Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome | Hematology-Oncology Therapy, 2e | AccessHemOnc | McGraw-Hill...
REGIMEN: PLASMA EXCHANGE: (WHOLE FRESH-FROZEN PLASMA OR CRYOPRECIPITATE-POOR PLASMA) * REGIMEN: GLUCOCORTICOIDS ...http://hemonc.mhmedical.com/content.aspx?bookid=1611§ionid=126669961
Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis - Full...
Experimental: Plasma Exchange Procedure: Plasma Exchange Plasma exchange is a procedure whereby blood is taken from the body ... Participants in this arm do not undergo plasma exchange. Drug: Glucocorticoids During the study, a standard glucocorticoids ... Plasma exchange - 7 exchanges and, either standard or low-dose glucocorticoids or ... No plasma exchange and, either standard or low-dose glucocorticoids. All studies will receive standard remission-induction ...https://clinicaltrials.gov/ct2/show/NCT00987389?term=Vasculitis&recr=Open&fund=01&rank=6
Therapeutic Plasma Exchange. (TPE)
Therapeutic plasma exchange (TPE) is an extracorporeal therapy treatment, which has been used successfully for limited ... glucocorticoids, plasma exchange and/or intravenous immunoglobulins. PubMed, Panminerva Med, 2017 Sep;59(3):254-268. (Also see ... Therapeutic Plasma Exchange (TPE). Hello, I am Jo Frowde, ISN Guide to Therapeutic Plasma Exchange. Therapeutic Plasma Exchange ... Therapeutic plasma exchange (TPE) is a treatment that removes plasma from your blood, which is then replaced with a substitute ...https://www.sclero.org/scleroderma/treatments/mainstream/therapeutic-plasma-exchange/a-to-z.html
Practice Changing UpDates
... standard treatment includes plasma exchange (PEX) and glucocorticoids. The role of additional up-front rituximab in acquired ...https://www.uptodate.com/contents/practice-changing-updates
What's new in hematology
... standard treatment includes plasma exchange (PEX) and glucocorticoids. The role of additional up-front rituximab in acquired ...https://www.uptodate.com/contents/whats-new-in-hematology
Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study group (EUVAS) therapeutic trials ...
24 High-dose glucocorticoids and plasma exchange were allowable. Local investigators made treatment decisions post-trials. No ... Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am ... Glucocorticoid use. Almost 300 patients (n=296; 63.4% of the 467, 55.3% of the 535) had data on glucocorticoid use. Within ... Total duration of glucocorticoid use was defined as months of glucocorticoid use within the original trial plus follow-up. ...https://ard.bmj.com/content/74/1/177
Low-dose Glucocorticoid Vasculitis Induction Study - Full Text View - ClinicalTrials.gov
Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am ... Any concomitant condition anticipated to likely require oral systemic glucocorticoids, immunosuppressants, biologics, plasma ... Low-dose Glucocorticoids Plus Rituximab Versus High-dose Glucocorticoids Plus Rituximab for Remission Induction in ANCA- ... Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA- ...https://clinicaltrials.gov/ct2/show/NCT02198248
Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS ... Plasma exchange (PEX) removes circulating plasma constituents including immunoglobulins. Its potential role in the treatment of ... Clinical trials have shown the effectiveness of cytotoxic drugs [20, 21], plasma exchange  and biological agents [9, 22]. ... Plasma exchange (PEX). All patients were allocated to treatment with PEX alongside standard of care if they fulfilled any of ...https://rd.springer.com/article/10.1186/s12891-015-0796-7
EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis | Annals of the Rheumatic Diseases
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS ... Plasma Exchange and Glucocorticoids for Treatment of Anti-Neutrophil Cytoplasm Antibody (ANCA) - Associated Vasculitis) is a ... Plasma exchange should be considered for patients with AAV and a serum creatine level of ,500 µmol/L (5.7 mg/dL) due to rapidly ... Complications of therapeutic plasma exchange: experience with 4857 treatments. Ther Apher Dial 2005;9:391-5. doi:10.1111/j.1744 ...http://ard.bmj.com/content/early/2016/06/23/annrheumdis-2016-209133.long
Henoch-Schönlein purpura (IgA Vasculitis) - ONA
Augusto, JF, Sayegh, J, Delapierre, L. "Addition of Plasma exchange to glucocorticoids for the treatment of severe Henoch- ... Plasma Exchange has been employed with some success on the basis of case reports in patients with refractory disease with ... Basaran, O, Cakar, N, Uncu, N. "Plasma Exchange therapy for severe gastrointestinal involvement of Henoch Schönlein purpura in ... Supportive care can be accomplished with fresh frozen plasma, blood products for active bleeding and coagulopathy. ...https://www.oncologynurseadvisor.com/hospital-medicine/henoch-sch%C3%B6nlein-purpura-iga-vasculitis/article/605141/
Pathogenesis and treatment of ANCA-associated vasculitis-a role for complement | SpringerLink
Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS ... Lockwood CM, Pinching AJ, Sweny P, Rees AJ, Pussell B, Uff J, Peters DK (1977) Plasma-exchange and immunosuppression in the ... Szpirt WM (2015) Plasma exchange in antineutrophil cytoplasmic antibody-associated vasculitis-a 25-year perspective. Nephrol ... Pusey CD, Rees AJ, Evans DJ, Peters DK, Lockwood CM (1991) Plasma exchange in focal necrotizing glomerulonephritis without anti ...https://link.springer.com/article/10.1007%2Fs00467-016-3475-5
Thrombotic thrombocytopenic purpura
If plasma exchange is ineffective, then glucocorticoids and vincristine may be tried. ... and daily plasma exchange commences (about one plasma volume/day, or 3 to 4 liters/day, in adults). ... Plasma exchanges enable about 80 to 90% of patients with TTP to survive an episode, usually with minimal organ damage. Lower ... Plasma exchange should be performed daily until platelet count recovery.. More definitive therapies?. Familial ADAMTS-13- ...https://www.psychiatryadvisor.com/hematology/thrombotic-thrombocytopenic-purpura/article/597453/
Dexamethasone and Chemotherapy With or Without Plasma Exchange in Patients With Newly Diagnosed Multiple Myeloma and Acute...
Plasma exchange is a process in which certain cells are separated from the plasma in the blood by a machine and then only the ... Dexamethasone and plasma exchange may be an effective treatment for acute kidney failure caused by multiple myeloma. It is not ... Patients undergo plasma exchange by cytocentrifugation or plasmafiltration over 2-3 hours in weeks 1 and 2 (7 treatments total ... A Randomised Controlled Trial of Adjunctive Plasma Exchange in Patients With Newly Diagnosed Multiple Myeloma and Acute Renal ...https://clinicaltrials.gov/ct2/show/NCT00416897?term=plasmapheresis+and+myeloma&rank=2
Dexamethasone and Chemotherapy With or Without Plasma Exchange in Patients With Newly Diagnosed Multiple Myeloma and Acute...
Plasma exchange is a process in which certain cells are separated from the plasma in the blood by a machine and then only the ... Dexamethasone and plasma exchange may be an effective treatment for acute kidney failure caused by multiple myeloma. It is not ... Patients undergo plasma exchange by cytocentrifugation or plasmafiltration over 2-3 hours in weeks 1 and 2 (7 treatments total ... PURPOSE: This randomized phase III trial is studying dexamethasone, chemotherapy, and plasma exchange to see how well they work ...https://clinicaltrials.gov/ct2/show/NCT00416897?term=multiple+myeloma&recr=Open&cond=multiple+myeloma&rank=16
Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP) - Full...
Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological Effects of Drugs. ... Plasma exchange is the standard treatment for TTP. Plasma exchange is a treatment that removes the plasma (the liquid portion ... undergo plasma exchange but will be randomized to receive either prednisone or cyclosporine as an adjunct to plasma exchange. ... Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP). The ...https://clinicaltrials.gov/ct2/show/NCT00713193
Most recent papers with the keyword Castleman | Read by QxMD
... glucocorticoid therapy and plasma exchange. Renal biopsy showed diffuse endocapillary proliferation and mesangiolysis without ... It is divided into 2 subtypes: the plasma cell variant and the hyaline vascular variant. The most common site is the hilum of ... Broad management guidelines have been published emphasizing the need for prompt treatment and the use of glucocorticoids as ...https://www.readbyqxmd.com/keyword/20754
The liver and systemic disease
... plasma exchange, and antibiotics have all been disappointing.. Portopulmonary hypertension. A number of novel therapies exist ... Experience with somatostatin analogs, β-blockers, cyclooxygenase inhibitors,glucocorticoids and immunosuppressants, pulmonary ... The natural history of HPS is that most patients develop progressive shunting and have worsening gas exchange over time. Second ... but it is clear that most patients have progressive intrapulmonary vasodilatation and worsening gas exchange over time. This ...https://www.psychiatryadvisor.com/gastroenterology-hepatology/the-liver-and-systemic-disease/article/596177/
Thrombocytopenia - Cancer Therapy Advisor
If TTP is highly suspected, consultation with a hematologist is helpful in determining the need for urgent plasma exchange, in ... There is no high quality evidence for the role of glucocorticoids.. If clinical suspicion is high for HIT Type 2, heparin ... First line therapies for ITP include glucocorticoids and IVIG.. B. Common Pitfalls and Side-Effects of Management of this ...https://www.cancertherapyadvisor.com/hospital-medicine/thrombocytopenia/article/601839/
Glomerulonephritis - The Clinical Advisor
If pulmonary hemorrhage is present, plasma exchange should also be considered. Once the disease is under control, patients are ... Anti-GBM antibody disease: Treatment is plasmapheresis, cyclophosphamide and glucocorticoids.. B. Common Pitfalls and Side- ... Cryoglobulinemia: Plasmapheresis, cyclophosphamide, and glucocorticoids are the mainstay of treatment. If hepatitis C is found ... Lupus: Induction therapy with cyclophosphamide and glucocorticoids is essential. Plasmapheresis has no added benefit. ...http://www.clinicaladvisor.com/hospital-medicine/glomerulonephritis/article/601981/
Chapter 326. The Vasculitis Syndromes | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill Medical
... therapy represents an important part of therapy and has been used in combination with glucocorticoids and plasma exchange. ... glomerulonephritis have been anecdotally reported to benefit from intensive plasma exchange combined with cytotoxic drugs. ... vasculitis even after ∼14 days of glucocorticoid therapy. A dramatic clinical response to a trial of glucocorticoid therapy can ... particularly in patients receiving glucocorticoids. All vasculitis patients who are receiving daily glucocorticoids in ...http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727127
Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy. - Nuffield...
Treatment with glucocorticoids-less so with intravenous immunoglobulins and plasma exchange-was associated with the most marked ... and/or plasma exchange at some point in their illness. ... The only patient who did not receive glucocorticoids showed the ... Glucocorticoid therapy appears particularly efficacious. Earlier rituximab administration and randomized trials are required to ... In contrast, all patients showed robust responses to treatment with glucocorticoids, intravenous immunoglobulins, ...https://www.ndcn.ox.ac.uk/publications/465562
... or have diagnosed alveolar haemorrhage should undergo plasma exchange in addition to cyclophosphamide and glucocorticoid ... Schäcke, H, Döcke, WD, Asadullah, K. "Mechanisms involved in the side effects of glucocorticoids". Pharmacol Ther. vol. 96. ... There is no standard recommendation for altering dose of initial glucocorticoid or cyclophosphamide in patients with renal ...https://www.clinicalpainadvisor.com/hospital-medicine/microscopic-polyangiitis/article/604606/
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task...
Adjunctive plasma exchanges to treat neuropsychiatric lupus: a retrospective study on 10 patients. Lupus 2007;16:817-22. ... A combination of glucocorticoids with immunosuppressive agents is effective in most patients (response rates up to 70%).25 63 ... Plasma exchange therapy has been used in severe cases26 27 76 and anticoagulation therapy in antiphospholipid-positive ... plasma exchange,26 27 intravenous immunoglobulin,28,-,30 and rituximab (anti-CD20 monoclonal antibody)31 have been used. ...https://ard.bmj.com/content/69/12/2074.long
Ophthalmologic Manifestations of Myasthenia Gravis: Overview, Patient History, Physical Examination
Long-term immunomodulation (with glucocorticoids and other immunosuppressants) * Rapid immunomodulation (eg, plasma exchange ...https://emedicine.medscape.com/article/1216417-overview
The patient was treated with antiviral medications and plasma exchange. The latter refers to a procedure that replaces the ... After several weeks glucocorticoids were added to the treatment. This was continued until the dose was tapered after a year. ... The glucocorticoid treatment, of course, was used to suppress inflammation occuring in the small and medium sized arteries. ...http://courses.washington.edu/conj/casestudies/neuronal_C.htm