*  Keith Ligon | Harvard Catalyst Profiles | Harvard Catalyst
... and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol. 2008; 73:427-37. PMID ... FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):540-53 ... Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred ... Neoplastic cells are a rare component in human glioblastoma microvasculature. Oncotarget. 2012 Jan; 3(1):98-106. PMID: 22298889 ...
  https://connects.catalyst.harvard.edu/Profiles/display/Person/85144
*  Post-Doctoral Research Fellow - Cancer Stem Cell Biology | GenomeWeb
... and non-neoplastic neural stem cells (NSCs). This position will require contributions both as an individual and as part of a ... which will build on results of comprehensive RNAi and CRISPR-Cas9 screening in Glioblastoma stem-like cells (GSCs) ... cell biology, and/or therapeutic discovery* Experience with model mammalian systems (murine, stem cells, etc.) is strongly ... The Paddison Lab using functional genetic approaches in mammalian stem cell model systems to uncover determinants of cell ...
  https://www.genomeweb.com/resources/jobs/post-doctoral-research-fellow-cancer-stem-cell-biology-1
*  Zika virus has oncolytic activity against glioblastoma stem cells | JEM
... with extensive contributions from nontransformed cells and a cellular hierarchy within the neoplastic compartment. Atop the ... Glioblastoma cancer stem cells evade innate immune suppression of self-renewal through reduced TLR4 expression. Cell Stem Cell. ... stem-like tumor cell population called glioblastoma stem cells (GSCs) or tumor-initiating cells (Chen et al., 2012). GSCs ... Stem cell models, challenges, and opportunities. Cell Stem Cell. 19:690-702. doi:10.1016/j.stem.2016.11.014. ...
  http://jem.rupress.org/content/214/10/2843?rss%253D1%2526ssource%253Dmfr=
*  EGFR Amplification and Glioblastoma Stem-Like Cells
... and clinical studies in all areas of stem cell biology and applications. The journal will consider basic, translational, and ... Stem Cells International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma ... "Glioblastoma stem-like cells: approaches for isolation and characterization," Journal of Cancer Stem Cell Research, vol. 2, ...
  https://www.hindawi.com/journals/sci/2015/427518/ref/
*  MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism | Cancer Research
... and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol 2008;73:427-37. ... Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008;2:333-44. ... Tumor and Stem Cell Biology MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism. Hirofumi ... Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer. Br J ...
  http://cancerres.aacrjournals.org/content/74/20/5903
*  Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging.
Glioblastoma / pathology*. Humans. Microfluidic Analytical Techniques / instrumentation*, methods. Neoplastic Stem Cells / ... Keywords: Medicine, Issue 58, BTSC, Tumor, cancer stem cell, cell migration, microfluidics, Glioblastoma Multiforme, GBM, ... If required after cell counting, additional stem cell medium is added to the BTSC suspension to give a cell density of 20,000 ... Cancer Stem Cells-Perspectives on Current Status and Future DirectionsAACR Workshop on Cancer Stem Cells. Cancer ResearchYear: ...
  http://www.biomedsearch.com/nih/Evaluation-cancer-stem-cell-migration/22217858.html
*  John J Laterra - Research Output - Johns Hopkins University
Regulation of glioblastoma stem cells by retinoic acid: Role for Notch pathway inhibition. Ying, M., Wang, S., Sang, Y., Sun, P ... Neoplastic Stem Cells Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling.. Woodard, ... Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity. Sun, P., Xia, S., Lal, B., Shi, ... HMMR maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Tilghman, J., Wu, H., Sang, Y., Shi, X., ...
  https://jhu.pure.elsevier.com/en/persons/john-j-laterra/publications/
*  NAVER Academic | p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.
Cell Proliferation, Gene Expression Regulation, Glioblastoma, Glioma, Humans, Immunohistochemistry, Mice, Neoplastic Stem Cells ... Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Michael F Clarke ... The epithelial-mesenchymal transition generates cells with properties of stem cells. Sendurai A Mani et al. ... An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Ittai Ben-Porath et al. ...
  http://academic.naver.com/article.naver?doc_id=146501449
*  Qingres-An academic Publisher
Hematopoietic stem cell-derived adipocytes promote neoplastic growth and cancer cell migration[6]. ... suppresses neoplastic cell proliferation and reduces tumor grade in a preclinical glioblastoma model and render the tumor more ... Hematopoietic stem cell-derived adipocytes promote tutor growth and cancer cell migration. Int J Cancer Res Mol Mech. 2017; 3(1 ... A Cell-autonomous positive-signalling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells. Biochem ...
  http://mo.qingres.com/htmls/Mo_942_Detail.html
*  Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and...
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4:440-452. [PubMed] ... The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell. 2015;16:225-238. ... Exp Cell Res. 2010;316:2099-2112. [PubMed]. 35. Scaffidi P, Misteli T. In vitro generation of human cells with cancer stem cell ... Endothelial cell differentiation of human breast tumour stem/progenitor cells. J Cell Mol Med. 2009;13:309-319. [PMC free ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4918945/
*  Otto Hannes Vogel | Stanford Medicine Profiles
Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III. Cancer research Emlet, D. R., Gupta, ... mature lymphocytes within a heterogeneous infiltrate of neoplastic and reactive inflammatory cells. Surface marker aberrancies ... found on known human neural stem cells.Cells with a cell surface marker profile characteristic of human neural stem cells were ... Some cells (12%) were CD34 positive, indicating the presence within the tumor of hematopoietic stem cells. Cells formed ...
  https://med.stanford.edu/profiles/hannes-vogel
*  adult optic nerve glioma 2005:2010[pubdate] *count=100 - BioMedLib™ search engine
Neoplastic Stem Cells / pathology. Optic Nerve Glioma / pathology. *[MeSH-minor] Adult Stem Cells / pathology. Biomarkers / ... Hartel PH, Rosen C, Larzo C, Nestor S: Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature ... Lasky JL 3rd, Choe M, Nakano I: Cancer stem cells in pediatric brain tumors. Curr Stem Cell Res Ther; 2009 Dec;4(4):298-305. ... The adult population presented more cases of basal cell carcinomas (18 cases), squamous cell carciomas (12 cases), meningiomas ...
  http://www.bmlsearch.com/?kwr=adult+optic+nerve+glioma+2005:2010%5Bpubdate%5D&cxts=100&stmp=b0
*  Leptomeningeal Dissemination of Malignant Glioma Simulating Cerebral Vasculitis | Stroke
Along the brain stem and spinal cord, neoplastic cells encased and invaded cranial nerves, including cranial nerve III, as well ... 3 16 The ability of leptomeningeal metastatic glioblastoma cells to encase, invade, and lead to thrombosis and narrowing of ... The finding of direct invasion of vessel walls by neoplastic glial cells in the present case may have accounted for local ... Encasement of leptomeningeal arteries and veins by cuffs of subarachnoid neoplastic cells, probably resulting in luminal ...
  http://stroke.ahajournals.org/content/26/12/2366
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Of note, we show that CD133-positive cells often associated with cancer stem-like cells in glioblastoma biopsies, do not ... we show that side population cells in human glioblastoma are non-neoplastic and exclusively stroma-derived. Tumour cells were ... tumor cells that display stem cell-like characteristics can undergo asymmetric cell division giving rise to tumor cells that ... As normal stem cells the cancer stem-like cells seem to adapt to hypoxic environments and will use metabolic pathways that ...
  https://www.jove.com/visualize?author=Rolf%20Bjerkvig%20
*  Eberhart, Rodriguez and Raabe Laboratories » Presentations and Awards
"Using human neural stem cells to model pediatric high grade gliomas: the role of p53, c-MYC, and EGFRvIII in neoplastic ... Kah Jing Lim (Poster) "Using the natural remedies Zeng Sheng Ping and curcumin to treat medulloblastoma and glioblastoma" ... Eli Bar (Invited Talk) "Hypoxia Increases The Expression Of The Stem-Cell Markers Side-Population and CD133 And Promotes ... Eric Raabe (Oral Presentation) "BRAF induces cellular transformation and senescence in human neural stem cells: a model of ...
  http://labs.pathology.jhu.edu/eberhart/?page_id=74
*  DRP1 inhibition induces AMPK activity in BTICsa. Lysate | Open-i
Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, Ohio, USA. ... DRP1 activation correlated with poor prognosis in glioblastoma, suggesting that mitochondrial dynamics may represent a ... Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland, Ohio, USA. ... inhibited DRP1 in non-BTIC tumor cells, suggesting that tumor cell differentiation induces a regulatory switch in mitochondrial ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4376639_nihms658407f6&req=4
*  A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer...
A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer ... Stem Cell Heterogeneity of Tumors Found In Vivo.'s profile, publications, research topics, and co-authors ... cells surrounding a hypoxic core of primarily non-stem senescent cells and diffuse, quiescent CSCs. Notably, non-stem cells ... In conclusion, we present a new ex vivo model in which phenotypically diverse stem and non-stem glioblastoma cell populations ...
  https://scholars.duke.edu/display/pub1121452
*  Ministero della Salute - PDF
Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA Oncology ... role in neoplastic growth and lymphatic spread C.R.O. AVIANO Oncology 1 Basic 4, ... Stem Cell Quick Guide: Stem Cell Basics Stem Cell Quick Guide: Stem Cell Basics What is a Stem Cell? Stem cells are the ... Roche Position on Human Stem Cells Roche Position on Human Stem Cells Background Stem cells and treating diseases. Stem cells ...
  http://docplayer.net/1899556-Ministero-della-salute.html
*  Molecular Neurogenetics
Neoplastic neural stem cells: One important issue of targeting brain tumor stem cells (BTSCs) is to avoid damaging normal stem ... We consider the inducible model a better model to recapitulate human glioblastoma, and it will be extremely interesting to ... Astrocyte-like type B cells in the adult SVZ are thought to be multipotent neural stem cells (NSCs). These cells give rise to ... Molecular principles in neural stem cells, neurogenesis and brain diseases. *Cancer stem cells, tumor heterogeneity and novel ...
  http://www.dkfz.de/en/normale-und-neoplastische-stammzellen/
*  Sixth nerve palsy - Wikipedia
Less common: Increased intracranial pressure, giant cell arteritis, cavernous sinus mass (e.g. meningioma, Brain stem ... In children, Harley reports typical causes as traumatic, neoplastic (most commonly brainstem glioma), as well as idiopathic. ... Glioblastoma aneurysm, metastasis), multiple sclerosis, sarcoidosis/vasculitis, postmyelography, lumbar puncture, stroke ( ... his view being that since the sixth nerve emerges straight forward from the brain stem, whereas other cranial nerves emerge ...
  https://en.wikipedia.org/wiki/Sixth_nerve_palsy
*  Cancer Stem Cell Niche in Brain Tumors - Xing Fan
... treatment-resistant neoplastic stem cells are critical for long-term tumor growth. Normal stem cells require signals from a ... cancer stem cell niche) regulates glioblastoma initiating cells in order to develop a novel therapeutic strategy for this ... treatment-resistant neoplastic stem cells are critical for long-term tumor growth. Normal stem cells require signals from a ... Fan, Xing (2016) γ-Secretase inhibitor-resistant glioblastoma stem cells require RBPJ to propagate. J Clin Invest 126:2415-8 ...
  http://grantome.com/grant/NIH/R01-CA148621-03
*  Frontiers | Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis | Oncology
Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... Our results suggest that Apc mutations lead to an increase in Prom1 expressing cells in the intestinal crypt stem cell ... and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its ... and pancreatic cancer as a cancer stem cell marker and has been used as such to predict colon cancer recurrence in humans. Its ...
  https://www.frontiersin.org/articles/10.3389/fonc.2014.00323/full
*  Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors - Full Text View - ClinicalTrials.gov
adult glioblastoma. adult giant cell glioblastoma. adult gliosarcoma. adult pilocytic astrocytoma. adult ependymoblastoma. ... adult brain stem glioma. adult central nervous system germ cell tumor. adult choroid plexus tumor. adult craniopharyngioma. ... Neoplastic Processes. Pathologic Processes. Donepezil. Cholinesterase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ... Genetic and Rare Diseases Information Center resources: Glioblastoma Glioma Meningioma Ependymoma Oligodendroglioma Anaplastic ...
  https://clinicaltrials.gov/show/NCT00369785
*  SOX2 gene | Cancer Genetics Web
Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells.. Cell. 2014; 157(3):580-94 [ ... 3D cell cultures prolonged the survival and in vitro proliferation of neoplastic IDH1(R132H)-positive cells, however, did not ... Cancer stem cells, as a subgroup of tumor cells, resemble critical properties of embryonic stem cells (ESCs) such as self- ... NMC cells display the ability to grow into stem cell-like spheres and express an exceptionally high level of the stem cell ...
  http://www.cancerindex.org/geneweb/SOX2.htm
*  Frontiers | Commentary: "Prom1 Function in Development, Intestinal Inflammation, and Intestinal Tumorigenesis" | Oncology
Besides progenitor cells, its expression is widespread throughout terminally differentiated cells as those found in glandular ... is related to its use as a stem and cancer stem cell marker (1). ... marks intestinal stem cells that are susceptible to neoplastic ... Glioblastoma formation from cell population depleted of prominin1-expressing cells. PLoS One (2009) 4(8):e6869. doi:10.1371/ ... is related to its use as a stem and cancer stem cell marker (1). Besides progenitor cells, its expression is widespread ...
  https://www.frontiersin.org/articles/10.3389/fonc.2015.00091/full