Programming of mouse obesity by maternal exposure to concentrated ambient fine particles | Particle and Fibre Toxicology | Full...
4o). In addition, we did not observe any significant effect of maternal exposure to CAP on the hypothalamic gene expression of ... findings together strongly suggest that ambient PM2.5 pollution is an environmental stressor that programs cardiometabolic ... Maternal exposure to CAP increases adiposity in adult offspring. To further document the effects of maternal exposure to CAP on ... Maternal exposure to CAP alters offspring birth weight and growth trajectory. To assess the long-term effects of maternal ...https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-017-0201-9
Maternal effect - Wikipedia
Diet Exposure In Utero on the Obesogenic and Diabetogenic Traits Through Epigenetic Changes in Adiponectin and Leptin Gene ... "Maternal undernutrition and cardiometabolic disease: a Latin American perspective". BMC Medicine. 13: 41. doi:10.1186/s12916- ... Since these genes are expressed in the (maternal) nurse cells and not in the oocyte or fertilised embryo, the maternal genotype ... This is a maternal, not an adaptive maternal effect. In order to be an adaptive maternal effect, the mother's environment would ...https://en.wikipedia.org/wiki/Maternal_effect
Exposure to Maternal Diabetes in Utero and DNA Methylation Patterns in the Offspring
... which are known to be associated with cardiometabolic traits. Gene enrichment analysis of the top 84 genes, each with p,=0.005 ... Multiple candidate genes and the UPS were identified for future study as possible links between exposure to maternal ... on the impact of exposure to maternal diabetes ,italic,in utero,/italic, on VCAM-1 levels in the offspring. ... more definitively investigate the potential for mediation of the effect of exposure to maternal diabetes ,italic,in utero,/ ...https://www.infona.pl/resource/bwmeta1.element.-psjd-doi-10_2478_immun-2013-0001
Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure...
Prenatal effects of maternal smoking on daughters' smoking: nicotine or testosterone exposure? Am J Public Health. 1999;89:1377 ... Effect of prenatal testosterone (T) exposure on mRNA expression of major steroidogenic genes in adrenals of adult female rats. ... contributes to several features of the programmed cardiometabolic phenotype (i.e., hypertension, insulin resistance, ... Adrenal Steroidogenic and Angiotensin II Receptor Gene Expression. To address the effect of prenatal testosterone exposure on ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5029475/
Glucocorticoid excess and the developmental origins of disease: two decades of testing the hypothesis--2012 Curt Richter Award...
... is associated with cardiometabolic disease and brain disorders in adulthood. The adaptive changes made by the fetus in response ... Prenatal Exposure Delayed Effects*. Stress, Physiological / physiology*. Stress, Psychological / physiopathology*. Grant ... Maternal-Fetal Exchange. Metabolic Syndrome X / embryology, etiology, physiopathology. Models, Biological*. Neuroendocrinology ... In a recent study we showed that alterations in DNA methylation at genes important in regulating cortisol levels, tissue ...http://www.biomedsearch.com/nih/Glucocorticoid-excess-developmental-origins-disease/22998948.html
Abstract MP59: Associations of Maternal Pre-pregnancy Body Mass Index and Gestational Weight Gain with Offspring Longitudinal...
Genotyping of mothers and offspring was carried out for 180 candidate genes related to cardio-metabolic outcomes. We created ... genetic propensity scores using a subset of 388 SNPs from 53 adiposity-related genes that were predictive of the exposures and ... Mapping genes underlying these associations with longitudinal change in BMI may potentially lead to targeted intervention ... Conclusions This study points to the strong relationship between maternal excess weight and weight gain in pregnancy with ...http://circ.ahajournals.org/content/127/Suppl_12/AMP59
Journal.pone.0035907 | Malnutrition | Fetus
Black RE (2008) Maternal and child undernutrition: global and regional exposures and health consequences.who. et al. Am J Clin ... 2011) Epigenetic gene promoter methylation at birth is associated with child's later adiposity. 2001: systematic analysis of ... We further propose that survivors of kwashiorkor will have a differential and lesser risk of obesity and its cardio-metabolic ... 2008) Maternal and Child Undernutrition Study Group. Gluckman PD. Badaloo AV. 3. et al. Walker SP. Forrester T. Reid M. ...https://es.scribd.com/document/247908189/Journal-pone-0035907
Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275...
... primates have shown global and gene specific alterations in DNA methylation and histone modifications after maternal exposure ... Impact of maternal obesity on offspring obesity and cardiometabolic disease risk. Reproduction2010;140:387-98. ... Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk ... The mean maternal BMI value in the data was 22.86. Therefore we took the maternal BMI value of 23 as the reference value and ...http://www.bmj.com/content/347/bmj.f4539%20
Altered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of...
Maternal high estradiol (E2) is a major characteristic of IVF-ET and lasts throughout the first trimester of pregnancy. The ... The maternal high E2 environment in the first trimester is correlated with increased risk of thyroid dysfunction. Frozen ET ... Levels of serum T3, FT3, T4, FT4, and TSH and levels of maternal E2 at different stages of the first trimester were examined. ... The aim of this study is to investigate whether the high E2 maternal environment in the first trimester increases the risk of ...https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-014-0240-0
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Medicine, Issue 44, mammary gland morphology, terminal end buds, mammary cancer, maternal dietary exposures, pregnancy, ... Thus, C. elegans provides a powerful platform with which to assess the impact of mutations, gene knockdown, and/or chemical ... Medicine, Issue 83, dried blood spots (DBS), Biomarkers, cardiometabolic risk, Inflammation, standard precautions, blood ... Exposure to alcohol during development can result in a constellation of morphological and behavioral abnormalities that are ...https://www.jove.com/visualize/abstract/23383038/increased-childhood-mortality-arsenic-drinking-water-matlab
Metabolomic profiling in blood from umbilical cords of low birth weight newborns | Journal of Translational Medicine | Full Text
Wolff GL, Kodell RL, Moore SR, Cooney CA: Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a ... in LBW children can be epigenetically programmed by intrauterine exposures that have the capacity to modify fetal genes through ... Finding discriminatory metabolites in umbilical cord blood plasma from LBW newborns with a higher risk to develop cardio-metabolic ... No differences were observed in maternal age, maternal BMI, pregnancy weight gain or type of delivery between the two groups. ...https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-142
Seed Grants 2013 - University of Maryland, Baltimore
Maternal-infant immunization for protection against B. Pertussis. Marcela Pasetti (UMB School of Medicine, Center for Vaccine ... Gaucher disease (GD), the most frequent lipid storage disorder is caused by mutations in the glucocerebrosidase gene. Patients ... Though medical history and lifestyle are important risk factors for cardiometabolic diseases, it is also clear that ... The study brings together investigators with expertise in air pollution exposure modeling, and environmental, cardiovascular ...https://www.umaryland.edu/ord/resources-for-investigators/find-funding-opportunities/umb-umcp-seed-grant-program/seed-grants-2013/
Genomes and Genes, Research Grants, Publications, Scientific Experts, Articles from Journal RESEARCH, Research Topics about ... Genomes and Genes. *Nos2 products*B2 products*Agtr2 products*Adra2a products*HCN4 products*ADRB1 products*ADRB2 products*ACE ... Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, Massachusetts 02215, USA. Am J Epidemiol 173 ... Stress and Subclinical Cardio-Metabolic Disease in Police: A Longitudinal Study. John M Violanti; Fiscal Year: 2013 ...https://www.labome.org/topics/physical/natural/biological/circulatory/cardiovascular/cardiovascular/hemodynamic/heart-rate-20007.html
Tulane University - Publications - Epidemiology
Zhao J, * Zhu Y, Xiong M. Genome-wide gene-gene interaction analysis for next-generation sequencing. Eur J Hum Genet 2015 Jul ... Adverse maternal and perinatal outcomes in adolescent pregnancies: The Global Network's Maternal Newborn Health Registry study ... Multiple cardiometabolic risk factors in the Southern Cone of Latin America: a population-based study in Argentina, Chile, and ... Morales, M.E, Derbes, R.S., Ade, C.M., Ortego, J., Stark, J., Deininger, P.L., and Roy-Engel, A.M. (2016). Heavy metal exposure ...http://www2.tulane.edu/publichealth/epi/publications.cfm
Publications in the DSHealth doctoral thesis series | Research | University of Helsinki
Systemic Exposure to Oral Infections - a Cardiometabolic Risk. 61/2017 Hanna Dyggve. Doberman Hepatitis - Role of Immunological ... Nicotine Dependence - Identifying the Contribution of Specific Genes. 43/2017 Marjaana Pussila. Cancer-preceding Gene ... Importance of Maternal Behaviour and Circulating Oxytocin for Successful Lactation in Sows -Effects of Prepartum Housing ... Gene Expression and Functional Studies on Psoriatic Epidermis. 61/2016 Kristina Malinovskaja-Gomez. Transdermal Iontophoresis ...https://www.helsinki.fi/en/research/doctoral-education/doctoral-schools-and-programmes/doctoral-school-in-health-sciences/publications-in-the-dshealth-doctoral-thesis-series
Genomes and Genes, Research Grants, Species, Scientific Experts about obesity ... Genomes and Genes. *adiponectin products*leptin products*FTO products*Lep products*PPARgamma products*Lepr products*leptin ... Maternal obesity depresses essential fatty acid transport in the placenta. PERRIE F O'TIERNEY-GINN; Fiscal Year: 2012 ... that in utero and early developmental exposures to environmental chemicals may play a role in the development of obesity and ...http://labome.org/topics/diseases/nutritional/nutrition/overnutrition/obesity-8302.html
Frontiers | The Elevated Susceptibility to Diabetes in India: An Evolutionary Perspective | Public Health
Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of ... genes related to energy/lipid metabolism represent one of three key groups of genes that show unique South Asian alleles or ... Non-linear relationship between birthweight and cardiometabolic risk factors in Chinese adolescents and adults. Diabet Med ( ... Beyond maternal size, various maternal micronutrient deficiencies have been shown to limit fetal weight gain (130). Recent work ...https://www.frontiersin.org/articles/10.3389/fpubh.2016.00145/full
UCLA Career Development Program in Cancer Prevention and Control Research - Roshan Bastani
Lentiviral Mediated Gene Transfer to Kidney. Recently added grants:. *Improving maternal and child health through prenatal ... 2015) Retinoblastoma and ambient exposure to air toxics in the perinatal period. J Expo Sci Environ Epidemiol 25:182-6 ... Associations with Cardiometabolic Disease Risk Factors. J Acad Nutr Diet 116:1387-94 ... 2015) Maternal diet during pregnancy and unilateral retinoblastoma. Cancer Causes Control 26:387-97 ...http://grantome.com/grant/NIH/R25-CA087949-14
Impact of Air Pollution on Vitamin D Status and Related Health Consequences | IntechOpen
... decrease of apoptosis and cell-cycle associated genes' expression. In turn animals with vdr gene knock-out were shown to ... First of all, it reflects total vitamin D derived from dietary intake and sunlight exposure as well as the conversion of ... 2010Low maternal vitamin D status and fetal bone development: cohort study. Journal of Bone and Mineral Research, 2511419PMID: ... 2010Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis, Maturitas, 653225236PMID: 20031348 ...https://www.intechopen.com/books/the-impact-of-air-pollution-on-health-economy-environment-and-agricultural-sources/impact-of-air-pollution-on-vitamin-d-status-and-related-health-consequences/
NIAAA Director's Report on Institute Activities to The 121st Meeting of the National Advisory Council on Alcohol Abuse and...
Researchers used fruit flies to identify genes that regulate the behavioral effects of alcohol. They identified a mutant gene, ... Fetal alcohol exposure also increased the pups' alcohol intake and the behavioral response to alcohol odor. This work suggests ... Childhood sleep problems were also related to maternal ratings of internalizing and externalizing problems during adolescence ... associated with obesity and the cardiometabolic syndrome is an important medical problem affecting up to 20% of western ...https://www.niaaa.nih.gov/about-niaaa/our-work/advisory-council/directors-reports-council/niaaa-directors-report-institute-121
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... gene targeting, gene, genes, DNA, PCR, Primers, sequencing, animal model ... The exposure of pups to CSS can also be used as an early life stress that has long term effects on behavior, physiology, and ... Medicine, Issue 83, dried blood spots (DBS), Biomarkers, cardiometabolic risk, Inflammation, standard precautions, blood ... on maternal behavior, growth, and behavioral neuroendocrinology. This manuscript will describe this chronic social stress ...https://www.jove.com/visualize/abstract/22253852/social-determinants-long-lasting-insecticidal-hammock-use-among-ra
Maternal history of diabetes is associated with increased cardiometabolic risk in Chinese. Nutr Diabetes 2014;4:e112pmid: ... gene-gene and gene-environment interactions also contribute to the diabetes epidemic and should be considered to assess the ... In addition, exposure to maternal overnutrition, obesity, or diabetes during pregnancy also predisposes the offspring to ... gene-gene interactions, and gene-environment interactions and to translate novel findings to clinical applications. ...http://hw-f5-diabetes.highwire.org/content/67/1/3
Programming of Fetal Insulin Resistance in Pregnancies with Maternal Obesity by ER Stress and Inflammation
Importantly, cytokine-induced fetal programming has been proposed in rats after maternal exposure to both TNF-α and IL-6 ... R. Gaillard, E. A. Steegers, L. Duijts et al., "Childhood cardiometabolic outcomes of maternal obesity during pregnancy: The ... M. Kuro-o, Y. Matsumura, H. Aizawa et al., "Mutation of the mouse klotho gene leads to a syndrome resembling ageing," Nature, ... Figure 2: Proposed model of interaction among maternal obesity, ER stress, and insulin resistance. Maternal obesity is related ...https://www.hindawi.com/journals/bmri/2014/917672/
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Medicine, Issue 44, mammary gland morphology, terminal end buds, mammary cancer, maternal dietary exposures, pregnancy, ... Mutations in genes leading to severe diseases where there is a strong negative selection against the phenotype, such as ... Dietary pattern and its association with the prevalence of obesity and related cardiometabolic risk factors among Chinese ... A high rate of new mutations may in part explain why genetic studies have so far failed to identify many genes predisposing to ...https://www.jove.com/visualize/abstract/22905228/dietary-pattern-its-association-with-prevalence-obesity-related
Godfrey KM[au] - PubMed - NCBI
Maternal body mass index: Relation with infant respiratory symptoms and infections.. Rajappan A, Pearce A, Inskip HM, Baird J, ... Pregnancy Trimester-Specific Exposure to Ambient Air Pollution and Child Respiratory Health Outcomes in the First 2 Years of ... Body mass index trajectories in the first two years and subsequent childhood cardio-metabolic outcomes: a prospective multi- ... DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood. ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Godfrey+KM%5Bau%5D&dispmax=50