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*  Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool‐2/α‐Pix | The EMBO Journal
... guanine nucleotide dissociation inhibitors (GDIs), and guanine nucleotide exchange factors (GEFs), regulate the cycling of ... Van Aelst L, D'Souza‐Schorey C (1997) Rho GTPases and signaling networks. Genes Dev 11: 2295-2322. ... Kim S, Lee SH, Park D (2001) Leucine zipper‐mediated homodimerization of the p21‐activated kinase‐interacting factor, beta Pix ... encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X‐linked mental retardation. Nat Genet 26: 247- ...
  http://emboj.embopress.org/content/23/17/3492.long
*  Housekeeping gene - Wikipedia
Rho guanine nucleotide exchange factor 10L ARHGEF11 Rho guanine nucleotide exchange factor 11 ARHGEF40 Rho guanine nucleotide ... constitutively at 5-12 CSK C-src tyrosine kinase DCT dopachrome tautomerase EFNA3 FKBP1A GDI1 GDP Dissociation inhibitor (Rab ... beta subunit GARS (gene)GARS NM_002047 glycyl-tRNA synthetase HARS NM_002109 histidyl-tRNA synthetase HARS2 NM_012208 histidyl- ... ARHGEF2 Rho guanine nucleotide exchange factor ARMET Mesencephalic astrocyte-derived neurotrophic factor AES amino terminal ...
  https://en.wikipedia.org/wiki/Housekeeping_gene
*  rho guanine nucleotide dissociation inhibitors Summary Report | CureHunter
rho guanine nucleotide dissociation inhibitors: amino acid sequence given in first source; MW=27 kDa; specifically regulates ... 01/01/2012 - "Although the Rho GDP dissociation inhibitor β (ARHGDIB) gene has been found to be ubiquitously expressed in ... 11/01/2014 - "Rho GDP dissociation inhibitor (GDI) beta, (RhoGDI2), has been identified as a proto-oncogene that is upregulated ... rho guanine nucleotide dissociation inhibitors. Subscribe to New Research on rho guanine nucleotide dissociation inhibitors ...
  http://www.curehunter.com/public/keywordSummaryC066667-rho-guanine-nucleotide-dissociation-inhibitors.do
*  X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)...
... demonstrated that the regulation of cell motility by XIAP depends on its interaction with the Rho GDP dissociation inhibitor ( ... X-linked inhibitor of apoptosis protein (XIAP) overexpression has been found to be associated with malignant cancer progression ... XIAP gene. *rho Guanine Nucleotide Dissociation Inhibitor beta. 35 Citations. 0 References ... X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)- ...
  https://www.semanticscholar.org/paper/X-linked-inhibitor-of-apoptosis-protein-%28XIAP%29-cell-Liu-Zhang/2758b2e83e0216319f25ed0202ee216238e4c17f
*  G-protein signaling - Regulation of CDC42 activity Pathway Map - PrimePCR | Life Science | Bio-Rad
Select your gene target of interest using an interactive pathway map, and select your plate. ... Rho GDP dissociation inhibitors (GDI) alpha, beta and gamma (RhoGDI alpha, LyGDI, RhoGDI gamma) are inhibitors of CDC42 ... The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange ... Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/g-protein-signaling-regulation-cdc42-activity
*  Frontiers | Actin Cytoskeleton Affects Schwann Cell Migration and Peripheral Nerve Regeneration | Physiology
By using bioinformatic tools and qRT-PCR, We identified and validated differentially expressed genes in these two signaling ... Moreover, by applying actin polymerization inhibitor cytochalasin D to sciatic nerve crushed rats, we studied the in vivo ... actin cytoskeleton signaling and regulation of actin-based motility by Rho. By using bioinformatic tools and qRT-PCR, We ... Overall, our data revealed the changes of actin cytoskeleton-related genes following peripheral nerve injury and stated the ...
  https://www.frontiersin.org/articles/10.3389/fphys.2018.00023/full
*  KEGG SSDB Paralog Search Result: mmu:234135
mmu:20182 retinoid X receptor beta K08525 520 145 ( -) 39 0.490 51 -, mmu:213498 Rho guanine nucleotide exchange factor (GEF) ... mmu:71746 ral guanine nucleotide dissociation stimulato K17639 709 109 ( -) 31 0.857 14 -, mmu:102640043 predicted gene, 36210 ... mmu:16427 inter alpha-trypsin inhibitor, heavy chain 4 942 116 ( -) 32 0.560 25 -, mmu:19259 protein tyrosine phosphatase, non- ... mmu:333329 cyclic nucleotide gated channel beta 1 K04952 1325 131 ( -) 36 0.329 70 -, mmu:56458 forkhead box O1 K07201 652 131 ...
  http://www.kegg.jp/ssdb-bin/ssdb_paralog?org_gene=mmu:234135
*  Hybrid 3′ untranslated regions suitable for efficient protein expression in mammalian cells - King Faisal Specialist Hospital &...
Thymosin, beta 10. TMSB10. 317. 1714. NM_004309. Rho GDP dissociation inhibitor (GDI) alpha. ARHGDIA. 1,206. 1702. ... Guanine nucleotide binding protein (G protein), beta polypeptide 2. GNB2. 386. 1030. ... Testis enhanced gene transcript (BAX inhibitor 1). TEGT. 1,847. 3438. NM_002568. Poly(A) binding protein, cytoplasmic 1. PABPC1 ... GDP dissociation inhibitor 2. GDI2. 785. 1395. NM_014225. Protein phosphatase 2 (formerly 2A), regulatory subunit A. PPP2R1A. ...
  http://www.freepatentsonline.com/9017965.html
*  Integrin beta-1-binding protein 1
Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix ... Observational study of gene-disease association. (HuGE Navigator). 18812969. integrin cytoplasmic domain-associated protein-1 ... Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the ... The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 ...
  https://pharos.nih.gov/idg/targets/O14713
*  G-protein signaling - RhoA regulation pathway Pathway Map - PrimePCR | Life Science | Bio-Rad
Select your gene target of interest using an interactive pathway map, and select your plate. ... Rho GDP dissociation inhibitors (GDIs) alpha, beta and gamma (RhoGDI alpha, LyGDI, and RhoGDI gamma) bind to RhoA and ... Rho/rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2) and Rho guanine nucleotide exchange factor (GEF) 3 (ARHGEF3) are ... Ras homolog gene family, member A (RhoA) is a member of a family of small GTPases. Rho GTPases control multiple cellular ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/cytoskeleton-remodeling/g-protein-signaling-rhoa-regulation-pathway
*  G-protein signaling Regulation of CDC42 activity
Rho GDP dissociation inhibitors (GDI) alpha, beta and gamma ( RhoGDI alpha, LyGDI, RhoGDI gamma ) are inhibitors of CDC42 ... The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange ... Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G ... The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange ...
  http://pathwaymaps.com/maps/389/
*  Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets
Kowluru A, Veluthakal R. Rho guanosine diphosphate-dissociation inhibitor plays a negative modulatory role in glucose- ... a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells. Biochem ... Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells ... In addition, the activation status of Rac1 was under the precise control of Tiam1, a guanine nucleotide exchange factor for ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3198065/
*  Yersinia pseudotuberculosis - Wikipedia
... guanine nucleotide dissociation inhibitor)-bound state whereas YopE and YpkA convert Rho proteins to their inactive GDP-bound ... The yop genes, yadA, ylpA, and the virC operon are considered the "Yop regulon" since they are coregulated by pYV-encoded VirF ... Members of this family of Yersinia pseudotuberculosis mitogens adopt a sandwich structure consisting of 9 strands in two beta ... YopT targets Rho GTPase, commonly named "RhoA", and uncouples it from the membrane, leaving it in an inactive RhoA-GDI ( ...
  https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis
*  List of MeSH codes (D12.644) - Wikipedia
... guanine nucleotide dissociation inhibitors MeSH D12.644.360.325.300 --- guanine nucleotide exchange factors MeSH D12.644. ... interferon-stimulated gene factor 3 MeSH D12.644.360.024.301.500 --- interferon-stimulated gene factor 3, alpha subunit MeSH ... rho gtp-binding proteins MeSH D12.644.360.525.700.050 --- cdc42 gtp-binding protein MeSH D12.644.360.525.700.050.500 --- cdc42 ... gtp-binding protein beta subunits MeSH D12.644.360.375.730 --- gtp-binding protein gamma subunits MeSH D12.644.360.375.940 --- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.644)
*  Rac2D57N, a dominant inhibitory Rac2 mutant that inhibits p38 kinase signaling and prevents surface ruffling in bone-marrow...
Rac signaling is regulated by three classes of proteins: guanine-nucleotide-dissociation inhibitors (GDIs), guanine-nucleotide- ... Olofsson, B. (1999). Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Cell Signal. 11, 545-554. ... Shirsat, N. V., Pignolo, R. J., Kreider, B. L. and Rovera, G. (1990). A member of the Ras gene superfamily is expressed ... Riches, D. W., and Underwood, G. A. (1991). Expression of interferon-beta during the triggering of macrophage cytocidal ...
  http://jcs.biologists.org/content/117/2/243
*  gq g11 gtp binding protein alpha subunits
Genomes and Genes, Scientific Experts, Publications, Species, Research Topics, Research Grants about gq g11 gtp binding protein ... Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Michelle A Booden. ... However, mechanisms regulating transcription of the human GNAQ gene encoding the Gq protein are unknown and single-nucleotide ... gtp binding protein beta subunits*estrenes*calcium channels*gtp binding protein gamma subunits*platelet aggregation*inositol ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/heterotrimeric/gtp/gq-g11-gtp-binding-protein-alpha-subunits-12352.html
*  G beta-gamma complex - Wikipedia
The Gβγ subunit has been shown to activate a Rho guanine nucleotide exchange factor (RhoGef) gene PLEKHG2 which is upregulated ... June 1998). "Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene ... This causes the replacement of GDP with GTP as well as the physical dissociation of the Gα and the Gβγ complex. Once separated ... beta, and gamma subunit genes". DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes. ...
  https://en.wikipedia.org/wiki/G_beta-gamma_complex
*  Development - A2A receptor signaling Pathway Map - PrimePCR | Life Science | Bio-Rad
Select your gene target of interest using an interactive pathway map, and select your plate. ... phosphorylates and activates Rho guanine nucleotide exchange factor (GEF) 7 (BETA-PIX) that, in turn, activates Ras-related C3 ... Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor (I-kB)/ Nuclear factor of kappa light polypeptide ... beta/gamma causes the exchange of GDP to GTP bound to G protein alpha subunits and the dissociation of the beta/gamma ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/gpcr/development-a2a-receptor-signaling
*  Net1 (Neuroepithelial Cell Transforming Gene 1 Protein) | SpringerLink
ARHGEF8; Net1A Rho family small GTPases control multiple cell functions, including organization of the actin cytoskeletal, cell ... Rho GAPs), and guanine nucleotide dissociation inhibitors (Rho GDIs). Rho GEFs activate Rho proteins by stimulating the release ... The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation. ... Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr Biol. ...
  https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_554
*  G protein-coupled receptor - Wikipedia
... guanine-nucleotide dissociation inhibitors (GDIs) and protein phosphatases. There may even be specific proteins of these ... Rho. Once bound to GTP, Rho can then go on to activate various proteins responsible for cytoskeleton regulation such as Rho- ... For example, beta-arrestin bound to β2-adrenoreceptors acts as an adaptor for binding with clathrin, and with the beta-subunit ... GPCR regulation is additionally mediated by gene transcription factors. These factors can increase or decrease gene ...
  https://en.wikipedia.org/wiki/G_protein%E2%80%93coupled_receptor
*  RHOB - Wikipedia
1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the ... is a protein which in humans is encoded by the RHOB gene. RHOB is a member of the Rho GTP-binding protein family. RHOB has been ... a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. United States. 277 (45): 42964-72. doi: ... 2002). "RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism ...
  https://en.wikipedia.org/wiki/RHOB
*  Gene Report for G00001754 - Genes2Cognition Neuroscience Research Programme
These data suggest that TCTP has guanine nucleotide dissociation inhibitor activity, and, moreover, implicate TCTP in the ... a guanine nucleotide exchange factor (GEF) for the Rho GTPase. 14-3-3 binding to AKAP-Lbc, induced by PKA, suppresses Rho ... In human fibroblasts, the guanine nucleotide exchange part of EF-1, EF-1 beta gamma delta, was found to co-localize with the ... Gene lists (6). Databases (8). Curated Gene. OTTHUMG00000015031 (Vega human gene). Gene. ENSG00000156508 (Ensembl human gene). ...
  http://www.genes2cognition.org/db/Gene/G00001754
*  RHOA - Wikipedia
... "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. ... Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 ( ... "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the ... "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member". FEBS Lett. 459 (3): 313-8. ...
  https://en.wikipedia.org/wiki/RHOA
*  NOVEL INHIBITORS OF RHO KINASE - Patent application - compounds and methods which may be useful as inhibitors of Rho kinase for...
... converted to active GTP-bound Rho by membrane-localized guanine-nucleotide exchange factors. GTP-bound Rho then binds and ... to use in dissociation culture, which is important for such procedures as clonal isolation following gene transfer and ... These isoforms are referred to as Rho kinase (ROK) alpha (referred to here as ROCK2), and Rho kinase (ROK) beta, also known as ... Inactive, GDP-bound Rho, complexed with a GDP dissociation inhibitor protein (GDI), is recruited to the plasma membrane in ...
  http://www.patentsencyclopedia.com/app/20090318485
*  Computational Analysis of Rho GTPase Cycling
Johnson JL, Erickson JW, Cerione RA (2009) New insights into how the Rho guanine nucleotide dissociation inhibitor regulates ... a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells. Biochem ... Genes Dev 11: 2295-2322. [PubMed]. 35. Pertz O (2010) Spatio-temporal Rho GTPase signaling - where are we now? J Cell Sci 123: ... 4. Zhao L, Wang H, Li J, Liu Y, Ding Y (2008) Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3542069/?lang=en-ca