Research - Canada's Michael Smith Genome Sciences Centre
The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors." Wang Y, Chen J, Yang W, Mo F, Senz J, Yap D, Anglesio MS, Gilks B, Morin GB, Huntsman DG. Neoplasia. 2015 Aug;17(8):650-60.. "MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation." Pon JR, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng SW, Morin GB, Hoodless PA, Hirst M, Marra MA. Nat Commun. 2015 Aug 6;6:7953. "Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage." Anglesio MS, Wang Y, Yang W, Senz J, Wan A, Heravi-Moussavi A, Salamanca C, Maines-Bandiera S, Huntsman DG, Morin GB. J Pathol. 2013 Feb;229(3):400-9.. "Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is ...http://www.bcgsc.ca/faculty/gmorin/research/
usmle: General Rules about Physician-Patient Relationships
There are three types of ovarian tumors that can produce large amounts of steroid hormones: 1.Sertoli-Leydig cell tumors originate from precursors of Sertoli and Leydig cells and usually produce male hormones, manifesting with masculinization or defeminization. 2.Fibroma-thecomas arise from stromal cells, are mostly composed of fibroblasts, and rarely manifest with endocrinologic signs. 3.Granulosa cell tumors develop from granulosa cells and may actively secrete estrogens. Precocious puberty appears if the patient is a preadolescent girl; adult women develop hyperplasia or carcinoma of the endometrium and fibrocystic change in the breast. Up to 20% to 25% of granulosa ...http://multanimatti.blogspot.com/2008/01/usmle-step-1-notes.html
Pleuropulmonary blastoma - Wikipedia
Pleuropulmonary blastoma (PPB) is a rare cancer originating in the lung or pleural cavity. It occurs most often in infants and young children but also has been reported in adults. In a retrospective review of 204 children with lung tumors, pleuropulmonary blastoma and carcinoid tumor were the most common primary tumors (83% of the 204 children had secondary tumors spread from cancers elsewhere in the body). Pleuropulmonary blastoma is regarded as malignant. The male:female ratio is approximately one. Symptoms may include coughing, an upper respiratory tract infection, shortness of breath, and chest pain. These symptoms are very non-specific, and can be caused by other types of tumor in the lung or mediastinum more generally, and by other conditions. Imaging (X-ray, CT, MRI) may be used to determine the presence and precise location of a ...https://en.wikipedia.org/wiki/Pleuropulmonary_blastoma
Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. - The Christie...
Inhibin is a peptide hormone produced by ovarian granulosa cells and testicular Sertoli cells. Ovarian granulosa cell and other sex cord-stromal tumors usually exhibit positive immunohistochemical staining with antiinhibin antibodies, and this may be valuable in differentiating these neoplasms from histologic mimics. In the present study, we investigated the immunohistochemical staining of testicular sex cord-stromal tumors using antiinhibin. Immunostaining with CAM5.2, vimentin, S-100 protein, desmin, epithelial membrane antigen (EMA), carcinoembryonic antigen (CEA), and placental alkaline phosphatase (PLAP) also was performed because few studies have investigated in detail the immunophenotype of testicular sex cord-stromal tumors. Fifteen of 16 Leydig ...http://christie.openrepository.com/christie/handle/10541/91874
QUERO HERNANDEZ, Armando; HERNANDEZ ARRIOLA, Javier; SOCORRO LOPEZ, Zoila y PEREZ BAUTISTA, Aarón. Blastoma Pleuropulmonar. Bol. Med. Hosp. Infant. Mex. [online]. 2004, vol.61, n.1, pp.55-59. ISSN 1665-1146.. Introduction. The pleuropulmonary blastoma is a rare malignant lung neoplasm usually observed in children younger than 6 years old. There are 3 types of pleuropulmonary blastoma: I cystic, III solid, and II mixed. Its clinical and biological behavior is aggressive. Case report. A female patient, 7 months old who 3 months previous to admission presented respiratory symptoms treated as neumonia and spillings, without clinical or radiological improvement. She was admitted with respiratory difficulty, hypomobility of the right hemitorax, and absence of respiratory sounds; a CAT scan of the thorax showed a lump that occupied more than 90% of the right hemitorax, heterogenous, with predominance of solid components. A resection of the middle right lobe was carried-out; the histopathologic studied ...http://www.scielo.org.mx/scielo.php?script=sci_abstract&pid=S1665-11462004000100007&lng=es&nrm=iso&tlng=en
Blastoma - definition of blastoma by The Free Dictionary
Define blastoma. blastoma synonyms, blastoma pronunciation, blastoma translation, English dictionary definition of blastoma. n. pl. blas·to·mas or blas·to·ma·ta A neoplasm composed of immature and undifferentiated cells. n , pl -mata or -mas pathol a. a tumour composed of...http://www.thefreedictionary.com/blastoma
Pleuropulmonary Blastoma | Diagnosis & Treatments | Angie Fowler Adolescent & Young Adult Cancer Institute | UH Rainbow Babies ...
University Hospitals Cleveland Medical Center is the flagship academic medical center at the core of UH's 18 hospital health system that serves patients across northern Ohio. Through faculty appointments at Case Western Reserve University School of Medicine and through research conducted with support from UH's Harrington Discovery Institute, physician-scientists at UH Cleveland Medical Center are advancing medical care through education and innovative research that brings the latest treatment options to patients regionally and around the world ...http://www.uhhospitals.org/rainbow/services/hematology-and-oncology/services/conditions-we-treat/pleuropulmonary-blastoma
Embryonal rhabdomyosarcoma - Wikipedia
Embryonal rhabdomyosarcoma (ERMS) is a rare histological form of cancer of connective tissue wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo. It is the most common soft tissue sarcoma occurring in children. ERMS is the more common of two major subtypes of rhabdomyosarcoma, the other being alveolar rhabdomyosarcoma. It has been informally classified as a "small round blue cell tumor" because of the characteristic microscopic appearance of its cells after histological staining with hematoxylin and eosin. The prognosis for rhabdomyosarcoma has improved greatly in recent decades, with over 70% of patients surviving for five years after diagnosis. Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M (2009). "Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for ...https://en.wikipedia.org/wiki/Embryonal_rhabdomyosarcoma
45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to...
TY - JOUR. T1 - 45 Gy is not sufficient radiotherapy dose for Group III orbital embryonal rhabdomyosarcoma after less than complete response to 12 weeks of ARST0331 chemotherapy. T2 - Pediatric Blood and Cancer. AU - Ermoian,Ralph P.. AU - Breneman,John. AU - Walterhouse,David O.. AU - Chi,Yueh Yun. AU - Meza,Jane. AU - Anderson,James. AU - Hawkins,Douglas S.. AU - Hayes-Jordan,Andrea A.. AU - Parham,David M.. AU - Yock,Torunn I.. AU - Donaldson,Sarah S.. AU - Wolden,Suzanne L.. PY - 2017. Y1 - 2017. N2 - Background: Recent Children's Oncology Group (COG) trials tested the efficacy of reduced therapy in an effort to lessen late effects compared to the Intergroup Rhabdomyosarcoma Study (IRS) IV regimen with associated hematologic and hepatic toxicity, and infertility. Here, we analyze the efficacy of 45 Gray (Gy) local radiotherapy (RT) in patients with Group III orbital embryonal rhabdomyosarcoma (ERMS) enrolled on the COG low-risk study ARST0331. Procedure: Sixty-two patients with Group III ...https://www.scholars.northwestern.edu/en/publications/45-gy-is-not-sufficient-radiotherapy-dose-for-group-iii-orbital-e
Testicular sex cord-stromal tumor in a boy with 2q37 deletion syndrome | BMC Medical Genomics | Full Text
This study provides novel insight into the genotype-phenotype correlations of the rare chromosomal disorder del2q37 syndrome. First, this case manifests typical clinical features of del2q37 syndrome, while the phenotypic presentation because of the 1p36 duplication was less evident except for intelligence disability . This finding suggests that haploinsufficiency of the genes at 2q37, rather than the segmental duplications of 1p36 or 20p12, shows dominant effects on the phenotypic presentation. Specific gene functions of GPCPD1 and the duplication of 20p12 remain to be clarified, structural variations at 20p14.3, wherein this gene is located, were identified in healthy individuals of Korean ethnicity . Therefore, the 20p14.3 duplication spanning the GPCPD1 locus was unlikely to alter the phenotype of del2q37 syndrome and to produce the carcinogenic condition. While the present case did not show profound phenotype of intellectual disability compared to other cases in the literature, we ...https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-7-19
Granulosa-Theca Cell Tumors Follow-up: Further Outpatient Care, Inpatient & Outpatient Medications, Transfer
Three major types of ovarian neoplasms are described, with epithelial cell tumors (>70%) comprising the largest group of tumors. Germ cell tumors occur less frequently (20%), while sex cord-stromal tumors make up the smallest proportion, accounting for approximately 8% of all ovarian neoplasms.https://emedicine.medscape.com/article/254489-followup
Lung tumor - Wikipedia
Lung tumors are neoplastic tumors of the lung These include: Primary tumors of the lung/pulmonary system: Bronchial leiomyoma, a rare, benign tumor Lung cancer, the term commonly used to refer to carcinoma of the lung Pulmonary carcinoid tumor Pleuropulmonary blastoma Neuroendocrine tumors of the lung Lymphomas of the lung. Sarcomas of the lung. Some rare vascular tumors of the lung Non-lung tumors which may grow into the lungs: Mediastinal tumors Pleural tumors Metastasis or secondary tumors/neoplasms with other origin: Metastasis to the lung Chong S, Lee KS, Chung MJ, Han J, Kwon OJ, Kim TS (2006). "Neuroendocrine ...https://en.wikipedia.org/wiki/Lung_tumor
Characterization of a new human embryonal rhabdomyosarcoma cell line, RMS-GR - UnissResearch
A human tumor cell line designated RMS-GR was established from an embryonal rhabdomyosarcoma. The monolayer cells were polygonal, round or spindle-shaped. The RMS-GR cell line became stable with a doubling time of 42 h. Tumorigenicity of the cells was confirmed by hetero-transplantion into nude mice. Electron microscopic images showed typical cytoplasmic inclusion of aggregated intermediate filaments and myofibril-like thin filaments. The expression of desmin, vimentin, actin and human myoglobin was recognized by cytofluorometric analyses, and a large fraction of CK-MM and small fractions of CK-BB and MCK-1 isoenzymes were found. Chromosomal analysis showed that the modal chromosome number was consistently near triploid with structural abnormalities mostly involving chromosomes 1, 3 and 8, and additional ...http://eprints.uniss.it/1326/
embryonal rhabdomyosarcoma - Humpath.com - Human pathology
Images Vaginal mass. In embryonal rhabdomyosarcoma, botryoid type. Cambium layer, rhabdomyoblasts vary from round to strap-shaped cells. (...)http://www.humpath.com/spip.php?page=article&id_article=1954
Is activin-βc a tumour suppressor in the inhibin knockout mice?
Inhibins and activins are essential for normal reproductive and endocrine function. Previous literature showed that loss of INHA encoding for inhibin-α subunit in mice results in development of gonadal (sex-cord stromal) and adrenal tumourigenesis. However, a strong paradox has emerged regarding the function of INHA in human tumours primarily due to conflicting studies. A correlation has been found between the overexpression of activin-A by the tumours in the inhibin-deficient mice and severe cancer-associated cachexia, which has a profound impact on survival. Therefore, activin antagonism has been used to modulate the sex-cord stromal tumour growth rate both in vivo and in vitro. Recent work has shown that activin-C is an additional activin-A antagonist, despite being considered biologically redundant for several years. A preliminary study conducted in the inhibin-deficient mouse model, showed that overexpression of activin-βC has a beneficial effect, modulating sex-cord stromal tumours ...https://ourarchive.otago.ac.nz/handle/10523/5560
Vincristine, Dactinomycin, and Cyclophosphamide in Treating Patients With Embryonal Rhabdomyosarcoma - Full Text View -...
OUTLINE: Patients receive vincristine IV, dactinomycin IV, and cyclophosphamide IV on day 1. Treatment repeats every 21 days for 8 courses in the absence of disease progression or unacceptable toxicity. Patients then receive vincristine IV and dactinomycin IV on day 1. Treatment repeats every 3 weeks for 8 courses in the absence of disease progression or unacceptable toxicity.. PROJECTED ACCRUAL: A total of 41 patients will be accrued for this study. ...https://clinicaltrials.gov/ct2/show/NCT00245089?recr=Open&cond=%22Rhabdomyosarcoma%22&rank=19
Atlas of Infectious Diseases: Pleuropulmonary and Bronchial Infections, Volume 6, 1e (Vol 6) by Gerald L. Mandell MD MACP |...
Download Atlas of Infectious Diseases: Pleuropulmonary and Bronchial Infections, Volume 6, 1e (Vol 6) ebook by Gerald L. Mandell MD MACPType: pdf, ePub, zip,http://blogomi.net/2015/03/atlas-of-infectious-diseases-pleuropulmonary-and-bronchial-infections-volume-6-1e-vol-6-by-gerald-l-mandell-md-macp/
cystic ovarian neoplasm - Ovarian Cancer - MedHelp
This was on my daughters pelvic ultrasound,The cyst contains internal septations and some dependently layering debris. differential diagnosis includes cystic ovarian neoplasm as well as the possibility...http://www.medhelp.org/posts/Ovarian-Cancer/cystic-ovarian-neoplasm/show/191242
Clinical, pathological and immunohistochemical features of a pulmonary blastoma in a horse | Veterinary Record
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center's RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...http://veterinaryrecord.bmj.com/content/164/6/182
Beyond Blastoma: An Interview With Ngaiire - Best Before
Best Before is a collective of Sydney-based creatives who straight-up love music and are looking for a community of people to share it with.http://www.bestbefore.co/beyond-blastoma-interview-ngaiire/
increased Leydig cell tumor incidence Mammalian Phenotype Term (MP:0009592)
The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.http://www.informatics.jax.org/vocab/mp_ontology/MP:0009592
Ovarian Cancer Treatment & Management: Approach Considerations, Choosing Appropriate Surgery, Surgical Staging
Malignant lesions of the ovaries include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies), germ-cell tumors, sex-cord stromal tumors, and other more rare types.https://emedicine.medscape.com/article/255771-treatment
Give Blood. Give Hope. Give Life. - Chris
Poster number two belongs to my friend Chris; sometimes we ride the bus together. He was eighteen months old when he was diagnosed with Embryonal Rhabdomyosarcoma. Rhabdo is a cancer of the muscle. He had chemo, radiation, surgery and blood products in his arsenal to fight his cancer. ...http://www.peterpowerhouse.org/blog/give-blood-give-hope-give-life-chris
Metadherin, p50, and p65 expression in epithelial ovarian neoplasms: an immunohistochemical study. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Ioanna Giopanou, Vasiliki Bravou, Panagiotis Papanastasopoulos, Ioannis Lilis, Panagiotis Aroukatos, Dionysios Papachristou, Sophia Kounelis, Helen Papadaki].http://www.sigmaaldrich.com/catalog/papers/24963474
Poll: Have you ever had a brush with death or felt you very nearly did?, page 1
a reply to: seattleratIm surprisingly fine. Thank you! My boyfriend at the time attacked me, then my neighbor found me and was in the process of undressing me when the paramedics showed up. My boyfriend was diagnosed with Medula Blastoma shortly after, he passed 8 months after that, and my stupid neighbor actually told me what happened months later and apologized. I forgave them both. The only thing I remember was coming too during the beating and it was brutal, I could hear my head getting pounded but didn't feel any pain. I thought I'm being killed and I want to see this persons eyes before I die, and I'm coming back to get him. I remember staring into his eyes and they seemed all black - that could have been from the concussion though ...http://www.abovetopsecret.com/forum/thread1120315/pg1