*  Hereditary Cancer Syndromes and Risk Assessment - ACOG
Hereditary Breast and Ovarian Cancer Syndrome. Hereditary breast and ovarian cancer syndrome is caused by germline mutations in one or both of the autosomal dominant DNA repair genes BRCA1 and BRCA2 (8). Although most cases of breast cancer and ovarian cancer in the United States occur sporadically, BRCA1 and BRCA2 mutations are present in 5-15% of cases of these types of cancer (9). The carrier frequency of hereditary breast and ovarian cancer syndrome is approximately 1 in 500 individuals in the general population, but it has a prevalence of 1 in 40 individuals in the Ashkenazi Jewish population (10). In men, BRCA mutations are associated with ...
  https://www.acog.org/Resources-And-Publications/Committee-Opinions/Committee-on-Genetics/Hereditary-Cancer-Syndromes-and-Risk-Assessment
*  NewYork-Presbyterian/Queens - Genetics and Cancer - Hereditary Breast Ovarian Cancer Syndrome (BRCA1 / BRCA2)
In 1990, DNA linkage studies on large families with the above characteristics identified the first gene associated with breast cancer. Scientists named this gene breast cancer 1, or BRCA1 (pronounced brak-uh). BRCA1 is located on chromosome 17. Mutations in the gene are transmitted in an autosomal dominant pattern in a family.. Since it was clear that not all breast cancer families were linked to BRCA1, studies continued and in 1994, scientists discovered another gene (similar to BRCA1) and named it BRCA2. BRCA2 is located on chromosome 13. Mutations in this gene are also transmitted in an autosomal dominant pattern in a family.. Both BRCA1 and BRCA2 are tumor suppressor genes that usually have the job of controlling cell growth and cell death. Everyone has two BRCA1 (one on each chromosome #17) and two BRCA2 genes (one on each chromosome #13). When a person has one altered ...
  http://www.nyhq.org/diw/Content.asp?PageID=DIW007227
*  Medline ® Abstract for Reference 36 of 'Overview of hereditary breast and ovarian cancer syndromes'
UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women's Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
  http://www.uptodate.com/contents/overview-of-hereditary-breast-and-ovarian-cancer-syndromes/abstract/36
*  Medline ® Abstract for Reference 79 of 'Overview of hereditary breast and ovarian cancer syndromes'
UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women's Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
  http://www.uptodate.com/contents/overview-of-hereditary-breast-and-ovarian-cancer-syndromes/abstract/79
*  Medline ® Abstract for Reference 99 of 'Overview of hereditary breast and ovarian cancer syndromes'
UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, Obstetrics, Gynecology, and Women's Health, Oncology, Pediatrics, Pulmonary, Critical Care, Sleep Medicine, Rheumatology, Surgery, and more.
  http://www.uptodate.com/contents/overview-of-hereditary-breast-and-ovarian-cancer-syndromes/abstract/99
*  Pancreatic and Breast Cancers Linked by BRCA Gene Mutation | Columbia University Department of Surgery
Many patients know of the association of the BRCA gene mutations with breast and ovarian cancers, but very few are aware that these mutations are linked to several gastroenterological cancers, including pancreatic cancer. Our researchers have found that approximately 10 percent of pancreatic cancers seen in The Pancreas Center are associated with breast and ovarian cancer syndromes caused by BRCA1 and BRCA2 mutations. Other researchers have found the link between pancreatic cancer and BRCA2 mutations to be as high as 19 percent.
  http://columbiasurgery.org/node/9441
*  Preferences for Hereditary Breast and Ovarian Cancer Information among Mexican, Cuban and Puerto Rican Women at Risk - Abstract...
|i|Background:|/i| Little is known about the preferences of at-risk Hispanic women to gain information on hereditary breast and ovarian cancer (HBOC). |i|Aims:|/i| This study s
  https://content.karger.com/Article/Abstract/284582
*  Free Download Who should be screened for hereditary breast and ovarian cancer PowerPoint Presentation Slides
Who should be screened for hereditary breast and ovarian cancer powerpoint presentation slides is available for free download uploaded in belonging ppt presentation Health & Wellness category, Download and Use!
  http://www.slidesfinder.com/presentation/who-should-be-screened-for-hereditary-bre-ppt-slides/1230.aspx
*  Plus it
We now present evidence that the germ-line p53 13964GC base substitution is identified in familial breast cancer patients but not in sporadic breast cancer patients and that the base change alters normal gene function. The functional studies support our theory that the p53 13964GC base change functions as a dominant mutation similar to the more common missense, nonsense, and splice-site mutations described previously for LFS. BRCA1 and BRCA2 mutations have been thought to account for 10-40% of hereditary breast cancers, but there are approximately 200-300 different mutations with different phenotypes, and detection of these mutations is often difficult and expensive. The p53 13964GC mutation represents a single noncoding base change that is easily detected and may be responsible for a significant number of hereditary breast cancers; this ...
  http://cancerres.aacrjournals.org/content/60/4/1062
*  Key function of mutation in hereditary breast and ovarian cancer gene discovered
It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers ...
  https://medicalxpress.com/news/2011-09-key-function-mutation-hereditary-breast.html
*  Factors associated with preimplantation genetic diagnosis acceptance among women concerned about hereditary breast and ovarian...
Young women diagnosed with cancer have the option of preserving their fertility by using assisted reproductive technology (ART) techniques prior to undergoing cancer treatment. This article presents a composite case of a ...
  https://repository.library.georgetown.edu/handle/10822/514969
*  Scientists identify new gene linked to breast cancer | CTV News
Researchers have identified one of the genes linked to hereditary breast cancer, in a Canadian-led study that could open the door to future gene therapies for women susceptible to the disease.
  https://www.ctvnews.ca/health/scientists-identify-new-gene-linked-to-breast-cancer-1.2346623
*  Newswise | Channels
Patients with certain advanced hereditary breast cancers may have new treatments options on the horizon, according to two studies presented this week at the annual San Antonio Breast Cancer Symposium. Susan Domchek, MD, executive director of the Basser Center for BRCA at Penn's Abramson Cancer Center, will present new results from the Mediola and OlympiAD trials showing continued success of treating BRCA-related metastatic breast cancer with the PARP inhibitor olaparib with limited side effects for patients.. ...
  https://www.newswise.com/articles/channels?channel=143
*  ASBD 2015 - Events
This multidisciplinary meeting is designed for health care professionals to advance their knowledge of the management of hereditary breast cancer, biomarkers, tumour heterogeneity, survivorship issues, diagnostic and molecular imaging, neoadjuvant therapy and breast cancer in the young woman.. ...
  http://www3.gehealthcare.com.au/en-au/events/asbd_2015
*  glossary:brca2 gene [Lymphedema People]
One of two genes shown in the 1990's to be implicated in hereditary breast cancer. These two genes are referred to as tumor supressor genes. It is the mutated form of these genes that dramatically increases ones risk of developing breast cancer. ...
  http://lymphedemapeople.com/wiki/doku.php?id=glossary:brca2_gene
*  Search FAQs - ACOG
BRCA1 and BRCA2 Mutations Cancer is caused by several different factors. A few types of cancer run in families. These types are called "hereditary" or "familial" cancer. They are caused by changes in genes that can be passed from parent to child. Changes in genes are called mutations. Hereditary breast and ovarian cancer (HBOC) syndrome is an inherited increased risk of breast cancer, ovarian cancer, and other types of cancer. HBOC syndrome is linked to mutations in several genes, but the most common are called BRCA1 and BRCA2. Inheriting one of these mutations increases the risk of getti... ...
  https://www.acog.org/Patients/FAQs?DateRange=lastsixmonths&Topics=6638fdc0-31d9-457c-8b36-91563c9151a4
*  Popular Requests: healthfinder.gov: : O: Ovarian Cancer - healthfinder.gov
This fact sheet describes the BRCA1 and BRCA2 genes and related link to hereditary breast and ovarian cancer. Learn what to do if a person tests positive for one of these alterations, and the consequences of genetic testing. Review Date: Wednesday, November 25, 2015 NIH National Cancer Institute ...
  https://healthfinder.gov/FindServices/SearchContext.aspx?topic=620&Branch=5
*  Somatic EGFR mutations in the epithelium or stroma of s | Open-i
Somatic EGFR mutations in the epithelium or stroma of sporadic and hereditary breast carcinomas. Each of the four columns (A-D, E-H, I-L and M-P) repres
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2361765_92-6602557f2&req=4
*  Abstract P273: Enhancement of Proteasomal Function Protects Against Proteinopathy and Myocardial Ischemia-Reperfusion Injury in...
The ubiquitin-proteasome system degrades most intracellular proteins, including misfolded proteins. Proteasome functional insufficiency (PFI) was observed in experimental proteinopathies and implicated in many human common diseases but its pathogenic role has not been established because a measure to enhance proteasome function in the cell has not been reported until very recently. We have recently discovered that overexpression of proteasome activator 28α (PA28α) enhances proteasome-mediated removal of abnormal proteins in the cell and protects against oxidative stress in cultured cardiomyocytes (FASEB J 2011; 25(3):883-93). Here we have extended the in vitro discoveries to intact animals. First, we created inducible transgenic mice with cardiomyocyte-restricted PA28α overexpression (CR-PA28αOE). CR-PA28αOE does not alter the homeostasis of normal proteins and cardiac function but increases the degradation of a surrogate misfolded protein in the heart. This marks the establishment of the ...
  http://circres.ahajournals.org/content/109/Suppl_1/AP273
*  Ritz Carlton Credit Card | Chase.com
The Ritz-Carlton Rewards Credit Card offers extraordinary service and helps turn your rewards into experiences. Use your Ritz-Carlton Rewards Credit Card for exclusive hotel perks.
  https://creditcards.chase.com/travel-credit-cards/ritz-carlton-rewards?categoryId=3&iCELL=683D&unitedclubsplit=2&unitedmileageplussplit=1
*  Response to microtubule-interacting agents in primary epithelial ovarian cancer cells - pdf descargar
Response to microtubule-interacting agents in primary epithelial ovarian cancer cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jul7/150078757088-Response-to-microtubule-interacting-agents-in-primary-epithelial-ovarian-cancer-cells.php
*  Ovarian cancer - Mayo Clinic
Ovarian cancer is a type of cancer that begins in the ovaries. Women have two ovaries, one on each side of the uterus. The ovaries - each about the size of an almond - produce eggs (ova) as well as the hormones estrogen and progesterone.. Ovarian cancer often goes undetected until it has spread within the pelvis and abdomen. At this late stage, ovarian cancer is more difficult to treat and is frequently fatal. Early-stage ovarian cancer, in which the disease is confined to the ovary, is more likely to be treated successfully.. Surgery and chemotherapy are generally used to treat ovarian cancer.. Early-stage ovarian cancer rarely causes any symptoms. Advanced-stage ovarian cancer may cause few and nonspecific symptoms that are often mistaken for more common ...
  http://www.mayoclinic.org/diseases-conditions/ovarian-cancer/basics/definition/con-20028096?footprints=mine&p=1