*  Xgeva Approved for Treatment of Giant Cell Tumor of the Bone - UNM Comprehensive Cancer Center
The drug targets the RANK ligand, thereby inhibiting bone destruction and potentially eliminating giant cells. Xgeva was ... Giant cell tumor of bone (GCTB) is a rare, aggressive, benign osteolytic tumor in which bone destruction is mediated by a ... FDA approves Xgeva to treat giant cell tumor of the bone. [FDA News Release]. U.S. Food and Drug Administration website. ... Xgeva Approved for Treatment of Giant Cell Tumor of the Bone. By ... Non-Small Cell Lung Cancer *Stage I Non-Small Cell Lung Cancer ...
  http://cancer.unm.edu/2013/07/17/xgeva-approved-for-treatment-of-giant-cell-tumor-of-the-bone/
*  Bone cancer, SEM - Stock Image M132/0781 - Science Photo Library
However, osteoclasts may become cancerous causing an osteoclastoma or giant cell tumour, a type of bone cancer that usually ... osteoclasts break down worn out bone and work with bone-forming cells called osteoblasts to repair bone. ... multi-nucleated cells that form from the fusion of several macrophage cells in bone and they move by extending cellular ... Coloured scanning electron micrograph (SEM) of a cancerous osteoclast cell (blue) on the surface of a bone (grey). Osteoclasts ...
  http://www.sciencephoto.com/media/254276/view
*  Method for eliciting an immune response to human telomerase reverse transcriptase - Patent # 8709995 - PatentGenius
... changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments ... useful for treatment of diseases such as cancers. ... "Telomere Reduction in Giant Cell Tumor of Bone and with Aging ... Heiser, A. et al., "Human dendritic cells transfected with renal tumor RNA stimulate polyclonal T-cell responses against ... Heiser, A. et al., "Induction of polyclonal prostate cancer-specific CTL using dendritic cells transfected with amplified tumor ...
  http://www.patentgenius.com/patent/8709995.html
*  Tykerb and Herceptin Combination Therapy Fails to Improve Outcomes for Early Stage HER2 Breast Cancer
Xgeva Reduces Giant-cell Tumor of the Bone. June 30, 2009. CIN Associated with Risk of Invasive Cervical Cancer. ... Overexpression of this protein leads to increased growth of cancer cells. Tykerb and Herceptin are treatments that target these ... Breast Cancer, Carcinoma In Situ Breast cancer, News, Stage I Node Negative Breast Cancer, Stages II-III Breast Cancer ... Breast Cancer News. Breast Cancer Links. *Signup for the Breast Cancer Newsletter ...
  http://news.cancerconnect.com/tykerb-and-herceptin-combination-therapy-fails-to-improve-outcomes-for-early-stage-her2-breast-cancer/
*  Bone Cancer | Medical City Dallas
Learn more about Bone Cancer at Medical City Dallas DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ... Giant cell tumor-a primary bone tumor that is malignant; most common in the arm or leg bones ... When cancer starts in bone tissue, it is called primary bone cancer. When cancer cells travel to the bone from another site in ... Bone cancer. American Cancer Society website. Available at: https://www.cancer.org/cancer/bone-cancer.html. Accessed October 9 ...
  https://medicalcityhospital.com/hl/?/12008/bone-cancers&com.dotmarketing.htmlpage.language=1
*  Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma | AJO
To our knowledge, this case report is the first to describe an assessment of the transformation of a benign GCT of bone into an ... evaluated by the same medical team.There are only a few case reports and case series of malignancy associated with GCT of bone ... we report a case of transformation of a benign giant cell tumor (GCT) of the calcaneus into an epithelioid angiosarcoma. The ... Cancer Treat Rev. 2010;36(1):1-7.. 3. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant-cell tumor of bone. J Bone Joint ...
  https://www.amjorthopedics.com/article/transformation-benign-giant-cell-tumor-bone-epithelioid-angiosarcoma
*  Giant-cell tumor of bone - Wikipedia
A number of tumors have giant cells, but are not true benign giant-cell tumors. These include, aneurysmal bone cyst, ... March 2008). "Giant cell tumor of bone: treatment and outcome of 214 cases". J. Cancer Res. Clin. Oncol. 134 (9): 969-78. doi: ... Giant-cell tumor of the bone accounts for 4-5% of primary bone tumors and about 20% of benign bone tumors. However, ... Giant-cell tumour of bone. Current Opinion in Oncology, 21, 338-344 Werner, M. (2006). Giant-cell tumour of bone: morphological ...
  https://en.wikipedia.org/wiki/Giant-cell_tumor_of_bone
*  Anti-CD13 antibody [22A5] (ab20136) | Abcam
Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens.. Cancer ... synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells ... Cancer. Cardiovascular. Cell Biology. Epigenetics. Metabolism. Developmental Biology. By research area. Immunology. ... Cell and tissue imaging tools. Cellular and biochemical assays. By product type. Proteins and Peptides. Proteomics tools. ...
  http://www.abcam.com/cd13-antibody-22a5-ab20136.html
*  Primary Tumors of Bone and Lung in Rats Following Local Deposition of Cupric-chelated N-Hydroxy-2-acetylaminofluorene | Cancer...
Three of the 28 tumors were rhabdomyosarcomas; an additional 3 giant-cell sarcomas were presumed to be extraosseous in origin. ... Nine of the tumors were predominantly of osteogenic cells, two of chondrogenic cells, one of fibrogenic cells, four of ... However, many of these tumors contained more than one type of neoplastic cell. Of note were four tumors composed of mixtures of ... Twenty-two tumors in 17 rats were composed of either bone-forming or bone marrow elements. ...
  http://cancerres.aacrjournals.org/content/27/5_Part_1/1000
*  Benign Osteoblastoma of the Sphenoid Bone
... giant cell tumor, aneurysmal bone cyst, and fibrous dysplasia.13. Definitive diagnosis is made by histological examination that ... Cancer. 1956;9:1044-1052. [PubMed]. * Choudhury A R, al Amin M S, Chaudhri K A, al Moutaery K R. Benign osteoblastoma of the ... osteoblast-like cells disseminated in an abundant conjunctive background surrounded by immature richly vascularized bone. No ... 4 Benign osteoblastoma is a rare tumor that constitutes ~1% of all primary bone tumors and 3% of all benign bone tumors.5 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2793891/
*  The Lancet Oncology Publishes Results Of XGEVA denosumab In Patients With Giant Cell Tumor Of Bone
... www.cancer.org/Cancer/BoneCancer/DetailedGuide/bone-cancer-what-is-bone-cancer. Accessed June 24, 2013. .. 5 Giant Cell Tumor ... Giant cell tumors of bone consist of stromal cells expressing RANKL and osteoclast-like giant cells expressing RANK receptor. ... Giant cell tumour of bone. Current Opinion in Oncology. 2009;21:338-344.. 4 Bone Cancer. American Cancer Society. website. http ... About Giant Cell Tumor of Bone. GCTB is a locally aggressive, benign tumor primarily afflicting younger adults between the ages ...
  http://www.amgen.com/media/news-releases/2013/07/the-lancet-oncology-publishes-results-of-xgeva-denosumab-in-patients-with-giant-cell-tumor-of-bone/
*  bone cancers Flashcards - Cram.com
Study Flashcards On bone cancers at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get ... spindle-shaped cell with multinucleated cells giant cell tumor bone growth covered by cap of cartilage projecting from surface ... "bone cancers","payreferer_url":"\/flashcards\/copy\/bone-cancers-342413","isGuest":true,"ga_id":"UA-272909-1","facebook":{" ...
  http://www.cram.com/flashcards/bone-cancers-342413
*  Tumors of Fibrous Tissue Origin | SpringerLink
Among all primary bone tumors nonossifying fibroma is the most frequently occurring one in children and adolescents. It is ... Kasahara K, Yamamuro T, Kasahara A. Giant cell tumour of bone: cytological studies. Br J Cancer 1979; 40: 201-9PubMedCrossRef ... foam cells and multinucleated giant cells. No bone formation is seen within the lesion. It develops eccentrically in a bone and ... Johnston J. Giant cell tumor of bone. The role of the giant cell in orthopedic pathology. Orthop Clin N Am 1977; 8: 751-70 ...
  https://link.springer.com/chapter/10.1007/978-1-4471-1951-7_5
*  Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA...
... and macrophage colony-stimulating factor in giant cell tumor of bone (6). Although in many cancers, the age of the patient ... Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells ... or bone (osteosarcoma, chondrosarcoma; ref. 1). Sarcomas are rare tumors, about 1% of all human cancers. Many of these tumors ... Cell lines. Division of Cancer Treatment and Diagnostics of the National Cancer Institute (DCTD/NCI) collected a panel of 63 ...
  http://mct.aacrjournals.org/content/14/11/2452
*  Giant Cell Tumor of Bone - an Overview
It is characterized by a proliferation of mononuclear stromal cells and the presence of many multi- nucleated giant cells with ... As most giant cell tumors are benign and are located near a joint in young adults, several authors favor an intralesional ... Although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that ... in the understanding of pathogenesis are essential to develop new treatments for this locally destructive primary bone tumor. ...
  http://abjs.mums.ac.ir/article_4701.html
*  Most recent papers with the keyword Giant cell tumor of bone | Read by QxMD
... miR-30c expression level in 62 pairs of giant cell tumor of bone cells tissue samples and five breast cancer-derived cell lines ... of miR-30c on giant cell tumor of bone cell metastasis and growth and provide therapeutic targets for giant cell tumor of bone ... Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% ... Giant cell tumors of bone (GCTB) are intermediate and locally aggressive bone tumor. Calcium phosphate cement (CPC) is a bone ...
  https://www.readbyqxmd.com/keyword/115617
*  Giant-cell carcinoma of the lung - Wikipedia
... that the prognosis of lung tumors with giant cells is worse than that of most other forms of non-small-cell lung cancer (NSCLC ... and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like ... Giant cells in a lung cancer are highly associated with the presence of spindle cells. The chromatin of malignant giant cells ... Both "tumor cell-tumor cell" and "leukocyte-tumor cell" emperipolesis (i.e. active penetration of the latter by the former) is ...
  https://en.wikipedia.org/wiki/Giant-cell_carcinoma_of_the_lung
*  Cancer Clinical Trial - Avelumab Treatment in Patients With Neuroendocrine
Cancer clinical trial. Clinical trial for Avelumab Treatment in Patients With Neuroendocrine Carcinomas (NEC G3) Progressive ... Study of Denosumab in Subjects With Giant Cell Tumor of Bone Phase 2. ... This removes the suppressive effect of PD-L1 on anti-tumor CD8+ T cells, resulting in restoration of cytotoxic T cell response. ... In intermediate NET the degree of T-cell tumor infiltration was associated with recurrence and survival and in a study with 80 ...
  http://inclinicaltrials.com/cancer/NCT03352934/
*  Giant cell tumor of bone: clinicopathologic and DNA flow cytometric analysis. Extraskeletal osteosarcoma: a clinicopathological...
Giant cell tumor of bone: clinicopathologic and DNA flow cytometric analysis. Extraskeletal osteosarcoma: a clinicopathological ... Various mixtures of cell types found resembled bone cells, cartilage cells, and connective tissue cells. Among the patients ... These cancers form bone and bone-like tissue outside the skeleton, and the prognosis for extraskeletal osteosarcoma is poor. A ... Giant cell tumor of bone: clinicopathologic and DNA flow cytometric analysis. Article Abstract:. Giant cell tumor of the bone ...
  http://www.readabstracts.com/Health/Giant-cell-tumor-of-bone-clinicopathologic-and-DNA-flow-cytometric-analysis.html
*  Nikos Athanasou - Wikipedia
... particularly breast cancer metastasis, Ewing sarcoma and giant cell-rich lesions such as giant cell tumour of bone and ... 1998). Human tumour-associated macrophages differentiate into osteoclastic bone-resorbing cells. J Pathol 184: 31-36. PMID ... 2005). Phenotypic and molecular studies on giant cell tumours of bone and soft tissues. Hum Pathol. 36: 945 - 954 PMID 16153456 ... Endocrinology 139: 4058 -4060 PMID 8756585 Athanasou N. (1996) The cellular biology of bone-resorbing cells. J Bone Joint ...
  https://en.wikipedia.org/wiki/Nikos_Athanasou
*  Bone - Wikipedia
... giant cell tumor of bone, and aneurysmal bone cyst. Cancer can arise in bone tissue, and bones are also a common site for other ... Blood cells that are created in bone marrow include red blood cells, platelets and white blood cells. Progenitor cells such as ... cancer) or create bone (a "sclerotic" cancer). Cancers of the bone marrow inside the bone can also affect bone tissue, examples ... lung cancer, prostate cancer, thyroid cancer, and kidney cancer. Secondary cancers that affect bone can either destroy bone ( ...
  https://en.wikipedia.org/wiki/Bone
*  List of cancer types - Wikipedia
Some types of cancer are named for the size and shape of the cells under a microscope, such as giant cell carcinoma, spindle ... islet cell Rectal cancer Bladder cancer Cervical cancer Endometrial cancer Extragonadal germ cell tumor Ovarian cancer Ovarian ... bone, cartilage, fat, nerve), each of which develop from cells originating in mesenchymal cells outside the bone marrow. ... cell cancer Urethral cancer Uterine sarcoma Vaginal cancer Vulvar cancer Wilms tumor Esophageal cancer Head and neck cancer ...
  https://en.wikipedia.org/wiki/List_of_cancer_types
*  Large cell - Wikipedia
Giant cell tumors include giant cell tumor of bone and giant cell tumor of the tendon sheath. Medicine portal Anaplastic large- ... Large cell is a term used in oncology. It does not refer to a particular type of cell; rather it refers to cells that are ... It is frequently used when describing lymphoma and lung cancer. It was more frequently used in the past than it is used today, ... cell lymphoma Buttock cell Nosology Giant Cell Tumors at the US National Library of Medicine Medical Subject Headings (MeSH) ...
  https://en.wikipedia.org/wiki/Large_cell
*  Alan L. Schiller - Wikipedia
Goldring SR, Schiller AL, Mankin HJ, Dayer JM, Krane SM (1986). "Characterization of cells from human giant cell tumors of bone ... England 2005-present America's Top Doctors for Cancer Partial list: Walsh EF, Mechrefe A, Akelman E, Schiller AL (2005). "Giant ... "Grading of bone tumors by analysis of nuclear DNA content using flow cytometry". The Journal of Bone and Joint Surgery. ... "A unique multifocal osteoblastoma-like tumor of the bones of a single lower extremity. Report of a case". The Journal of Bone ...
  https://en.wikipedia.org/wiki/Alan_L._Schiller
*  Bone tumor - Wikipedia
... giant cell tumor of bone, aneurysmal bone cyst, and fibrous dysplasia of bone. Malignant primary bone tumors include ... Stage 1A bone cancer Stage 1B bone cancer Stage 2A bone cancer Stage 2B bone cancer Stage 3 bone cancer Since, by definition, ... Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and " ... UK bone cancer statistics from Cancer Research UK UMDNJ Basic pathology concepts in diagnosis of bone tumors Cancer.Net: Bone ...
  https://en.wikipedia.org/wiki/Bone_tumor