Intradermal Injection of Capsaicin in Humans Produces Degeneration and Subsequent Reinnervation of Epidermal Nerve Fibers:...
1990) Protein gene product 9.5-immunoreactive nerve fibres and cells in human skin. Cell Tissue Res 261:25-33. ... Nerve and tissue antigens were localized using primary antibodies to protein gene product (PGP) 9.5 (1:800; Ultraclone, Isle of ... In normal skin the epidermis is heavily innervated by nerve fibers immunoreactive for protein gene product (PGP) 9.5, whereas ... 1991) An immunocytochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 ...http://www.jneurosci.org/content/18/21/8947
Glial cell line-derived neurotrophic factor gene therapy ameliorates chronic hyperprolactinemia in senile rats.
0/Antigens, Nuclear; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Nerve Tissue Proteins; 0/NeuN protein, rat; 9002-62-4/ ... Nerve Tissue Proteins / metabolism. Neurons / cytology, metabolism. Prolactin / analysis, blood, secretion. Rats. Rats, Sprague ... Genes, Reporter / genetics. Genetic Therapy / methods*. Genetic Vectors / genetics, pharmacology. Glial Cell Line-Derived ... We assessed the effectiveness of glial cell line-derived neurotrophic factor (GDNF) gene therapy to restore TIDA neuron ...http://www.biomedsearch.com/nih/Glial-cell-line-derived-neurotrophic/20219648.html
The Evolution of Lipophilin Genes from Invertebrates to Tetrapods: DM-20 Cannot Replace Proteolipid Protein in CNS Myelin |...
1974) Isolation of myelin from nerve tissue. Methods Enzymol 31:435-444. ... The proteolipid protein (PLP) gene encodes two myelin-specific protein isoforms, DM-20 and PLP, which are members of the highly ... 1993) A proteolipid protein gene family: expression in sharks and rays and possible evolution from an ancestral gene encoding a ... 1999) Identification of a new exon in the myelin proteolipid protein gene encoding novel protein isoforms that are restricted ...http://www.jneurosci.org/content/20/11/4002
IL17B Gene - GeneCards | IL17B Protein | IL17B Antibody
... proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Complete information for IL17B gene (Protein Coding), Interleukin 17B, including: function, ... Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell ... Summaries for IL17B Gene Entrez Gene Summary for IL17B Gene. * The protein encoded by this gene is a T cell-derived cytokine ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=IL17B
Newborns of obese parents have altered DNA methylation patterns at imprinted genes. - NextBio article
NNAT protein, human Nerve Tissue Proteins PEG10 protein, human PEG3 protein, human PLAGL1 protein, human Proteins SGCE protein ... Membrane Proteins Nerve Tissue Proteins Obesity Parents Pregnancy Proteins Reproducibility of Results Sarcoglycans Sequence ... Tumor Suppressor Proteins mesoderm specific transcript protein Insulin-Like Growth Factor II ... Cell Cycle Proteins Kruppel-Like Transcription Factors Membrane Proteins ...http://www.nextbio.com/b/search/article.nb?id=24158121
What is Marfan syndrome? :: DNA Learning Center
NF1 is a large gene that encodes three slightly different neurofibromin proteins, found in nerve and muscle tissue. SOURCE: ... The misshapen protein from the mutated gene weakens the tendons, ligaments and other connective tissues in the body.. SOURCE: ... The misshapen protein from the mutated gene weakens the tendons, ligaments and other connective tissues in the body. ... The CFTR gene encodes a protein that transports sodium and chloride (salt) ions in the bo. SOURCE: DNAi. ...https://www.dnalc.org/view/15955-What-is-Marfan-syndrome-.html
Soft tissue tumours- Peripheral nerves Flashcards by Sally-Anne Phillips | Brainscape
Study Soft tissue tumours- Peripheral nerves flashcards from Sally-Anne Phillips ... cell of origin, arises from cell with bialletic inactivation of NF1 tumour-suppressor gene of protein neurofibrin ... Soft tissue tumours- Peripheral nerves Flashcards Preview Pathology FRCS , Soft tissue tumours- Peripheral nerves , Flashcards ... nerve function may be preserved by careful dissection, excising the lesion parallel to nerve fascicles so the lesion may be ...https://www.brainscape.com/flashcards/soft-tissue-tumours-peripheral-nerves-2577715/packs/2961035
What causes muscular dystrophy? :: DNA Learning Center
NF1 is a large gene that encodes three slightly different neurofibromin proteins, found in nerve and muscle tissues. SOURCE: ... NF1 is a large gene that encodes three slightly different neurofibromin proteins, found in nerve and muscle tissues.. SOURCE: ... NF1 is a large gene that encodes three slightly different neurofibromin proteins, found in nerve and muscle tissue. SOURCE: ... The NF2 gene produces a protein, called merlin, in the schwann cells that wrap around the axons of nerve cells. Merlin is a ...https://www.dnalc.org/view/15958-What-causes-muscular-dystrophy-.html
KCNB1 - Potassium voltage-gated channel subfamily B member 1 - Oryctolagus cuniculus (Rabbit) - KCNB1 gene & protein
... making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Major ... by Src or FYN tyrosine-protein kinases and tyrosine phosphatase PTPRE in primary Schwann cells and sciatic nerve tissue.By ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 9986.ENSOCUP00000017212 ... Protein-protein interaction databases. STRING: functional protein association networks. More...STRINGi. 9986.ENSOCUP00000017212 ...http://www.uniprot.org/uniprot/Q9MZ19
Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. -...
... the data show that risk-associated polymorphisms do affect gene expression or the function of the encoded protein; in some ... These considerations give unique importance to postmortem human brain tissue in elucidating the genetic mechanisms underlying ... instances, expression of downstream or interacting partners of the gene are also altered. A further striking finding is that ... Genetic advances now make possible a novel approach that focuses on how allelic variation in risk-associated genes affects ...https://www.psych.ox.ac.uk/publications/110390
What goes up must come down - UCL Discovery
Receptor, Proteins, Membrane Proteins, nerve, Nerve Tissue Proteins, Animal, Drosophila melanogaster, Feedback, Gene Expression ... Insect Proteins) RN - 0 (Kek1 protein) RN - 0 (Membrane Proteins) RN - 0 (Nerve Tissue Proteins) PT - NEWS DA - 19991207 IS - ... UI - 20030563 LA - Eng RN - EC 2.7.11.- (Receptor, Epidermal Growth Factor) RN - 0 (sprouty protein) RN - 0 ( ... Regulation, Developmental, genetics, Insect Proteins, physiology, Receptor, Epidermal Growth Factor. UCL classification:. UCL ...http://discovery.ucl.ac.uk/22317/
Genes, cognition, and communication: insights from neurodevelopmental disorders. - PSY
Nevertheless, it has proved difficult for researchers to identify genes that would explain substantial amounts of variance in ... Finally, research on phenotypic correlates of allelic variation in the genes ASPM and microcephalin is considered; initial ... it fits with a multifactorial model of how complex human traits are influenced by numerous genes that interact with one another ... interest in these as genes for brain size or intelligence has been dampened by a failure to find phenotypic differences in ...https://www.psy.ox.ac.uk/publications/9511
Pfizer to Acquire FoldRx Pharmaceuticals ( NEW YORK and CAMBRIDGE Mass. Sept. 1 ...)
Transthyretin (TTR) is an amyloidogenic protein secreted by the liver. Mutations in the TTR gene have been linked to several ... Deposition of TTR amyloid in the peripheral nerve tissue results in transthyretin amyloid polyneuropathy (ATTR-PN), a sensory, ... By applying FoldRx's proprietary expertise in protein folding and its platform for drug and target discovery, the company is ... Tafamidis is a new chemical entity, first-in-class, oral, disease-modifying agent that stabilizes the protein transthyretin ( ...http://www.bio-medicine.org/medicine-technology-1/Pfizer-to-Acquire-FoldRx-Pharmaceuticals-10540-1/
Cardiac nitric oxide: emerging role for nNOS in regulating physiological function. - Radcliffe Department of Medicine
... protein trafficking, allosteric modulation of nNOS and redox modification to alter NO bioavailability once synthesised. ... These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, ... Allosteric Regulation, Animals, Gene Expression Regulation, Enzymologic, Heart, Humans, Myocardium, Nerve Tissue Proteins, ... These mechanisms are diverse and include regulation of gene expression, posttranscriptional regulation, protein trafficking, ...https://www.rdm.ox.ac.uk/publications/106375
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in...
... and interacting genes influence susceptibility to schizophrenia, Proc. Natl. Acad. Sci. U.S.A. 103 (33) (2006) 12469-12474] and ... a regulator of white matter development and a candidate gene for schizophrenia, may also be associated with psychotic symptoms ... suggest that psychosis susceptibility or modifier genes may act across diseases. We hypothesised that oligodendrocyte lineage ... Nerve Tissue Proteins, Oligodendrocyte Transcription Factor 2, Polymorphism, Single Nucleotide, Psychotic Disorders ...https://www.psych.ox.ac.uk/publications/622646
Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies. - Wellcome...
... the rationales for normalization and argue that in well-conducted psychiatric gene expression studies using human brain tissue ... of interest relative to that of a housekeeping gene or genes (also called reference genes), to overcome various sources of ... We also review the conceptual and empirical basis for the category of housekeeping genes-i.e., genes with a ubiquitous and ... This pragmatism extends to the issue of whether normalization should be to one or multiple reference genes. We end by making ...https://www.win.ox.ac.uk/publications/97961
Gene expression analysis by quantitative PCR using RNA | Open-i
Expression of the genes (Saa3, Cxcl9, Ccl8, Ccl5, Cxc ... Gene expression analysis by quantitative PCR using RNA from the ... Gene Expression Profiling*. *Gene Expression Regulation*. *Neospora/metabolism*. *Nerve Tissue Proteins/biosynthesis* ... The expression of 772 protein-coding genes (2.1% of all analyzed genes and 3.4% of protein-coding genes) in the brains of the ... The expression of 772 protein-coding genes (2.1% of all analyzed genes and 3.4% of protein-coding genes) in the brains of the ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4300462_srep07936-f4&req=4
SEMA3F | Cancer Genetics Web
rac1 GTP-Binding Protein. *Nerve Tissue Proteins. *Membrane Glycoproteins. *Tumor Suppressor Gene ... Osprey software was used to construct the interaction network of DEGs, and genes at protein-protein interaction (PPI) nodes ... A total of 162 genes were deregulated. Only 5 genes were overexpressed in all carcinomas including fibronectin 1 (FN1), tissue ... the protein product of the nf2 gene, results in a decrease in expression of the anti-angiogenic protein SEMA3F through a Rac-1- ...http://www.cancerindex.org/geneweb/SEMA3F.htm
Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes...
Gene Expression Regulation, Developmental. Mice. Mice, Knockout. Microarray Analysis. Nerve Tissue Proteins / genetics, ... 0/Nerve Tissue Proteins; 0/RNA, Double-Stranded; 0/RNA-Binding Proteins; 0/stau2 protein, mouse; EC 22.214.171.124/TRIM32 protein, ... Here, we show that the double-stranded RNA-binding protein Stau2 is distributed asymmetrically during progenitor divisions in ... Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes ...http://www.biomedsearch.com/nih/Asymmetric-Segregation-Double-Stranded-RNA/22902295.html
Gene therapy and CNS infant hypotonia
This conception of therapy through molecular adequacy has been appropriated for gene therapy in nerve tissue also. Chief ... With the generation of a correctly restored protein or peptide product, or the prevention of undesirable ones through ... Gene therapy approaches, by contrast, are more likely to be suited to applications where tissue type is relatively uniform and ... Proposals for gene therapy in central nervous system tissue have attained significant successes in delivery vehicles that ...https://www.oatext.com/gene-therapy-and-cns-infant-hypotonia.php
NHS Direct Wales - Encyclopaedia : Neurofibromatosis type 1
Normally, the NF1 gene is responsible for producing a protein that helps regulate the growth of nerve tissue. The protein ' ... This leads to the cells producing an incomplete protein that's much less effective at switching off the growth of nerve tissue ... Optic nerve tumours. If your child develops a tumour inside the nerve connecting the eye and the brain (the optic nerve) and it ... As a result, the growth of nerve tissue isn't properly controlled.. In half of all cases of NF1, the genetic mutation is passed ...https://www.nhsdirect.wales.nhs.uk/encyclopaedia/n/article/neurofibromatosistype1
NAVER Academic | Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice
Animals, Gene Expression, physiology, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Nerve Tissue Proteins, metabolism, ...https://academic.naver.com/article.naver?doc_id=146466272
Alnylam Completes Enrollment of Phase II Clinical Trial and Initiates Open-Label Extension (OLE) Stu - AOL Finance
... in the TTR gene which cause abnormal TTR amyloid protein deposits to accumulate in various tissues including peripheral nerves ... Mutations in TTR cause abnormal amyloid proteins to accumulate and damage body organs and tissue, such as the peripheral nerves ... TTR protein is produced primarily in the liver and is normally a carrier for retinol binding protein. ... RNAi is a natural process of gene silencing that occurs in organisms ranging from plants to mammals. By harnessing the natural ...https://www.aol.com/article/finance/2013/09/30/alnylam-completes-enrollment-of-phase-ii-clinical-/20733233/
Survival of motor neuron gene downregulation by RNAi: towards a cell culture model of spinal muscular atrophy. - Oxford...
These results illustrate that double-stranded RNA can be an effective gene silencing approach even in a protein that is ... SMA is caused by mutations in the survival of motor neuron gene (SMN). The SMN protein is ubiquitously expressed and plays a ... The siRNAs reduced both Smn RNA and protein levels in the P19 cells compared to controls. ... has proved useful for gene function studies, and should be especially well suited to studying diseases resulting in embryonal ...https://www.neuroscience.ox.ac.uk/publications/652030
ZFIN Publication: Mieda et al., 1999
Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism*; Rhombencephalon/embryology; Rhombencephalon/metabolism*; ... Zebrafish ten-m3 and ten-m4 encode proteins highly similar to the product of Drosophila pair-rule gene ten(m)/odd Oz (odz). ... Amino Acid Sequence; Animals; DNA, Complementary/analysis; Drosophila; Drosophila Proteins*; Gene Expression*; In Situ ... Compartmentalized expression of zebrafish ten-m3 and ten-m4, homologues of the Drosophila ten(m)/odd Oz gene, in the central ...https://zfin.org/ZDB-PUB-991020-9