hr and a ...
  https://medical-dictionary.thefreedictionary.com/Actraphane
*  Humulin 70-30 (Insulin (Human Recombinant)): Side Effects, Interactions, Warning, Dosage & Uses
Insulin (Human Recombinant)) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... human insulin isophane suspension and 30% human insulin injection [rDNA origin]) is a human insulin suspension. Human insulin ... is highest when the glucose lowering effect of the insulin is maximal. As with all insulin preparations, the glucose lowering ... Independent adjustment of the basal or prandial dose is not possible when using a premixed insulin. ...
  https://www.rxlist.com/humulin-70-30-drug.htm
*  Sensor-Augmented Insulin-Pump Therapy in New-onset Diabetes After Transplantation - Full Text View - ClinicalTrials.gov
Glucose Metabolism Disorders. Metabolic Diseases. Insulin, Globin Zinc. Isophane insulin, beef. Insulin. Insulin Lispro. ... Active Comparator: Basal insulin NPH insulin titration regimen, as specified in the IPT-NODAT study ... Insulin, Short-Acting. Isophane Insulin, Human. Insulin, Isophane. Hypoglycemic Agents. Physiological Effects of Drugs. ... Drug: Insulin lispro, Humalog (Eli Lilly) in insulin pump Drug: Human insulin isophane, Humulin N (Eli Lilly) Other: Standard ...
  https://clinicaltrials.gov/ct2/show/NCT01680185?recr=Open&intr=%22Insulin%22&rank=4
*  Health Care Tips
The action of insulin drugs also varies from day to day. Intermediate acting insulin cover the requirements of basal insulin ... One such a kind of insulin is Intermediate insulin also referred as NPH (Neutral Protamine Hagedorn) or Isophane. They help to ... Recombinant human insulin effectively regulates blood glucose level in type 2 diabetes. The main ingredient of this drug ... Intermediate acting insulin and its drugs October 20th, 2017 , Author: admin There are many types of insulin drugs that treat ...
  http://christdot.org/?option=com_content&view=article&id=1242:more-catholic-than-the-pope&catid=6:catholicism&Itemid=74
*  Insulin analog - Wikipedia
Zinc combinations of insulin are used for slow release of basal insulin. Basal insulin support is required throughout the day ... "Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus". Cochrane Database of ... Glucose Control - Lantus receives FDA approval for flexible administration Analog Insulin. ... intended to supply the basal level of insulin during the day and particularly at nighttime (basal insulin). The first insulin ...
  https://en.wikipedia.org/wiki/Insulin_analog
*  Diabetes in dogs - Wikipedia
The body uses glucose for energy. Without insulin, glucose is unable to enter the cells where it will be used for this and ... The general form of this treatment is an intermediate-acting basal insulin with a regimen of food and insulin every 12 hours, ... The most commonly used intermediate-acting insulins are NPH, also referred to as isophane, or Caninsulin, also known as ... Eating a partial meal means a reduction in insulin dose. Basal and reduced insulin dose information should be part of initial ...
  https://en.wikipedia.org/wiki/Diabetes_in_dogs
*  Isophane insulin suspension | definition of isophane insulin suspension by Medical dictionary
Looking for online definition of isophane insulin suspension in the Medical Dictionary? isophane insulin suspension explanation free. What is isophane insulin suspension? Meaning of isophane insulin suspension medical term. What does isophane insulin suspension mean?
  http://medical-dictionary.thefreedictionary.com/isophane+insulin+suspension
*  Efficacy and Safety of Insulin Glargine Versus. Neutral Protamine Hagedorn (NPH) Insulin in Children With Type 1 Diabetes Above...
Primary Objective:. 6 To assess the efficacy of insulin glargine given once daily (QD) on glycosylated hemoglobin (HbA1c) levels over a period of 24 weeks in children with type 1 diabetes mellitus (T1DM) aged at least 6 years to less than 18 years.. Secondary Objectives:. ...
  https://clinicaltrials.gov/ct2/show/record/NCT01223131
*  Comparison of Lantus and Neutral Protamine Hagedorn (NPH) Insulin in the Dawn Phenomenon - Full Text View - ClinicalTrials.gov
Title: COMPARISON of LANTUS and NPH INSULIN IN THE DAWN PHENOMENON. I. Background and Significance. Diabetes mellitus affects greater than 6% of the population, with type 2 more prevalent than type 1. For individuals with type 1 diabetes, the challenge has been to replicate insulin secretion of the healthy pancreas to maintain blood glucose as close to the non-diabetic range as possible. Insulin regimes using insulins with varied activity profiles (multiple daily injections or MDI) and continuous subcutaneous insulin infusion (CSII) have been somewhat successful in 'mimicking' normal pancreatic function (1, 2). For individuals with type 1 diabetes, the benefits of near-normal, long-term glycemic control in delaying the development and slowing the progression of long-term complications was demonstrated in the Diabetes Control ...
  https://clinicaltrials.gov/ct2/show/study/NCT00694122?view=results
*  6-month Comparison of Morning Lantus Versus Neutral Protamine Hagedorn Insulin in Young Children With Type 1 Diabetes - Study...
Restriction Description: If no publication has occurred within 12 months of the completion of the study, the Investigator shall have the right to publish/present independently the results of the study. The Investigator shall provide the Sponsor with a copy of any such presentation/publication for comment at least 30 days before any presentation/submission for publication. If requested by the Sponsor, any presentation/submission shall be delayed up to 90 days, to allow the Sponsor to preserve its proprietary rights ...
  https://clinicaltrials.gov/ct2/show/results/NCT00993473
*  Plus it
Lipoatrophy as a cutaneous complication of insulin therapy became extremely rare since the introduction of recombinant human insulin. Recently, some cases of lipoatrophy were reported in association with the use of rapid-acting insulin analogs, like lispro insulin, in combination with pump therapy (1,2). If long-acting insulin analogs are exempt from this, the complications are not known.. We report the case of a 39-year-old type 1 diabetic Caucasian woman (weight 50 kg, BMI 21.4 kg/m2) with diabetes duration of 8 years. She began intensified insulin therapy with two premixed insulin injections before breakfast and dinner and regular insulin before lunch (20 IU/day, 72% neutral protamine Hagedorn insulin). ...
  http://care.diabetesjournals.org/content/28/12/2983.1
*  Search for NPH PURIFIED PORK ISOPHANE INSULIN Within Specific Sites
Use Google powered SiteComber to search within various sites for NPH PURIFIED PORK ISOPHANE INSULIN. Links to searches for NPH PURIFIED PORK ISOPHANE INSULIN can be found here.
  http://sitecomber.com/s/NPH-PURIFIED-PORK-ISOPHANE-INSULIN
*  Plus it
OBJECTIVE: Insulin glargine (HOE 901, 21(A)-Gly-30(B)a-L-Arg-30(B)b-L-Arg human insulin) is a novel recombinant analog of human insulin with a shift in the isoelectric point producing a retarded absorption rate and an increased duration of action that closely mimics normal basal insulin secretion. It recently received approval from the Food and Drug Administration. The aim of this study was to evaluate 2 formulations of insulin glargine for safety and efficacy in the treatment of patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: In a 4-week trial, 256 patients with type 1 diabetes received either NPH insulin or insulin glargine containing 30 microg/ml zinc (insulin glargine[30]) or 80 microg/ml zinc ...
  http://care.diabetesjournals.org/content/23/8/1137
*  Buy Novolin NPH (Human Insulin Isophane), Cheap Brand Novolin NPH, Online Novolin NPH (Human Insulin Isophane), Discount...
Buy Novolin NPH Insulin Vial (Human Insulin Isophane), Cheap Novolin NPH Insulin Vial, Brand Novolin NPH Insulin Vial - Pharmacy Rx World
  https://www.pharmacyrxworld.com/buy-Novolin-NPH-Insulin-Vial.html
*  Comparison of the Change in Fat Distribution in Overweight and Obese Subjects With Type 2 Diabetes After Insulin Treatment -...
This trial is conducted in Europe. The aim of this clinical trial is to compare the change in trunk fat mass, assessed by Double Energy X-ray Absorptiometry (DEXA) after 26 weeks of treatment with insulin detemir or insulin NPH (Neutral Protamine Hagedorn) (both combined with insulin aspart at the main meals) in overweight and obese subjects with type 2 diabetes ...
  https://clinicaltrials.gov/ct2/show/NCT00795600
*  Precautions and Warnings With NPH Insulin/Regular Insulin
If you have liver disease, let your doctor know before you use NPH insulin/regular insulin. This eMedTV article offers more precautions and warnings with NPH insulin/regular insulin and includes information on who should not use this medication.
  http://endocrine-system.emedtv.com/nph-insulin-regular-insulin/precautions-and-warnings-with-nph-insulin-regular-insulin-p2.html
*  Addition of Neutral Protamine Lispro Insulin or Insulin Glargine to Oral Type 2 Diabetes Regimens for Patients with Suboptimal...
Results:. Improvement in HbA1c levels was similar in both groups (1.83% and 1.89% for NPL and glargine, respectively). The difference between the groups was 0.06 percentage point (95% CI, âˆ'0.1 to 0.15 percentage points). Secondary outcomes did not differ between groups. Hemoglobin A1c levels less than 7% occurred in 62% of patients receiving NPL and 64% of patients receiving glargine (difference, 2.0 percentage points [CI, âˆ'1.1 to 5.0 percentage points]). Fasting plasma glucose levels less than 5.6 mmol/L (,100 mg/dL) occurred in 40% of patients receiving NPL and 41% of patients receiving glargine (difference, 1.0 percentage point [CI, âˆ'0.9 to 3.0 percentage points]). Any hypoglycemic event occurred in 74% of patients receiving NPL and 67% of patients receiving glargine (difference, 7 percentage points [CI, âˆ'5 to 13 percentage points]). Continuous glucose level monitoring in the patients who had this measurement did not differ statistically. ...
  http://annals.org/aim/article-abstract/743228/addition-neutral-protamine-lispro-insulin-insulin-glargine-oral-type-2
*  Insulin glargine structural formula - Stock Image C022/4904 - Science Photo Library
Insulin glargine structural formula illustration. Insulin glargine is a recombinant human insulin analogue produced by recombinant DNA technology utilizing a non-pathogenic laboratory strain of Escherichia coli. Insulin glargine differs from human insulin in that the amino acid asparagine at position A21 is replaced by glycine and two arginines are added to the C-terminus of the B-chain. Pink=A-chain, light brown=B-chain, yellow=sulfur, red=differences from human insulin - Stock Image C022/4904
  http://www.sciencephoto.com/media/622843/view
*  Hagedorn temperature - Wikipedia
The Hagedorn temperature is the temperature in theoretical physics where hadronic matter (i.e. ordinary matter) is no longer stable, and must either "evaporate" or convert into quark matter; as such, it can be thought of as the "boiling point" of hadronic matter. The Hagedorn temperature exists because the amount of energy available is high enough that matter particle (quark-antiquark) pairs can be spontaneously pulled from vacuum. Thus, naively considered, a system at Hagedorn temperature can accommodate as much energy as one can put in, because the formed quarks provide new degrees of freedom, and thus the Hagedorn temperature would be an impassable absolute hot. However, if this phase is viewed as quarks instead, it becomes apparent that the matter has transformed into quark matter, which can be further heated. It is about the same as the mass-energy of the lightest hadrons, the pion, at 130-140 MeV per particle or about 2 × 1012 K. This energy range can be routinely probed in particle ...
  https://en.wikipedia.org/wiki/Hagedorn_temperature
*  A Study of LY2605541 in Participants With Type 2 Diabetes Mellitus - Tabular View - ClinicalTrials.gov
Have been receiving basal insulin (neutral protamine Hagedorn [NPH], detemir, or glargine) and a stable dose of 0 to 3 oral antihyperglycemic medications (OAMs) used as specified in the local prescribing information for at least 90 days prior to screening. At least 1 of the OAMs must be dosed at, or above, half the maximum daily dose allowed by local regulations or at the maximally tolerated ...
  https://clinicaltrials.gov/ct2/show/record/NCT01582451
*  Safety and efficacy of inhaled insulin (AERx((R)) iDMS(1)) compared with subcutaneous insulin therapy in patients with Type 1...
article{7558afcf-6e4b-4673-877e-5973c991f8f0, abstract = {Assessment of the long-term safety and efficacy of liquid inhaled insulin via AERx((R)) insulin Diabetes Management System (iDMS) in a basal/bolus treatment regimen of adults with Type 1 diabetes. Patients were randomized 2 : 1 to prandial inhaled (n = 205) or subcutaneous (s.c.) (n = 99) insulin, plus one/two daily injections of neutral protamine Hagedorn (NPH) insulin for 12 months. The primary endpoints were pulmonary function tests (PFT) and baseline changes in chest X-rays at 12 months. Safety and efficacy assessments were measured at regular intervals. PFTs after 12 months were comparable between the groups, except for reduced per cent of predicted carbon monoxide lung diffusing capacity with inhaled insulin (difference: -2.03%, P = 0.04) occurring after the ...
  https://lup.lub.lu.se/search/publication/1404956
*  Humulin I (isophane insulin)
Humulin I vials, pre-filled pens (KwikPens) and cartridges (for use with Humapen or Autopen Classic pens) all contain human isophane insulin. They are used to treat diabetes.
  http://www.netdoctor.co.uk/medicines/diabetes/a6865/humulin-i-isophane-insulin/
*  2omi - Proteopedia, life in 3D
Insulin NPH (neutral protamine hagedorn) has for long been one of the most important therapeutic formulations for the treatment of diabetes. The protracted action profile of NPH formulations is gained from crystallizing insulin with zinc in the presence of the basic poly-arginine peptide protamine. In spite of its long history and successful use, the binding mode of the insulin-protamine complex is not known. In this study, three different systems were used to study protamine binding to insulin. In the first system, crystals of an insulin-protamine complex grown in the presence of urea and diffracting to 1.5A resolution were analyzed. In the second system, a shorter peptide consisting of 12 arginine residues was co-crystallized with insulin in order to reduce the flexibility and thereby improve the electron ...
  http://proteopedia.org/wiki/index.php/2omi
*  Plus it
Exogenous insulin treatment has been shown to improve food intake and host weight of cachectic tumor-bearing (TB) rats, but the composition of the host weight gain has not been quantitated. Sixty-six Fischer 344 rats were randomized to seven groups: early nontumor-bearing (NTB) (n = 10) who underwent compositional analysis (CA) on the day the methylcholanthrene sarcoma was implanted in TB rats; pretreatment-NTB (n = 10) and pretreatment-TB (n = 10) who underwent CA 25 days later when rats began treatment with saline or insulin; and finally saline-treated NTB (n = 9), saline-treated TB (n = 9), insulin-treated NTB (n = 9), and insulin-treated TB (n = 9), who underwent CA following 5 days of treatment with daily saline or neutral protamine hagedorn insulin 2 units/100 g. Body weight and food intake were measured daily. For compositional ...
  http://cancerres.aacrjournals.org/content/48/10/2784
*  Insulin Combination Therapy in Type 2 Diabetes Mellitus | Annals of Internal Medicine | American College of Physicians
Drs. Hassan, Hassan, and Gupta and Drs. Mikhail and Wali criticize the open-label design of our study. However, when insulin glargine is compared with NPH insulin, blinding cannot be justified for several reasons. First, NPH insulin is a turbid suspension whereas insulin glargine is a clear solution. Therefore, patients can easily identify the type of insulin they are using whenever the cartridge is transparent (with or without lettering). Second, filling both insulins in nontransparent cartridges can result in the administration of an incorrect dose of insulin; patients must be aware of and in control of the level of insulin in the cartridge. Third, it is necessary to thoroughly mix NPH insulin by rotating ...
  http://annals.org/aim/article/717391/insulin-combination-therapy-type-2-diabetes-mellitus
*  Global Insulin Glargine Market Outlook 2016-2021 | Medgadget
Global Insulin Glargine Market The Global Insulin Glargine Industry Report 2015 is a professional and in-depth study on the current state of the Insulin Gl
  https://www.medgadget.com/2016/12/global-insulin-glargine-market-outlook-2016-2021.html
*  Comparison of Insulin Detemir Given Once or Twice Daily in Type 1 Diabetes - Full Text View - ClinicalTrials.gov
This trial is conducted in Europe. The aim of this research study is to compare the efficacy (reduction in HbA1c and in blood glucose levels) of insulin detemir once daily injection compared to insulin detemir twice daily injection administered as basal insulin for the treatment of type 1 diabetes and to verify the safety of use (number and severity of episodes of hypoglycemia, body weight and side effects ...
  https://clinicaltrials.gov/ct2/show/NCT00117780
*  NPH Varies 20 to 30 Percent Daily | Diabetes Health
A new basal insulin now in Phase III trials worldwide promises to offer a smoother action than NPH with a more predictable activity curve.. Insulin detemir, developed by Novo Nordisk, is an intermediate-acting basal insulin analog administered as a clear solution. Novo Nordisk spokeswoman Susan Jackson says, "Compared to NPH insulin, detemir is absorbed with less variability and provides a flatter action profile.". In comparison trials that pitted detemir and NPH against each other, researchers found that absorption of NPH varied 20 to 30 percent on a daily basis. Also, because NPH is a suspension insulin, the concentration may change because of inadequate mixing. NPH in a vial must be rolled between the hands until the components are mixed. If NPH is used in a pen, the pen needs to be inverted at least 20 ...
  https://www.diabeteshealth.com/nph-varies-20-to-30-percent-daily/
*  Penfill Side Effects
Are Penfill Side Effects Putting Your Health at Risk? | Jun 13, 2017 Check these Penfill side effect reports: A 71-year-old male patient was diagnosed with NA, treated with PENFILL 30R (INSULIN HUMAN, INSULIN HUMAN INJECTION, ISOPHANE) and reported depression. Dosage: .
  http://patientsville.com/medication/penfill_side_effects.htm