*  Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer | Development
... distal cardiac enhancer contains a high-affinity binding site for the cardiac-restricted zinc finger transcription factor GATA4 ... The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first ... Transcription of Nkx2-5 in pharynx, thyroid and stomach is controlled by regulatory elements separable from the cardiac ... We describe a cardiac enhancer, located about 9 kilobases upstream of the Nkx2-5 gene, that fully recapitulates the expression ...
  http://dev.biologists.org/content/126/1/75
*  Linda Boxer, MD, PhD | Stanford Medicine Profiles
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB journal Kobayashi, S., Lackey, T ... Transcription factor GATA4 regulates cardiac BCL2 gene expression in vitro and in vivo FASEB JOURNAL Kobayashi, S., Lackey, T ... Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma ... The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell ...
  https://med.stanford.edu/profiles/linda-boxer?tab=teaching
*  JCI - Making the blastocyst: lessons from the mouse
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm ... Transcription factor control of PE/EPI specification. Two transcription factors, the closely related Gata family members Gata4 ... Notably, the two transcription factors are expressed in a random "salt and pepper" pattern that seems to be unrelated to cell ... Transcription factor control of TE/ICM segregation. TE and ICM lineage segregation is controlled by a small group of ...
  https://www.jci.org/articles/view/41229
*  Table of Contents | Development
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm ... Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax ... The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates K.L. Chow, D.H. ... The homeobox-containing gene XANF-1 may control development of the Spemann organizer A.G. Zaraisky, V. Ecochard, O.V. ...
  http://dev.biologists.org/content/121/11
*  HAND2 - Wikipedia
"The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ... The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... "The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ...
  https://en.wikipedia.org/wiki/HAND2
*  Interactive Fly, Drosophila
The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the albumin gene enhancer in liver precursor ... The transcription factor GATA4, which has been implicated in regulating cardiac gene expression, is sufficient to induce ... The GATA-4/5/6 genes encode transcription factors implicated previously in the regulation of cardiac-specific differentiation ... GATA4 also interacts with the cardiac-expressed basic helix-loop-helix transcription factor dHAND (also known as HAND2). GATA4 ...
  http://www.sdbonline.org/sites/fly/gene/serpnt2d.htm
*  Development and Structure of the Cardiac Conduction System | SpringerLink
... including the known molecular and cellular factors that regulate development of the conduction system are outlined. Part II ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-60.PubMed ... The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene ... Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007;27:8571-82.PubMedCentral ...
  https://link.springer.com/chapter/10.1007/978-1-4939-2739-5_1
*  JCI - Curcumin prevents and reverses murine cardiac hypertrophy
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... P300 Functions as a coactivator of transcription factor GATA-4. J. Biol. Chem. 276:37178-37185. View this article via: CrossRef ... p300 is a critical HAT in muscle that modifies chromatin and associated transcription factors and promotes gene activation (6, ... and expose prohypertrophic genes for activation by cardiogenic transcription factors. Several lines of evidence have shown that ...
  https://www.jci.org/articles/view/32865
*  Bmp and Fgf signaling are essential for liver specification in zebrafish | Development
Among Gata transcription factor genes in zebrafish, gata4 and gata6, but not gata5, are expressed in the hepatic endoderm (see ... Among the transcription factor genes expressed in the liver, hhex and prox1 are the earliest markers of liver development in ... Gata4 and Gata6 are required for the expansion and differentiation of liver progenitors. Gata transcription factors have been ... two transcription factor genes also expressed in mouse (Burke and Oliver, 2002) and chick (Zhang et al., 2004) hepatoblasts. ...
  http://dev.biologists.org/content/134/11/2041
*  Defining the progenitor cell niche of the developing kidney - Leif Oxburgh
2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad ... 2015) Fibroblast growth factor signaling in the vasculature. Curr Atheroscler Rep 17:509 ...
  http://grantome.com/grant/NIH/R01-DK078161-07
*  High Glucose Is Necessary for Complete Maturation of Pdx1-VP16-Expressing Hepatic Cells into Functional Insulin-Producing Cells...
The liver genes include three transcription factors (TGF-α, GATA-4, and HNF-4) and two genes of liver functional proteins ( ... Interestingly, Pax4, along with the other transcription factors Pax6, Isl-1, and MafA and β-cell function-related genes SUR1, ... A vector containing a chimeric gene of the zeocin resistance gene (zeor) and a green fluorescence protein gene under the ... However, Pdx1-VP16 is unable to activate the late-stage pancreatic transcription factors Pax-4, Pax-6, Isl-1, and MafA as well ...
  http://diabetes.diabetesjournals.org/content/53/12/3168.long
*  The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... The expression of the noradrenergic marker genes th and dbh is strongly reduced, as well as the transcription factors gata2 and ... The bHLH transcription factor Hand2 belongs to the network of regulatory factors implicated in the specification and ... Transcription factor AP-2 regulates expression of the dopamine beta-hydoxylase gene. J. Neurochem. 65,510 -516. ...
  http://dev.biologists.org/content/133/20/4015
*  The Hepatocyte Nuclear Factor 3 α Gene, HNF3α (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal...
The results suggested that two genes, cysteine protease cathepsin B and transcription factor GATA-4, were the selected targets ... The transcription factor HNF3α is a member of the forkhead gene family, and the involvement of the HNF3α gene in liver ... Li J., Vogt P. K. The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork ... Hepatocyte nuclear factor 3 α belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head ...
  http://cancerres.aacrjournals.org/content/62/18/5273
*  GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes | Diabetes
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 1997;11:1048-1060pmid: ... Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 1997;11:1061-1072 ... GATA4 is a zinc finger transcription factor closely related to GATA6. Mutations in GATA4 have been described in familial and ... The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the ...
  http://diabetes.diabetesjournals.org/content/63/8/2888.full
*  GATA4 and the Two Sides of Gene Expression Reprogramming | Circulation Research
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997; 11: 1061- ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11: 1048-1060. ... Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q. Transcription factor GATA4 regulates cardiac BCL2 gene ... The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene ...
  http://circres.ahajournals.org/content/98/6/715
*  GATA4 - Wikipedia
Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. This gene encodes a member of the GATA ... "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for ... Tremblay JJ, Viger RS (1999). "Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a ... and they are thought to be under the influence of the GATA4 transcription factor. GATA4 inactivation, with GATA4-null mice, ...
  https://en.wikipedia.org/wiki/GATA4
*  Myosin heavy chain Datasets | BioGPS
Genome-Wide Analysis of Gene Program Activation by Defined Cardiac Transcription Factor Tbx5, Gata4 and Myocardin ... Factors: 1 Tags: cell, estrogen, genome, heart, histone, histone h3, left, left ventricle, lysine, myosin, myosin heavy chain, ... Factors: 1 Tags: cell, ectoderm, fatty acid, genome, glucose, heart, mesoderm, muscle, muscle cell, myosin, myosin heavy chain ... Factors: 1 Tags: aorta, blood vessel, cell, genome, glucose, hypertension, insulin, muscle, myosin, myosin heavy chain, ...
  http://biogps.org/dataset/tag/myosin%20heavy%20chain/
*  Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging | Circulation
... where it interacts with the transcription factor (GATA4) to initiate transcription of hypertrophic fetal genes such as atrial ... The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of ... and transcription factor A, mitochondrial (TFAM) but not nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) mRNA (Figure 3D ... target genes of NFAT, increased significantly in OWT but not OmCAT hearts. D, Age-dependent increased phosphorylation of GATA-4 ...
  http://circ.ahajournals.org/content/119/21/2789
*  Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability | Circulation...
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997; 11: 1061- ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11: 1048-1060. ... Because GATA4 is a transcription factor, the obvious hypothesis is that a subset of cardiac-expressed genes involved in ... The transcription factor GATA4 is a critical regulator of cardiac gene expression where it controls embryonic development, ...
  http://circres.ahajournals.org/content/98/6/837
*  Differentiation of Pluripotent Embryonic Stem Cells Into Cardiomyocytes | Circulation Research
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997; 11: 1061- ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11: 1048-1060. ... and MHC gene expression. However, several critical cardiac transcription factor transcripts (Nkx2.5, GATA-4, and MEF2C) are ... mRNAs encoding GATA-4 and Nkx2.5 transcription factors appear in EBs before mRNAs encoding atrial natriuretic factor (ANF), ...
  http://circres.ahajournals.org/content/91/3/189
*  ZFPM2 gene - Genetics Home Reference
Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and ... From NCBI Gene:. The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription ... ZFPM2 gene. zinc finger protein, FOG family member 2. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, ...
  https://ghr.nlm.nih.gov/gene/ZFPM2
*  Patent US7732199 - Process for making transplantable cardiomyocytes from human embryonic stem cells - Google Patents
... cardiotropic factors such as atrial natriuretic factor, cripto, and cardiac transcription regulation factors, such as GATA-4, ... It regulates many cardiac genes and plays a role in cardiogenesis. *Nkx2.5, a cardiac transcription factor expressed in cardiac ... GATA-4 is a transcription factor that is highly expressed in cardiac mesoderm. Strong GATA-4 immunoreactivity was observed in ... GATA-4, a transcription factor that is highly expressed in cardiac mesoderm and persists in the developing heart. ...
  http://www.google.com/patents/US7732199?dq=5958006
*  VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells | Journal of...
... the cardiac transcription factors Nkx2.5 and GATA4, and the cardiac genes encoding MLC2v, cTNT, α-MHC and β-MHC were analyzed ( ... mRNA expression analysis in the presence and absence of VEGF of Flk-1 and the cardiogenic transcription factors Nkx2.5 and GATA-4 ... By contrast, cardiac transcription factor and cardiac marker expression was only downregulated upon treatment with PI3K ... Gene expression of endothelial and cardiac markers in isolated Flk-1+ cells upon interference with PI3K-PKC signaling. Gene ...
  http://jcs.biologists.org/content/124/11/1819
*  GATA4, 5 and 6 mediate TGFβ maintenance of endodermal gene expression in Xenopus embryos | Development
Candidate genes include the homeobox-containing transcription factor, Mixer, and the paired-like homeobox gene, Pitx2 (Engleka ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11,1048 -1060. ... Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11,1061 -1072. ... The zinc finger-containing transcription factors GATA-4,-5, and -6 - ubiquitously expressed regulators of tissue-specific gene ...
  http://dev.biologists.org/content/132/4/763
*  Gata4 regulates the formation of multiple organs | Development
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11,1048 -1060. ... Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11,1061 -1072. ... a single transcription factor regulates the formation of many organs. Gata6 is a closely related transcription factor with an ... finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene ...
  http://dev.biologists.org/content/132/17/4005