*  A short-term in vivo model for giant cell tumor of bone | BMC Cancer | Full Text
The tumors were composed of the typical components of GCT, including (CD51+/CD68+) multinucleated giant cells whichwere ... This is the first in vivo model for giant cell tumors of bone which opens new perspectives to study this disease and to test ... There is no existing cell line that contains all the cell and tissue tumor components of GCT and thus in vitro testing of anti- ... The FISH demonstrated that the tumors were composed of human cells interspersed with chick-derived capillaries. A reliable ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-11-241
*  Xgeva Approved for Treatment of Giant Cell Tumor of the Bone - UNM Comprehensive Cancer Center
The drug targets the RANK ligand, thereby inhibiting bone destruction and potentially eliminating giant cells. Xgeva was ... Giant cell tumor of bone (GCTB) is a rare, aggressive, benign osteolytic tumor in which bone destruction is mediated by a ... FDA approves Xgeva to treat giant cell tumor of the bone. [FDA News Release]. U.S. Food and Drug Administration website. ... Xgeva Approved for Treatment of Giant Cell Tumor of the Bone. By ... Non-Small Cell Lung Cancer *Stage I Non-Small Cell Lung Cancer ...
  http://cancer.unm.edu/2013/07/17/xgeva-approved-for-treatment-of-giant-cell-tumor-of-the-bone/
*  Bone Cancer | Denver Health
Giant cell tumor-a primary bone tumor that is malignant; most common in the arm or leg bones ... When cancer starts in bone tissue, it is called primary bone cancer. When cancer cells travel to the bone from another site in ... When cancer starts in bone tissue, it is called primary bone cancer. When cancer cells travel to the bone from another site in ... Giant cell tumor-a primary bone tumor that is malignant; most common in the arm or leg bones ...
  https://www.denverhealth.org/conditions/b/bone-cancer
*  Giant Cell Tumors of the Axial Skeleton
High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including ... "Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone," Calcified Tissue International, vol. 75, ... M. Balke, L. Schremper, C. Gebert et al., "Giant cell tumor of bone: treatment and outcome of 214 cases," Journal of Cancer ... "Treatment of giant-cell tumors of long bones with curettage and bone-grafting," Journal of Bone and Joint Surgery. Series A, ...
  https://www.hindawi.com/journals/sarcoma/2012/410973/ref/
*  Bone cancer, SEM - Stock Image M132/0781 - Science Photo Library
However, osteoclasts may become cancerous causing an osteoclastoma or giant cell tumour, a type of bone cancer that usually ... osteoclasts break down worn out bone and work with bone-forming cells called osteoblasts to repair bone. ... multi-nucleated cells that form from the fusion of several macrophage cells in bone and they move by extending cellular ... Coloured scanning electron micrograph (SEM) of a cancerous osteoclast cell (blue) on the surface of a bone (grey). Osteoclasts ...
  http://www.sciencephoto.com/media/254276/view
*  Method for eliciting an immune response to human telomerase reverse transcriptase - Patent # 8709995 - PatentGenius
... changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments ... useful for treatment of diseases such as cancers. ... "Telomere Reduction in Giant Cell Tumor of Bone and with Aging ... Heiser, A. et al., "Human dendritic cells transfected with renal tumor RNA stimulate polyclonal T-cell responses against ... Heiser, A. et al., "Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor ...
  http://www.patentgenius.com/patent/8709995.html
*  Tykerb and Herceptin Combination Therapy Fails to Improve Outcomes for Early Stage HER2 Breast Cancer
Xgeva Reduces Giant-cell Tumor of the Bone. June 30, 2009. CIN Associated with Risk of Invasive Cervical Cancer. ... Overexpression of this protein leads to increased growth of cancer cells. Tykerb and Herceptin are treatments that target these ... Breast Cancer, Carcinoma In Situ Breast cancer, News, Stage I Node Negative Breast Cancer, Stages II-III Breast Cancer ... Breast Cancer News. Breast Cancer Links. *Signup for the Breast Cancer Newsletter ...
  http://news.cancerconnect.com/tykerb-and-herceptin-combination-therapy-fails-to-improve-outcomes-for-early-stage-her2-breast-cancer/
*  Bone Cancer | Medical City Dallas
Learn more about Bone Cancer at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Giant cell tumor-a primary bone tumor that is malignant; most common in the arm or leg bones ... When cancer starts in bone tissue, it is called primary bone cancer. When cancer cells travel to the bone from another site in ... Bone cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/bone-cancer.html. Accessed October 9 ...
  https://medicalcityhospital.com/hl/?/12008/bone-cancers&com.dotmarketing.htmlpage.language=1
*  Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma | AJO
To our knowledge, this case report is the first to describe an assessment of the transformation of a benign GCT of bone into an ... evaluated by the same medical team.There are only a few case reports and case series of malignancy associated with GCT of bone ... we report a case of transformation of a benign giant cell tumor (GCT) of the calcaneus into an epithelioid angiosarcoma. The ... Cancer Treat Rev. 2010;36(1):1-7.. 3. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint ...
  https://www.amjorthopedics.com/article/transformation-benign-giant-cell-tumor-bone-epithelioid-angiosarcoma
*  Cryosurgery as Additional Treatment in Tenosynovial Giant Cell Tumors
High-quality papers concerning the entire range of bone and soft tissue sarcomas in both adults and children, including ... effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells," ... "Diffuse-type tenosynovial giant cell tumour: current treatment concepts and future perspectives," European Journal of Cancer, ... Cryosurgery as Additional Treatment in Tenosynovial Giant Cell Tumors. F. G. M. Verspoor, A. Scholte, I. C. M. van der Geest, G ...
  https://www.hindawi.com/journals/sarcoma/2016/3072135/ref/
*  Giant-cell tumor of bone - Wikipedia
A number of tumors have giant cells, but are not true benign giant-cell tumors. These include, aneurysmal bone cyst, ... March 2008). "Giant cell tumor of bone: treatment and outcome of 214 cases". J. Cancer Res. Clin. Oncol. 134 (9): 969-78. doi: ... Giant-cell tumor of the bone accounts for 4-5% of primary bone tumors and about 20% of benign bone tumors. However, ... Giant-cell tumour of bone. Current Opinion in Oncology, 21, 338-344 Werner, M. (2006). Giant-cell tumour of bone: morphological ...
  https://en.wikipedia.org/wiki/Giant-cell_tumor_of_bone
*  Giant Cell Fibroblastoma (GCF, Juvenile Dermatofibrosarcoma Protuberans) - The Clinical Advisor
"Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: dermatofibrosarcoma protuberans and giant ... "Giant cell fibroblastoma: a juvenile form of dermatofibrosarcoma protuberans". Cancer. vol. 64. 1989. pp. 2154-61. ... There are also a variable number of pleomorphic hyperchromatic spindle cells and multinucleated tumor cells. ... Giant Cell Tumor of the Tendon Sheath (Tenosynovial giant cell tumor, localized type). ...
  https://www.clinicaladvisor.com/dermatology/giant-cell-fibroblastoma-gcf-juvenile-dermatofibrosarcoma-protuberans/article/587879/
*  Bone Cancers | CancerIndex
... giant cell tumors, and osteosarcomas and organized it by tumor type, providing a detailed discussion of background, imaging, ... Other less common types of bone cancer include: Chondrosarcoma (a cancer arising in cartilage cells, usually found in adults ... Bone Cancers Bone Cancers. Primary bone tumours are tumours that start in the bone. In contrast, secondary bone cancer is where ... Bone Metastases (secondary bone cancer). Bone Cancer FAQ. Information Patients and the Public (9 links). Bone and connective ...
  http://www.cancerindex.org/clinks2c.htm
*  Anti-CD13 antibody [22A5] (ab20136) | Abcam
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.. Cancer ... synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells ... Cancer. Cardiovascular. Cell Biology. Epigenetics. Metabolism. Developmental Biology. By research area. Immunology. ... Cell and tissue imaging tools. Cellular and biochemical assays. By product type. Proteins and Peptides. Proteomics tools. ...
  http://www.abcam.com/cd13-antibody-22a5-ab20136.html
*  Primary Tumors of Bone and Lung in Rats Following Local Deposition of Cupric-chelated N-Hydroxy-2-acetylaminofluorene | Cancer...
Three of the 28 tumors were rhabdomyosarcomas; an additional 3 giant-cell sarcomas were presumed to be extraosseous in origin. ... Nine of the tumors were predominantly of osteogenic cells, two of chondrogenic cells, one of fibrogenic cells, four of ... However, many of these tumors contained more than one type of neoplastic cell. Of note were four tumors composed of mixtures of ... Twenty-two tumors in 17 rats were composed of either bone-forming or bone marrow elements. ...
  http://cancerres.aacrjournals.org/content/27/5_Part_1/1000
*  Prolia Solution For Injection 60Mg Drug Medication Dosage Information
Xgeva is also used to treat giant cell tumor of the bone. ... due to cancer and to prevent bone fractures and other bone ... Muscle And/Or Bone Pain Incidence: ,8.0%* Severity: MILD Onset: EARLY Low White Blood Cells Incidence: ,9.0%* Severity: ... Bone Pain Incidence: 4.0-19.0%* Severity: MODERATE Onset: DELAYED Anemia Incidence: 4.0-21.0%* Severity: MODERATE Onset: ... DENOSUMAB (den oh sue mab) slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and ...
  https://www.cvs.com/drug/prolia/solution-for-injection/60mg
*  The Lancet Oncology Publishes Results Of XGEVA denosumab In Patients With Giant Cell Tumor Of Bone
... www.cancer.org/Cancer/BoneCancer/DetailedGuide/bone-cancer-what-is-bone-cancer. Accessed June 24, 2013. .. 5 Giant Cell Tumor ... Giant cell tumors of bone consist of stromal cells expressing RANKL and osteoclast-like giant cells expressing RANK receptor. ... Giant cell tumour of bone. Current Opinion in Oncology. 2009;21:338-344.. 4 Bone Cancer. American Cancer Society. website. http ... About Giant Cell Tumor of Bone. GCTB is a locally aggressive, benign tumor primarily afflicting younger adults between the ages ...
  http://www.amgen.com/media/news-releases/2013/07/the-lancet-oncology-publishes-results-of-xgeva-denosumab-in-patients-with-giant-cell-tumor-of-bone/
*  bone cancers Flashcards - Cram.com
Study Flashcards On bone cancers at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get ... spindle-shaped cell with multinucleated cells giant cell tumor bone growth covered by cap of cartilage projecting from surface ... "bone cancers","payreferer_url":"\/flashcards\/copy\/bone-cancers-342413","isGuest":true,"ga_id":"UA-272909-1","facebook":{" ...
  http://www.cram.com/flashcards/bone-cancers-342413
*  Tumors of Fibrous Tissue Origin | SpringerLink
Among all primary bone tumors nonossifying fibroma is the most frequently occurring one in children and adolescents. It is ... Kasahara K, Yamamuro T, Kasahara A. Giant cell tumour of bone: cytological studies. Br J Cancer 1979; 40: 201-9PubMedCrossRef ... foam cells and multinucleated giant cells. No bone formation is seen within the lesion. It develops eccentrically in a bone and ... Johnston J. Giant cell tumor of bone. The role of the giant cell in orthopedic pathology. Orthop Clin N Am 1977; 8: 751-70 ...
  https://link.springer.com/chapter/10.1007/978-1-4471-1951-7_5
*  Role of MicroRNA-103a Targeting ADAM10 in Abdominal Aortic Aneurysm
... and giant cell tumors of bone [27-30]. It has been found that, besides ADAM12, several ADAMs, including ADAM9, 10, 17, and 19, ... "Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells," ... Cell Culture. Smooth muscle cells (SMCs) were grown in RPMI1640 medium (GIBCO Laboratories, NY, US) and HEK293T cells were ... J. Guo, L. He, P. Yuan et al., "ADAM10 overexpression in human non-small cell lung cancer correlates with cell migration and ...
  https://www.hindawi.com/journals/bmri/2017/9645874/
*  Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA...
... and macrophage colony-stimulating factor in giant cell tumor of bone (6). Although in many cancers, the age of the patient ... Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells ... or bone (osteosarcoma, chondrosarcoma; ref. 1). Sarcomas are rare tumors, about 1% of all human cancers. Many of these tumors ... Cell lines. Division of Cancer Treatment and Diagnostics of the National Cancer Institute (DCTD/NCI) collected a panel of 63 ...
  http://mct.aacrjournals.org/content/14/11/2452
*  Giant Cell Tumor of Bone - an Overview
It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with ... As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional ... Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that ... in the understanding of pathogenesis are essential to develop new treatments for this locally destructive primary bone tumor. ...
  http://abjs.mums.ac.ir/article_4701.html
*  Most recent papers with the keyword Giant cell tumor of bone | Read by QxMD
... miR-30c expression level in 62 pairs of giant cell tumor of bone cells tissue samples and five breast cancer-derived cell lines ... of miR-30c on giant cell tumor of bone cell metastasis and growth and provide therapeutic targets for giant cell tumor of bone ... Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% ... Giant cell tumors of bone (GCTB) are intermediate and locally aggressive bone tumor. Calcium phosphate cement (CPC) is a bone ...
  https://www.readbyqxmd.com/keyword/115617
*  Nikos Athanasou - Wikipedia
... particularly breast cancer metastasis, Ewing sarcoma and giant cell-rich lesions such as giant cell tumour of bone and ... 1998). Human tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells. J Pathol 184: 31-36. PMID ... 2005). Phenotypic and molecular studies on giant cell tumours of bone and soft tissues. Hum Pathol. 36: 945 - 954 PMID 16153456 ... Endocrinology 139: 4058 -4060 PMID 8756585 Athanasou N. (1996) The cellular biology of bone-resorbing cells. J Bone Joint ...
  https://en.wikipedia.org/wiki/Nikos_Athanasou
*  Bone - Wikipedia
... giant cell tumor of bone, and aneurysmal bone cyst. Cancer can arise in bone tissue, and bones are also a common site for other ... Blood cells that are created in bone marrow include red blood cells, platelets and white blood cells. Progenitor cells such as ... cancer) or create bone (a "sclerotic" cancer). Cancers of the bone marrow inside the bone can also affect bone tissue, examples ... lung cancer, prostate cancer, thyroid cancer, and kidney cancer. Secondary cancers that affect bone can either destroy bone ( ...
  https://en.wikipedia.org/wiki/Bone