*  Patent US5200313 - Nucleic acid hybridization assay employing detectable anti-hybrid antibodies - Google Patents
A nucleic acid hybridization assay employing an immobilized or immobilizable polynucleotide probe selected to form DNA.RNA or ... A DNA probe is cloned into the vector which is then propagated in a bacterial host. Multiple RNA copies of the cloned DNA probe ... DNA sequence encoding the Machado-Joseph disease gene and uses thereof. US5876935 *. 8 Jan 1997. 2 Mar 1999. Dade Behring Inc. ... Publication number. 07188114, 188114, US 5200313 A, US 5200313A, US-A-5200313, US5200313 A, US5200313A. ...
  http://www.google.ca/patents/US5200313
*  Analysis of recent segmental duplications in the bovine genome | BMC Genomics | Full Text
Characterizing the impact of copy-number and single basepair variation for genes embedded within these regions will be a ... A high-resolution map of segmental DNA copy number variation in the mouse genome. PLoS Genet. 2007, 3: e3-10.1371/journal.pgen. ... At the gene level, for those duplicated genes or gene families in these mammals, both mutation (gene duplication, inactivation ... generating a great variation in gene number and content among extant mammals [39]. Similarly, gene duplication and inactivation ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-10-571
*  Gene duplication - Wikipedia
Lee JA, Lupski JR (October 2006). "Genomic rearrangements and gene copy-number alterations as a cause of nervous system ... It can be defined as any duplication of a region of DNA that contains a gene. Gene duplications can arise as products of ... Often the resulting genomic variation leads to gene dosage dependent neurological disorders such as Rett-like syndrome and ... If one copy of a gene experiences a mutation that affects its original function, the second copy can serve as a 'spare part' ...
  https://en.wikipedia.org/wiki/Gene_duplication
*  Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. - Full Text...
Genetic: Genetic study of DNA copies Gene expression profiling, DNA copy number variation ... Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. (GENOMGUS). ... The purpose of this study is to describe DNA copy number variations and gene expression profiles of bone marrow plasma cells of ... Large Scale Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From Monoclonal ...
  https://clinicaltrials.gov/ct2/show/NCT01079429
*  Julie M. Gastier-Foster, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio
Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays. BMC Genomics. Vol. 8, no. ... Gene-resolution analysis of DNA copy number variation using oligonucleotide expression microarrays. BMC Genomics. Vol. 8, no. ... Variability in interpreting and reporting copy number changes by array-based technology in clinical laboratories. Genet Med. ... Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D. Ann Neurol. Vol. 68 ...
  https://www.nationwidechildrens.org/julie-m-gastier-foster
*  FAM76A - Wikipedia
"Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines". The ... who had a copy number gain from 1p36.1-35, showed similar delays. In another case report, a patient with a copy number loss of ... Copy number gain/loss of FAM76A-along with neighboring genes-has shown to produce detrimental phenotypes. In one case report, a ... Genes that flank FAM76A on the telomeric side include IFI6, CHMP1AP1, and RPEP3, while genes that flank FAM76A on the ...
  https://en.wikipedia.org/wiki/FAM76A
*  Using expression arrays for copy number detection: an example from E. coli | BMC Bioinformatics | Full Text
We have developed a robust and flexible methodology for high-resolution analysis of DNA copy number of whole genomes, using ... Microarray-based comparative genomic hybridization (array CGH) has enabled the high-resolution detection of DNA copy number ... Copy number is obtained from fluorescence signals after processing with novel normalization, spatial artifact correction, data ... The sequencing of many genomes and tiling arrays consisting of millions of DNA segments spanning entire genomes have made high- ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/1471-2105-8-203
*  LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal...
Variation in DNA copy number and gene expression among primary ovarian tumors and associated abdominal deposits Supp Fig S2. ... Variation in DNA copy number among primary ovarian tumors and associated abdominal deposits. A, copy number genome in line view ... Regions of discrete copy number amplification Supp Table S6. Regions of discrete copy number deletion ... D, differential copy number and gene expression plots of the primary tumor and most distant abdominal deposit for patient 6496. ...
  http://cancerres.aacrjournals.org/content/72/16/4060.figures-only
*  Archive - Public defence of a PhD - University of Antwerp
Nov Study of copy number and DNA sequence variations in candidate genes for obesity PhD defence Evi Aerts - Department of ... Jan The role of vasopressin (Avpr1a) and oxytocin (OXTR) receptor gene variation as a proximate base for inter-and ... Sep Next-generation sequencing of genes for hereditary hearing loss: from gene identification to diagnostic implementation PhD ... Apr Sources of individual variation in immune traits on a within individual, a between individual and a local/population scale ...
  https://www.uantwerpen.be/en/research-and-innovation/phd/public-phd-defences/archive/
*  USP6 | Cancer Genetics Web
Identification of genes with correlated patterns of variations in DNA copy number and gene expression level in gastric cancer. ... A set of 158 genes showing Pearson correlation coefficients over 0.6 between DNA copy number changes and mRNA expression level ... To identify DNA copy number changes that had a direct influence on mRNA expression in gastric cancer, cDNA microarray-based ... To identify gene copy number alterations predictive of metastatic potential or aggressive transformation, array-based ...
  http://www.cancerindex.org/geneweb/USP6.htm
*  The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants | CMAJ
... from variations in the DNA sequence, copy number of genes, its organization and epigenetic changes. Some variations may be ... Data were also analyzed for copy number and other structural variations (copy number variants [CNVs]/structural variants [SVs ... Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genes. Am J Med Genet B ... A discovery resource of rare copy number variations in individuals with autism spectrum disorder. G3 (Bethesda) 2012;2:1665-85. ...
  http://www.cmaj.ca/content/190/5/E126.full.print
*  Analysis of Population-Genetic Properties of Copy Number Variations | SpringerLink
... copy number variations (CNVs) which comprise insertions, deletions and duplications of... ... Diversity and population-genetic properties of copy number variations and multicopy genes in cattle. DNA Res 23(3):253-262 ... Perry GH, Dominy NJ, Claw KG et al (2007) Diet and the evolution of human amylase gene copy number variation. Nat Genet 39(10): ... Analysis of Population-Genetic Properties of Copy Number Variations. In: Bickhart D. (eds) Copy Number Variants. Methods in ...
  https://link.springer.com/protocol/10.1007/978-1-4939-8666-8_14
*  Rare Kidney Disease Caused by Copy Number Variation
Copy number variations are large chunks of DNA either duplicated or deleted from our genes when passed down to children. CFHR5 ... identified an inherited kidney disorder caused by a copy number variation of the gene CFHR5. ... "It is a potentially serious disease, but easily detectable from a simple DNA or blood test." Although scientists do not yet ... Why Only One Identical Twin is at Risk for Autoimmune Diseases Rare Mutation Reduces Sensitivity to Pain New Gene Therapy ...
  http://www.medindia.net/news/Rare-Kidney-Disease-Caused-by-Copy-Number-Variation-73184-1.htm
*  DNA Losses, Gains Play Role in Autism Disorders | Medpage Today
An international team of researchers has found that insertions and deletions of DNA in a host of genes play a role in autism ... So-called "copy number variations" -- insertions or deletions of DNA -- that interfere with genes are 19% more common in people ... "These gene copy variations are turning up in a number of disorders so it is no surprise that they may be involved in autism as ... These copy number variations are 69% more common when they interfere with genes already implicated in autism. ...
  https://www.medpagetoday.com/neurology/autism/20574
*  CapitalBio to Provide Roche NimbleGen Array Services in China | GenomeWeb
... comparative genomic hybridization and copy number variation, and DNA methylation services to Asian customers. ... Beijing-based CapitalBio has been certified to offer NimbleGen gene expression, ... The Same Genes Keep Getting Asked to Prom. Researchers find that historical factors influence which genes are the most highly ... comparative genomic hybridization and copy number variation, and DNA methylation services to Asian customers. ...
  https://www.genomeweb.com/arrays/capitalbio-provide-roche-nimblegen-array-services-china
*  ADHD, Autism May Sometimes Share Gene... ( By Jenifer Goodwin HealthDay Rep...)
Instead of finding one or more ADHD or autism genes research is b... What we are beginning to understand is that genes don't ... code for diso...,ADHD,,Autism,May,Sometimes,Share,Gene,Mutations,medicine,medical news today,latest medical news,medical ... This means that on certain chromosomes, bits of DNA were deleted or duplicated. The copy number variations were on genes ... had identifiable abnormalities known as copy number variations, which are changes in the DNA that cause an abnormal number of ...
  http://www.bio-medicine.org/medicine-news-1/ADHD--Autism-May-Sometimes-Share-Gene-Mutations-84299-1/
*  John R. Pringle | Stanford Medicine Profiles
... products of erroneous DNA repair events that can lead to further genome rearrangements and extended gene copy number variations ... To identify other genes that may be involved in these processes, we screened yeast genomic DNA libraries for heterologous genes ... Starting with a strain deleted for the chromosomal copy of MSB1 but containing MSB1 on a high-copy-number plasmid, mutants were ... MOLECULAR ANALYSIS OF SACCHAROMYCES-CEREVISIAE CHROMOSOME-I - ON THE NUMBER OF GENES AND THE IDENTIFICATION OF ESSENTIAL GENES ...
  https://med.stanford.edu/profiles/john-pringle
*  Familial Hypercholesterolemia (FH)
... with frequent occurrence of large gene rearrangements (DNA copy number variations, deletions and insertions). Selected ... Genetic mutation screening for the LDLR, PCSK9 and LDLRAP1 genes can be done using DNA extracted from white blood cells and PCR ... Patients with one abnormal copy of the LDLR gene (heterozygotes) may have premature cardiovascular disease at 30-50 years of ... DNA-based evidence of a mutation in the LDLR or other FH related gene. ...
  http://www.psychiatryadvisor.com/labmed/familial-hypercholesterolemia-fh/article/612490/
*  Radium-223 Inhibits Osseous Prostate Cancer Growth by Dual Targeting of Cancer Cells and Bone Microenvironment in Mouse Models ...
However, the impact of genetic alterations, such as mutations in or copy-number variation of DNA repair mechanism genes, on the ... The numbers above the bars represent the number of mice with visceral metastasis per the number of mice in a respective group. ... For example, publicly available genomic data in LNCaP cells reveal several defects in DNA repair genes, such as ATM and BRCA2 ( ... The number of osteoblasts relative to bone surface in mice bearing LuCaP 58 tumors (n = 11, P = 0.0014). H, The number of ...
  http://clincancerres.aacrjournals.org/content/23/15/4335.long
*  Variations in gut microbiota and fecal metabolic phenotype associated with Fenbendazole and Ivermectin Tablets by 16S rRNA gene...
Dna Copy Number Variations. Stretches of genomic DNA that exist in different multiples between individuals. Many copy number ... DNA sequencing DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. During DNA ... Variations in gut microbiota and fecal metabolic phenotype associated with Fenbendazole and Ivermectin Tablets by 16S rRNA gene ... A form of interference microscopy in which variations of the refracting index in the object are converted into variations of ...
  https://www.bioportfolio.com/resources/pmarticle/2003507/Variations-in-gut-microbiota-and-fecal-metabolic-phenotype-associated-with-Fenbendazole-and.html
*  Frontiers | The Genetics of Reading Disabilities: From Phenotypes to Candidate Genes | Psychology
... understanding of epigenetic mechanisms whereby environmental events may alter behavioral expression of genetic variations. A ... emerging research on gene-brain relationships; and (d) current understanding of epigenetic mechanisms whereby environmental ... rapidly expanding research on genetic heterogeneity and gene candidates for dyslexia and other reading disabilities; (c) ... emerging research on gene-brain relationships; and (d) current ... events may alter behavioral expression of genetic variations. A ...
  https://www.frontiersin.org/articles/10.3389/fpsyg.2012.00601/full
*  Organizing Committee
... including DNA copy number variation, gene expression, microRNA, and protein analysis. His research in these pathways has led ... His research program focuses on MGMT and the regulation of repair genes, DNA damage signaling, genotoxicity, cancer formation ... DNA repair and genotoxic signaling Mechanisms of chemical carcinogenesis Mechanisms of anticancer drugs and DNA damage- ... At CSHL, her work has focused on understanding the epigenetic regulation of DNA repair. She is also an academic tutor at the ...
  https://epigenetics.geneticconferences.com/organizing-committee.php
*  Workgroup Chairs
In 2004, his team co-discovered global gene copy number variation (CNV) as a common form of genetic variation in human DNA. His ... She is particularly interested in how genes shape risk for PTSD. Much of this work is done through the PTSD working group of ... He also has a longstanding effort in the mapping of genes for Crohn's disease and ulcerative colitis where he helped found and ... He has published over 800 articles, has received a number of national and international awards for his work, is a member of the ...
  http://www.med.unc.edu/pgc/about-us/people-1/workgroup-chairs
*  The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk -...
We thank Jennifer Engle and Ruth Jarbadan for aid in DNA extraction and sample preparation. ... The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk. Authors ... To study the effect of UGT2B17 and UGT2B28 copy number variation (CNV) on CRC risk, 665 Caucasian CRC cases and 621 Caucasian ... A copy number variation in PKD1L2 is associated with colorectal cancer predisposition in korean population, International ...
  http://onlinelibrary.wiley.com/doi/10.1002/cncr.28009/abstract