*  A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms...
Genetic interactionsMolecular mechanismsGene-specific transcription factors Saccharomyces cerevisiae Background. Predicting the ... This is in part mediated by gene-specific transcription factors (GSTFs). Understanding the basis of genetic interactions ... Here, we have investigated the nature of genetic interactions between gene-specific transcription factors in baker's yeast. ... To investigate the nature of genetic interactions between gene-specific transcription factors (GSTFs) in Saccharomyces ...
  https://0-bmcbiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12915-015-0222-5
*  Genetic and Physical Interactions between Microphthalmia Transcription Factor and PU.1 Are Necessary for Osteoclast Gene...
Genetic and Physical Interactions between Microphthalmia Transcription Factor and PU.1 Are Necessary for Osteoclast Gene ... The microphthalmia transcription factor (MITF), a basic-helix-loop-helix zipper factor, regulates distinct target genes in ... how lineage-specific gene regulation can be achieved by the combinatorial action of two broadly expressed transcription factors ... We hypothesized that interaction with the Ets family factor PU.1, whose expression is limited to hematopoietic cells, might be ...
  https://research-repository.griffith.edu.au/handle/10072/63181
*  Phenotype of autosomal recessive congenital microphthalmia mapping to chromosome 14q32 | British Journal of Ophthalmology
1996) Transcription factor genes and the developing eye: a genetic perspective. Hum Mol Genet 5:1471-1488. ... At least 14 transcription factors that are essential for normal mammalian eye development have been described, along with 32 ... Four transcription factors (PAX2, PAX3,PAX6, and CRX) have been associated with ocular disease in humans, but none has been ... is syntenic with a region of mouse chromosome 12 which contains a number of transcription factors, some of which are important ...
  http://bjo.bmj.com/content/83/8/919
*  Journal of Alzheimer's Disease - Volume 13, issue 3 - Journals - IOS Press
Keywords: Alzheimer's disease, genetic association, gene variation, mitochondria transcription factor DOI: 10.3233/JAD-2008- ... The TFAM-gene encodes the mitochondrial transcription factor A, a protein that controls the transcription, replication, damage ... Mitochondrial Transcription Factor A (TFAM) Gene Variation and Risk of Late-Onset Alzheimer's Disease ... Impact Factor 2017: 3.731. The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate ...
  https://content.iospress.com/journals/journal-of-alzheimers-disease/13/3
*  Hypopituitarism - The Clinical Advisor
A number of genetic mutations in genes encoding transcription factors necessary for differentiation of anterior pituitary cells ... PROP-1 gene mutations are the most common known cause of genetic MPHD and may occur as familial MPHD or sporadically. ... Congenital pituitary transcription factor defects may lead to formation of only a very small pituitary gland and the appearance ... Congenital hypopituitarism is due to pituitary dysplasia or tissue-specific transcription factor mutations. Pituitary dysplasia ...
  https://www.clinicaladvisor.com/endocrinology-metabolism/hypopituitarism/article/595547/
*  Genetic factors in pathogenesis of diabetes mellitus after kidney tran | TCRM
The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ... There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development. ... Currently, predisposing genetic factors have been considered important in PTDM development. ... The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, ...
  https://www.dovepress.com/genetic-factors-in-pathogenesis-of-diabetes-mellitus-after-kidney-tran-peer-reviewed-article-TCRM
*  Frontiers | Stress Inducible Expression of AtDREB1A Transcription Factor in Transgenic Peanut (Arachis hypogaea L.) Conferred...
GG20) lines were developed using AtDREB1A gene, encoding for a transcription factor, through Agrobacterium-mediated genetic ... GG20) lines were developed using AtDREB1A gene, encoding for a transcription factor, through Agrobacterium-mediated genetic ... one of the important strategies is to genetically engineer the ruling peanut varieties using transcription factor regulating ... The inheritance of AtDREB1A gene in individual transgenic plants (T1 and T2) was confirmed using PCR. In homozygous transgenic ...
  https://www.frontiersin.org/articles/10.3389/fpls.2016.00935/full
*  softdrink and flavoured low fat milk - AnabolicMinds.com
The fructose in sucrose induces undesirable genetic changes in liver transcription factors and various fat-storing genes. Not ... The fructose in sucrose induces undesirable genetic changes in liver transcription factors and various fat-storing genes. Not ...
  http://anabolicminds.com/forum/weight-loss/73166-softdrink-flavoured-low.html
*  Frontiers | A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to...
Variables of the model are metabolite concentrations, gene expression levels, transcription factor activities, metabolic fluxes ... Variables of the model are metabolite concentrations, gene expression levels, transcription factor activities, metabolic fluxes ... Mathematical modeling has the potential to provide a coherent and quantitative description of the interplay between gene ... Mathematical modeling has the potential to provide a coherent and quantitative description of the interplay between gene ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2014.00124/full
*  Hidden Viral Gene Discovered In GMO Crops - Slashdot
TRANSCRIPTION FACTORS. GENE. PROTEIN. The PROMOTER is a genetic sequence that comes UPSTREAM of a GENE which is recognized by ... TRANSCRIPTION FACTORS. TRANSCRIPTION FACTORS bind to PROMOTER sequences and start the transcription of the GENE found ... 1. Why is that viral gene in there? When you insert a new gene (such as an herbicide resistance gene in Monsanto's Roundup ... I'm no expert on the matter, but from my knowledge genetic engineering is usually done by isolating a desirable gene, ...
  https://science.slashdot.org/story/13/01/22/2324246/hidden-viral-gene-discovered-in-gmo-crops?sdsrc=prevbtmprev
*  TEAD3 TEA domain transcription factor 3 [Homo sapiens (human)] - Gene - NCBI
Find tests for this gene in the NIH Genetic Testing Registry (GTR) ... TEAD3 TEA domain transcription factor 3 [Homo sapiens] TEAD3 TEA domain transcription factor 3 [Homo sapiens]. Gene ID:7005 ... This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the ... Gene Ontology Provided by GOA Function. Evidence Code. Pubs. DNA binding transcription factor activity IBA Inferred from ...
  https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7005
*  Similar articles for PubMed (Select 17606985) - PubMed - NCBI
Comprehensive genetic analysis of transcription factor pathways using a dual reporter gene system in budding yeast. ... Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1. ... Transcription factor hStaf/ZNF143 is required for expression of the human TFAM gene. ... Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=17606985
*  JCI Insight - Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice
Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians. Diabetes. 2003;52(5):1292 ... Transcription factor forkhead box protein C2 (FOXC2), a gene required for formation and maturation of collecting vessels, ... it is now clear that additional factors (e.g., genetic inheritance, hormonal disorders, and aging) also contribute to obesity. ... A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci U S A. 2001;98(22):12677-12682.. View this article ...
  https://insight.jci.org/articles/view/85096
*  Rice Cytokinin GATA Transcription Factor1 Regulates Chloroplast Development and Plant Architecture | Plant Physiology
2005) Genetic analysis of Arabidopsis GATA transcription factor gene family reveals a nitrate-inducible member important for ... 2008) Two GATA transcription factors are downstream effectors of floral homeotic gene action in Arabidopsis. Plant Physiol 147 ... 2011) Ectopic expression of different cytokinin-regulated transcription factor genes of Arabidopsis thaliana alters plant ... The CYTOKININ-RESPONSIVE GATA TRANSCRIPTION FACTOR1/GNC-like (CGA1/GNL) transcription factor was originally identified in ...
  http://www.plantphysiol.org/content/162/1/132
*  Genetic and Physiological Activation of Osmosensitive Gene Expression Mimics Transcriptional Signatures of Pathogen Infection...
Computational, transgenic, and functional approaches revealed that two GATA transcription factors previously implicated in ... Microarray profiling of wild type worms exposed to non-lethal hypertonicity identified a suite of genes that were also ... transcriptional similarities which might be controlled via regulation of tissue-specific GATA transcription factors. ... are also essential for coordinated tissue-specific activation of osmosensitive gene expression and promote survival under ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009010
*  Nfya - Nuclear transcription factor Y subunit alpha - Mus musculus (Mouse) - Nfya gene & protein
NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1. ... box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its ... Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' ... sequence-specific DNA binding Source: MGI ,p>Inferred from Genetic Interaction,/p> ,p>Used to describe "traditional" genetic ...
  http://www.uniprot.org/uniprot/P23708
*  Oncogenic Transcription Factors: Target Genes
... are a class of proteins that are essential for the regulation of gene expression and for the control of protein expression in ... Figure 1. Transcription factor (TF) activation and signalling pathway in cancer. TF activity is triggered by genetic ... Libermann TA and Zerbini LF (2006) Targeting transcription factors for cancer gene therapy. Current Gene Therapy 6 (1): 17-33. ... Transcription factors (TFs) are a class of proteins that are essential for the regulation of gene expression and for the ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0006049.html
*  Role of Group II Secretory Phospholipase A2 in Atherosclerosis | Arteriosclerosis, Thrombosis, and Vascular Biology
Genetic control of inflammatory gene induction and NF-kB-like transcription factor activation in response to an atherogenic ... Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak ... of the sPLA2 transgene on an inbred genetic background is also advantageous for reducing variability caused by genetic factors ... Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model. J Clin Invest. 1996; ...
  http://atvb.ahajournals.org/content/19/5/1284.long
*  JCI - Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways
Molecular genetic studies. The gene encoding the homeobox transcription factor, NKX2.5, contains 2 exons that encode a 324- ... Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes ... The homeobox transcription factor, tinman, a Drosophila NK-gene, has been of particular interest because it is expressed in the ... myocyte enhancer factor-2 (MEF2) (9, 12), myosin light chain 2V (MLC2V) (9), atrial natriuretic factor gene (9, 13), brain ...
  https://www.jci.org/articles/view/8154
*  Pbx2 - Pre-B-cell leukemia transcription factor 2 - Mus musculus (Mouse) - Pbx2 gene & protein
Activates transcription of PF4 in complex with MEIS1 (By similarity). ... embryonic limb morphogenesis Source: MGI ,p>Inferred from Genetic Interaction,/p> ,p>Used to describe "traditional" genetic ... help/gene_ontology' target='_top'>More...,/a>,/p>GO - Molecular functioni. *transcription factor binding Source: MGI ... transcription factor complex Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function ...
  http://www.uniprot.org/uniprot/O35984
*  Pou4f2 - POU domain, class 4, transcription factor 2 - Mus musculus (Mouse) - Pou4f2 gene & protein
Cooperates with the transcription factor ISL1 to achieve RGC fate specification in the developing retina (PubMed:25775587). ... Plays also a role in RGC axon formation and guidance by regulating gene expression of specific target genes (PubMed:8995448, ... Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed: ... in promoter of target genes (PubMed:7904822, PubMed:8290353, PubMed:7935408, PubMed:9111308, PubMed:10414983, PubMed:16152597, ...
  http://www.uniprot.org/uniprot/Q63934
*  WikiGenes
To assess the genetic mechanisms, we examined the transcription factor genes ARIX (recently identified as a causative gene for ... In contrast with other transcription factor genes, the variations in PMX2B show a high prevalence, with deletions being more ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... These results suggest a possible interaction between PMX2B and other schizophrenia-precipitating factors, increasing the risk ...
  https://www.wikigenes.org/e/ref/e/14709596.html
*  KLF6 - Wikipedia
... association of Zf9 transcription factor gene". Plastic and Reconstructive Surgery. 111 (7): 2133-9. doi:10.1097/01.PRS. ... Bayat A, Watson JS, Stanley JK, Ferguson MW, Ollier WE (Jun 2003). "Genetic susceptibility to dupuytren disease: ... Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. It is a tumor suppressor gene. This gene ... KLF6 has been shown to interact with Sp1 transcription factor. Kruppel-like factors GRCh38: Ensembl release 89: ENSG00000067082 ...
  https://en.wikipedia.org/wiki/KLF6
*  meis1 - Homeobox protein Meis1 - Xenopus laevis (African clawed frog) - meis1 gene & protein
Binds to a highly conserved region in the promoter of the neural crest marker gene zic3. ... Induces expression of a number of neural crest marker genes as part of a heterodimer with isoform b of pbx1, to specify neural ... transcription factor complex Source: UniProtKB ,p>Inferred from Genetic Interaction,/p> ,p>Used to describe "traditional" ... or inferences about a gene drawn from the phenotype of a mutation in a different gene.,/p> ,p>More information in the ,a href=" ...
  http://www.uniprot.org/uniprot/P79937
*  Shiladitya DasSarma - Wikipedia
Coker, James A.; DasSarma, Shiladitya (2007-01-01). "Genetic and transcriptomic analysis of transcription factor genes in the ... and the function of many genes and genetic elements, including multiple replication origins, general transcription factors, and ... The work also suggested that certain genes are acquired through horizontal gene transfers, such as the genes for aerobic ... In the 1990's, he organized and led the team that deciphered the first genome sequence and genetic code for a salt-loving ...
  https://en.wikipedia.org/wiki/Shiladitya_DasSarma