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*  The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... The expression of the noradrenergic marker genes th and dbh is strongly reduced, as well as the transcription factors gata2 and ... The bHLH transcription factor Hand2 belongs to the network of regulatory factors implicated in the specification and ... Transcription factor AP-2 regulates expression of the dopamine beta-hydoxylase gene. J. Neurochem. 65,510 -516. ...
  http://dev.biologists.org/content/133/20/4015
*  Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer | Development
... distal cardiac enhancer contains a high-affinity binding site for the cardiac-restricted zinc finger transcription factor GATA4 ... The homeobox gene Nkx2-5 is the earliest known marker of the cardiac lineage in vertebrate embryos. Nkx2-5 expression is first ... Transcription of Nkx2-5 in pharynx, thyroid and stomach is controlled by regulatory elements separable from the cardiac ... We describe a cardiac enhancer, located about 9 kilobases upstream of the Nkx2-5 gene, that fully recapitulates the expression ...
  http://dev.biologists.org/content/126/1/75
*  Linda Boxer, MD, PhD | Stanford Medicine Profiles
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo. FASEB journal Kobayashi, S., Lackey, T ... Transcription factor GATA4 regulates cardiac BCL2 gene expression in vitro and in vivo FASEB JOURNAL Kobayashi, S., Lackey, T ... Nerve growth factor- and epidermal growth factor-regulated gene transcription in PC12 pheochromocytoma and INS-1 insulinoma ... The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell ...
  https://med.stanford.edu/profiles/linda-boxer?tab=teaching
*  Table of Contents - March 01, 1997, 322 (2) | Biochemical Journal
Regulation of the rat cardiac troponin I gene by the transcription factor GATA-4 Anne M. MURPHY, W. Reid THOMPSON, Ling Fan ... Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and ... cAMP prevents the glucose-mediated stimulation of GLUT2 gene transcription in hepatocytes Franck RENCUREL, Gérard WAEBER, ... Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-κB binding to DNA Song Kyu PARK, Hsin Lee LIN, ...
  http://www.biochemj.org/content/322/2/
*  JCI - Making the blastocyst: lessons from the mouse
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm ... Transcription factor control of PE/EPI specification. Two transcription factors, the closely related Gata family members Gata4 ... Notably, the two transcription factors are expressed in a random "salt and pepper" pattern that seems to be unrelated to cell ... Transcription factor control of TE/ICM segregation. TE and ICM lineage segregation is controlled by a small group of ...
  https://www.jci.org/articles/view/41229
*  Table of Contents | Development
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm ... Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax ... The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates K.L. Chow, D.H. ... The homeobox-containing gene XANF-1 may control development of the Spemann organizer A.G. Zaraisky, V. Ecochard, O.V. ...
  http://dev.biologists.org/content/121/11
*  Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm ... Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid ... Functions of mammalian smad genes as revealed by targeted gene disruption in mice [In Process Citation]. Cytokine Growth Factor ... Genes Dev. 1995;9:2105-2116 15. Zhou X, Sasaki H, Lowe L. et al. Nodal is a novel TGF-beta-like gene expressed in the mouse ...
  http://www.ijbs.com/v06p0569.htm
*  HAND2 - Wikipedia
"The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... transcription factor binding. • activating transcription factor binding. • E-box binding. • protein binding. • protein ... The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... "The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ...
  https://en.wikipedia.org/wiki/HAND2
*  Anti-Müllerian hormone in disorders of sex determination and differentiation
Transcription factor GATA-4 enhances Mullerian inhibiting substance gene transcription through a direct interaction with the ... by transcription factor TFII-I (11). Cloning of 3.6kb of the 5'-flanking sequences of the human AMH gene allowed to identify a ... protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Müllerian hormone gene. Mol Cell Biol 1998;18 ... Nuclear receptor steroidogenic factor 1 regulates the Müllerian inhibiting substance gene: a link to the sex determination ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302005000100005&lng=en&nrm=iso&tlng=en
*  Frontiers | ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects in Vitro Proliferation...
... and genes for more established cardiac lineages (Nkx2.5, Tbx5, Mef2c, GATA4). ALDHhi cells, but not ALDHlo cells, formed clones ... and genes for more established cardiac lineages (Nkx2.5, Tbx5, Mef2c, GATA4). ALDHhi cells, but not ALDHlo cells, formed clones ... RT-PCR analysis of ALDHhi and ALDHlo cells demonstrated a differential pattern of pluripotency genes (Oct4, Nanog) ... RT-PCR analysis of ALDHhi and ALDHlo cells demonstrated a differential pattern of pluripotency genes (Oct4, Nanog) ...
  https://www.frontiersin.org/articles/10.3389/fcvm.2018.00090/full
*  JCI - Curcumin prevents and reverses murine cardiac hypertrophy
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ... P300 Functions as a coactivator of transcription factor GATA-4. J. Biol. Chem. 276:37178-37185. View this article via: CrossRef ... p300 is a critical HAT in muscle that modifies chromatin and associated transcription factors and promotes gene activation (6, ... and expose prohypertrophic genes for activation by cardiogenic transcription factors. Several lines of evidence have shown that ...
  https://www.jci.org/articles/view/32865
*  Interactive Fly, Drosophila
The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the albumin gene enhancer in liver precursor ... The transcription factor GATA4, which has been implicated in regulating cardiac gene expression, is sufficient to induce ... The GATA-4/5/6 genes encode transcription factors implicated previously in the regulation of cardiac-specific differentiation ... GATA4 also interacts with the cardiac-expressed basic helix-loop-helix transcription factor dHAND (also known as HAND2). GATA4 ...
  http://www.sdbonline.org/sites/fly/gene/serpnt2d.htm
*  Development and Structure of the Cardiac Conduction System | SpringerLink
... including the known molecular and cellular factors that regulate development of the conduction system are outlined. Part II ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-60.PubMed ... The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene ... Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007;27:8571-82.PubMedCentral ...
  https://link.springer.com/chapter/10.1007/978-1-4939-2739-5_1
*  Bmp and Fgf signaling are essential for liver specification in zebrafish | Development
Among Gata transcription factor genes in zebrafish, gata4 and gata6, but not gata5, are expressed in the hepatic endoderm (see ... Among the transcription factor genes expressed in the liver, hhex and prox1 are the earliest markers of liver development in ... Gata4 and Gata6 are required for the expansion and differentiation of liver progenitors. Gata transcription factors have been ... two transcription factor genes also expressed in mouse (Burke and Oliver, 2002) and chick (Zhang et al., 2004) hepatoblasts. ...
  http://dev.biologists.org/content/134/11/2041
*  Defining the progenitor cell niche of the developing kidney - Leif Oxburgh
2011) Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected] Proc Natl Acad ... 2015) Fibroblast growth factor signaling in the vasculature. Curr Atheroscler Rep 17:509 ...
  http://grantome.com/grant/NIH/R01-DK078161-07
*  GATA4 - Wikipedia
Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. This gene encodes a member of the GATA ... "Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for ... Tremblay JJ, Viger RS (1999). "Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a ... and they are thought to be under the influence of the GATA4 transcription factor. GATA4 inactivation, with GATA4-null mice, ...
  https://en.wikipedia.org/wiki/GATA4
*  MYC-Induced Epigenetic Activation of GATA4 in Lung Adenocarcinoma | Molecular Cancer Research
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. ... The recruitment of GATA4 to its own promoter suggests some further auto-regulation of this transcription factor (Fig. 6). ... GATA family transcription factors activate lactase gene promoter in intestinal Caco-2 cells. Am J Physiol Gastrointest Liver ... GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 2002 ...
  http://mcr.aacrjournals.org/content/11/2/161
*  GATA4 and the Two Sides of Gene Expression Reprogramming | Circulation Research
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997; 11: 1061- ... GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11: 1048-1060. ... Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q. Transcription factor GATA4 regulates cardiac BCL2 gene ... The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene ...
  http://circres.ahajournals.org/content/98/6/715
*  High Glucose Is Necessary for Complete Maturation of Pdx1-VP16-Expressing Hepatic Cells into Functional Insulin-Producing Cells...
The liver genes include three transcription factors (TGF-α, GATA-4, and HNF-4) and two genes of liver functional proteins ( ... Interestingly, Pax4, along with the other transcription factors Pax6, Isl-1, and MafA and β-cell function-related genes SUR1, ... A vector containing a chimeric gene of the zeocin resistance gene (zeor) and a green fluorescence protein gene under the ... However, Pdx1-VP16 is unable to activate the late-stage pancreatic transcription factors Pax-4, Pax-6, Isl-1, and MafA as well ...
  http://diabetes.diabetesjournals.org/content/53/12/3168.long
*  The Hepatocyte Nuclear Factor 3 α Gene, HNF3α (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal...
The results suggested that two genes, cysteine protease cathepsin B and transcription factor GATA-4, were the selected targets ... The transcription factor HNF3α is a member of the forkhead gene family, and the involvement of the HNF3α gene in liver ... Li J., Vogt P. K. The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork ... Hepatocyte nuclear factor 3 α belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head ...
  http://cancerres.aacrjournals.org/content/62/18/5273
*  GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes | Diabetes
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 1997;11:1048-1060pmid: ... Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 1997;11:1061-1072 ... GATA4 is a zinc finger transcription factor closely related to GATA6. Mutations in GATA4 have been described in familial and ... The GATA family zinc finger transcription factors GATA4 and GATA6 are known to play important roles in the development of the ...
  http://diabetes.diabetesjournals.org/content/63/8/2888.full
*  Specification and patterning of the respiratory system* | StemBook
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060. Article ... While the role of transcription factors in modulating gene expression has been well studied, a growing literature now ... many of these genes are transcription factors that are preferentially activated during ES cell differentiation, and their ... GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J. Biol. Chem. ...
  https://www.stembook.org/node/467
*  Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging | Circulation
... where it interacts with the transcription factor (GATA4) to initiate transcription of hypertrophic fetal genes such as atrial ... The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of ... and transcription factor A, mitochondrial (TFAM) but not nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) mRNA (Figure 3D ... target genes of NFAT, increased significantly in OWT but not OmCAT hearts. D, Age-dependent increased phosphorylation of GATA-4 ...
  http://circ.ahajournals.org/content/119/21/2789
*  Myosin heavy chain Datasets | BioGPS
Genome-Wide Analysis of Gene Program Activation by Defined Cardiac Transcription Factor Tbx5, Gata4 and Myocardin ... Factors: 1 Tags: cell, estrogen, genome, heart, histone, histone h3, left, left ventricle, lysine, myosin, myosin heavy chain, ... Factors: 1 Tags: cell, ectoderm, fatty acid, genome, glucose, heart, mesoderm, muscle, muscle cell, myosin, myosin heavy chain ... Factors: 1 Tags: aorta, blood vessel, cell, genome, glucose, hypertension, insulin, muscle, myosin, myosin heavy chain, ...
  http://biogps.org/dataset/tag/myosin%20heavy%20chain/