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*  Effects of ghrelin administration during chemotherapy with advanced esophageal cancer patients - Hiura - 2012 - Cancer - Wiley...
Efficacy of ghrelin as a therapeutic approach for age related physiological changes. Endocrinology. 2008; 149: 3722-3728.. * ... Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia. Endocrinology. 2010; 151: 3773-3782.. ... Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402: 656-660.. *CrossRef, ... A role for ghrelin in the central regulation of feeding. Nature. 2001; 409: 194-198.. *CrossRef, ...
  http://onlinelibrary.wiley.com/doi/10.1002/cncr.27430/references?globalMessage=0
*  417 ORAL ETHANOL SUPPRESSES OVERNIGHT ENDOGENOUS GHRELIN SECRETION IN NONDIABETIC AND TYPE 2 DIABETIC SUBJECTS. | JIM
In normal humans, ghrelin concentrations are inhibited by food intake, but the effect of specific nutrients on ghrelin dynamics ... Ghrelin is a novel gastric hormone that serves as a hunger signal and a putative growth hormone (GH) secretagogue in humans. ... 417 ORAL ETHANOL SUPPRESSES OVERNIGHT ENDOGENOUS GHRELIN SECRETION IN NONDIABETIC AND TYPE 2 DIABETIC SUBJECTS.. L. Gamache, C ... These data demonstrate that low-dose oral ethanol prior to sleep suppresses endogenous ghrelin in both nondiabetic and insulin- ...
  http://jim.bmj.com/content/54/1/S151.3
*  Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children - Full Text View - ClinicalTrials.gov
Ghrelin's actions are mediated by GH secretagogue receptor (GHSR). Ghrelin synthesis occurs predominantly in epithelial cells ... Ghrelin's actions are mediated by GH secretagogue receptor (GHSR). Ghrelin synthesis occurs predominantly in epithelial cells ... As the ligand for GHSR, ghrelin stimulates secretion of GH. In both rodents and humans, ghrelin regulates hunger though its ... As the ligand for GHSR, ghrelin stimulates secretion of GH. In both rodents and humans, ghrelin regulates hunger though its ...
  https://clinicaltrials.gov/ct2/show/NCT00830141
*  Influence of different storage conditions and anticoagulants on the measurement of total and acylated ghrelin in dogs: a...
... acidification of plasma samples decreased the stability of total ghrelin and impeded determination of acylated ghrelin with the ... While acylated ghrelin showed to be very instable, its analysis should be performed within an hour of sample collection or ... When samples were stored at under −20°C, three freeze/thaw cycles during storage did not alter total ghrelin concentration if ... Under the conditions assessed in this study, total ghrelin concentration was stable when stored at room temperature or under ...
  http://veterinaryrecord.bmj.com/content/172/11/289
*  Most recent papers with the keyword CRH | Read by QxMD
The gastric hormone ghrelin, in addition to its GH-secretagogue effects, stimulates food intake after both central and ... In the present study we further investigated the feeding regulatory role of the ghrelin-GH axis in a mouse model of isolated GH ... Effects of growth hormone-releasing hormone gene targeted ablation on ghrelin-induced feeding. ... and serum ghrelin levels in mice homozygous for GHRHKO allele (-/-) and heterozygous (+/-) control animals... ...
  https://www.readbyqxmd.com/keyword/40468
*  GHRELIN, MORE THAN A NATURAL OREXIGENIC FACTOR
5. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in ... et al Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate ... Ghrelin - structure, action, regulation. Ghrelin is a 28-amino acid peptide encoded by a gene located on the short arm of ... The discovery of ghrelin-specific receptors in the brain areas involved with mood and emotions led to the idea that ghrelin ...
  http://www.medicina-interna.ro/articol.php?articol=991&lang=ro
*  PLOS ONE: Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin
Here, we demonstrate that ghrelin elicits a marked upregulation of the hypothalamic mammalian target of rapamycin (mTOR) ... Of note, central inhibition of mTOR signaling with rapamycin decreased ghrelin's orexigenic action and normalized the mRNA ... there is a paucity of data about the possible action of ghrelin on alternative metabolic pathways at this level. ... ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway. ...
  http://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0046923&imageURI=info:doi/10.1371/journal.pone.0046923.g005
*  Plus it
... both total ghrelin (B) and octanoylated ghrelin (C) were significantly increased in stomach extracts. Plasma total ghrelin ... A similar increase was observed in stomach ghrelin content for both total and bioactive octanoylated ghrelin (total ghrelin: Wt ... Circulating bioactive ghrelin levels are increased in Tg mice.. We identified a BAC, which contained the ghrelin gene and its ... Analysis of rat insulin II promoter-ghrelin Tg mice and rat glucagon promoter-ghrelin Tg mice. J Biol Chem 280: 15247- 15256, ...
  http://diabetes.diabetesjournals.org/content/58/4/840
*  The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.
... the molecular mechanisms initiated by the activation of the ghrelin receptor, which in turn lead to A ... Ghrelin is a stomach-derived peptide that increases food intake through the activation of hypothalamic AMP-activated protein ... We then centrally administered ghrelin, Ex527, and Ex527 + ghrelin to the rats. We found that ghrelin increased food intake at ... ghrelin, or with vehicle, ghrelin, sirtinol, and sirtinol + ghrelin), the data were analyzed by two-way ANOVA, followed by a ...
  http://www.biomedsearch.com/nih/Central-Pathway-Essential-Orexigenic-Action/21386086.html
*  Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin | Gut
... acylated ghrelin and desacyl ghrelin. Acylated ghrelin induces a positive energy balance, while desacyl ghrelin has been ... Hosoda H , Kojima M, Matsuo H, et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal ... acylated ghrelin, which has n-octanoylated serine in position 3; and desacyl ghrelin.2 Other minor forms of ghrelin are also ... Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur J Pharmacol2003;476: ...
  http://gut.bmj.com/content/54/1/18
*  A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans | Diabetes
The clear preprandial rise and postprandial fall in plasma ghrelin levels support the hypothesis that ghrelin plays a ... single measurements might serve as surrogates for 24-h profiles to estimate overall ghrelin levels. Circulating ghrelin also ... Intermeal ghrelin levels displayed a diurnal rhythm that was exactly in phase with that of leptin, with both hormones rising ... Ghrelin, insulin, and leptin were measured by radioimmunoassay in plasma samples drawn 38 times throughout a 24-h period in 10 ...
  http://diabetes.diabetesjournals.org/content/50/8/1714.short?cited-by=yes&legid=diabetes
*  Ghrelin Levels in Early IVF Pregnancies - Full Text View - ClinicalTrials.gov
... for determination of serum ghrelin, hCG and progesterone levels. In addition, ghrelin levels were assayed in these groups, 2-h ... Ghrelin has been detected in the decidualized endometrium, as well as in human and rat placenta, with a distinctive temporal ... Maternal Serum Ghrelin Levels in Early IVF Pregnancies: Lack of Prognostic Value for Gestational Outcome and Altered Post- ... Ghrelin is a pleiotropic hormone recently involved in the control of growth and metabolism, whose circulating levels fluctuate ...
  https://clinicaltrials.gov/ct2/show/NCT00469807
*  The Prokinetic Face of Ghrelin
showed that ghrelin or GHRP-6 (100 𝜇. g/kg) had no effect in septic rats [33], Chen et al. showed that ghrelin (20 𝜇. g/kg) ... showed that IV ghrelin 20 𝜇. g/kg accelerated intestinal transit in rats [29]. This prokinetic effect of ghrelin on intestinal ... showed that ghrelin induced MMCs in fed conscious freely moving mice [22]. In dogs, however, ghrelin was shown to have no ... The effects of ghrelin on the fasting, not fed, human stomach was similar to in vivo studies. In fasted volunteers, ghrelin ...
  https://www.hindawi.com/journals/ijpep/2010/493614/
*  Metabolic and Cardiovascular Effects of Ghrelin
Two major forms of ghrelin are found in tissues and plasma: n-octanoyl-modified ghrelin and des-acyl ghrelin [7]; ghrelin is ... 2. Tissue Distribution of Ghrelin and Ghrelin Receptor. Ghrelin is predominantly produced by the stomach, but it is also widely ... have proposed that ghrelin might modulate intracellular energy balance in a cell specific manner: ghrelin would be able to ... Ghrelin secretion seems to be under cholinergic control, since ghrelin levels are raised by cholinergic agonists and reduced by ...
  https://www.hindawi.com/journals/ijpep/2010/864342/
*  Ghrelin in Female and Male Reproduction
... Joëlle Dupont, Virginie Maillard, Stéphanie Coyral-Castel, Christelle Ramé, and Pascal ... Ghrelin could be a component of the complex series of nutrient sensors such as adipokines, and nuclear receptors, which ... Ghrelin and one of its functional receptors, GHS-R1a (Growth Hormone Secretagogue Receptor 1a), were firstly studied about 15 ... The objective of this paper was to report the available information about the ghrelin system and its role at the level of the ...
  https://www.hindawi.com/journals/ijpep/2010/158102/abs/
*  Ghrelin Normal After Gastric Bypass | Medpage Today
Roux-en-Y gastric bypass surgery restored normal regulation of the appetite hormone ghrelin, an analysis of the STAMPEDE trial ... "The improvement in ghrelin following surgery is clinically relevant, since high or impaired meal-suppressed acylated ghrelin ... "They tend to have lower fasting ghrelin levels and then after a meal ghrelin levels don't go down like they should." ... After adjusting for fasting ghrelin and gender, meal-induced acylated ghrelin suppression was improved by RYGB surgery at 12 ...
  https://www.medpagetoday.com/endocrinology/obesity/43097
*  Anti-Ghrelin antibody (ab64325) | Abcam
Rabbit polyclonal Ghrelin antibody validated for WB, IHC and tested in Human. Referenced in 1 publication. Immunogen ... O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- ... A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with a singly unsaturated carboxylic acid.. Amidation of Leu-98 ... Diminished endometrial expression of ghrelin and ghrelin receptor contributes to infertility.. Reprod Sci 17:823-32 (2010). ...
  http://www.abcam.com/ghrelin-antibody-ab64325.html
*  Ghrelin and Leptin - Hunger, Weight, Obesity
We explore the science behind the hormones ghrelin and leptin, which are responsible for regulating appetite. ... Ghrelin is designed to work together with leptin, a hormone your body releases when you've eaten enough. Under normal ... Not only can a high-sugar diet reduce the body's ability to suppress ghrelin, but it can also lower leptin levels - essentially ... Essentially, part of why you feel hungry is because of a hormone known as ghrelin, which is produced in the stomach and ...
  http://www.refinery29.com/amp/2014/07/66948/ghrelin-facts
*  Ghrelin | 9780123736857 | VitalSource
Buy or Rent Ghrelin as an eTextbook and get instant access. ... Ghrelin Edition by Litwack, Gerald and Publisher Academic Press ...
  https://www.vitalsource.com/en-au/products/ghrelin-litwack-gerald-v9780123736857
*  Ghrelin octanoylation mediated by an orphan lipid transferase | PNAS
Disrupting ghrelin signaling by targeting the ghrelin or ghrelin receptor genes blunts weight gain from a high-fat diet. ... Arrow denotes location of octanoylated ghrelin. Ghrelin peptide standards were mouse SIL acyl (m/z 3,338) and des-acyl ghrelin ... Ghrelin peptides standards were rat des-acyl ghrelin (m/z 3,188) and dog octanoyl des Q ghrelin (m/z 3,228). (C) MS ... des-acyl ghrelin) or acyl ghrelin to show that the human medullary thyroid carcinoma cell line (TT cell line) produces ghrelin ...
  http://www.pnas.org/content/105/17/6320?ijkey=a7fe1932c50284dac29fd7cd6b4c67e71185f179&keytype2=tf_ipsecsha
*  Ghrelin Protects Cardiovascular Cells from Damage
Ghrelin prevents doxorubicin-induced cardiotoxicity through TNF-alpha/NF-kappaB pathways and mitochondrial protective ... Ghrelin Protects Cardiovascular Cells from Damage. Study Abstract. We had reported that increased levels of endogenous ghrelin ... This suggests ghrelin affects the TNF-alpha/NF-kappaB activation pathways, up-regulating TNF-alpha, to produce anti-oxidative ... Moreover, ghrelin increased mitochondrial anti-apoptosis related gene protein expression such as bcl-2 and MnSOD, reduced ...
  https://www.wellnessresources.com/news/ghrelin-protects-cardiovascular-cells-from-damage
*  Leptin Versus Ghrelin
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  https://www.noteflight.com/scores/view/c13f5ec0a8b90a4045cfe822906a17f5011806a6
*  Hormones That Control Appetite: Leptin and Ghrelin | HubPages
Controlling the leptin and ghrelin levels may help to control obesity. ... Leptin is a hormone that reduces appetite and ghrelin is a hormone that increases it. ... Ghrelin and Its Discovery. Ghrelin was discovered by Masayasu Kojima and his colleagues. A ghrelin molecule is made of 28 amino ... Function of Ghrelin. The hypothalamus contains ghrelin receptors as well as leptin receptors. When the ghrelin molecules join ...
  https://hubpages.com/education/Hormones-That-Control-Appetite-Leptin-and-Ghrelin
*  Ghrelin in Cystic Fibrosis - Full Text View - ClinicalTrials.gov
Ghrelin in Cystic Fibrosis (ghrelin). The safety and scientific validity of this study is the responsibility of the study ... Background to ghrelin Ghrelin is a naturally occurring hormone found in the blood which stimulates appetite. In healthy ... Ghrelin is the only physiological circulating factor that is known to increase food intake. Administration of acylated ghrelin ... If ghrelin is identified as having an important pathophysiological role in CF it may lead to a future study of its efficacy as ...
  https://clinicaltrials.gov/ct2/show/NCT00763477?recr=Open&cond=%22Cystic+Fibrosis%22&rank=6
*  Recombinant Human Ghrelin Receptor protein (ab114485) Protocols
There are no specific protocols for Recombinant Human Ghrelin Receptor protein (ab114485). Please download our general ...
  http://www.abcam.com/recombinant-human-ghrelin-receptor-protein-ab114485-protocols.html