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*  Research on the Environment and Children's Health: Retinoblastoma - Full Text View - ClinicalTrials.gov
Keywords provided by Memorial Sloan Kettering Cancer Center: Retinoblastoma. Sporadic heritable retinoblastoma. Paternal ... The purpose of the study is to investigate the role of paternal exposures in the etiology of sporadic heritable retinoblastoma ... Genetic counseling regarding RB1 gene mutation analysis must be done prior to registration onto study. ... demographic and exposure information by telephone interview [ Time Frame: 5 years 4 months ]. ...
  https://clinicaltrials.gov/ct2/show/NCT00582049?cond=%22retinoblastoma%22&rank=5
*  Plus it
... making these loci a useful tool for the analysis of long-term genetic effects of paternal exposure, similar to that following ... Cancer Research Online ISSN: 1538-7445. Cancer Research Print ISSN: 0008-5472. Journal of Cancer Research ISSN: 0099-7013. ... the SM-PCR technique can therefore provide a useful tool for the analysis of long-term genetic effects of paternal exposure, ... our data raise the important issue of long-term genetic effects of paternal exposure to cyclophosphamide in humans. ...
  http://cancerres.aacrjournals.org/content/68/10/3630
*  Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model
Paternal ethnicity (which can be an indicator of both genetic background as well as environmental exposures) has also been ... Association of paternal age at birth and the risk of breast cancer in offspring: a case control study. BMC Cancer 5, 143, (2005 ... Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. J Natl Cancer Inst 89, 238- ... Paternal cigarette smoking is associated with childhood cancers42.. Although the evidence for the contribution of paternal life ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4919621/
*  Study shows that genetic quality of sperm deteriorates as men age | Lawrence Livermore National Laboratory
New research indicates that the genetic quality of sperm worsens as men get older, increasing a man's risk of being infertile, ... or exposure to chemotherapy or radiation treatment for cancer. Understanding the effects of paternal age has become more ... Study shows that genetic quality of sperm deteriorates as men age. Study shows that genetic quality of sperm deteriorates as ... Dwarfism, a genetic disorder that affects bone growth, is the most common growth-related birth defect, occurring in about one ...
  https://www.llnl.gov/news/study-shows-genetic-quality-sperm-deteriorates-men-age
*  Saúde Pública - Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners...
... and genetic diseases in the off spring, including cancer [27]. Furthermore, exposure of rodents to germ cell mutagens can have ... There is a wealth of epidemiological evidence linking paternal exposure to chemical agents with an increased risk of pregnancy ... Xenoestrogen action in prostate cancer: pleiotropic effects dependent on androgen receptor status. Cancer Res 2005;65(1):54-65 ... Mechanisms of prostate cancer progression to androgen independence. Best Pract Res Clin Endocrinol Metab 2008;22(2):373-88. ...
  https://scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712011000400016&lng=pt&nrm=iso&tlng=en
*  NIOSHTIC-2 Publications Search - 20037103 - Biologic markers in the epidemiology of reproduction.
... either as outcomes or to indicate exposure or susceptibility. Literature on effect markers such as semen analysis and early ... Exposure of both genders may result in cancer or chromosomal damage, potentially increasing individual risk of cancer. Germ ... Defects in genetic coding for products critical for embryonic or fetal development have been hypothesized to play a causative ... A couple's reproductive success depends on a delicate physiochemical balance between and within the paternal, maternal, and ...
  https://www.cdc.gov/niosh/nioshtic-2/20037103.html
*  rs2198843 - SNPedia
Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. [PMID 18798002. ] Coffee consumption, genetic ... Assessment of interactions between PAH exposure and genetic polymorphisms on PAH-DNA adducts in African American, Dominican, ... Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes. ... susceptibility and bladder cancer risk. [PMID 19479063. ] Phase I metabolic genes and risk of lung cancer: multiple ...
  https://snpedia.com/index.php/Rs2198843
*  Birth defect - Wikipedia
... led researchers to investigate whether the cancer was a result of paternal radiation exposure. A significant association ... King CR (1986). "Genetic counseling for teratogen exposure". Obstetrics and Gynecology. 67 (6): 843-6. doi:10.1097/00006250- ... medication or drug exposures, maternal infections and diseases, and environmental and occupational exposures. Paternal smoking ... Correlations between paternal smoking and the increased risk of offspring developing childhood cancers (including acute ...
  https://en.wikipedia.org/wiki/Congenital_disorder
*  Cancer epigenetics - Wikipedia
Friedler G (December 1996). "Paternal exposures: impact on reproductive and developmental outcome. An overview". Pharmacol. ... February 2007). "Genetic unmasking of an epigenetically silenced microRNA in human cancer cells". Cancer Research. 67 (4): 1424 ... than genetic mutations in a cell's transformation to cancer. In cancers, loss of expression of genes occurs about 10 times more ... in the field defect surrounding the cancer from which the cancer likely arose (see Table). It appears that cancers may ...
  https://en.wikipedia.org/wiki/Cancer_epigenetics
*  PETER ROST: PHARMA MARKETING EXPERT WITNESS. AWP, MEDICAL DEVICE EXPERT.: Did you get screwed?
Some of the studies on paternal age and genetic disorders are cited below. Why is this science unknown to the general public ... prostate cancer, etc. etc. has been so successful that most people will argue that there is no male biological clock that ... facts show that the very opposite is true and that sperm stem cell DNA is very prone to mutation with age and toxic exposures. ... Sure, there are lots of things we don't know, I'm sure that includes impact of paternal age, but to say there is a big ...
  http://peterrost.blogspot.com/2007/07/did-you-get-screwed.html
*  Translational Toxicology and Therapeutics: Windows of Developmental Susceptibility in Reproduction and Cancer | Toxicology |...
3.7 Mechanisms of Cancer in Offspring from Paternal Exposures 117. 3.8 Parental Exposures Associated with Cancer in Offspring ... 2 What Mutagenic Events Contribute to Human Cancer and Genetic Disease? 61. Michael D. Waters ... 8.3 Environmental Exposures and Cancer 271. 8.3.1 Environmental Exposures and Disease: Is This the Pandemic of the Twenty-First ... Part Two Exposures that Could Alter the Risk of Cancer Occurrence, and Impact Its Indolent or Aggressive Behavior and ...
  https://www.wiley.com/en-us/Translational+Toxicology+and+Therapeutics%3A+Windows+of+Developmental+Susceptibility+in+Reproduction+and+Cancer-p-9781119023623
*  Silent Spring Institute
Exposures investigated. Maternal age and paternal age How exposure was measured. Other: Family Cancer database ... Genetic characterization included. If the study analyzed relationships between environmental factors and inherited genetic ... Breast cancer outcome investigated. Primary incident breast cancer Ethnic groups with separate analysis. If this study provided ... Other breast cancer risk factors, such as family history, age at first birth, and hormone replacement therapy use, that were ...
  http://sciencereview.silentspring.org/epid_detail.cfm?id=305
*  Summer 2017 Newsletter | BRP | DCCPS/NCI/NIH
Parental Smoking Linked to Increased Frequency of Genetic Changes in Children Who Develop Childhood Cancer ... Findings support that prenatal and early-life tobacco smoke exposure should be especially limited in children. ... Dose-response relationships were observed for paternal smoking during preconception and for maternal smoking during ... and adherence to cancer-related medical and behavioral regimens. We focus on cancer risk behaviors at all points on the cancer ...
  https://cancercontrol.cancer.gov/brp/e-newsletter/summer-2017.html
*  THE IMPRINTED BRAIN THEORY | Edge.org
Where purely genetic factors are concerned, the theory proposes that increased expression of paternal genes like IGF2 will ... This will result in the features listed in the figure: higher birth weight, an increased vulnerability to cancer (which is ... which persuasively argues that ASDs can often be linked to increased testosterone exposure in utero and to the more lateralized ... In mice, only paternal genes are expressed in the amygdalas and there is good evidence suggesting that the same is true in ...
  https://www.edge.org/conversation/christopher_badcock-the-imprinted-brain-theory
*  Genes Related To Childhood Cancer Linked To Parents' Smoking, Study Finds
ALL is the most common childhood cancer, and predominantly occurs in children under the… ... Researchers at the University of California San Fransisco are trying to better understand childhood cancers, particularly acute ... Two-thirds of the samples had at least one of the genetic deletions the researchers were looking for. When they looked at the ... Our results suggest that paternal pre-conception smoking, which is known to cause oxidative damage to sperm DNA, may lead to a ...
  https://www.romper.com/p/genes-related-to-childhood-cancer-linked-to-parents-smoking-study-finds-50345
*  Acute Lymphoblastic Leukemia - ONA
We offer clinical cancer updates, treatment guidance, and research news to the oncology nursing community. Visit us often for ... or DNA-damaging agents and paternal exposure to pesticides and fungicides. Benzene exposure is more frequently associated with ... The concept of "cancer clusters" - the observation of what seems to be a higher than expected incidence of cancer in a ... Genetic predisposing factors for the development of ALL include genetic syndromes such as Down syndrome, Klinefelter syndrome, ...
  https://www.oncologynurseadvisor.com/pediatrics/acute-lymphoblastic-leukemia/article/620431/
*  Call for Abstracts
... that paternal exposures prior to conception and during pregnancy result in increased risk of certain birth defects and cancers. ... Birth defects may be the result of genetic or environmental factors. This includes errors of morphogenesis, infection, ...
  https://neonatology.insightconferences.com/call-for-abstracts.php
*  Paternal Effects on Fertilization, Embryo Development, and Pregnancy Outcome | SpringerLink
Inskip H. Stillbirth and paternal preconceptional radiation exposure. Lancet 1999;354:1400-1.Google Scholar ... Genetic anomalies in mammalian germ cells and their significance for human reproductive and developmental risk. Environ Health ... Br J Cancer 1998;78:301-11.Google Scholar. *. 8.. Dickinson HO, Parker L, Binks K, Wakeford R, Smith J. The sex ratio of ... Much of this was probably related to the idea that the paternal influence was an "all or nothing" event: If the semen ...
  https://link.springer.com/chapter/10.1007/978-1-4613-0149-3_4
*  Ovarian Cancer - Hereditary/Genetic Factors
... a detailed family history from both maternal and paternal lineages must be obtained to determine the genetic susceptibility for ... In contrast, an acquired somatic mutation that occurs in cells as a result of DNA damage during life's various exposures cannot ... The National Institute of Health Consensus Statement on Ovarian Cancer and the Cancer Genetic Studies Consortium (CGSC) ... Two or more cancers within one individual. This could include breast and ovarian cancer, endometrial and colon cancer, or ...
  http://www.neurologyadvisor.com/obstetrics-and-gynecology/ovarian-cancer--hereditarygenetic-factors/article/618069/
*  Infertility in Men - Parents.com
... exposure to certain environmental toxins or chemicals; taking certain medications (like steroids); genetic conditions; certain ... And some research has linked paternal age to conditions like autism in their children. ... infections, like sexually transmitted diseases chlamydia and gonorrhea; and cancer and its treatments like chemotherapy and ...
  https://www.parents.com/getting-pregnant/infertility/causes/health-101-infertility-in-men/
*  SafeFetus Drug Search
... aberrations in children exposed in utero producing chromosomal gaps and rings with subsequent risk of cancer and genetic damage ... Occupational exposure of the mother to antineoplastic agents during pregnancy carries risk to the fetus, increasing fetal loss ... Doubtful association between paternal use of the drug and congenital anomalies in their offsprings including: anencephaly, ... Always consult your doctor if you have any questions about exposures during pregnancy and lactation, and before you take any ...
  http://safefetus.com/search.php/index/details/DrugId/309/TradeName/Cerubidine/TradeId/3794
*  Pregnancy Risk Assessment
History: Teratogen Exposure *See Teratogen Exposure. *Includes Occupational Exposures in Pregnancy. *Includes Herbal Teratogens ... History: Family related risk (consider genetic counselor if positive history) * History: Ethnicity (screen parents for carrier ... Advanced Paternal Age. *Maternal age risk doubled if father's age ,55 years ... History: Family related risk (consider genetic counselor if positive history) * History: Ethnicity (screen parents for carrier ...
  http://www.fpnotebook.com/OB/Prevent/PrgncyRskAssmnt.htm
*  Sven Sandin | Profilsida | Karolinska Institutet
Infectious agents and cancer 2011;6(1):8-. Prospective Study of UV Exposure and Cancer Incidence Among Swedish Women. Yang L, ... Infectious agents and cancer 2010;5():7-. Birth Characteristics and Risk of Prostate Cancer: the Contribution of Genetic ... CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2011;20(4):683-90. ADVANCING PATERNAL AND MATERNAL AGE ARE BOTH IMPORTANT FOR ... Prospective Study of Solar Exposure, Dietary Vitamin D Intake, and Risk of Breast Cancer among Middle-aged Women. Kuper H, Yang ...
  https://ki.se/people/svesan
*  Goal 3 - Exposure Science and the Exposome
Endocr Relat Cancer 24(2):83-96. [Abstract]. Researchers examine whether exposure of prostate cancer cells (LNCaP, C4-2) to low ... Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced ... Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes ... Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. Environ Health Perspect ...
  https://www.niehs.nih.gov/about/strategicplan/strategicplan2012/implementation/goal3/index.cfm
*  Breast Cancer Survivors - Dr. Darrin Lew
2004) identified paternal exposures to pesticides and smoking as factors associated with these congenital malformations. Very ... Biomarkers of genetic integrity or damage Sat, 01 Jul 2017 , Environmental Health ... Unfortunately, the use of tamoxifen in breast cancer patients is associated with an increased risk of endometrial cancer.712 A ... breast cancer activists focusing on avoidable chemical exposures have adopted the slogan Prevention is the Cure.74 The ...
  https://www.drdarrinlew.us/breast-cancer.html