The impact of corticosteroids on growth and bone health | Archives of Disease in Childhood
Glucocorticoids (GC) are important regulators of diverse physiological systems and are often used in the treatment of a number ... Glucocorticoid inhibition of FSH-induced estrogen production in cultured rat granulosa cells. Steroids1978;32:639-48. ... Glucocorticoid effects on somatomedins and somatomedin inhibitors. J Clin Endocrinol Metab1985;61:618-26. ... A UK Consensus Group on management of glucocorticoid-induced osteoporosis: an update. J Intern Med1998;244:271-92. ...http://adc.bmj.com/content/87/2/93.long
Synthetic glucocorticoids are known to copy the effect of natural cortisol and, when given prior to birth, the glucocorticoid, ... "Synthetic glucocorticoids mimic the biological reaction when the mother is stressed, so we wanted to see if babies who were ... The glucocorticoid, dexamethasone, is typically administered after birth to temporarily improve respiratory function, Medical ... Expectant mothers who might give birth prematurely are often treated with an infusion of glucocorticoids. These drugs, wrote ...http://www.newsinferno.com/mental-health-risks-tied-to-steroid-injections-meant-to-stop-premature-birth/
Citation tools | The Journal of Immunology
"Paracrine rather than systemic glucocorticoids are biologically active in the thymus." The Journal of Immunology 198.1 ...http://www.jimmunol.org/highwire/citation/341258/download
Hypersensitivity reactions to systemic glucocorticoids
Glucocorticoids are prescribed for their immunosuppressive, antiproliferative, anti-inflammatory, and antiallergenic effects ... Alternative glucocorticoids for use in cases of adverse reaction to systemic glucocorticoids: a study on 10 patients. Br J ... An early report in the 1950s described 6700 glucocorticoid injections given to 2256 patients . There were 20 instances of ... Hypersensitivity reactions to systemic glucocorticoids. Author. Rima Rachid, MD. Rima Rachid, MD ...http://www.uptodate.com/contents/hypersensitivity-reactions-to-systemic-glucocorticoids
Protective effect of VK2 on glucocorticoid-treated MC3T3-E1 cells
Kim BY, Yoon HY, Yun SI, Woo ER, Song NK, Kim HG, Jeong SY and Chung YS: In vitro and in vivo inhibition of glucocorticoid- ... Glucocorticoids (GCs) have been extensively used in the treatment of a variety of diseases, due to their potent anti- ... Shi C, Huang P, Kang H, Hu B, Qi J, Jiang M, Zhou H, Guo L and Deng L: Glucocorticoid inhibits cell proliferation in ... Sasaki N, Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E and Asano Y: Vitamin K2 inhibits glucocorticoid-induced bone loss ...https://spandidos-publications.com/ijmm/39/1/160
Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid Arthritis - Full Text View -...
Subjects receiving intramuscular glucocorticoids e.g methylprednisolone (£120 mg/month) must be on a stable dosing regimen for ... The subject has received intra-articular glucocorticoids within 1 month of screening. ... oral glucocorticoids e.g. prednisolone (£10mg/day) must be on stable dosing regimens for at least 4 weeks prior to screening ...https://clinicaltrials.gov/ct2/show/NCT00674635
Chapter 342. Disorders of the Adrenal Cortex | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill...
Glucocorticoid excess is diagnosed by employing a dexamethasone suppression test. Dexamethasone, a potent glucocorticoid, ... cortisol and glucocorticoid receptor (GR) action. GRE, glucocorticoid response elements; HSP, heat shock proteins; NADPH, ... dexamethasone are not preferred as they result in increased glucocorticoid exposure due to extended glucocorticoid receptor ... Glucocorticoid resistance. Upregulation of cortisol production due to GR mutations results in flooding of the MR by cortisol. ...http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727147
Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors. Rocco Piazza, Petra ... Glucocorticoids (GCs) are a crucial component in all protocols for the treatment of human lymphoid malignancies, including ... Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors ... Reversal of glucocorticoid resistance in human lymphoid malignancies with histone deacetylase inhibitors ...http://cancerres.aacrjournals.org/content/68/9_Supplement/2464
Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through...
Powers JH, Hillmann AG, Tang DC, Harmon JM: Cloning and expression of mutant glucocorticoid receptors from glucocorticoid- ... Resistance to glucocorticoids (GC) is considered to be one of the most important factors in the prognosis of leukemia [1, 2]. ... Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute ... Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. The Journal of ...https://jclinbioinformatics.biomedcentral.com/articles/10.1186/2043-9113-1-36
Predictors for vertebral fractures and fracture threshold in patients using oral glucocorticoids - Nuffield Department of...
Predictors for vertebral fractures and fracture threshold in patients using oral glucocorticoids Share Share Share Share ... Predictors for vertebral fractures and fracture threshold in patients using oral glucocorticoids ...https://www.ndorms.ox.ac.uk/publications/126741
"Population-based assessment of adverse events associated with long-ter" by Jeffrey R. Curtis, Andrew O. Westfall et al.
These individuals were surveyed about glucocorticoid use and symptoms of 8 AEs commonly attributed to glucocorticoid use. ... More than 90% of individuals reported at least 1 AE associated with glucocorticoid use; 55% reported that at least 1 AE was ... We sought to determine the prevalence of glucocorticoid-associated AEs in a large US managed care population. METHODS: Using ... Physicians should be vigilant for glucocorticoid-related AEs and should counsel patients about possible risks, even among low- ...http://escholarship.umassmed.edu/qhs_pp/802/
Cells | Free Full-Text | Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword
However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will focus on the ... Glucocorticoid-induced apoptosis affects the skeletal system, muscular system, circulatory system, nervous system, endocrine ... Lastly, we will discuss the pro- and anti-apoptotic effects of glucocorticoids in cancers and their clinical implications. ... Interestingly, several cell types have an anti-apoptotic response to glucocorticoids that is cytoprotective. ...http://mdpi.com/2073-4409/2/2/202/xml
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms | Clinical Science
2. Glucocorticoids bind to glucocorticoid receptors in the cytoplasm which then dimerize and translocate to the nucleus, where ... 4. It is increasingly recognized that glucocorticoids change the chromatin structure. Glucocorticoid receptors also interact ... on glucocorticoid-responsive genes, resulting in increased transcription. Glucocorticoids may increase the transcription of ... Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms. Peter J. Barnes. Clinical Science Jun 01, 1998, 94 (6) 557- ...http://www.clinsci.org/content/94/6/557
Rebel Science News: Anesthetics and Glucocorticoids for ALS
I now understand that it was a combination of the anesthetics and the glucocorticoid anti-inflammatory drug, routinely given ... This is not the first time that glucocorticoid drugs have been implicated in spectacular ALS remissions. In 2011, famous ALS ... Schmid published an ALS remission story in which he explained how he kept his ALS under control with powerful glucocorticoids. ... also the story of US Authors Guild's director Paul Aiken whose ALS went into remission after injections with the glucocorticoid ...http://rebelscience.blogspot.co.il/2014/08/anesthetics-and-glucocorticoids-for-als.html
Fracture risk with intermittent high-dose oral glucocorticoid therapy. - Nuffield Department of Orthopaedics, Rheumatology and...
To evaluate the risk of fracture in patients receiving intermittent therapy with high-dose oral glucocorticoids (GCs).The study ... Fracture risk with intermittent high-dose oral glucocorticoid therapy. Share Share Share Share ... To evaluate the risk of fracture in patients receiving intermittent therapy with high-dose oral glucocorticoids (GCs).The study ... Humans, Osteoporosis, Spinal Fractures, Hip Fractures, Fractures, Spontaneous, Glucocorticoids, Risk, Risk Factors, ...https://www.ndorms.ox.ac.uk/publications/126241
Molecular Vision: Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal...
Glucocorticoids, potent inhibitors of immune responses, act through glucocorticoid receptors (GRs) to depress the activities of ... Characterization of a glucocorticoid receptor and the direct effect of dexamethasone on herpes simplex virus infection of ... In fact, topical or systemic application of glucocorticoids results in the reactivation of herpes keratitis [9,10], and ... Reily MM, Pantoja C, Hu X, Chinenov Y, Rogatsky I. The GRIP1:IRF3 interaction as a target for glucocorticoid receptor-mediated ...http://www.molvis.org/molvis/v15/a98/
Glucocorticoids in hippocampal development - Wikipedia
The adult hippocampus is highly enriched in type I (mineralocorticoid, MR) and type II (glucocorticoid, GR) glucocorticoid ... More research is needed to understand the role of glucocorticoids in the context of human hippocampal development. Purves, Dale ... Seckl, JR; Meaney, MJ (Dec 2004). "Glucocorticoid programming". Annals of the New York Academy of Sciences. 1032: 63-84. doi: ... The following will provide an introduction to hippocampal development with particular focus on the role of glucocorticoid ...https://en.wikipedia.org/wiki/Glucocorticoids_in_hippocampal_development
Glucocorticoid - Wikipedia
... glucocorticoids could induce a potent diuresis. Glucocorticoids bind to the cytosolic glucocorticoid receptor (GR), a type of ... glucocorticoid-induced TNF receptor) Glucocorticoid receptor Immunosuppressive drug Membrane glucocorticoid receptor Metyrapone ... Glucocorticoids may be used in low doses in adrenal insufficiency. In much higher doses, oral or inhaled glucocorticoids are ... Any glucocorticoid can be given in a dose that provides approximately the same glucocorticoid effects as normal cortisol ...https://en.wikipedia.org/wiki/Glucocorticoid
Glucocorticoid receptor - Wikipedia
Membrane glucocorticoid receptor Familial/sporadic glucocorticoid resistance (Chrousos Syndrome) Selective glucocorticoid ... The GR is abnormal in familial glucocorticoid resistance. In central nervous system structures, the glucocorticoid receptor is ... "Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through ... The glucocorticoid receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor ...https://en.wikipedia.org/wiki/Glucocorticoid_receptor
Membrane glucocorticoid receptor - Wikipedia
Membrane glucocorticoid receptors (mGRs) are a group of receptors which bind and are activated by glucocorticoids such as ... "Novel insights into mechanisms of glucocorticoid action and the development of new glucocorticoid receptor ligands". Steroids. ... In accordance, glucocorticoids are known to affect cognition, stress-adaptive behavior, and neuroendocrine output (e.g., ... mGRs have been implicated in the rapid effects of glucocorticoids in the early central stress response via modulating neuronal ...https://en.wikipedia.org/wiki/Membrane_glucocorticoid_receptor
Glucocorticoid deficiency 1 - Wikipedia
Glucocorticoid deficiency 1 (FGD or GCCD) is an adrenocortical failure characterized by low levels of plasma cortisol produced ... Clark AJ, McLoughlin L, Grossman A (October 1993). "Familial glucocorticoid deficiency associated with point mutation in the ... Tsigos C, Arai K, Hung W, Chrousos GP (November 1993). "Hereditary isolated glucocorticoid deficiency is associated with ... cause familial glucocorticoid deficiency type 2". Nature Genetics. 37 (2): 166-170. doi:10.1038/ng1501. PMID 15654338. ...https://en.wikipedia.org/wiki/Glucocorticoid_deficiency_1
Glucocorticoid remediable aldosteronism - Wikipedia
Glucocorticoid remediable aldosteronism (GRA), also describable as aldosterone synthase hyperactivity, is an autosomal dominant ... McMahon GT, Dluhy RG (October 2004). "Glucocorticoid-remediable aldosteronism". Arq Bras Endocrinol Metabol. 48 (5): 682-6. doi ... However, in subjects with glucocorticoid-remediable aldosteronism, ACTH increases the activity of existing aldosterone synthase ... April 2007). "A German family with glucocorticoid-remediable aldosteronism". Nephrol. Dial. Transplant. 22 (4): 1123-30. doi: ...https://en.wikipedia.org/wiki/Glucocorticoid_remediable_aldosteronism
Selective glucocorticoid receptor modulator - Wikipedia
Both non-selective glucocorticoids and selective glucocorticoid receptor agonists work by binding to and activating the ... Just like glucocorticoids, SEGRAMs bind to and activate GR. However, in contrast to glucocorticoids, SEGRAMs selectively ... Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as ... Ayroldi E, Macchiarulo A, Riccardi C (December 2014). "Targeting glucocorticoid side effects: selective glucocorticoid receptor ...https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator
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