*  Patent US5200313 - Nucleic acid hybridization assay employing detectable anti-hybrid antibodies - Google Patents
A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA.RNA or ... A DNA probe is cloned into the vector which is then propagated in a bacterial host. Multiple RNA copies of the cloned DNA probe ... DNA sequence encoding the Machado-Joseph disease gene and uses thereof. US5876935 *. 8 Jan 1997. 2 Mar 1999. Dade Behring Inc. ... Publication number. 07188114, 188114, US 5200313 A, US 5200313A, US-A-5200313, US5200313 A, US5200313A. ...
  http://www.google.ca/patents/US5200313
*  Analysis of recent segmental duplications in the bovine genome | BMC Genomics | Full Text
Characterizing the impact of copy-number and single basepair variation for genes embedded within these regions will be a ... A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet. 2007, 3: e3-10.1371/journal.pgen. ... At the gene level, for those duplicated genes or gene families in these mammals, both mutation (gene duplication, inactivation ... generating a great variation in gene number and content among extant mammals [39]. Similarly, gene duplication and inactivation ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-571
*  Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. - Full Text...
Genetic: Genetic study of DNA copies Gene expression profiling, DNA copy number variation ... Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. (GENOMGUS). ... The purpose of this study is to describe DNA copy number variations and gene expression profiles of bone marrow plasma cells of ... Large Scale Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From Monoclonal ...
  https://clinicaltrials.gov/ct2/show/NCT01079429
*  Julie M. Gastier-Foster, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio
Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays. BMC Genomics. Vol. 8, no. ... Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays. BMC Genomics. Vol. 8, no. ... Variability in interpreting and reporting copy number changes by array-based technology in clinical laboratories. Genet Med. ... Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D. Ann Neurol. Vol. 68 ...
  https://www.nationwidechildrens.org/julie-m-gastier-foster
*  FAM76A - Wikipedia
"Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines". The ... who had a copy number gain from 1p36.1-35, showed similar delays. In another case report, a patient with a copy number loss of ... Copy number gain/loss of FAM76A-along with neighboring genes-has shown to produce detrimental phenotypes. In one case report, a ... Genes that flank FAM76A on the telomeric side include IFI6, CHMP1AP1, and RPEP3, while genes that flank FAM76A on the ...
  https://en.wikipedia.org/wiki/FAM76A
*  LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal...
Variation in DNA copy number and gene expression among primary ovarian tumors and associated abdominal deposits Supp Fig S2. ... Variation in DNA copy number among primary ovarian tumors and associated abdominal deposits. A, copy number genome in line view ... Regions of discrete copy number amplification Supp Table S6. Regions of discrete copy number deletion ... D, differential copy number and gene expression plots of the primary tumor and most distant abdominal deposit for patient 6496. ...
  http://cancerres.aacrjournals.org/content/72/16/4060.figures-only
*  USP6 | Cancer Genetics Web
Identification of genes with correlated patterns of variations in DNA copy number and gene expression level in gastric cancer. ... A set of 158 genes showing Pearson correlation coefficients over 0.6 between DNA copy number changes and mRNA expression level ... To identify DNA copy number changes that had a direct influence on mRNA expression in gastric cancer, cDNA microarray-based ... To identify gene copy number alterations predictive of metastatic potential or aggressive transformation, array-based ...
  http://www.cancerindex.org/geneweb/USP6.htm
*  Rare Kidney Disease Caused by Copy Number Variation
Copy number variations are large chunks of DNA either duplicated or deleted from our genes when passed down to children. CFHR5 ... identified an inherited kidney disorder caused by a copy number variation of the gene CFHR5. ... "It is a potentially serious disease, but easily detectable from a simple DNA or blood test." Although scientists do not yet ... Why Only One Identical Twin is at Risk for Autoimmune Diseases Rare Mutation Reduces Sensitivity to Pain New Gene Therapy ...
  http://www.medindia.net/news/Rare-Kidney-Disease-Caused-by-Copy-Number-Variation-73184-1.htm
*  ADHD, Autism May Sometimes Share Gene... ( By Jenifer Goodwin HealthDay Rep...)
Instead of finding one or more ADHD or autism genes research is b... What we are beginning to understand is that genes don't ... code for diso...,ADHD,,Autism,May,Sometimes,Share,Gene,Mutations,medicine,medical news today,latest medical news,medical ... This means that on certain chromosomes, bits of DNA were deleted or duplicated. The copy number variations were on genes ... had identifiable abnormalities known as copy number variations, which are changes in the DNA that cause an abnormal number of ...
  http://www.bio-medicine.org/medicine-news-1/ADHD--Autism-May-Sometimes-Share-Gene-Mutations-84299-1/
*  John R. Pringle | Stanford Medicine Profiles
... products of erroneous DNA repair events that can lead to further genome rearrangements and extended gene copy number variations ... To identify other genes that may be involved in these processes, we screened yeast genomic DNA libraries for heterologous genes ... Starting with a strain deleted for the chromosomal copy of MSB1 but containing MSB1 on a high-copy-number plasmid, mutants were ... MOLECULAR ANALYSIS OF SACCHAROMYCES-CEREVISIAE CHROMOSOME-I - ON THE NUMBER OF GENES AND THE IDENTIFICATION OF ESSENTIAL GENES ...
  https://med.stanford.edu/profiles/john-pringle
*  Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models ...
However, the impact of genetic alterations, such as mutations in or copy-number variation of DNA repair mechanism genes, on the ... The numbers above the bars represent the number of mice with visceral metastasis per the number of mice in a respective group. ... For example, publicly available genomic data in LNCaP cells reveal several defects in DNA repair genes, such as ATM and BRCA2 ( ... The number of osteoblasts relative to bone surface in mice bearing LuCaP 58 tumors (n = 11, P = 0.0014). H, The number of ...
  http://clincancerres.aacrjournals.org/content/23/15/4335.long
*  Stephen W. Scherer - Wikipedia
Scherer's discoveries led to the initial description of genome-wide copy number variations (CNVs) of genes and DNA, including ... Global variation in copy number in the human genome. 2006. Nature 444, 444-454. Google Scholar Citation Conrad et al. Origins ... In retrospect, it's so simple to see these copy number variations were not at all biological outliers, just outliers of the ... Functional impact of global rare copy number variation in autism spectrum disorders. 2010. Nature 466, 368-372. Google Scholar ...
  https://en.wikipedia.org/wiki/Stephen_W._Scherer
*  Gene Duplication | Physics Forums - The Fusion of Science and Community
Copy number variation (CNV) of DNA sequences is functionally significant but has yet to be fully ascertained. We have ... So, of the ~ 30,000 genes we each have, ~ 3,000 come in multiple copies (e.g., more than the 2 from each parent) and the number ... The data obtained delineate linkage disequilibrium patterns for many CNVs, and reveal marked variation in copy number among ... A total of 1,447 copy number variable regions (CNVRs), which can encompass overlapping or adjacent gains or losses, covering ...
  https://www.physicsforums.com/threads/gene-duplication.145185/
*  Workgroup Chairs
In 2004, his team co-discovered global gene copy number variation (CNV) as a common form of genetic variation in human DNA. His ... She is particularly interested in how genes shape risk for PTSD. Much of this work is done through the PTSD working group of ... He also has a longstanding effort in the mapping of genes for Crohn's disease and ulcerative colitis where he helped found and ... He has published over 800 articles, has received a number of national and international awards for his work, is a member of the ...
  http://www.med.unc.edu/pgc/about-us/people-1/workgroup-chairs
*  The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk -...
We thank Jennifer Engle and Ruth Jarbadan for aid in DNA extraction and sample preparation. ... The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk. Authors ... To study the effect of UGT2B17 and UGT2B28 copy number variation (CNV) on CRC risk, 665 Caucasian CRC cases and 621 Caucasian ... A copy number variation in PKD1L2 is associated with colorectal cancer predisposition in korean population, International ...
  http://onlinelibrary.wiley.com/doi/10.1002/cncr.28009/abstract
*  Modeling Gene Regulation in Liver Hepatocellular Carcinoma with Random Forests
Additionally, we downloaded DNA copy-number variation (GISTIC2-processed) and DNA methylation levels from Firehose database ( ... Changes in gene expression can be associated with copy-number variation (CNV) as well as with more complex patterns of ... gene expression in liver hepatocellular carcinoma with a statistical model that incorporates copy-number variation and DNA ... proposed a lasso regularized regression model that incorporates copy-number variation, DNA methylation levels, TF, and miRNA- ...
  https://www.hindawi.com/journals/bmri/2016/1035945/
*  New Gene Study of ADHD Points to Defects in Brain Signalin... ( PHILADELPHIA Dec. 4 2011 -- Ped...)
Gene,Study,of,ADHD,Points,to,Defects,in,Brain,Signaling,Pathways,medicine,advanced medical technology,medical laboratory ... The researchers searched for copy number variations (CNVs), which are deletions or duplications of DNA sequences. They then ... "Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit ... All the genes were members of the glutamate receptor gene family, with the strongest result in the gene GMR5. Glutamate is a ...
  http://www.bio-medicine.org/medicine-technology-1/New-Gene-Study-of-ADHD-Points-to-Defects-in-Brain-Signaling-Pathways-22617-1/
*  Regulation of the metabolic changes in Chronic Fatigue Syndrome: role of CNV
... known as Copy Number Variation (CNV). CNV may be inherited (parent to child) or caused by the environment (epigenetics). Our ... hypothesize that a reason for the change in the metabolism in CFS/ME may be a change in the number of genes at the genomic DNA ... We extended the gene expression project involving a larger number of patients and more comprehensive Affymetrix Gene ... Our preliminary data using gene expression Affymetrix U133 plus 2 microarrays showed that genes mapped to 132 metabolic ...
  http://www.nova.edu/academic-affairs/faculty-research-grant/winners1314/chronic-fatigue-syndrome1.html
*  Academic Programs Faculty - Last Initial T - Wake Forest School of Medicine
Proto-Oncogenes; DNA Copy Number Variations; Genetic Markers; Prostatectomy; Genes, p16 Academic: 336-716-7975. Department: 336 ...
  http://www.wakehealth.edu/School/FacultySR.htm?st=T&li=T&ft=R
*  Frontiers | Quantification of fungal abundance on cultural heritage using real time PCR targeting the β-actin gene |...
... which is known to appear as a single-copy gene in fungi. To this end, five different indoor thermal insulation materials ... these techniques have many drawbacks that lead to an underestimation of the cell numbers and do not provide a comprehensive ... which is known to appear as a single-copy gene in fungi. To this end, five different indoor thermal insulation materials ... rapid and reliable tool to detect and quantify fungal abundance using the β-actin gene, ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2014.00262/full
*  Illumina Introduces the HiSeq X™ Ten Sequencing System | Business Wire
... copy number variation analysis, methylation studies, gene expression profiling, and low-multiplex analysis of DNA, RNA, and ... The HiSeq X Ten System is ideal for population-scale projects focused on the discovery of genotypic variation to understand and ... The HiSeq X Ten System is ideal for population-scale projects focused on the discovery of genotypic variation to understand and ... Building on the proven performance of Illumina SBS technology, HiSeq X Ten utilizes a number of advanced design features to ...
  https://www.businesswire.com/news/home/20140114006291/en/Illumina-Introduces-HiSeq-X%E2%84%A2-Ten-Sequencing-System
*  Illumina Introduces TruSeq® Stranded mRNA and Total RNA Sequencing Sample Preparation Solutions - AOL Finance
... copy number variation analysis, methylation studies, gene expression profiling, and low-multiplex analysis of DNA, RNA, and ... "These types of samples are a rich source of information on changes in gene expression and regulation associated with cancer and ... The new reagent kits enable researchers to quickly and easily conduct gene expression studies that provide a complete view of ... Additionally, the company recently introduced TruSeq DNA HT Sample Preparation Kits, which contain 96 unique index pairs pre- ...
  https://www.aol.com/2012/09/18/illumina-introduces-truseq-stranded-mrna-and-total/
*  Dr. Stanislaw Burzynski's "personalized gene-targeted cancer therapy": Can he do what he claims for cancer? - Science-Based...
... is used to examine gene copy number variation in the tumor. Polymerase Chain Reaction (PCR) or DNA sequencing is used to ... a test designed to measure gene copy number and thus detect amplified genes. The result is a report like this example report ... based on a commercially available but not FDA-approved gene expression profile test and calls it "personalized gene-targeted ... Stanislaw Burzynski's "personalized gene-targeted cancer therapy": Can he do what he claims for cancer?. David Gorski on ...
  https://sciencebasedmedicine.org/stanislaw-burzynskis-personalized-gene-targeted-cancer-therapy/
*  Illumina To Announce First Quarter 2014 Financial Results On Tuesday, April 22, 2014 - TheStreet
... copy number variation analysis, methylation studies, gene expression profiling, and low-multiplex analysis of DNA, RNA and ... and marketer of life science tools and integrated systems for the analysis of genetic variation and function. We provide ...
  https://www.thestreet.com/story/12629919/1/illumina-to-announce-first-quarter-2014-financial-results-on-tuesday-april-22-2014.html