Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.
The survival of mice with pleiotrophin-producing gliomas was shorter than that of mice with gliomas that did not produce ... Orthotopically implanted gliomas formed from GL261 cells that were engineered to produce pleiotrophin showed increased ... Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.. ... The growth of pleiotrophin-producing GL261 gliomas was inhibited by treatment with the ALK inhibitor crizotinib, the ALK ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:881946
Cancers | Free Full-Text | Extra-Neural Metastases of Malignant Gliomas: Myth or Reality?
Malignant gliomas are usually locally invasive tumors, though extra-neural metastases can sometimes occur late in the course of ... Malignant glioma metastases usually involve the regional lymph nodes, lungs and pleural cavity, and occasionally the bone and ... The incidence of these metastases from primary intra-cranial malignant gliomas is low; it is estimated at less than 2% of all ... Extra-neural metastases from gliomas frequently occur late in the course of the disease (median of two years), and generally ...http://www.mdpi.com/2072-6694/3/1/461
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer
These families all had at least 2 verified glioma cases and a third reported or verified glioma case in the same family or 2 ... CDKN2A/B, family history, glioma, MLH1, MSH2, TP53 National Category Cancer and Oncology Neurology Identifiers. URN: urn:nbn:se ... Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. ... An alternative approach to identifying such genes is to examine cancer pedigrees, which include glioma as one of several cancer ...http://www.diva-portal.org/smash/record.jsf?pid=diva2:765420
Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma - Full Text View - ClinicalTrials...
Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma. The safety and scientific ... A Phase I Single Arm Open Label Study of Erlotinib and 13-cis-Retinoic Acid (CRA) in Patients With Recurrent Malignant Gliomas ... Glioma. Astrocytoma. Gliosarcoma. Oligodendroglioma. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ Cell ... Genetic and Rare Diseases Information Center resources: Glioma Glioblastoma Anaplastic Astrocytoma Gliosarcoma ...https://clinicaltrials.gov/ct2/show/NCT01103375?cond=%22Anaplastic+oligodendroglioma%22&rank=11
Personal History of Diabetes, Genetic Susceptibility to Diabetes, and Risk of Brain Glioma: A Pooled Analysis of Observational...
We examined self-reported diabetes history in relation to glioma risk, as well as effect modification by seven glioma risk- ... Although we found no significant interactions between diabetes and 7 glioma risk-associated SNPs on glioma risk, statistical ... risk of glioma and the potential for effect modification of the diabetes-glioma association by genetic susceptibility to glioma ... and were glioma-free at the time of glioma diagnosis. Controls from case-control studies were frequency-matched by age, sex, ...http://cebp.aacrjournals.org/content/23/1/47?rss=1
The chemokine GRO-α (CXCL1) confers increased tumorigenicity to glioma cells : Carcinogenesis - oi
... we have investigated whether GRO-α regulates the tumor characteristics of glioma cells. We found first that resected glioma ... we have investigated whether GRO-α regulates the tumor characteristics of glioma cells. We found first that resected glioma ... The implantation of GRO-α glioma clones into the brain of nude mice caused the early demise of mice and this was associated ... As malignant gliomas are thought to arise from glia progenitors or their differentiated counterparts, astrocytes or ...http://oxfordindex.oup.com/view/10.1093/carcin/bgi182
"Angiocentric Glioma: A Case Series." by Sophia F Shakur, Matthew J McGirt et al.
METHODS: The children in the 3 cases of angiocentric glioma were 10, 10, and 13 years old. Two presented with intractable ... The authors present the first 3 pediatric cases of angiocentric glioma encountered at their institution and review the ... CONCLUSIONS: Among 25 cases of angiocentric glioma, seizure was the most common symptom at presentation. Magnetic resonance ... Angiocentric glioma was recently recognized as a distinct clinicopathological entity in the 2007 World Health Organization ...https://scholarlyworks.lvhn.org/pathology-laboratory-medicine/115/
The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and Human Glioma
The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, ... the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma ... in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma. ...http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015390
AZD7451 for Recurrent Gliomas - Full Text View - ClinicalTrials.gov
Thus, inhibition of glioma invasion is a potentially promising strategy.. Work in the Neuro-Oncology Branch laboratory of Dr. ... It can prevent glioma cells from entering into normal brain tissue, and slow or stop the growth of additional tumors. ... Glioma. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. ... Recurrent glioma patients have very limited treatment options. A major cause of gliomarelated morbidity and mortality is the ...https://clinicaltrials.gov/ct2/show/NCT01468324
EpCAM-conjugated magnetic beads for the selective separation of glioma cells from healthy brain cells using microfluidics
Browse: Home / EpCAM-conjugated magnetic beads for the selective separation of glioma cells from healthy brain cells using ... In order to test the hypothesis, we will evaluate the binding of anti-epCAM-labeled magnetic beads to F98 rat glioma cells ... Leidong Mao / December 16, 2016 / Comments Off on EpCAM-conjugated magnetic beads for the selective separation of glioma cells ... Project Title: EpCAM-conjugated magnetic beads for the selective separation of glioma cells from healthy brain cells using ...http://reu.engr.uga.edu/?p=843
Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas - Full Text View - ClinicalTrials.gov
Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas. The recruitment status of this study is unknown. The ... Adult Brain Tumor Adult Brain Stem Glioma Adult Diffuse Astrocytoma Adult Ependymoma Adult Grade II Meningioma Adult ... Phase II) V. To evaluate the time to progression of low grade gliomas treated with protons. (Phase II) VI. To evaluate the ... Genetic and Rare Diseases Information Center resources: Glioma Oligodendroglioma Brain Tumor, Adult Meningioma Ependymoma ...https://clinicaltrials.gov/ct2/show/NCT01024907
GDF-15 contributes to proliferation and immune escape of malignant gliomas - Zurich Open Repository and Archive
The impact of GDF-15 on glioma growth in vivo was assessed in syngeneic mice.RESULTS: GDF-15 is expressed by gliomas of ... The impact of GDF-15 on glioma growth in vivo was assessed in syngeneic mice.RESULTS: GDF-15 is expressed by gliomas of ... Immunologically, the depletion of glioma-derived GDF-15 enhances the susceptibility of mouse glioma cells towards syngeneic NK ... Immunologically, the depletion of glioma-derived GDF-15 enhances the susceptibility of mouse glioma cells towards syngeneic NK ...http://www.zora.uzh.ch/id/eprint/34877/
Study of Platelet Derived Growth Factor Receptor (PDGFR) in Recurrent Malignant Gliomas - Full Text View - ClinicalTrials.gov
Malignant gliomas (MG), including anaplastic gliomas (AG) and glioblastoma (GBM), are the most common primary brain tumor. ... Study of Platelet Derived Growth Factor Receptor (PDGFR) in Recurrent Malignant Gliomas. The safety and scientific validity of ... Glioma. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. ... This study is designed to test the hypothesis that patients with malignant gliomas with PDGFR amplification are sensitive to ...https://clinicaltrials.gov/ct2/show/NCT01140568
Molecules | Free Full-Text | Resistance to DNA Damaging Agents Produced Invasive Phenotype of Rat Glioma Cells-Characterization...
Therefore, development of glioma in vivo models that more accurately resemble the situation observed in patients emerges. ... Previously, we established RC6 rat glioma cell line resistant to DNA damaging agents including antiglioma approved therapies ... in preclinical studies for the examination of new approaches to counteract both chemoresistance and invasion of glioma cells. ... induced invasive phenotype of RC6 cells with significant behavioral impediments implying usefulness of orthotopic RC6 glioma ...http://www.mdpi.com/1420-3049/21/7/843
Abstract 510: A novel role for Olig2 in the regulation of glioma invasion | Cancer Research
Genetically relevant murine glioma model as well as patient-derived glioma stem cells (GSCs) were utilized to identify the ... Abstract 510: A novel role for Olig2 in the regulation of glioma invasion. Shiv K. Singh, Nicole Giannonatti, Robert Kupp, ... A major clinical obstacle in the treatment of GBMs is the ability of glioma cells to invade the surrounding brain parenchyma, ... A novel role for Olig2 in the regulation of glioma invasion. [abstract]. In: Proceedings of the 106th Annual Meeting of the ...http://cancerres.aacrjournals.org/content/75/15_Supplement/510
Study of glioma susceptibility in dogs may yield insights for humans | Veterinary Sciences Tomorrow
Study of glioma susceptibility in dogs may yield insights for humans. Posted on June 1, 2016. by Vetscite ... Gliomas are the most common form of malignant primary brain tumors in humans and the second most common in dogs. Several dog ... A new study of the genetic factors underlying glioma formation in dogs may hold clues to how these common and often untreatable ... Future investigation of all three genes may yield a better understanding of the causes and potential treatments of glioma in ...http://vetscite.org/2016/06/study-of-glioma-susceptibility-in-dogs-may-yield-insights-for-humans/
6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients - Full Text View - ClinicalTrials.gov
Anaplastic Glioma of Brain Glioblastoma Multiforme Brain Cancer Drug: Capecitabine Drug: Celecoxib (Celebrex) Drug: ... Anaplastic Glioma. Brain Cancer. 6-Thioguanine. Capecitabine. Celecoxib. Temozolomide. Xeloda. Temodar. TMZ. CCNU. 6-TG. ... 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma Patients. This study has been completed. ... Glioma. Brain Neoplasms. Astrocytoma. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. ...https://clinicaltrials.gov/ct2/show/NCT00504660?term=glioblastoma&rank=6
Store-operated Ca2+ entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation | Journal of...
The human glioma cell lines U251, SNB19, U87, and LN229 and the rat glioma cell line C6 were purchased from the Chinese Academy ... Orai1 expression in glioma samples and glioma cell lines. As one important Ca2+ membrane channel protein, Orai1 is the key ... C) Western blot analysis of p-Pyk2 expression in non-neoplastic brain tissues, glioma samples (WHO II and IV), and two glioma ... In the current study, we verified the expression of Orai1 in different grades of glioma tissues and several glioma cell lines. ...https://jeccr.biomedcentral.com/articles/10.1186/s13046-014-0098-1
Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma - Full Text View -...
recurrent glioma. MRI. Spectroscopy. Recurrent grade IV glioma (glioblastoma), with two additional exploratory arms for ... Glioma. Astrocytoma. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ Cell and Embryonal. Neoplasms by ... Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma (GKS). This study ... Study Design: A single-center, single-arm, one-stage phase II clinical trial for patients with recurrent grade IV glioma ( ...https://clinicaltrials.gov/ct2/show/NCT01011231
Optic Nerve Glioma | SpringerLink
Gliomas of the anterior visual pathway. Surv Ophthalmol. 1994;38:427-52.CrossRefPubMedGoogle Scholar ... Optic nerve glioma: an update. Int Ophthalmol. 2014;34(4):999-1005.CrossRefPubMedGoogle Scholar ... Optic pathway gliomas in neurofibromatosis-1: controversies and recommendations. Ann Neurol. 2007;61:189-98.CrossRefPubMed ... Long-term outcome in children with gliomas of the anterior visual pathway. Pediatr Neurol. 2003;28:262-70.CrossRefPubMedGoogle ...https://link.springer.com/chapter/10.1007%2F978-981-10-7668-8_9
Glioma Brain Tumor
Democrat Senator Edward Kennedy has been diagnosed with Glioma, a kind of brain tumor. Tests carried out on the 76 -year old ... gliomas.. Gliomas do not affect tissues outside the nervous system; do not usually spread outside the brain and spinal cord. ... A variety of techniques are used in the treatment of Gliomas. a) Surgery is an effective method to cure slow-growing tumors and ... Gliomas located in brain stem area are difficult to treat even if they are benign. The brain stem is a critical area of the ...http://www.medindia.net/news/healthwatch/Glioma-Brain-Tumor-37000-1.htm
Pilocytic astrocytoma/glioma - Neurology - MedHelp
Pilocytic astrocytoma/glioma CancerTumor If someone has had chemotherapy treatments for the above mentioned (brain) tumor, does ... Pilocytic astrocytoma and glioma are benign tumors of the brain and may or may not be cancerous which means these tumors ... Pilocytic astrocytoma and glioma are benign tumors of the brain and may or may not be cancerous which means these tumors ... Pilocytic astrocytoma/glioma. If someone has had chemotherapy treatments for the above mentioned (brain) tumor, does it mean he ...https://www.medhelp.org/posts/Neurology/Pilocytic-astrocytoma-glioma/show/796383
glioma - Science-Based Medicine
Hash Oil for Gliomas? What Would You Do?. A friend asked me to look at the evidence for hash oil as a treatment for glioma. His ... Tag: glioma. CancerPublic HealthScience and the Media. No, a rat study with marginal results does not prove that cell phones ... It recurred very rapidly after surgery and radiotherapy and the latest tissue diagnosis shows an aggressive grade IV glioma. ...https://sciencebasedmedicine.org/tag/glioma/
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and ...http://www.bio-medicine.org/medicine-products/Gliomas-22929-1/
Brain stem glioma - Canadian Cancer Society
The treatment of brain stem gliomas depends on: the type of tumour the size and location of the tumour whether the cancer has ... Brain stem glioma. Brain stem gliomas are a type of glioma that starts in the brain stem. They often grow in the middle of the ... Types of brain stem gliomas. The 2 main types of gliomas that occur in children are focal or low-grade gliomas and diffuse ... Most brain stem gliomas are pontine gliomas, which start in the part of the brain stem called the pons. ...http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal-childhood/childhood-brain-and-spinal-tumours/brain-stem-glioma/?region=pe