*  ASMscience | Malignancies of the Immu
Therefore, malignancies of the immune system are not only interesting models of normal immune cells but are also excellent ... are primarily represented by the malignant lymphomas and a smaller number of nonlymphoid neoplasms that originate from cells ... Development of T3/T cell receptor gene expression in human pre-T neoplasms. Blood 69:1062-1067.[PubMed]. ... T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia reflect 'end-stage' recombinations: ...
  http://www.asmscience.org/content/book/10.1128/9781555818722.ch109
*  GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia
Leukemic pre-B cells express Notch receptors, ligands and target genes. RT-PCR results for Notch receptors, ligands and target ... μ GSI-I and ,90% cell death for 2.5. μ GSI-I. The RS4;11 pre-B-cell line was very sensitive to the drug, with cell death ... Notch receptors, ligands and target genes are all expressed in freshly isolated pre-B lymphoblasts. Notch signaling events ... GSI-I treatment induces apoptosis in pre-B-cell lines and primary patient blasts. (a) Precursor-B ALL cell viability for 697 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3170956/?lang=en-ca
*  How Essential is the Pre-T-Cell Receptor? | Springer for Research & Development
This function is performed mostly by the lymphocytes that form two major cell lineages: the... ... In transgenic mice the introduced functional T cell receptor ß gene prevents expression of endogenous ß genes. Cell 52 831-841. ... Function of the pre-T-cell receptor a chain in T-cell development and allelic exclusion at the T-cell receptor ß locus. Proc. ... Essential role of the pre-T-cell receptor in allelic exclusion of the T-cell receptor ß locus. Immunity J. 7 601-607.Google ...
  https://rd.springer.com/chapter/10.1007/978-1-4757-2778-4_22
*  Harald von Boehmer - Wikipedia
Analysis and expression of a cloned pre-T cell receptor gene. Science 266,1208-1212 (1994); Fehling, H.J., Krotkova, A., Saint- ... A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell ... Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus. Immunity 7, 601-607 (1997). ... Ruf, C. and von Boehmer, H.: Crucial role of the pre-T cell receptor in development of alpha beta but not gamma delta T cells. ...
  https://en.wikipedia.org/wiki/Harald_von_Boehmer
*  A Knockdown Punch To The Brain | The New York Academy Of Sciences
Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters. DNA Cell Biol. 24: 736- ... siRNA-Induced Widespread Gene Knockdown in the Adult Mouse Brain*Effects of Local Infusion of Mu Opioid Receptor-Targeted Small ... Targeting brain AT1 receptors by RNA interference. Hypertension 47: 145-146.. siRNA-Induced Widespread Gene Knockdown in the ... LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. J. Cell Biol. 170: 935- ...
  https://www.nyas.org/ebriefings/a-knockdown-punch-to-the-brain/
*  George Yancopoulos - Wikipedia
"Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common ... "An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors". Molecular Cell. 1 (1): 25-34 ... May 1996). "The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo". Cell. 85 (4): 501-12. ... May 1996). "Agrin acts via a MuSK receptor complex". Cell. 85 (4): 513-23. doi:10.1016/S0092-8674(00)81252-0. PMID 8653787. ...
  https://en.wikipedia.org/wiki/George_Yancopoulos
*  The AMEDEO Literature Guide
In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells for Acute ... Induction of Cell Death in Growing Human T-Cells and Cell Survival in Resting Cells in Response to the Human T-Cell Leukemia ... Correction: In Vitro Pre-Clinical Validation of Suicide Gene Modified Anti-CD33 Redirected Chimeric Antigen Receptor T-Cells ... NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.. PLoS One. 2017;12:e0171164. ...
  http://amedeo.com/medicine/leu/j1020.htm
*  JCI - Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine
Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters. DNA Cell Biol. 2005;24(11 ... of an array of mu opioid receptor variants produced by alternative pre-mRNA splicing of the single-copy mu opioid receptor gene ... Genomic database analysis suggests that as many as 12% of human GPCR genes (excluding olfactory receptor genes) generate ... Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Proc Natl Acad Sci U S A. ...
  https://www.jci.org/articles/view/88760
*  Follicular Mucinosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Pre T Cell Antigen Receptor Alpha. Protein Coding. 13.88. DISEASES inferred 15 ... and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, t cells and bone, and related phenotypes ... Cellular components related to Follicular Mucinosis according to GeneCards Suite gene sharing:. #. Name. GO ID. Score. Top ... Pathways related to Follicular Mucinosis according to GeneCards Suite gene sharing:. #. Super pathways. Score. Top Affiliating ...
  https://www.malacards.org/card/follicular_mucinosis?search=t
*  Gene-expression patterns reveal underlying biological processes in Kawasaki disease | Genome Biology | Full Text
Notably, higher levels of transcripts of the gene for carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) were ... In an initial survey, we used DNA microarrays to examine patterns of gene expression in peripheral whole blood from 20 children ... Acute KD is characterized by dynamic and variable gene-expression programs that highlight the importance of neutrophil ... Acute KD was characterized by increased relative abundance of gene transcripts associated with innate immune and ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-12-r261
*  CXCR4 acts as a costimulator during thymic beta-selection. - PubMed - NCBI
... beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene ... Migration of pre-T cell lines SCIET27 (pre-TCR-deficient) and SCB29 (pre-TCR-expressing) to 20nM SDF-1α or BSA (n=5). Data in a ... Bar graphs show percentage of migrated DN3 cells as a fraction of total cell input, ± s.d. (n=2). (h) DN3 thymocytes pre- ... n=2. (e) SCB29 cells were stimulated for the indicated time periods with SDF-1α, and staining for CXCR4 (green) and pre-TCR ( ...
  https://www.ncbi.nlm.nih.gov/pubmed/20010845?access_num=20010845&link_type=MED&dopt=Abstract
*  Frontiers | Diversity of Immunoglobulin Light Chain Genes in Non-Teleost Ray-Finned Fish Uncovers IgL Subdivision into Five...
In addition, sterlet possesses sigma-like VL and J-CL genes, which are transcribed separately and both encode protein products ... In addition, sterlet possesses sigma-like VL and J-CL genes, which are transcribed separately and both encode protein products ... We show that this species has three loci encoding IgL kappa-like chains with a translocon-type gene organization and a single ... We show that this species has three loci encoding IgL kappa-like chains with a translocon-type gene organization and a single ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2018.01079/full
*  CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity | JEM
1996) Functions of TCR and pre-TCR subunits: lessons from gene ablation. Curr Opin Immunol 8:383-393, pmid:8793999.. ... 1996) Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes. Curr Opin Immunol 8: ... CD5 is a monomeric cell surface glycoprotein expressed on thymocytes, all mature T cells, and a subset of B cells, B-1 cells (( ... Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature. 360:225-231. (See ...
  http://jem.rupress.org/content/188/12/2301
*  Gene placement and competition control T cell receptor γ variable region gene rearrangement | JEM
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature. 311:727-733. ... T cell receptor δ gene mutant mice: independent generation of αβ T cells and programmed rearrangements of γδ TCR genes. Cell. ... Interleukin 7 receptor control of T cell receptor γ gene rearrangement: role of receptor-associated chains and locus ... Gene placement and competition control T cell receptor γ variable region gene rearrangement. Na Xiong, Li Zhang, Chulho Kang, ...
  http://jem.rupress.org/content/205/4/929
*  prph2 Literature [Xenopus] - Xenbase Gene Catalog
Identification of the pre-T-cell receptor alpha chain in nonmammalian vertebrates challenges the structure-function of the ... Gene. October 2, 2002; 298 (2): 173-82.. Investigating the mechanisms of retinal degenerations with antisense oligonucleotides. ... Mol Biol Cell. April 1, 2004; 15 (4): 2027-37.. Role of subunit assembly in autosomal dominant retinitis pigmentosa linked to ... Gene Literature (19). GO Terms (5). Nucleotides (54). Proteins (21). Interactants (52). Wiki. ...
  http://www.xenbase.org/gene/attribution.do?objName=FEATURE&objId=985593&objNameSrt=FEAT&attPage=PAPER&action=VIEW&litOnly=1&att=prph2&tabId=2&
*  LAT - Linker for activation of T-cells family member 1 - Homo sapiens (Human) - LAT gene & protein
... high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and ... and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity ... immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 ( ... Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at ...
  http://www.uniprot.org/uniprot/O43561
*  Pbx2 - Pre-B-cell leukemia transcription factor 2 - Mus musculus (Mouse) - Pbx2 gene & protein
... with the exception of physiological receptor-ligand interactions which are annotated in the ,a href="http://www.uniprot.org/ ... Pre-B-cell leukemia transcription factor 2Add BLAST. 430. Amino acid modifications. Feature key. Position(s). Description ... p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of ... sp,O35984,PBX2_MOUSE Pre-B-cell leukemia transcription factor 2 OS=Mus musculus OX=10090 GN=Pbx2 PE=1 SV=1 ...
  http://www.uniprot.org/uniprot/O35984
*  Prkch - Protein kinase C eta type - Mus musculus (Mouse) - Prkch gene & protein
In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene ... induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by ... In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) ... In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection ...
  http://www.uniprot.org/uniprot/P23298
*  Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination | JEM
SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint ... region of the T cell receptor and Ig genes, giving rise to a large repertoire of specificities (5). In mature B cells, CSR ... Regulation of switching and production of IgA in human B cells in donors with duplicated alpha1 genes. Eur. J. Immunol. 31:3622 ... Radiation-induced delayed cell death in a hypomorphic Artemis cell line. Hum. Mol. Genet. 15:1303-1311. ...
  http://jem.rupress.org/content/205/13/3031
*  Lymphoid Development and Function in IL-7R-Deficient Mice | SpringerLink
... antigen receptor gene rearrangement, and cytokine responsiveness. For... ... and T-cell progenitor development have been thoroughly defined on the basis of cell surface marker expression, ... Status of xL chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells. J. Immunol ... Groettrup, M. and von Boehmer, H. (1993) A role for a pre-T-cell receptor in T-cell development. Immunol. Today 14, 610-614. ...
  https://link.springer.com/chapter/10.1007/978-1-4757-2753-1_3
*  Molecular Pathways and Mechanisms Regulating the Recombination of Immunoglobulin Genes during B-Lymphocyte Development |...
... genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of... ... The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) ... gene repertoire of developing precursor B-lymphocytes in mouse bone marrow mediated by the pre-B-cell receptor. Immunity 1997; ... Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature 1984; 311(5988):727-733.CrossRef ...
  https://link.springer.com/chapter/10.1007/978-1-4419-0296-2_11
*  CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development. | JEM
Pre-TCR function was mimicked by the induction of CD3 signaling in thymocytes of recombination activating gene (RAG)-deficient ... CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development.. L A Gravestein, W van Ewijk, F ... CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development. ... precursor T cell stage and is regulated by the pre-TCR. Therefore, we investigated whether CD27 contributes to pre-TCR-mediated ...
  http://jem.rupress.org/content/184/2/675
*  PRKCH Gene - GeneCards | KPCL Protein | KPCL Antibody
Complete information for PRKCH gene (Protein Coding), Protein Kinase C Eta, including: function, proteins, disorders, pathways ... In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene ... In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene ... protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRKCH&keywords=hsa-mir-1343-3p
*  Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts | BMC Medical Genetics | Full...
Pre-publication history. *. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471- ... Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts. ... Expression of TLR2 in the human immune system is most predominant in myelomonocytic cells, followed by B cells, CD56+16+ cells ... killer cells requires cross talk with antigen-presenting cells involving toll-like receptor 2 and 4 and the mannose receptor in ...
  https://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2350-11-17
*  Changing the Paradigms of Treatment in Peripheral T-cell Lymphoma: From Biology to Clinical Practice | Clinical Cancer Research
... the thymus represents the site of T-cell receptor gene rearrangement, and is the reference point that differentiates the pre- ... and low-frequency mutations in genes that affect other T-cell functions, including T-cell receptor (TCR) signaling (CD28, FYN; ... T-cell neoplasms: organ of origin or involvement and associated chromosomal and genetic alterations. Pre-thymic/thymic T-cell ... The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell ...
  http://clincancerres.aacrjournals.org/content/20/20/5240.full