Keith Ligon | Harvard Catalyst Profiles | Harvard Catalyst
... and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol. 2008; 73:427-37. PMID ... FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):540-53 ... Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred ... Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget. 2012 Jan; 3(1):98-106. PMID: 22298889 ...https://connects.catalyst.harvard.edu/Profiles/display/Person/85144
Post-Doctoral Research Fellow - Cancer Stem Cell Biology | GenomeWeb
... and non-neoplastic neural stem cells (NSCs). This position will require contributions both as an individual and as part of a ... which will build on results of comprehensive RNAi and CRISPR-Cas9 screening in Glioblastoma stem-like cells (GSCs) ... cell biology, and/or therapeutic discovery* Experience with model mammalian systems (murine, stem cells, etc.) is strongly ... The Paddison Lab using functional genetic approaches in mammalian stem cell model systems to uncover determinants of cell ...https://www.genomeweb.com/resources/jobs/post-doctoral-research-fellow-cancer-stem-cell-biology-1
Zika virus has oncolytic activity against glioblastoma stem cells | JEM
... with extensive contributions from nontransformed cells and a cellular hierarchy within the neoplastic compartment. Atop the ... Glioblastoma cancer stem cells evade innate immune suppression of self-renewal through reduced TLR4 expression. Cell Stem Cell. ... stem-like tumor cell population called glioblastoma stem cells (GSCs) or tumor-initiating cells (Chen et al., 2012). GSCs ... Stem cell models, challenges, and opportunities. Cell Stem Cell. 19:690-702. doi:10.1016/j.stem.2016.11.014. ...http://jem.rupress.org/content/214/10/2843?rss%253D1%2526ssource%253Dmfr=
EGFR Amplification and Glioblastoma Stem-Like Cells
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma ... "Glioblastoma stem-like cells: approaches for isolation and characterization," Journal of Cancer Stem Cell Research, vol. 2, ...https://www.hindawi.com/journals/sci/2015/427518/ref/
MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism | Cancer Research
... and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol 2008;73:427-37. ... Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008;2:333-44. ... Tumor and Stem Cell Biology MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism. Hirofumi ... Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br J ...http://cancerres.aacrjournals.org/content/74/20/5903
Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging.
Glioblastoma / pathology*. Humans. Microfluidic Analytical Techniques / instrumentation*, methods. Neoplastic Stem Cells / ... Keywords: Medicine, Issue 58, BTSC, Tumor, cancer stem cell, cell migration, microfluidics, Glioblastoma Multiforme, GBM, ... If required after cell counting, additional stem cell medium is added to the BTSC suspension to give a cell density of 20,000 ... Cancer Stem Cells-Perspectives on Current Status and Future DirectionsAACR Workshop on Cancer Stem Cells. Cancer ResearchYear: ...http://www.biomedsearch.com/nih/Evaluation-cancer-stem-cell-migration/22217858.html
ReactionFlow: an interactive visualization tool for causality analysis in biological pathways | BMC Proceedings | Full Text
... that occur within a cell. Through interviews with domain experts, we identified four common tasks that require an understanding ... and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol. 2008, 73: 427-437. ... Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells. Nature. 2011, 414 (6859): 105-111.View ... stem-cell researchers aim at initiating pathways that will precipitate a desired cellular differentiation into specific cell ...https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-9-S6-S6
John J Laterra - Research Output - Johns Hopkins University
Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition. Ying, M., Wang, S., Sang, Y., Sun, P ... Neoplastic Stem Cells Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.. Woodard, ... Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity. Sun, P., Xia, S., Lal, B., Shi, ... HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Tilghman, J., Wu, H., Sang, Y., Shi, X., ...https://jhu.pure.elsevier.com/en/persons/john-j-laterra/publications/
Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype. - PubMed ...
Neoplastic Stem Cells/drug effects*. *Neoplastic Stem Cells/radiation effects*. *Peptides/metabolism ... Glioblastoma multiforme (GBM) contains a population of cells that exhibit stem cell phenotypes. These cancer stem cells (CSCs) ... Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype.. Fouse SD1 ... Response of primary glioblastoma cells to therapy is patient specific and independent of cancer stem cell phenotype ...https://www.ncbi.nlm.nih.gov/pubmed/24311636
NAVER Academic | p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Cell Proliferation, Gene Expression Regulation, Glioblastoma, Glioma, Humans, Immunohistochemistry, Mice, Neoplastic Stem Cells ... Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Michael F Clarke ... The epithelial-mesenchymal transition generates cells with properties of stem cells. Sendurai A Mani et al. ... An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Ittai Ben-Porath et al. ...http://academic.naver.com/article.naver?doc_id=146501449
Qingres-An academic Publisher
Hematopoietic stem cell-derived adipocytes promote neoplastic growth and cancer cell migration. ... suppresses neoplastic cell proliferation and reduces tumor grade in a preclinical glioblastoma model and render the tumor more ... Hematopoietic stem cell-derived adipocytes promote tutor growth and cancer cell migration. Int J Cancer Res Mol Mech. 2017; 3(1 ... A Cell-autonomous positive-signalling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells. Biochem ...http://mo.qingres.com/htmls/Mo_942_Detail.html
Frontiers | NG2 cells (polydendrocytes) in brain physiology and repair | Neuroscience
... and neural stem cells and exist throughout the gray and white matter of the developing and mature central nervous system (CNS ... and neural stem cells and exist throughout the gray and white matter of the developing and mature central nervous system (CNS ... also referred to as oligodendrocyte precursor cells or polydendrocytes, represent a major resident glial cell population that ... also referred to as oligodendrocyte precursor cells or polydendrocytes, represent a major resident glial cell population that ...https://www.frontiersin.org/articles/10.3389/fnins.2014.00133/full
DelMar Presents Clinical Update on VAL-083 From Ongoing First- and Second-Line Trials in Patients with MGMT-unmethylated GBM at...
In this poster, the authors discuss their preclinical finding that when glioblastoma stem cell lines are treated with VAL-083 ... Downregulation of BDR4 as a Novel Anti-Neoplastic Mechanism ... Proliferation of a Panel of Eight Glioblastoma Stems Cell Lines ... Dianhydrogalactitol (VAL-083) Reduces Glioblastoma Tumor Growth In Vivo Upon Bevacizumab-induced Hypoxia ... "In our much-awaited Phase 2 study of VAL-083 in patients with MGMT-unmethylated, Bevacizumab-Naïve Recurrent Glioblastoma ...https://lifesciencesbc.ca/announcements/delmar-presents-clinical-update-on-val-083-from-ongoing-first-and-second-line-trials-in-patients-with-mgmt-unmethylated-gbm-at-the-society-for-neurooncology-annual-meeting/
Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and...
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4:440-452. [PubMed] ... The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015;16:225-238. ... Exp Cell Res. 2010;316:2099-2112. [PubMed]. 35. Scaffidi P, Misteli T. In vitro generation of human cells with cancer stem cell ... Endothelial cell differentiation of human breast tumour stem/progenitor cells. J Cell Mol Med. 2009;13:309-319. [PMC free ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4918945/
Influence of DNMT inhibitors on radiation-induced γH2A | Open-i
A549 and U373MG cells growing in chamber slides were exposed to DNMT inhibitors for 18 hours, irr ... Methods: A549 (lung cancer) and U373MG (glioblastoma) cells were exposed to radiation with or without six DNMT inhibitors (5- ... Gene Expression Regulation, Neoplastic/drug effects. *Glioblastoma/pathology. *Histones/analysis. *Humans. *Hydralazine/ ... Methods: A549 (lung cancer) and U373MG (glioblastoma) cells were exposed to radiation with or without six DNMT inhibitors (5- ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3375186_1748-717X-7-39-7&req=4
Otto Hannes Vogel | Stanford Medicine Profiles
Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III. Cancer research Emlet, D. R., Gupta, ... mature lymphocytes within a heterogeneous infiltrate of neoplastic and reactive inflammatory cells. Surface marker aberrancies ... found on known human neural stem cells.Cells with a cell surface marker profile characteristic of human neural stem cells were ... Some cells (12%) were CD34 positive, indicating the presence within the tumor of hematopoietic stem cells. Cells formed ...https://med.stanford.edu/profiles/hannes-vogel
adult optic nerve glioma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Neoplastic Stem Cells / pathology. Optic Nerve Glioma / pathology. *[MeSH-minor] Adult Stem Cells / pathology. Biomarkers / ... Hartel PH, Rosen C, Larzo C, Nestor S: Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature ... Lasky JL 3rd, Choe M, Nakano I: Cancer stem cells in pediatric brain tumors. Curr Stem Cell Res Ther; 2009 Dec;4(4):298-305. ... The adult population presented more cases of basal cell carcinomas (18 cases), squamous cell carciomas (12 cases), meningiomas ...http://www.bmlsearch.com/?kwr=adult+optic+nerve+glioma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
Leptomeningeal Dissemination of Malignant Glioma Simulating Cerebral Vasculitis | Stroke
Along the brain stem and spinal cord, neoplastic cells encased and invaded cranial nerves, including cranial nerve III, as well ... 3 16 The ability of leptomeningeal metastatic glioblastoma cells to encase, invade, and lead to thrombosis and narrowing of ... The finding of direct invasion of vessel walls by neoplastic glial cells in the present case may have accounted for local ... Encasement of leptomeningeal arteries and veins by cuffs of subarachnoid neoplastic cells, probably resulting in luminal ...http://stroke.ahajournals.org/content/26/12/2366
FACS-based Isolation of Neural and Glioma Stem Cell ...
... we demonstrated the ability to prospectively isolate stem cell populations from fresh human germinal matrix and glioblastoma ... Here we describe in detail the purification methodology of EGF-bound (i.e., EGFR+) human neural and glioma cells with stem cell ... The ability to prospectively isolate stem cell populations using native ligand-binding ability opens new doors for ... ligand in fluorescence-activated cell sorting (FACS). We demonstrated that FACS-isolated EGF-bound neural and glioblastoma ...https://bio-protocol.org/e2659
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Of note, we show that CD133-positive cells often associated with cancer stem-like cells in glioblastoma biopsies, do not ... we show that side population cells in human glioblastoma are non-neoplastic and exclusively stroma-derived. Tumour cells were ... tumor cells that display stem cell-like characteristics can undergo asymmetric cell division giving rise to tumor cells that ... As normal stem cells the cancer stem-like cells seem to adapt to hypoxic environments and will use metabolic pathways that ...https://www.jove.com/visualize?author=Rolf%20Bjerkvig%20
Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas
A. Ernst, S. Hofmann, R. Ahmadi et al., "Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures ... "Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target ... Wild-type tumor cells, lymphocytes, macrophages, and endothelial cells show a granular staining in the cytoplasm-cell membrane ... Based on the suggested functions of PMP22, EMP3 may be involved in cell proliferation, cell-cell interactions, and apoptosis. ...https://www.hindawi.com/journals/bmri/2013/756302/
Eberhart, Rodriguez and Raabe Laboratories » Presentations and Awards
"Using human neural stem cells to model pediatric high grade gliomas: the role of p53, c-MYC, and EGFRvIII in neoplastic ... Kah Jing Lim (Poster) "Using the natural remedies Zeng Sheng Ping and curcumin to treat medulloblastoma and glioblastoma" ... Eli Bar (Invited Talk) "Hypoxia Increases The Expression Of The Stem-Cell Markers Side-Population and CD133 And Promotes ... Eric Raabe (Oral Presentation) "BRAF induces cellular transformation and senescence in human neural stem cells: a model of ...http://labs.pathology.jhu.edu/eberhart/?page_id=74
DRP1 inhibition induces AMPK activity in BTICsa. Lysate | Open-i
Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, Ohio, USA. ... DRP1 activation correlated with poor prognosis in glioblastoma, suggesting that mitochondrial dynamics may represent a ... Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, Ohio, USA. ... inhibited DRP1 in non-BTIC tumor cells, suggesting that tumor cell differentiation induces a regulatory switch in mitochondrial ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4376639_nihms658407f6&req=4
Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in...
... sustain glioblastoma (GBM) onset and progression, and, therefore, HDAC inhibitors (HDACi) represent a promising class of... ... Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens. Stem Cells 27:1722-1733CrossRef ... Here, we analyzed the effects of ITF2357 (givinostat), a pan-HDACi, in GBM models for its anti-neoplastic potential. ... Glioblastoma Cancer stem cells HDACs HDACs' inhibitor Givinostat ITF2357 Francesco Marampon and Flavio Leoni have contributed ...https://link.springer.com/article/10.1007%2Fs00432-018-2800-8
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer...
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer ... Stem Cell Heterogeneity of Tumors Found In Vivo.'s profile, publications, research topics, and co-authors ... cells surrounding a hypoxic core of primarily non-stem senescent cells and diffuse, quiescent CSCs. Notably, non-stem cells ... In conclusion, we present a new ex vivo model in which phenotypically diverse stem and non-stem glioblastoma cell populations ...https://scholars.duke.edu/display/pub1121452