Patente US5348876 - IgG3 antibodies with shortened hinge region and a complement activation test - Google Patentes
... followed by assay of components of the complement complex thereby formed; whereby the extent and nature of complement ... Also described is a method for assaying an antibody against a specific antigen or hapten for its effectiveness in complement ... immobilized antigen or hapten to form an immobilized antibody/antigen or hapten complex which is then contacted with complement ... Bindon et al., "Human Monoclonal IgG Isotypes Differ in Complement Activating Function at the Level Of C4 as Well as C1q".. ...http://www.google.es/patents/US5348876?dq=flatulence
Patent US6664052 - Genetic polymorphism in a complement receptor - Google Patents
Complement receptors CR1 and CR2 are active in the immune response and autoimmune diseases. The susceptibility and severity of ... A method and a package for identifying single nucleotide polymorphisms in complement receptor is useful in identifying ... autoimmune disease is determined by genotyping or phenotyping an individual for complement receptor. ... hereditary limitations in the host's complement receptor genes through delivery of a translatable complement receptor gene to a ...http://www.google.com/patents/US6664052?dq=6,073,142
Complement receptor 2 - Wikipedia
1987). "A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32". J. ... of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 ... The CR2 gene of primates produces only the smaller isoform, CR2; primate complement receptor 1, which recapitulates many of the ... 1989). "Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human ...https://en.wikipedia.org/wiki/Complement_receptor_2
The molecular genetics of human complement C4: implications for mapping MHC disease susceptibility genes
... the C4A and C4B genes.Comparison of the C4 gene sequences representing the same C4 allotype revealed that most C4 allotypes are ... The gamma block contains approximately 20 known genes including the complement C4 genes. The gamma block can contain between I ... This high degree of homology and the presence of up to 3 C4 genes on any MHC haplotype makes PCR separation of the C4 genes ... To conclude, the present study adds to our knowledge of the C4 gene polymorphism, provides insights into MHC and C4 gene ...https://espace.curtin.edu.au/handle/20.500.11937/1013
Hydralazine binds covalently to complement component-C4: Different reactivity of C4A AND C4B Gene-Products - Kingston...
Hydralazine binds covalently to complement component-C4: Different reactivity of C4A AND C4B Gene-Products ... Hydralazine binds covalently to complement component-C4: Different reactivity of C4A AND C4B Gene-Products. FEBS letters, 184(2 ...http://eprints.kingston.ac.uk/19436/
Items by Morley, Professor Bernard J - Opus
Regulation of transcription of the TATA-less human complement component C4 gene. The Journal of Immunology. , 160, pp. 4353- ... Tissue specific transcriptional control of the human complement C4 gene is directed by the first 126bp of the promoter. ... The organization of the human complement factor I gene (IF): a member of the serine protease gene family. Genomics. , 24 (1), ... Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes. Genes ...http://opus.bath.ac.uk/view/person_id/5066.date.html
Complement and c4 null alleles in severe chronic adult periodontitis.
Complement factor C4 is a nearby, polymorphic, functionally relevant gene region. Although associated with chronic mucosal ... Changes in complement levels may reflect chronic, recurring inflammation. C4 gene deficiencies are associated with ... C4 allotypes and C4 gene numbers in 37 patients with severe chronic periodontitis and in 150 voluntary controls. Plasma levels ... Partial C4 gene deficiencies were more frequent in patients than in controls (odds ratio 2.4, 95% confidence interval 1.1-5.5, ...http://umu.diva-portal.org/smash/record.jsf?pid=diva2:157113
Immunogenetics | Springer for Research & Development
Molecular Analysis of Complement Component C4 Gene Copy Number Alison S. L. Castley, O. Patricia Martinez ... It is now recognized that this diverse range of gene systems involved in the control of the immune response have been shown to ... As a result many new molecular and cellular methods have been developed for identifying these genes and their polymorphisms, ...https://rd.springer.com/book/10.1007/978-1-61779-842-9
HLA A1-B8-DR3-DQ2 - Wikipedia
July 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers and HSP ... one expects 1/2 of adjacent genes to have new gene-alleles, unless the genes are small and very close together. This dynamic ... More recent studies indicate that risk lies solely between B8-DR3 region, this includes 3 class I genes, the class III gene ... There are many genes that lie on either side of HLA-B, TNF alpha is over expressed. Closer to DR3, C4A is null in B8-DR3 ...https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls -...
Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.. * ... Genetic Variation of the Fc Gamma Receptor 3B Gene and Association with Rheumatoid Arthritis. *Rute B. Marques, Mohamed M. ... CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus.. *M ... Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. ...https://www.semanticscholar.org/paper/Genome-wide-association-study-of-copy-number-in-of-Craddock-Hurles/487bdf4060657eb937d5dba14941fb1694d6ac1e
Frontiers | HERV-K(HML-2), the Best Preserved Family of HERVs: Endogenization, Expression, and Implications in Health and...
We will then focus on the genes and proteins encoded by HERV-K(HML-2) as well as inactivation of these proviruses by ... We will then focus on the genes and proteins encoded by HERV-K(HML-2) as well as inactivation of these proviruses by ... C4), located in the complement C4 gene cluster. Nucleic Acids Res (1994) 22(24):5211-7. doi:10.1093/nar/22.24.5211 ... Endogenous retroviral LTRs as promoters for human genes: a critical assessment. Gene (2009) 448(2):105-14. doi:10.1016/j.gene. ...https://www.frontiersin.org/articles/10.3389/fonc.2013.00246/full
Human Complement C4 ELISA Kit | Abcam
Abcam's Complement C4 ELISA Kit (ab108825) suitable for Cell culture supernatant, Saliva, Milk, Urine, Cerebral Spinal Fluid in ... Entrez Gene: 720 Human. *Entrez Gene: 721 Human. *Entrez Gene: 100293534 Human ... A Complement C4 specific antibody has been precoated onto 96-well plates and blocked. Standards or test samples are added to ... Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla ...http://www.abcam.com/human-complement-c4-elisa-kit-ab108825.html
RNF5 - Wikipedia
"Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci". Nucleic Acids ... E3 ubiquitin-protein ligase RNF5 is an enzyme that in humans is encoded by the RNF5 gene. The protein encoded by this gene ... expression and mapping of a novel RING-finger gene (RNF5), a human homologue of a putative zinc-finger gene from Caenorhabditis ... 2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. ...https://en.wikipedia.org/wiki/RNF5
Browse our C4B ELISA Kits
... complement component 4B (Childo blood group) , complement C4-like protein , complement component 4, gene 2 ... basic complement C4 , complement C4-B , complement C4B1a , complement component 4A , complement component 4B , complement ... Increased transcription of the complement C4 gene in the Rag1 (show RAG1 ELISA Kits)(-/-) intestine. ... Human Complement Component 4B (C4B) interaction partners * results suggest that the C4B gene number associates positively with ...http://www.antibodies-online.com/complement-system-pathway-11/c4b-elisa-kit-29426/
Site-specific reverse splicing of a HEG-containing group I intron in ribosomal RNA.
7576718 - Length polymorphism of the human complement component c4 gene is due to an ancient retr.... 2468578 - Complete ... Genes, rRNA. Introns*. Molecular Sequence Data. Mutagenesis, Insertional. Myxomycetes / genetics. Nucleic Acid Conformation. ... The group I-like ribozyme DiGIR1 and the group I splicing ribozyme DiGIR2 as well as the I-DirI homing endonuclease gene (HEG) ... The location and orientation of the 786 nt I-DirI homing endonuclease gene (HEG), within the distal region of the DiGIR2 P2 ...http://www.biomedsearch.com/nih/Site-specific-reverse-splicing-HEG/15817568.html
C4A - Wikipedia
Complement C4-A is a protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement factor ... "Heterogeneity of human C4 gene size. A large intron (6.5 kb) is present in all C4A genes and some C4B genes". Immunogenetics. ... Carroll MC, Porter RR (Jan 1983). "Cloning of a human complement component C4 gene". Proceedings of the National Academy of ... "Entrez Gene: C4A complement component 4A (Rodgers blood group)". Dawkins RL, Uko G, Christiansen FT, Kay PH (Sep 1983). "Low C4 ...https://en.wikipedia.org/wiki/C4A
Mutation screening in British 21-hydroxylase deficiency families and development of novel microsatellite based approaches to...
Mapping of steroid 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex ... Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. Proc ... Sinnott PJ, Costigan C, Dyer PA, Harris R, Strachan T. Extended MHC haplotypes and CYP21/C4 gene organisation in Irish 21- ... Sinnott PJ, Livieri C, Sampietro M, Marconi M, Harris R, Severi F, Strachan T. CYP21/C4 gene organisation in Italian 21- ...http://pubmedcentralcanada.ca/pmcc/articles/PMC1734295/?lang=en-ca
anti-C4B Primary Antibodies
... complement component 4B (Childo blood group) , complement C4-like protein , complement component 4, gene 2 ... basic complement C4 , complement C4-B , complement C4B1a , complement component 4A , complement component 4B , complement ... Increased transcription of the complement C4 gene in the Rag1 (zeige RAG1 Antikörper)(-/-) intestine. ... Human Complement Component 4B (C4B) Interaktionspartner * results suggest that the C4B gene number associates positively with ...https://www.antikoerper-online.de/komplementsystem-pathway-11/c4b-antibody-29425/
Ghent University Academic Bibliography
Genome-wide copy number variation scan identifies complement component C4 as novel susceptibility gene for Crohn's disease ...https://biblio.ugent.be/publication?q=author%3D%22Georges%2C+Michel
Anaphylatoxin - Wikipedia
Ogata, R. T.; Rosa, P. A.; Zepf, N. E. (1989). "Sequence of the gene for murine complement component C4". The Journal of ... that are produced as part of the activation of the complement system. Complement components C3, C4 and C5 are large ... coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as ... This term is reserved only for fragments of the complement system. C3, C4A, C4B, C4B-1, C5, FBLN1, FBLN2 Allergy Anaphylatoxin ...https://en.wikipedia.org/wiki/Anaphylatoxin
Annals of Human Genetics - Volume 52, Issue 2 - May 1988 - Wiley Online Library
Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes ( ... The assignment of the human gene coding for complement C5 to chromosome 9q22-9q33. (pages 111-116). S. J. JEREMIAH, L. F. WEST ... Restriction fragment length polymorphisms of the complement component C4 loci on chromosome 6: studies with emphasis on the ... The human alpha-1-antitrypsin-related sequence gene: isolation and investigation of its expression (pages 151-160). G. D. ...http://onlinelibrary.wiley.com/doi/10.1111/ahg.1988.52.issue-2/issuetoc
STK19 - Wikipedia
1996). "Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype". Immunogenetics. 43 (4): ... are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338-47. ... "Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes ... "Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex ...https://en.wikipedia.org/wiki/STK19
A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
September 2008). "Autoimmune-associated HLA-B8-DR3 haplotypes in Asian Indians are unique in C4 complement gene copy numbers ... A multigene haplotype is a set of inherited alleles covering several genes, or gene-alleles. Long haplotypes, like A30::DQ2, ... Müller CR, Ehninger G, Goldmann SF (January 2003). "Gene and haplotype frequencies for the loci hLA-A, hLA-B, and hLA-DR based ... Ayed K, Ayed-Jendoubi S, Sfar I, Labonne MP, Gebuhrer L (October 2004). "HLA class-I and HLA class-II phenotypic, gene and ...https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
Frequencies of Certain Complement Protein Alleles and Serum Levels of Anti-Heat-Shock Protein Antibodies in Cerebrovascular...
Allotypes of the 2 genes encoding the fourth component of complement, C4, and that encoding the third component of complement, ... the silent allele of 1 of the 2 genes encoding C4, a component of the complement system.9 The C4B*Q0 allele was found with ... Study of Polymorphisms of the C4A, C4B, and C3 Genes. C4 typing was performed according to Awdeh and Alper19 with the ... Phenotyping of human complement component C4. Biochem J. 1986;239:763-767. ...http://stroke.ahajournals.org/content/31/11/2648
WikiGenes - Immunodiffusion
Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... Complete absence of the third component of complement in man. Ballow, M., Shira, J.E., Harden, L., Yang, S.Y., Day, N.K. J. ... Activation of the classical pathway of complement by Hageman factor fragment. Ghebrehiwet, B., Silverberg, M., Kaplan, A.P. J. ...https://www.wikigenes.org/e/mesh/e/1313.html