*  HLA-DR2 - Wikipedia
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA ... This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups. DR2 serotypes are associated ... DR2 is linked to the HLA-DR51. derived from IMGT/HLA Stewart G, McLeod J, Basten A, Bashir H (1981). "HLA family studies and ... Miyamori H, Kato Y, Kobayashi K, Hattori N (1983). "HLA antigens in Japanese patients with primary biliary cirrhosis and ...
  https://en.wikipedia.org/wiki/HLA-DR2
*  Complex Regional Pain Syndromes - Renal and Urology News
HLA associations with CRPS in adults have also been identified. A twofold increase of HLA-A3, B7, and DR2(15) MHC antigens was ... How do these pathogens/genes/exposures cause the disease? * Other clinical manifestations that might help with diagnosis and ... How do these pathogens/genes/exposures cause the disease?. It is thought that in a susceptible host (stressed adolescent) that ...
  http://www.renalandurologynews.com/pediatrics/complex-regional-pain-syndromes/article/623092/
*  Aplastic Anemia: Practice Essentials, Background, Etiology
... human leukocyte antigen (HLA)-DR2 is overrepresented among European and United States patients with aplastic anemia, and its ... Mutations have been found in the TERC and TERT genes and are thought to confer a susceptibility to aplastic anemia. These genes ... Mutations in the perforin gene are responsible for some cases of familial hemophagocytosis [22] ; mutations in SAP, a gene ... Nine genes have been found to be causative for DBA, and they are inherited in an autosomal dominant manner. [28] Approximately ...
  https://emedicine.medscape.com/article/198759-overview
*  HLA-DR15 - Wikipedia
DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens. Serotypes are unknown the ... HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high ... DQB1*0501 haplotype is associated with systemic lupus erythematosus HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA ... 2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356-9. doi:10.1097/SMJ. ...
  https://en.wikipedia.org/wiki/HLA-DR15
*  HLA-DRB5 - Wikipedia
HLA class II histocompatibility antigen, DRB5 beta chain is a protein that in humans is encoded by the HLA-DRB5 gene. The ... Liu CP, Bach FH, Wu SK (1988). "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms ... Owerbach D, Rich C, Taneja K (1986). "Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent ... Lee BS, Rust NA, McMichael AJ, McDevitt HO (1987). "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles". ...
  https://en.wikipedia.org/wiki/HLA-DRB5
*  HLA-DR16 - Wikipedia
DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens. DR16 is associated with ... HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the ... HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes. derived from IMGT/HLA Cruz-Robles D, Reyes P, Monteón-Padilla ... Park M, Park Y, Song E, Park H, Kim T, Park D, Park K, Cho B (2005). "Association of HLA-DR and -DQ genes with Graves disease ...
  https://en.wikipedia.org/wiki/HLA-DR16
*  HLA-DR3 - Wikipedia
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 ... DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1* ... Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4. Some DR3 also react with HLA-DR17 and/or HLA-DR18. The ... 2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens. 69 (2): ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  HLA-DR51 - Wikipedia
HLA-DR2 HLA-DR15 - DRB1*15 HLA-DR16 - DRB1*16 Gorski J, Rollini P, Mach B (1987). "Structural comparison of the genes of two ... HLA-DR51 is a HLA-DR serotype that recognizes the antigens encoded by the minor DR locus HLA-DRB5. DRB3, DRB4, and DRB5 are ... "Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 ... Gongora R, Figueroa F, Klein J (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol. 51 (1): 23-31. ...
  https://en.wikipedia.org/wiki/HLA-DR51
*  Genetics and Susceptibility to Leprosy
HLA) system as well as non-HLA genes. These genes affect the individual's susceptibility to the disease, including bacillary ... Genetic factors in leprosy involve the human leukocyte antigen ( ... Class II antigens of the HLA complex that are associated with ... tuberculoid and lepromatous leprosy respectively include HLA-DR2 and HLA-DQ1 respectively. ... Genetic factors in leprosy involve the human leukocyte antigen (HLA) system as well as non-HLA genes. These genes affect the ...
  https://www.news-medical.net/health/Genetics-and-Susceptibility-to-Leprosy.aspx
*  Autoimmunity - Wikipedia
HLA DR2 is strongly positively correlated with Systemic Lupus Erythematosus, narcolepsy and multiple sclerosis, and negatively ... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ... Three main sets of genes are suspected in many autoimmune diseases. These genes are related to: Immunoglobulins T-cell ... Molecular Mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, ...
  https://en.wikipedia.org/wiki/Autoimmunity
*  Autoimmunity - Wikipedia
HLA DR2 is strongly positively correlated with Systemic Lupus Erythematosus, narcolepsy[11] and multiple sclerosis, and ... any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and ... The contributions of genes outside the MHC complex remain the subject of research, in animal models of disease (Linda Wicker's ... Molecular Mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, ...
  https://en.m.wikipedia.org/wiki/Autoimmune
*  Pathophysiology of Abdominal Aortic Aneurysm - Genetic Factors and Homocysteine Metabolism | IntechOpen
6.1.5. Human leukocyte antigen genes. The Human Leukocyte Antigen (HLA) system is a genetically determined series of antigens ... an increased frequency of the HLA-DR2(15) allele has been demonstrated in aneurysm patients. Other studies have shown HLA-DR B1 ... gene, distinct. structurally, other. M. M. P. from, genes, co-expressed. is, the. T. I. M. P. with, during. gene, embryogenesis ... gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis. The ...
  https://www.intechopen.com/books/diagnosis-screening-and-treatment-of-abdominal-thoracoabdominal-and-thoracic-aortic-aneurysms/pathophysiology-of-abdominal-aortic-aneurysm-genetic-factors-and-homocysteine-metabolism/
*  Seiji Nishino | Stanford Medicine Profiles
All nine hypocretin-deficient patients were human leuckocyte antigen (HLA) DR2 positive, while two who had normal CSF ... Positional cloning of this gene is in progress, and a human homologue of this gene, or a gene with a functional relationship to ... as well as the positivity of the human leukocyte antigen (HLA) DR2/DQ6 (DQB1*0602). The symptoms of narcolepsy can also occur ... HLA) allele, DQB1*0602 [most often in combination with HLA-DR2 (DRB1*15)]. Genetic transmission is, however, likely to be ...
  https://med.stanford.edu/profiles/seiji-nishino
*  APLASTIC ANEMIA ~ the simptoms, cause and treatment | majelis ilm
HLA)-DR2 is overrepresented among European and United States patients with aplastic anemia, suggesting a role for antigen ... Mutations in perforin gene are responsible for some cases of familial hemophagocytosis11 ; mutations in SAP, a gene encoding ... BMT with an HLA-matched sibling donor. HLA-matched sibling-donor BMT is the treatment of choice for a young patient with SAA ( ... Avoiding transfusions from family members is important because of possible sensitization against non-HLA tissue antigens of the ...
  https://deenoverduniya.wordpress.com/2011/08/18/anemia-aplastic-the-simptoms-cause-and-treatment/
*  HLA B7-DR15-DQ6 - Wikipedia
One B7-DR2-DQ6 derives from the fact that DR15 is a split antigen of the DR2 broad antigen serotype. The other B7-DR2-DQ1 stems ... HLA A*0201Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 The gene-allele representation of the haplotype is: HLA A*0301Cw ... "HLA gene and haplotype frequencies in Dutch blood donors". Tissue Antigens. 48 (5): 562-74. doi:10.1111/j.1399-0039.1996. ... HLA B7-DR15-DQ6 was found to have an association with postmenopausal osteoporosis in a Greek population. DR2 (15 or 16) -DQ6.2 ...
  https://en.wikipedia.org/wiki/HLA_B7-DR15-DQ6
*  Influence of Secondary Antiphospholipid Syndrome and Secondary Sjögren's Syndrome on Patient's Quality of Life with Systemie...
... including antigens HLA class II DR2, DR3 [8], but many other genes outside of this system) [4,9-14], hormones, [15-17] ( ... An important role in its development are genetic factors (including HLA DR2, HLA-DR3, HLA-B7, HLA DQ) and environmental (viral ... Castaño-Rodríguez N, Diaz-Gallo LM, Pineda-Tamayo R, Rojas-Villarraga A, Anaya JM (2008) Meta-analysis of HLA-DRB1 and HLA-DQB1 ... Genes Immun 10(5): 373-379.. *Suarez-Gestal M, Calaza M, Endreffy E, Pullmann R, Ordi-Ros J, et al. (2009) Replication of ...
  http://googlescholar.medcraveonline.com/scholars/article_fulltext/4919
*  KAKEN - Research Projects | Molecular Analysis of the HLA Gene Region by Large DNA Cloning (KAKENHI-PROJECT-01490022)
HLA / YAC Cloning / class I antigen / CpG island / disease susceptibility gene / tenascin / YAC / パルスフィ-ルド電気泳動 / コスミド / 疾患感受性 ... Publications] N. Figueroa et al.: 'Primate DRB6 pseudogenes : clue to the evolutionary origin of the HLA-DR2 haplotype' ... Publications] M. Janatipour et al.: 'Search for MHC associated genes in human : Five new genes ceutromeric to HLA-DP with yet ... Publications] N.Okamoto: 'Orientation of HLA-DNA gene and identification of a CpG island associated gene adjacent to DNA in ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01490022/
*  Davidson College: WWW Homepage Template for Biology Students
MS is much more common in people with the MHC class II allele HLA-DR2 (Martin et al., 1992). The involvement of these genes ... and promotes the expression of HLA antigen on cell surfaces (Wells, 1997) . (return to the top of the page). References Becher ... If T cells encounter antigen-presenting cells that present their specific antigen, then they are activated and stimulated to ... Certain genes may make some individuals more susceptible to environmental factors. When around these factors, an autoimmune ...
  http://www.bio.davidson.edu/courses/Immunology/Students/spring2000/majure/restricted/paper.html
*  HLA-DRB6 Gene - GeneCards | HLA-DRB6 Pseudogene
Complete information for HLA-DRB6 gene (Pseudogene), Major Histocompatibility Complex, Class II, DR Beta 6 (Pseudogene), ... Molecular function for HLA-DRB6 Gene. GENATLAS Biochemistry: HLA-DR,beta 6 pseudogene,found on DR1,DR2 and DR10 haplotypes *HLA ... Suggested Antigen Peptide Sequences for HLA-DRB6 Gene. GenScript: Design optimal peptide antigens:. *MHC class II antigen ( ... HLA-DRB1 HLA-DQA2 HLA-DRB6 HLA-DQB1 HLA-DRB5 HLA-DQB2 HLA-DQA1 CYP21A1P HLA-DQB1-AS1 HLA-DPB1 ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-DRB6
*  Actigraphy | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
A connection between an immune gene, the human leukocyte antigen (HLA) allele HLA-DR2, and narcolepsy in humans had already ... Narcolepsy was shown to be associated with the human leukocyte antigen (HLA) DR2 in the Japanese population (Honda et al. 1984; ... 1997a). No new gene was found in 86 kb of genomic sequence surrounding the HLA DQ gene (Ellis et al. 1997). A study on the ... nearby HLA gene, DQB1*0602.. Humans are not like dogs. "After we found the gene, the research went fast. We decided to look at ...
  https://pharmaceuticalintelligence.com/tag/actigraphy/
*  HLA-DR11 - Wikipedia
HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA- ... Hu C, Wu C, Lee C, Wu C, Tsai H, Chen P, Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody ... studies on HLA class II genes and autoantibody profiles in Japanese mothers". Autoimmunity. 26 (2): 95-101. doi:10.3109/ ... DQB1*0301 haplotype is associated with hepatitis B virus persistence HLA-DR11 is genetically linked to HLA-DR52 and HLA-DQ7(3) ...
  https://en.wikipedia.org/wiki/HLA-DR11
*  Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria |...
Antigen presentation by Mϕ and DCs was determined by measuring proliferation and IFN-γ secretion of the HLA-DR2-restricted CD4+ ... Accordingly, IFN-γ was required to induce strong IL-12p35 gene transcription (Fig. 3B ). In the absence of IFN-γ, only LPS- ... Antigen-presenting capacity of Mϕ-1 versus Mϕ-2. To determine the antigen-presenting capacity of Mϕ-1 and Mϕ-2, cells were ... Accordingly, activated Mϕ-2 but not Mϕ-1 down-modulated their antigen-presenting and costimulatory molecules (HLA-DR, CD86, and ...
  http://www.pnas.org/content/101/13/4560.long
*  HLA-??????????????? ???? ??????
Reijonen H, Ilonen J, Akerblom HK, Knip M, Dosch HM: Multi-locus analysis of HLA class II genes in DR2-positive IDDM haplotypes ... Thomson G: HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet 1984, 36:1309-1317. ... DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus. Tissue ... 1. Noble JA, Valdes AM, Cook M, Klitz W, Thomson G, Erlich HA: The role of HLA class II genes in insulin-dependent diabetes ...
  http://www.ld.ru/reviews/ilist-4446.html
*  Immunogenetics of Hashimoto's thyroiditis | Springer for Research & Development
... class I genes encoding HLA antigens A, B and C, class II genes encoding HLA-DR, DP and DQ molecules and class III genes [99]. ... In Asians, HLA class I (A2, B16, B35, B46, B51, B54, C3) and HLA class II (DR2, DR9, DR53, DQ4) genes showed an association ... HLA class III genes and non-HLA genes of the HLA region. The HLA class III region lies between class I and II genes and encodes ... but not with the HLA-DP and HLA class I (HLA-A, HLA-B and HLA-C) genes [113, 114, 121]. However, some studies could not reveal ...
  https://rd.springer.com/article/10.1186/1740-2557-2-1
*  BestReferat.ru
Experiments from our laboratories revealed that human leucocyte antigen D-related allele 2 (HLA DR2) predispose for a more ... of disease pathogenesis and the rest is accounted by three other genes. A similar kind of approach is warranted in ... Results and discussion HLA DR2 association. Figure 1 presents the data on the distribution of HLA DR2, a high risk allele, in ... There are two other studies confirming the HLA DR2 association (table 1): all these studies suggested that HLA DR2 correlates ...
  http://www.bestreferat.ru/referat-124053.html